LOCUS       NM_194464               6211 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus inositol 1,4,5-triphosphate receptor associated 1
            (Irag1), mRNA.
ACCESSION   NM_194464
VERSION     NM_194464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6211)
  AUTHORS   Majer,M., Prueschenk,S. and Schlossmann,J.
  TITLE     Loss of PKGIbeta/IRAG1 Signaling Causes Anemia-Associated
            Splenomegaly
  JOURNAL   Int J Mol Sci 22 (11), 5458 (2021)
   PUBMED   34064290
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6211)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 6211)
  AUTHORS   Biswas,S., Kojonazarov,B., Hadzic,S., Majer,M., Bajraktari,G.,
            Novoyatleva,T., Ghofrani,H.A., Grimminger,F., Seeger,W.,
            Weissmann,N., Schlossmann,J. and Schermuly,R.T.
  TITLE     IRAG1 Deficient Mice Develop PKG1beta Dependent Pulmonary
            Hypertension
  JOURNAL   Cells 9 (10), 2280 (2020)
   PUBMED   33066124
  REMARK    GeneRIF: IRAG1 Deficient Mice Develop PKG1beta Dependent Pulmonary
            Hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6211)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   5  (bases 1 to 6211)
  AUTHORS   Chen,W., Oberwinkler,H., Werner,F., Gassner,B., Nakagawa,H.,
            Feil,R., Hofmann,F., Schlossmann,J., Dietrich,A., Gudermann,T.,
            Nishida,M., Del Galdo,S., Wieland,T. and Kuhn,M.
  TITLE     Atrial natriuretic peptide-mediated inhibition of microcirculatory
            endothelial Ca2+ and permeability response to histamine involves
            cGMP-dependent protein kinase I and TRPC6 channels
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (9), 2121-2129 (2013)
   PUBMED   23814119
REFERENCE   6  (bases 1 to 6211)
  AUTHORS   Antl,M., von Bruhl,M.L., Eiglsperger,C., Werner,M., Konrad,I.,
            Kocher,T., Wilm,M., Hofmann,F., Massberg,S. and Schlossmann,J.
  TITLE     IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation
            and thrombus formation
  JOURNAL   Blood 109 (2), 552-559 (2007)
   PUBMED   16990611
REFERENCE   7  (bases 1 to 6211)
  AUTHORS   Geiselhoringer,A., Werner,M., Sigl,K., Smital,P., Worner,R.,
            Acheo,L., Stieber,J., Weinmeister,P., Feil,R., Feil,S., Wegener,J.,
            Hofmann,F. and Schlossmann,J.
  TITLE     IRAG is essential for relaxation of receptor-triggered smooth
            muscle contraction by cGMP kinase
  JOURNAL   EMBO J 23 (21), 4222-4231 (2004)
   PUBMED   15483626
  REMARK    GeneRIF: conclude that cGMP-dependent relaxation of hormone
            receptor-triggered smooth muscle contraction essentially depends on
            the interaction of cGKI-IRAG with IP(3)RI
REFERENCE   8  (bases 1 to 6211)
  AUTHORS   Geiselhoringer,A., Gaisa,M., Hofmann,F. and Schlossmann,J.
  TITLE     Distribution of IRAG and cGKI-isoforms in murine tissues
  JOURNAL   FEBS Lett 575 (1-3), 19-22 (2004)
   PUBMED   15388327
REFERENCE   9  (bases 1 to 6211)
  AUTHORS   Schlossmann,J., Ammendola,A., Ashman,K., Zong,X., Huber,A.,
            Neubauer,G., Wang,G.X., Allescher,H.D., Korth,M., Wilm,M.,
            Hofmann,F. and Ruth,P.
