LOCUS       NM_001114664            6049 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus IQ motif and Sec7 domain 2 (Iqsec2), transcript
            variant 1, mRNA.
ACCESSION   NM_001114664
VERSION     NM_001114664.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6049)
  AUTHORS   Bai,G., Li,H., Qin,P., Guo,Y., Yang,W., Lian,Y., Ye,F., Chen,J.,
            Wu,M., Huang,R., Li,J., Lu,Y. and Zhang,M.
  TITLE     Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under
            physiological and pathological conditions
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37787765
REFERENCE   2  (bases 1 to 6049)
  AUTHORS   Levy,N.S., Borisov,V., Lache,O. and Levy,A.P.
  TITLE     Molecular Insights into IQSEC2 Disease
  JOURNAL   Int J Mol Sci 24 (5), 4984 (2023)
   PUBMED   36902414
  REMARK    GeneRIF: Molecular Insights into IQSEC2 Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6049)
  AUTHORS   Jada,R., Borisov,V., Laury,E., Halpert,S., Levy,N.S., Wagner,S.,
            Netser,S., Walikonis,R., Carmi,I., Berlin,S. and Levy,A.P.
  TITLE     Daily Brief Heat Therapy Reduces Seizures in A350V IQSEC2 Mice and
            Is Associated with Correction of AMPA Receptor-Mediated Synaptic
            Dysfunction
  JOURNAL   Int J Mol Sci 24 (4), 3924 (2023)
   PUBMED   36835332
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6049)
  AUTHORS   Kane,O., McCoy,A., Jada,R., Borisov,V., Zag,L., Zag,A.,
            Schragenheim-Rozales,K., Shalgi,R., Levy,N.S., Levy,A.P. and
            Marsh,E.D.
  TITLE     Characterization of spontaneous seizures and EEG abnormalities in a
            mouse model of the human A350V IQSEC2 mutation and identification
            of a possible target for precision medicine based therapy
  JOURNAL   Epilepsy Res 182, 106907 (2022)
   PUBMED   35344748
  REMARK    GeneRIF: Characterization of spontaneous seizures and EEG
            abnormalities in a mouse model of the human A350V IQSEC2 mutation
            and identification of a possible target for precision medicine
            based therapy.
REFERENCE   5  (bases 1 to 6049)
  AUTHORS   Mehta,A., Shirai,Y., Kouyama-Suzuki,E., Zhou,M., Yoshizawa,T.,
            Yanagawa,T., Mori,T. and Tabuchi,K.
  TITLE     IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to
            Autism by Affecting Functions of Neural Circuits in the Medial
            Prefrontal Cortex
  JOURNAL   Cells 10 (10), 2724 (2021)
   PUBMED   34685703
  REMARK    GeneRIF: IQSEC2 Deficiency Results in Abnormal Social Behaviors
            Relevant to Autism by Affecting Functions of Neural Circuits in the
            Medial Prefrontal Cortex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6049)
  AUTHORS   Sanda,M., Kamata,A., Katsumata,O., Fukunaga,K., Watanabe,M.,
            Kondo,H. and Sakagami,H.
  TITLE     The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact
            with IRSp53 through its proline-rich sequence
  JOURNAL   Brain Res 1251, 7-15 (2009)
   PUBMED   19083995
  REMARK    GeneRIF: Our present findings suggest that IQ-ArfGEF/BRAG1 may play
            roles downstream of NMDA receptors through the interaction with
            multivalent PSD proteins such as IRSp53 and PSD-95.(BRAG1 PROTEIN,
            MOUSE)
REFERENCE   7  (bases 1 to 6049)
  AUTHORS   Sakagami,H., Sanda,M., Fukaya,M., Miyazaki,T., Sukegawa,J.,
            Yanagisawa,T., Suzuki,T., Fukunaga,K., Watanabe,M. and Kondo,H.
  TITLE     IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6
            that interacts with PSD-95 at postsynaptic density of excitatory
            synapses
  JOURNAL   Neurosci Res 60 (2), 199-212 (2008)
   PUBMED   18164504
REFERENCE   8  (bases 1 to 6049)
  AUTHORS   Casanova,J.E.
  TITLE     Regulation of Arf activation: the Sec7 family of guanine nucleotide
            exchange factors
  JOURNAL   Traffic 8 (11), 1476-1485 (2007)
   PUBMED   17850229
  REMARK    Review article
REFERENCE   9  (bases 1 to 6049)
  AUTHORS   Filippova,G.N., Cheng,M.K., Moore,J.M., Truong,J.P., Hu,Y.J.,
            Nguyen,D.K., Tsuchiya,K.D. and Disteche,C.M.
