LOCUS       NM_001033354            6818 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus IQ motif and Sec7 domain 3 (Iqsec3), transcript
            variant 1, mRNA.
ACCESSION   NM_001033354 XM_145005 XM_901274 XM_901278 XM_901286 XM_901290
            XM_917851 XM_925317 XM_925321 XM_925323
VERSION     NM_001033354.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6818)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6818)
  AUTHORS   Kim,S., Park,D., Kim,J., Kim,D., Kim,H., Mori,T., Jung,H., Lee,D.,
            Hong,S., Jeon,J., Tabuchi,K., Cheong,E., Kim,J., Um,J.W. and Ko,J.
  TITLE     Npas4 regulates IQSEC3 expression in hippocampal somatostatin
            interneurons to mediate anxiety-like behavior
  JOURNAL   Cell Rep 36 (3), 109417 (2021)
   PUBMED   34289353
  REMARK    GeneRIF: Npas4 regulates IQSEC3 expression in hippocampal
            somatostatin interneurons to mediate anxiety-like behavior.
REFERENCE   3  (bases 1 to 6818)
  AUTHORS   Kim,S., Kim,H., Park,D., Kim,J., Hong,J., Kim,J.S., Jung,H.,
            Kim,D., Cheong,E., Ko,J. and Um,J.W.
  TITLE     Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases
            Somatostatin Expression in the Hippocampus
  JOURNAL   Cell Rep 30 (6), 1995-2005 (2020)
   PUBMED   32049026
  REMARK    GeneRIF: Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and
            Decreases Somatostatin Expression in the Hippocampus.
            Erratum:[Cell Rep. 2024 May 28;43(5):114254. doi:
            10.1016/j.celrep.2024.114254.. PMID: 38748876]
REFERENCE   4  (bases 1 to 6818)
  AUTHORS   Kinoshita-Kawada,M., Hasegawa,H., Hongu,T., Yanagi,S., Kanaho,Y.,
            Masai,I., Mishima,T., Chen,X., Tsuboi,Y., Rao,Y., Yuasa-Kawada,J.
            and Wu,J.Y.
  TITLE     A crucial role for Arf6 in the response of commissural axons to
            Slit
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30674481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6818)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 6818)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 6818)
  AUTHORS   Sakagami,H., Katsumata,O., Hara,Y., Tamaki,H., Watanabe,M.,
            Harvey,R.J. and Fukaya,M.
  TITLE     Distinct synaptic localization patterns of brefeldin A-resistant
            guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse
            retina
  JOURNAL   J Comp Neurol 521 (4), 860-876 (2013)
   PUBMED   22886754
  REMARK    GeneRIF: BRAG2 localized to postsynaptic processes at bipolar
            dyads, while BRAG3 localized to postsynaptic components at
            conventional synapses in mouse retina
REFERENCE   8  (bases 1 to 6818)
  AUTHORS   Fukaya,M., Kamata,A., Hara,Y., Tamaki,H., Katsumata,O., Ito,N.,
            Takeda,S., Hata,Y., Suzuki,T., Watanabe,M., Harvey,R.J. and
            Sakagami,H.
  TITLE     SynArfGEF is a guanine nucleotide exchange factor for Arf6 and
            localizes preferentially at post-synaptic specializations of
            inhibitory synapses
  JOURNAL   J Neurochem 116 (6), 1122-1137 (2011)
   PUBMED   21198641
REFERENCE   9  (bases 1 to 6818)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   10 (bases 1 to 6818)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115799.10 and AC153982.8.