  TITLE     Regulation of intracellular calcium by a signalling complex of
            IRAG, IP3 receptor and cGMP kinase Ibeta
  JOURNAL   Nature 404 (6774), 197-201 (2000)
   PUBMED   10724174
REFERENCE   10 (bases 1 to 6211)
  AUTHORS   Shaughnessy,J.D. Jr., Largaespada,D.A., Tian,E., Fletcher,C.F.,
            Cho,B.C., Vyas,P., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mrvi1, a common MRV integration site in BXH2 myeloid leukemias,
            encodes a protein with homology to a lymphoid-restricted membrane
            protein Jaw1
  JOURNAL   Oncogene 18 (12), 2069-2084 (1999)
   PUBMED   10321731
  REMARK    GeneRIF: Reports use of non-AUG (CUG) translation initiation codon
            in one of the transcript variants of MRVI1 gene in mouse and human.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159206.2, AK020536.1,
            AC184052.2 and AK141821.1.
            
            On Oct 22, 2013 this sequence version replaced NM_194464.2.
            
            Summary: This gene is a putative tumor suppressor gene that is
            frequently disrupted by mouse AIDS-related virus (MRV). The encoded
            protein participates in signaling by nitric oxide (NO) to inhibit
            intracellular calcium release and platelet aggregation in
            cardiovascular tissue. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Oct 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63407.1, AK157169.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC159206.2         134259-134661       c
            404-598             AK020536.1         2-196
            599-614             AC184052.2         194912-194927       c
            615-1235            AK020536.1         197-817
            1236-3616           AK141821.1         275-2655
            3617-6211           AC184052.2         133606-136200       c
FEATURES             Location/Qualifiers
     source          1..6211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.9 cM"
     gene            1..6211
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /note="inositol 1,4,5-triphosphate receptor associated 1"
                     /db_xref="GeneID:17540"
                     /db_xref="MGI:MGI:1338023"
     exon            1..449
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..598
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     CDS             539..3109
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /note="protein MRVI1; JAW1-related protein MRVI1; murine
                     retrovirus integration site 1 protein; inositol
                     1,4,5-triphosphate receptor-associated cGMP kinase
                     substrate; retroviral integration site 1; inositol
                     1,4,5-trisphosphate receptor-associated cGMP kinase
                     substrate; MRV integration site 1"
                     /codon_start=1
                     /product="inositol 1,4,5-triphosphate receptor associated
                     1"
                     /protein_id="NP_919446.2"
                     /db_xref="CCDS:CCDS21749.1"
                     /db_xref="GeneID:17540"
                     /db_xref="MGI:MGI:1338023"
                     /translation="MPHIPEDEEPPGEPQAAQTQDSPSAGPFPSPPTIVLTGDASSPE
                     GETDKNLVNRAPSPHRRLSHRHLKVSTASLTSVDPSGHVIDLVNDQLPDISISEEDKK
                     KNLALLEEAKLVSERFLTRRGRKSRSSLGDSPSAVSPNLSSGASPASSRSCSLTISTS