  TITLE     Boundaries between chromosomal domains of X inactivation and escape
            bind CTCF and lack CpG methylation during early development
  JOURNAL   Dev Cell 8 (1), 31-42 (2005)
   PUBMED   15669143
REFERENCE   10 (bases 1 to 6049)
  AUTHORS   Tsuchiya,K.D., Greally,J.M., Yi,Y., Noel,K.P., Truong,J.P. and
            Disteche,C.M.
  TITLE     Comparative sequence and x-inactivation analyses of a domain of
            escape in human xp11.2 and the conserved segment in mouse
  JOURNAL   Genome Res 14 (7), 1275-1284 (2004)
   PUBMED   15197169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083816.21.
            
            On May 6, 2022 this sequence version replaced NM_001114664.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB275281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN02415135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-967               AC083816.21        165295-166261       c
            968-997             AC083816.21        143511-143540       c
            998-1259            AC083816.21        107305-107566       c
            1260-1661           AC083816.21        106141-106542       c
            1662-2557           AC083816.21        100809-101704       c
            2558-2719           AC083816.21        99103-99264         c
            2720-2842           AC083816.21        98330-98452         c
            2843-3009           AC083816.21        97021-97187         c
            3010-3149           AC083816.21        94834-94973         c
            3150-3248           AC083816.21        94035-94133         c
            3249-3348           AC083816.21        91498-91597         c
            3349-3510           AC083816.21        90581-90742         c
            3511-3684           AC083816.21        88654-88827         c
            3685-3734           AC083816.21        88142-88191         c
            3735-6049           AC083816.21        85238-87552         c
FEATURES             Location/Qualifiers
     source          1..6049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..6049
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /note="IQ motif and Sec7 domain 2"
                     /db_xref="GeneID:245666"
                     /db_xref="MGI:MGI:3528396"
     exon            1..967
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..4700
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and SEC7 domain-containing protein 2"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001108136.1"
                     /db_xref="CCDS:CCDS53224.1"
                     /db_xref="GeneID:245666"
                     /db_xref="MGI:MGI:3528396"
                     /translation="MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRI
                     EELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHREL
                     RESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLH
                     HENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAG
                     GGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPP
                     TSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKV
                     EMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
                     SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTS
                     GEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
                     SATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDG
                     SREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEAD
                     GCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLG
                     KCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRH
                     SWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGL
                     SRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERL
                     IEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKN
                     LRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRL
                     VCCCQLYEVPDPNRPQRLGLHQREVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSY
                     YQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEK
                     QKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGR
                     RNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKR
                     GKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQY
                     CQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVP
                     GPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKH
                     FIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSP
                     HTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV"
     exon            968..997
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1259
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1661
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2557
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2719
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2842
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3009
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3149
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3248
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3348
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3510
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3684
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3734
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..6049
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6030..6035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /note="hexamer: CATAAA"
     polyA_site      6049
                     /gene="Iqsec2"
                     /gene_synonym="Brag1"
                     /note="major polyA site"
ORIGIN      
        1 gtccttccga gccctggcgg tggcggtggc ggtggtggtg gcggcggcgg cggcggcggc
       61 ggtagcctta gctcctgcgc cccgtgccgc cggccccagc gctgtctccc gggcccccta
      121 gggcccccgg gcccccgagc ccggtgcgcg ccctcgcgtc ccgccggccc cctcccccgg
      181 ctgggcccgg gggagggtgg cgccgtgagc gagcggggac tgggctctcc tgcccgttcc
      241 cctgtccctg ggccgccagg atggaggcgg ggtccggtcc tccgggtggc ccgggatctg
      301 agagccccaa ccgggcggtg gagtacctgc tggagctgaa caacatcatc gagagtcagc
      361 agcagctgtt ggagacccag cggcggcgca tagaagagct ggagggccag ttggaccagc
      421 tcacccagga gaaccgcgac ctgcgggagg agagccagct gcaccgtggg gaactgcacc
      481 gggaccccct tggcgcacgg gatagtcctg gccgcgaaag ccagtaccag aacctgcgtg
      541 agacccagtt ccaccaccgc gagctgcggg agagccagtt ccaccaggcg tcccgggacg
      601 tgggctaccc gaaccgggat ggcgcttacc agaaccggga agctatctat cgggataagg
      661 agcgagaagc ctcctatcaa cttcaggaca ctaccggtta cacagcccgc gagcgcgacg
      721 tggcccaatg ccacctgcac catgagaacc cagccctggg tcgcgagcgt ggcgggaggg
      781 aggctgggcc agcgcacccg ggccgcgaga aggaagccgg ctattccgcg gcggtgggcg
      841 tggggcagcg gccaccgcgg gagcggggcc agttgagtcg tggcgcatcc agaagctcca
      901 gtcctggcgc tggcggaggt cacagcacca gtaccagcac cagcccggct acaaccctcc
      961 agagaaaatc tgatggtgag aattccagaa cagtcagtgt ggagggtgat gccccaggca
     1021 gtgacctgag cacagcggtt gatagtcctg ggagccaacc cccctaccgg ctgagccaac
     1081 taccccccac cagcagccac atggggggcc cccctgccgg ggtgggcctt ccttgggctc
     1141 agagggcacg cctgcagcca gccagtgtcg ccctgaggaa gcaggaggag gaggagatca
     1201 agcgctccaa ggccctgtca gacagctatg aactctccac agacctgcag gacaagaagg
     1261 tggaaatgct ggagaggaag tatgggggct ccttcctgag ccgcagggct gccaggacca
     1321 tccagacagc ctttcgacag taccgtatga ataagaactt tgagcggctg cgcagctcag
     1381 cttcagagag ccgcatgtcc cgccgcatca tcttgtccaa catgcggatg cagttctcct
     1441 ttgaggagta cgagaaagca cagaaccctg catacttcga gggcaagcct gcctcattgg
     1501 atgagggtgc catggctggc gcccggagcc accggcttga acggggcctc ccttatggag
     1561 gctcctgtgg tgggggcatc gatggtggtg gaagttcagt caccacatct ggagagtttt
     1621 ctaatgacat cacagagctc gaggactcct tctccaaaca ggtaaagtct ctggctgaat
     1681 ccattgatga ggccctgaac tgccacccat cagggcctat gtctgaggag ccagggtcag
     1741 cccaactgga gaagcgggaa tcaaaggaac agcaagaaga cagctcagcc acatccttca
     1801 gtgacctccc cctgtacttg gatgacccag ttcctcctcc atcacctgag cgactgccca
     1861 gcacagagcc cccaccccaa ggccgccctg agttctgggc accagctccc ctcccaccag
     1921 ttcctccacc aatgccacca gggacccggg aagatggtag ccgtgaggaa ggcactcgaa
     1981 ggggtcctgg gtgcttggag tgccgggatt tccggctccg ggctgcacac ctccccctcc
     2041 tcaccattga gcctcccagt gacagttctg tagacctgag tgaccgctca gatcgcggct
     2101 ctgtccaccg ccagctggtg tatgaggctg atggctgcag cccccatggg accctgaagc
     2161 acaaggggcc accaggcagg gccccaatcc cacaccgcca ctaccctgcc cctgagggtc
     2221 cagctccagc cccaccaggg cccctgccac cagcccccaa tagtggtact gggcccagtg
     2281 gtgtggctgg aggtcggagg ttggggaagt gtgaggcagc aggtgagaac tctgatggtg
     2341 gagacaatga gagtctggag agctccagca actctaatga gaccatcaac tgcagctctg
     2401 gctcctcctc tcgggatagc ctgagggaac cgccagccac tggcctgtgc aagcagactt
     2461 accagcggga gacaaggcac agctgggact cgccagcctt caacaatgat gtggtacaaa