            
            On Aug 31, 2022 this sequence version replaced NM_001033354.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169437.1, SRR7652917.719604.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-626               AC115799.10        125480-126105       c
            627-710             AC115799.10        96612-96695         c
            711-981             AC115799.10        80752-81022         c
            982-2090            AC115799.10        64963-66071         c
            2091-2252           AC115799.10        63069-63230         c
            2253-2375           AC153982.8         151095-151217       c
            2376-2542           AC153982.8         150562-150728       c
            2543-2682           AC153982.8         148829-148968       c
            2683-2808           AC153982.8         147668-147793       c
            2809-2908           AC153982.8         145297-145396       c
            2909-3070           AC153982.8         145010-145171       c
            3071-3163           AC153982.8         142744-142836       c
            3164-3213           AC153982.8         141090-141139       c
            3214-6818           AC153982.8         134022-137626       c
FEATURES             Location/Qualifiers
     source          1..6818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.28 cM"
     gene            1..6818
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /note="IQ motif and Sec7 domain 3"
                     /db_xref="GeneID:243621"
                     /db_xref="MGI:MGI:2677208"
     exon            1..626
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..3675
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and SEC7 domain-containing protein 3"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 3
                     isoform 1"
                     /protein_id="NP_001028526.1"
                     /db_xref="CCDS:CCDS20491.1"
                     /db_xref="GeneID:243621"
                     /db_xref="MGI:MGI:2677208"
                     /translation="MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLD
                     ELSAENRSLWEHQQLLQAQPPPGLVPPPPSAPLPAPAVTAPAAAAAQEPLQDHGQLIP
                     ASPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAIADKEKERPSSCCAAAGA
                     LLQHASPAALGKGVLSRRPENETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGG
                     MEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGRQQPALAT
                     ALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEK
                     IRNSLLESRLPRRISLRKVRAPTAESLVAEKALLEGCGLLGLPLGRSPSLPPTFAGSL
                     TELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEA
                     AAREPESGPGSGDEAGGLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGA
                     QTAQATAEPAAAQAEQEDTADQEVSEVPASEQMDPPSEDSEAAESRAQSAQEPAVAQA
                     VVEEAVATEAEEEEEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKE
                     ALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGF
                     IPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALR
                     KFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMY
                     SPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKV
                     EKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPK
                     KKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQ
                     KFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSVRSAGAQGDPQSKQGSPTAKREA
                     MAGEKAAESSGEVSIHNRLQTSQHSPKLGVERGAPAPSPPTSPPPLPPDPQPSPLREQ
                     PPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTP
                     LRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSMLLRRRYSSGSRSLV"
     exon            627..710
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            711..981
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            982..2090
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2252
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2375
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2542
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2682
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2808
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2908
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3070
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3163
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3213
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..6818
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6818
                     /gene="Iqsec3"
                     /gene_synonym="BRAG3; mKIAA1110; synarfGEF"
                     /note="major polyA site"
ORIGIN      
        1 agagctgctg ggctgctggg ctcctgcgcg ctcacgctcc ccgccgcccg cctaggcgca
       61 ggcagggcgc aggcggcggc gggcggcatg gagagcctgc tggagaaccc ggtgcgcgcc
      121 gtgctctacc tcaaggagct cacggccatc gtgcagaacc agcaaagcct catccatacc
      181 cagcgccagc gcatcgatga gctggagcgg cgtctagacg agctgagcgc ggagaaccgc
      241 agcctgtggg aacaccagca gttgctgcaa gcccagcctc cgcctgggct ggttcccccg
      301 ccgccgtctg ccccactgcc tgctcctgca gtcactgctc cggccgccgc tgcggcccag
      361 gaaccgcttc aggaccacgg acagctcata cccgcttcac cggagccgcc gcttcagcac
      421 cacggtcagc tcctggcgca gccccaacct gcacccagca gcagggttca gactcctcag
      481 tcgccccacc agcacccggt ggcacccggg gccatagctg acaaggagaa ggagcgtccc
      541 tcgagttgtt gtgctgccgc gggagccctg cttcaacacg catcccccgc cgccctcggc
      601 aagggcgtcc tgagcaggag acccgagaat gagactgtgc tacaccaatt ctgctgccct
      661 gccgctgaca ccgagcagaa gcctgcctgc tccgacctgg cttcccaaag tgatggctcc
      721 tgtgcccagg ccggtggggg catggaggac tccgtggtgg cagcggtggc agccggcaga
      781 cccagtgccc atgccccgaa ggctcaagcc ccggagctac agcaggagga ggagcggcca
      841 ggggcagtgg gctccccacg ggctggcccc ctccgcgcgg cctctcctgg ccggcagcag
      901 cctgccctgg cgacggcgct ctgctcccac actcctgctg cctccgaata cgaactctcc
      961 cttgacctaa agaataaaca gattgaaatg ctagaacaca aatacggggg ccacctggta
     1021 tcccgacgcg ccgcgtgcac cattcaaacc gcttttcgcc agtaccagct cagcaagaac
     1081 tttgagaaga tccgtaactc gctcctggag agccgcctgc ctcggcggat ctcactgcgc
     1141 aaggtgaggg cgcccacagc ggagagtctg gtggcagaga aggcgctcct ggagggctgt
     1201 gggctccttg ggctcccgct ggggcgctcg ccctcgctgc cgcccacctt cgctggctcg
     1261 ctcaccgagc tggaggactc ctttaccgag caggtgcagt ccctggccaa gtccatcgac
     1321 gacgccctca gcacctggag cctcaagacc atgtgctcgc tgcaagagag tggcgcgtac
     1381 cagctccacc aggcgctgca cccgagtgcg ggacagccag gcctggagac cgaggcggcg
     1441 gcgcgggagc cagagagcgg ccccgggtct ggagatgagg ccggtggtct gcctcagggt