                     PGLDICSGPQSPLPGAPPQQKGHEDGVSSPCPGEPNVSKGLADLKQNDQRKVSQGRLA
                     PRSPTVEKTKELTVEQKENFDPLQHVEATPMAQASGASISGKMALNSPQPGPAEMELG
                     RQLLKTAREGNPLPRTTAQGSGGTVSPHSLGQGSAGEPMGPKAGSKAELRSPVSRPPL
                     IRGVSWDSSPEEPGPLLQKVLAKLPLAEEEKRFPGKAKPAKPPGLKDFQIQVQPVRMQ
                     KLTKLREEHILMRNQNLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNI
                     SDILLRKLRVHKSLTGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLT
                     EENTEKELENFKASITSSANIWYHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAV
                     RQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTAR
                     SMSLTMGKNMPRRRVSVAVVPKFNALNLPGQAPSSSPMPSLPALSESSNGKSSISVSP
                     ALPALLENGKTNAEANCEVGAPVPLPSCLEETSQETKAKAEEEAYSKGYQEGVKKTEE
                     LQDLKEEEEEEQKTESPEEPEEVEETQEDEKDQGSSKLEELVHFLQVMYPKLCQHWQV
                     IWMMAAVMLVLSVVLGLYSSYNSCTEEADGPPGRSTCSAAQRDSWWSSGLQQELPAEQ
                     "
     exon            599..699
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..770
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..944
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1022
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1075
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1123
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1735
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1814
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1938
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..1969
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2110
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2242
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2384
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2434
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2542
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2607
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2727
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2865
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..6211
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6174..6179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /note="hexamer: AATAAA"
     polyA_site      6198
                     /gene="Irag1"
                     /gene_synonym="Irag; Mrvi1; Ris1"
                     /note="major polyA site"
ORIGIN      
        1 acagagtcca gcatcttcaa ctgctccccg ccccaaggca ctgccatcgg ctatgggggt
       61 gccccttgca aaagcctggg gataggggct actattcagg cccaaccttc cttgaaccct
      121 aggctggctg gaaggcttct cctgctttca acccagagcc aggctgcagg gggccctggt
      181 ggaacactgg ttcccagtcc cagcccctca tccagcccct ctctgaggag gaggcaggca
      241 gctggggctc tgcagccaga gcttttcagc ttggagctct ggagccagat gtaacattga
      301 ccttaaatgg taaaagctcc ccagagtgaa gagaggctgg ccgggaggaa aggggaataa
      361 ctcagtttta ggtaagtcat cgctattgcc tagaataacc tgcctcttca gcccaaggga
      421 agcagagagg cgtcttctcc tccttaaagc ctgcggagcc caagcctctt ggagcatctt
      481 tggggttggc acagcagagg ttccaggcac gcacagccac tccaaccagg cggctgccat
      541 gccccacatt cctgaggatg aggagccccc cggagagcca caggcagccc agacccaaga
      601 ctctccctct gcaggaccat ttcccagccc tcccacaatc gtcctgacgg gggatgccag
      661 ttcacctgaa ggagagactg acaaaaacct agtcaacagg gctcccagcc ctcaccggag
      721 gctttcccac cgacacctga aggtctccac tgcttcgctg acttctgtgg acccctcggg