     2521 ggcgacatta cagaattggc ctcaacctct tcaataagaa gccagagaag ggtatccagt
     2581 atttgatcga acgaggcttc ctgtctgaca ctcctgttgg ggtggctcac ttcatcctgg
     2641 agaggaaagg cctgagccgg cagatgatag gggaattcct ggggaatcgg cagaagcagt
     2701 tcaacagaga tgtgttggac tgtgtggtgg atgagatgga cttctcctct atggatttgg
     2761 acgatgcact caggaagttc caatcccata tccgagttca gggggaggcc cagaaagtgg
     2821 agcgactcat tgaagctttc agccagcggt actgtgtctg taaccctgcc ctcgtacgcc
     2881 agttccggaa cccagacacc atcttcatcc ttgcttttgc catcatcctc ctcaataccg
     2941 atatgtacag ccccagtgtc aaggctgaac gcaagatgaa gctggatgac ttcattaaga
     3001 acctgagagg agttgacaat ggtgaagaca tcccccgcga ccttctagta ggcatctacc
     3061 agcgcatcca aggtcgtgaa ctgaggacca atgatgacca tgtgtcccag gtgcaggctg
     3121 tggagcgcat gattgttggc aagaaaccgg tcctgtcgct ccctcaccgt cgactggttt
     3181 gctgctgcca gctctatgag gtgccagatc caaaccgtcc ccaaaggctg gggctgcatc
     3241 agcgggaggt caccaaaatt ttccagaaga agaagatctt ggtgacatac agcttccgtc
     3301 agtcctttcc cctggtggaa atgcatatgc agctcttcca gaattcatat tatcagtttg
     3361 ggatcaagtt actgtctgca gtacctggag gggaacgaaa agtcctcatc atctttaatg
     3421 ctcctagcct ccaagacagg ctacgcttta cctctgacct gcgggagtcc attgctgagg
     3481 tgcaggagat ggagaagtat cgtgtggaat cggagctgga aaagcagaaa ggtatgatgc
     3541 ggcctaatgc ctcacagcct ggaggagcca aggactcagt gaatgggact ctggcccgca
     3601 gtagtctgga ggacacttat ggggcaggcg atgggctcaa gcggggtgca ctcagtagtt
     3661 ccctgcgaga cctctctgat gcagggaagc gggggcggcg taacagcgtg ggatcgctgg
     3721 acagcaccat cgaagggtct gttattagca gtccacgccc tcaccagagg atgccacctc
     3781 cgcccccacc cccgccgcca gaggagtaca agagccagag gccagtctcc aactcctcat
     3841 ctttcctggg ctccctattt ggaagcaaga ggggcaaagg gcccttccag atgccaccac
     3901 caccaacagg ccaggcctct gcctcgtctt catctgcttc ctccacccac caccaccatc
     3961 accaccacca ccatggtcac agccatggtg gcctgggggt gctacctgat gggcagtcca
     4021 agctccaggc cctgcatgcc cagtattgcc aaggaccggg ccctgcccca ccaccctacc
     4081 tcccacccca gcaaccccct ctgcctccac cccctcagca gcctccaccc ctgccccagc
     4141 tgggctccat tccaccacca cctgcctcag ccccacctgt ggggccacat cgacacttcc
     4201 atgcccatgg cccagttcca ggaccccagc attatacctt gggccggcca ggcagagccc
     4261 caagacgagg ggctggagga caccctcagt ttgctccaca cggccgccac cccttgcacc
     4321 agcccacatc cccattaccc ctgtacagtc ctgctccaca gcaccctcct gcccataaac
     4381 agggccccaa gcacttcatc ttcagtcacc acccacagat gatgccagca gcaggtgcag
     4441 ctgggggccc tgggtcccgg ccaccagggg gatcctattc ccaccctcac cacccccaat
     4501 caccactgtc accacactca cccatcccac ctcatccctc ctaccctccc ctgcccccac
     4561 cctcacctca caccccacat tcacccctac cacccacctc cccccatggc ccactgcacg
     4621 cctctgggcc ccctggcacg gctaatccac ccagtgcaaa ccccaaggcc aagccaagcc
     4681 ggatcagcac tgtggtctga ggaacgggat gagtgtactg gggagcagga tagtctggag
     4741 aaatccacag gagagggacc ttgcccctct cttcttcctc ggttttttca aaatatatat
     4801 acacactcag cagtgtcttt ctttccactt cctctgtatc tccagaccct tcttccaacc
     4861 cccagcagtt gtcatggggt ttcctttcag attggagggc ccttgccact tgcagcctga
     4921 acgtagggca ctgcagtgct gggaagtggt aagagcctct cagtaggcct cgtcctcctg
     4981 ttcctgtctt cctctcctct ttcttgtccc tggaggtcta gttggtgacc tcagacctct
     5041 aggcaaatgt gagcttcctt gcaagctggt ggagaaggca ggcttctgga gctgcagagg
     5101 tgaaggcttt ccccagagct cctctggctg tgtggggcta ggagagagct ctgtagagct
     5161 gtggccaaac ctcagctggc gcagccctcc ctctgacctc agggcctagc cacacacctc
     5221 catgtgtctt tctgccttgc ctgctggagg acacacagac cgtcagtgca ctctatgggt
     5281 ggaaccccgc ttgtgctggc ccccactgag ggcagtgctt cctctcttga gccagtctgt
     5341 gccctctctc ctaataggcc ccagcccaga cctctttggc ttcaggaact tgccttgccc
     5401 tgcaatgttc ttatcctgat caaagtccag acaggttttt actttggagg cgggggaggg
     5461 ggggctcagg tctgggatga gaagggtacc gccctccctc acccatattg catgcccccc
     5521 ttccttctac ttttcccacc ttcgactgaa gacaatgcac tttacagata tcacccacac
     5581 atatctcact ggggcagggc acccagcatc agccctcggg aaagactccc agaggaccac
     5641 cctgagccca agatgtcctt cctgaggcag agattgaagc catcagagca ggggctgtga
     5701 gccagaatgc ccaagcccct cttgttcatc aaaatctcca ctgcctcgcc agcccctttg
     5761 cagccctgtt tatttattat aaatatattt tttacaagtc tcagctcctc ttcttgccct
     5821 acattcagct cctttcacag tccctgcctt tctctcccct gtccagtatg ggctgcaata
     5881 cagacagaca gatgggccct ctatgtcaaa gggtccctgg ggcttggggt tgtgggaggg
     5941 cgttggtagg agggactgta tggagaggag ctggggttca ggcattgtct ttttccctcc
     6001 ttgtatataa gaatgtatat ttgatgcctc ataaaagacc ttgtgctca
//