     1501 cacagcggta ccctcatgat ggctttccgg gacgttacgg tgcagatcgc taaccagaac
     1561 atctctgttt cctcctccac cgccctgtct gtggccaact gtctgggtgc acagaccgcc
     1621 caggccacag ccgagcctgc tgccgcccaa gccgaacaag aggacaccgc ggatcaggag
     1681 gtctcggaag tcccagcctc ggaacagatg gacccaccca gtgaggactc agaggcagcg
     1741 gagagccgcg cccagagcgc acaggaaccc gcggtggcac aggccgtggt ggaggaggcg
     1801 gtggctacag aggcagagga ggaagaggag ggggccaaac aggcagggaa gggggcagag
     1861 gccgagggag gcgacaactc tgagcagctg agcagcagca gcgcttccac caagtctgcc
     1921 aaatccagct cagaggcttc tgccgctgcc tccaaggagg ccctgcaggc tgtgatcctg
     1981 agcttgcccc gctatcactg cgagaaccca gccagctgca ggtcccccac gctctccaca
     2041 gacaccctgc gcaagcggct gtaccgcatc ggcctcaacc tcttcaacat aaatccggac
     2101 aagggcatcc agttcctgat ctcacgtggc ttcatccctg acacccccat cggtgtggcc
     2161 cacttcctcc tccagcgtaa aggcctcagc cgccagatga taggagagtt cctgggcaac
     2221 agcaagaagc agttcaaccg ggacgtgctg gactgtgtgg tagatgagat ggacttttcc
     2281 aacatggagc tggatgaagc cctgaggaag tttcaagccc acatccgtgt gcagggggaa
     2341 gcacagaagg tggagcgact catagaagct ttcagccagc gctactgcat gtgcaatcct
     2401 gaggtggtgc aacagttcca caacccagac accatcttca tcctggcctt tgccatcatc
     2461 cttctcaaca ccgacatgta cagccccaac atcaagcctg accggaagat gatgctagaa
     2521 gactttatcc ggaacctccg aggtgtggat gatggtgcag acatccccag agaactggtg
     2581 gtaggcatct atgagaggat ccagcaaaag gagctcaaat ccaatgagga ccatgtcaca
     2641 tatgtcacca aggtggagaa gtccatcgtg ggcatgaaga cggtgctgtc aatgccacac
     2701 cgtcgcctgg tctgctgtag ccggctcttc gaggtgaccg atgtgaacaa gctacagaaa
     2761 caagcagcac accagagaga agtgttcctc ttcaatgatc tgcttgtgat tctcaagcta
     2821 tgcccaaaga agaagagctc cttcacgtac accttctgca aggcagtcgg cctgttaggc
     2881 atgcgctttc acctcttcga gaacgagtat tactcccatg gcatcaccct ggcaacccca
     2941 ctctcgggct ccgagaagaa gcaggtgctg cacttctgtg ccctgggctc cgacgagatg
     3001 cagaagttcg tggaagacct gaaggagtcc atcgctgagg tgacagagct ggagcagatc
     3061 cggatagaat gggaactgga gaagcagcag ggcacaaaga ctctctccgt aaggtctgct
     3121 ggagcccaag gggacccaca gtcgaagcaa ggatcaccca cagccaagag ggaggcgatg
     3181 gcaggagaga aagcggcgga gagctcgggg gaggtgtcaa ttcacaacag gcttcaaacg
     3241 tcccagcaca gccccaagtt gggggtcgag aggggagcgc ctgcaccatc accaccaaca
     3301 tcaccaccgc cgttgccgcc agacccacag cctagccccc tgagggagca gcccccaccg
     3361 ctgccactgc caccacccac acctccaggc accctggtac agtgccagca gattgtcaag
     3421 gtcattgtcc tggacaaacc ctgcttggcc cgcatggagc ccctgctgag ccaggctctg
     3481 tcctgttacg cctcatcctc ctcagactcc tgtggctcca cacccttgcg tggtccaggc
     3541 tccccagtta aggtcatcca ccagcctcca ctgcccccgc ccccgccccc atacaaccac
     3601 cctcatcagt tctgcccccc aggctccatg ctgctccggc gccgttactc cagcggctcc
     3661 aggagcctgg tgtaggctct acccttagcg ccccgatgtc ccagtgggct gtcctttggg
     3721 aatctgggct gctcgtcggc actgctcaca tctaggcgta atgccttcct ggccactggt
     3781 cactattgta gaaagagaat gccttggcaa gatggtttgc ttgacccaac catccttcac
     3841 taactgattt gagtaccttg ccaccaatgt gtaaccacct tctcactctt ctagggggtc
     3901 ccacatggcc agatggacct tctcctctgt gttcaccatg ctccccttat tagattgtag
     3961 attgaaggaa actgaagcca aggggcctgt gggctgatgg gcttgcaatc ttggtctatc
     4021 agtgtccatg tcttgggcca agaacaaaag gctgaacctg ccagcagcac cctccaggac
     4081 aggggccggc taccccagca taaggtgtat ctatgccccc agctgaatca aggaaagcta
     4141 tccctggctc cctggcagga cctaggcgta gtagaaggga gctctgtcta ctgcgtctgt