      781 gcatgtcatt gacctggtga atgaccagct gccggacatc agcatctcag aagaggacaa
      841 gaaaaaaaac ctggcacttc tggaagaagc caagttggtg agtgagcggt tcctgacccg
      901 ccgtgggagg aaatcaagga gcagcctcgg agactcccca tcagctgttt ctccaaacct
      961 cagctctggg gcttctcctg catcctccag gagctgctcc ctcaccatct ccacatcacc
     1021 aggtttggac atatgcagtg gccctcagtc ccctctgcca ggagcaccac cacagcaaaa
     1081 gggacatgag gacggggtct cctcgccttg ccccggagag cctaatgtct ccaaagggct
     1141 agctgacctg aagcagaatg accagagaaa agtgtctcaa ggcagactgg ctcctcgctc
     1201 tcccacagtg gagaaaacca aggaacttac agtagaacaa aaggaaaact ttgatcccct
     1261 tcagcacgtg gaggccacgc ccatggctca ggcttctgga gcaagcatca gtgggaaaat
     1321 ggctctgaac agcccccagc ctggccctgc tgagatggag ctggggaggc agctcctgaa
     1381 gacagcccgg gaaggcaacc ctctgcccag aaccacagcc cagggctcag gaggaacggt
     1441 ctccccacat tccctggggc agggctctgc tggagagcct atgggaccca aggctggctc
     1501 caaggctgag ctgaggtccc ctgtgtcccg gccccccctg attcgggggg tctcctggga
     1561 cagcagccct gaagaacccg gtcccctgct gcagaaggtg ctcgctaagc tgcccctggc
     1621 agaggaagag aagcggtttc caggcaaagc caagccagcc aagccacctg ggctcaaaga
     1681 cttccagata caagtgcagc cggtgcgcat gcagaagctg accaagctcc gggaggaaca
     1741 catcctgatg agaaaccaga acctggtggg gttcaagctc cctgaactga gtgaggccgc
     1801 ggagcaggac aaaggagtct cacctgaact cgccccagca gctgaggaag aagagtccaa
     1861 gagtggtctg gatgtgatgc ccaacatttc tgacatattg ctgcgcaaac ttagggttca
     1921 caagtcactc actggaagcg cccctccact cactgaaaag gaagttgaga acgtgtttgt
     1981 acaactgtcc ttggccttta gaaatgacag ctacaccttg gagtctagaa ttaaccaggc
     2041 tgaaagggag cgcaacctga cagaagagaa cacggagaag gaactggaaa acttcaaagc
     2101 ctccataacg tcctcagcaa acatctggta ccactgcgaa caccgggaga cctatcagaa
     2161 acttctggaa gacatcgccg tcttgcatcg tctggctgcc cgcctctcca gtcgggctga
     2221 agtggtgggt gctgttcgcc aggaaaagcg catgtcaaag gccacggaag tgatgatgca
     2281 gtatgtggag aatctgaaga gaacgtatga gaaggaccat gctgagctca tggaatttaa
     2341 gaaacttgca aatcagaatt ccagtcgcag ctgtgggccc tctgaagacg gggttcctcg
     2401 aacggcgcga tctatgtccc tcacaatggg aaagaacatg ccccgccgga gggtcagcgt
     2461 tgctgtggtt cccaagttta atgccctgaa cctgcctggc caagccccga gctcttcacc
     2521 catgccttcc ctaccagctc tgtctgaatc gtccaatggg aagagcagca tctccgtctc
     2581 cccagcgctg cctgcacttt tggaaaatgg aaagacaaat gcagaggcta actgcgaagt
     2641 gggtgcccct gtgccactcc caagctgtct ggaggagacg agccaggaga ccaaggccaa
     2701 ggcagaggaa gaagcctaca gcaaaggata ccaggaaggg gtaaagaaga ccgaagaact
     2761 tcaagacctg aaggaggagg aggaggaaga acagaagacg gagagtcccg aggaaccaga
     2821 agaggtagaa gaaacccagg aggacgagaa ggaccaggga agcagcaaac ttgaagaact
     2881 ggtccacttc ctacaagtca tgtatcctaa attgtgtcaa cactggcaag tgatctggat
     2941 gatggccgca gtgatgctgg tcttgagtgt tgttctcggg ctgtacagtt cctataactc
     3001 ctgcacagag gaggccgatg ggccccctgg gagatccacc tgctctgcag cccagcggga
     3061 ctcctggtgg agctccggac tccagcaaga gctgccagca gagcagtagg acatcggact
     3121 ccttagtcat gccctgctct agtgcattca tcccaacacc ctgcccctaa gtacagtgtg
     3181 tcaggcccaa accgggcaca tgtggccacc catcccattg gggaacaagg aggctctctc
     3241 ctgtcattca tggaagctac tcgcaacaac ctgatgcttt gaagggatca acaaaagatc
     3301 aaattgtgct ctgggaaagt gcctggttga taaagaatca accttcatta aggactctag
     3361 cacaagggaa gggtcctgcc cctggctcag atggattagg agaactgaaa tcccttcatt
     3421 caggggaaag tgagaaacct actttccctt tctcctccct gtgtttcatg gtcagtaaga