     4201 tatccaaacc tatagtcagg aaactggttc ttagctcccc agggatgttg gctccctgaa
     4261 ccatgtccac tctcctgcct tccccagacc caggaaagac ccaagaaaga gaagggtcca
     4321 gggtattcag ttctgtctgg gtcagttcaa cgtggccctg cgacggtgag gtcatgtctg
     4381 caaagtgcac ttttaaagaa catttcttgg ttctctaagc cttaaacgct cggccagtac
     4441 cgagtgtaca caggcagtta tccgtaaaca catgtgagaa ccaggttgat gacttcctgg
     4501 tggaaccaga agcaaggaaa tggggtttca gctctgcccg gccgaggtat gacttggcct
     4561 ggaggcgggg attcctggtg tatgactgtg cagcctctgt acaaagacaa ggtgaagcag
     4621 tggggttcca gagtcactgt gccaaccctg ttgtcctagc tttgaaacag tccctccctg
     4681 gaaaatgatg ctggcttcca gcagggatgg cctagagttc ctggatcttt gaaactgcag
     4741 agcagagcag agcaggaaaa ctcatcagct tcccaggcct tcatcagcac cagagccagc
     4801 acaggtagcc ctggccctac agagccccag agacaacacg ggtggtgtca cggatggtca
     4861 cattcatgct gttttcaggg acatctttca caagccaggc cagcctcctt tgtcctatgc
     4921 caacagctat atctgactgt cctcaagatg tcctcctatc agagcctgtt tttaaagttt
     4981 ccctagaggc aagaggcaca gtgaacgttg ccatggttgg aagtgaatta gcttttcctg
     5041 gtccctacta tacccccccc caagattcag tactctgaac cagataggag gcataaataa
     5101 cccaggctat tagaggggcc aaatgacccc atttcacatg tatgcatgtg tacatgcgtg
     5161 catgtgtgca tgtgtgcgtg tgagtgtgtg tgtgagtgag tgtgtgtgag tgtgtgtgtg
     5221 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt ttcacccaaa ggtcattatg
     5281 atgtcaccca gggcatttct ggcctattcc tgtaactttt ggccaatata ctgtctcccc
     5341 agaggctccc tgcctgtgtt cttctgagtt ggctgccttg ggccccttct agagcaccgg
     5401 tatttcagaa aatcatcaga atctgtcagg ctggaacagc tgacagatag gtgccatgcc
     5461 tagacacctc acccacctgg gccggagcag aaagggcaga gcctggggaa cgcacagagc
     5521 tttgattgtg attggatgaa caagataact gaaaatagag gggagtatat gactaatatg
     5581 gaggatgtgg ggtatgaagg agtgtgagtt atgaatgtgt cttagcatgt ttctggagtg
     5641 gaggtcatga tgtcgagggc tgatgaagag ggacatagcc ctagatagcc cagttcccat
     5701 tgcaaaccct gctctctgct cacatctggc ttcatgctaa cagtgccctc tgcccctccc
     5761 agctcagctg aagcctgact ttccagatga gctccagcat cagcagaggt ttggggcctg
     5821 gcccacctgc acaggctctg agaacccaga gcctcagcac tctgcacctt ttctacaggg
     5881 agaggcttac tcaaggttgc tgtagtagct cacctacacc ctgctagcca gagcaaagtc
     5941 ctgcacagga agccacactg cttggggtca cagcatggaa catccctgag ctggcaggac
     6001 tttgagcccc cagtagccca gtgcaggaag aactggccca ccttactgat caggcaaagt
     6061 taaagcccta gcacctgttc tcatatcagc caccctgcaa atggtgggat tcatctgtac
     6121 cttagtccct agagacctgg gagaagcctc ctccccatcc tgatggcagg gcctccattt
     6181 ttttgtagag gcccagaaag aggctcttga gactccagtt gtctcaaaaa ttaggggaga
     6241 ggtggagtgc tagctgagct cccagatcca agcaccctaa aaacgcccca gtccatcaac
     6301 tctctaggcc ttactttggg gagcctggga tcctcttcca atttctccat ttggccccaa
     6361 ctctagaacc aagtgggagg tggaaccagc tttcttacct ccttttaggc aatcccacct
     6421 agtgtagtcc tgtcttggca gcctttcctg gaagctggcc tgtctgtctt ttcgtcagca
     6481 aagatgtctt gctcccacaa atatgtattg gtcctgggtt tttgctcccc ctactccagt
     6541 gtccaaagag taccgggatg tctctgttac ctggtagagg ttcccgatgt cattcatctg
     6601 tctgtctctg catcagctga ccatcttcca gtggtacctc tcctcccctg ctcacccctc
     6661 accagatgga gtgatagctc tctggggaca ggcagggtgg ctgcactcag caactaatcc
     6721 aaatggcaaa tattttgtaa caaaatagcc cagaggtatt ttatctgttc aattcctaga
     6781 gttttagaga ttctattgaa ctgtgtcact tgagcaaa
//