     3481 attgtactta ggcgccagca ctgaccataa ggctcagtct tggagtcaca acatattgtc
     3541 ccacttccca ctttatgtat cacaaccgtt ctttcgcctt ccctctccct ttcagaatta
     3601 cctttttttt ttttttttca gagagtggga aagctttctc ataaaaatgc acaggctaaa
     3661 agtagcccca tgctagaaag gaaacaggaa gatgtgaatt aatatataat gaatctgtat
     3721 acatatagac tatacacatg tttgtgcaca aagacaccca ctctctggaa gtgtgctctg
     3781 ctcagtggca cccatgtcat gccatccagt tggttttcac taggtataga gcagtagtca
     3841 ccaggtacca acacagggag ccctccacac actctgaaga tgtttgaacc tctgagaaat
     3901 catatcttcg ttccacttca tatgccaggt tggagctgct gtttgacagt ctgttccctg
     3961 gttgcttgct ccgtttgaaa gtgatcctac acagttaacc cacctcttgg gtaagaaaag
     4021 gtgtgccttc cacttctgac tctcactctg ccatgcacct tgggactaca gtattcatga
     4081 gatttccaac tctaatgtgt ccttccacag acctgttcag cattaacctg aaggcagtgc
     4141 gttctcctcc agcatggcgg ctctccacgc tgctgacagt ttccttcatg cagctctctt
     4201 cagtcagaga tggggcttct cttgtggttg cttttctggt tcgttgtttt tgttgctatc
     4261 acttatgtag tatgtattgt gagccaaaaa tcatctgtgt tataggcagt aattcattcg
     4321 tcctcaagaa tagaaaaatc tgaaatagat atcactcgct ccatgttcaa ataaggaaat
     4381 agaagcataa atgatacaaa agtacacaca cacacacaca caccagtgca tgaagtgcat
     4441 atgcacacat acacacatac aatgtttcaa cttgccaagc atctatagct aggaagtcat
     4501 tcacactata gtggtctggc tccagggact gcactcctac accttcacct gtgggtgcct
     4561 tctccagctg ggtgccttcc ggtctgattc caccccacac ctcagctgac ccttcagctg
     4621 ctcatggttc tcagatggca ctgcacctct ccctgtcctt taactcagaa gcatctttgc
     4681 tgccttagtc ctctttctca ccgctcttga ggaccaaccg taagcacttc cccttggtac
     4741 atgcctctgt gacctccttc cacactcttg catacccagc ctagtggggg gcacccctct
     4801 tagtgcttct ggcacttgtt aaattttagt cattgagctg tatctactgt ctaacttatt
     4861 tatatatctg tctccctgga tgttttccct caagaactct gtcttaccat ttcttgtcta
     4921 ggtacctagc atggcaaacc tgtgggagag agtcatttga tgttggttaa aagaacaagt
     4981 aaacattcaa ggtggagagc agcccagaac atgtgacatt ttgaggtggc ccagtagtgt
     5041 caccttcatg acaatttcta ttcccatgag aaagctgtga ctttctgact gattcatggt
     5101 ctcatcttat ttttatcttt ctcggagaga gcaagaatga aataagacta tagcaacacc
     5161 attttcaagt ccaagaacct gactccatgc aatcagtccc ttcagagaga catgcacccc
     5221 ccaccaccac cccaactagg cctcacttta aaatactgtt tttgaagaaa cgtctttaca
     5281 gtggctagaa agagaaagag aagcccaagg atgtgccatt aaaggtaatg aggttcagag
     5341 ccaggcaggg ggatttcatg gacaggggta gggcttacct ggaggcttcc agggccttag
     5401 atacagctca aggagattta actacataag cacgtccgag acaaagccag gatttacagg
     5461 gaatgaagag agagcagctg ttgggcagga ctttgcgggg gtgggggggt gtccagtctc
     5521 agcccatccc cacagcaaaa gaagatccag cctgagtgag cccattgtcc atttggccac
     5581 aaatttccca ccccctttct gggtgagaga gttgaggaga acatgagtaa actgtttcag
     5641 catcaccact ggcctccaac gcctgcaggc gtcctcaggt acagaccagc agccacgctg
     5701 ctccagcagt aaagacagtt gaggacaagg acctctccag agagcatagc catatttggg
     5761 atggcatggc tgaaagcaca ctgttggact accggttcag gaaggcgagt cacagctgct
     5821 cccacacatg gccagtgaca tggaagccag ccttgtgttt ccagacgtaa ctgtgaaatg
     5881 gaataaaagt ttcccactca agatgcccct gaaagctggc atttctgctt gagcctgagg
     5941 gtctggttgc caaggatgtg tttgcatcac cagtgatgtc acttcctaaa aggaccttca
     6001 tgttctagct gtgaagttat gtgggctgtt tctttgtgca gcctggaaga gggtatggca
     6061 agggagacac tggacgtacc tgtcaccgac tgtcagtccc taacactgtt aaacctcaca
     6121 caggtaggtg tggcagtgtt gaactttaag agtgtcacat agctgagttt gaaaataaat
     6181 gcacatttcc aaaccgttgg cagaagtcaa a
//
