LOCUS       NM_001113419            2397 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus Iqcj and Schip1 fusion protein (Iqschfp), mRNA.
ACCESSION   NM_001113419
VERSION     NM_001113419.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2397)
  AUTHORS   Martin,P.M., Cifuentes-Diaz,C., Devaux,J., Garcia,M., Bureau,J.,
            Thomasseau,S., Klingler,E., Girault,J.A. and Goutebroze,L.
  TITLE     Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a
            Multipartner Ankyrin- and Spectrin-binding Protein Involved in the
            Organization of Nodes of Ranvier
  JOURNAL   J Biol Chem 292 (6), 2441-2456 (2017)
   PUBMED   27979964
REFERENCE   2  (bases 1 to 2397)
  AUTHORS   Papandreou,M.J., Vacher,H., Fache,M.P., Klingler,E.,
            Rueda-Boroni,F., Ferracci,G., Debarnot,C., Piperoglou,C., Garcia
            Del Cano,G., Goutebroze,L. and Dargent,B.
  TITLE     CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1
            association with AnkG contributes to the maintenance of the axon
            initial segment
  JOURNAL   J Neurochem 134 (3), 527-537 (2015)
   PUBMED   25950943
REFERENCE   3  (bases 1 to 2397)
  AUTHORS   Martin,P.M., Carnaud,M., Garcia del Cano,G., Irondelle,M.,
            Irinopoulou,T., Girault,J.A., Dargent,B. and Goutebroze,L.
  TITLE     Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late
            component of nodes of Ranvier and axon initial segments
  JOURNAL   J Neurosci 28 (24), 6111-6117 (2008)
   PUBMED   18550753
REFERENCE   4  (bases 1 to 2397)
  AUTHORS   Kwasnicka-Crawford,D.A., Carson,A.R. and Scherer,S.W.
  TITLE     IQCJ-SCHIP1, a novel fusion transcript encoding a
            calmodulin-binding IQ motif protein
  JOURNAL   Biochem Biophys Res Commun 350 (4), 890-899 (2006)
   PUBMED   17045569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124370.3, AC093360.7, AC122913.4 and AC121306.12.
            
            On Oct 7, 2010 this sequence version replaced NM_001113419.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription from the neighboring IQ motif containing J (Iqcj) and
            schwannomin interacting protein 1 (Schip1) genes. This locus
            produces a transcript that is composed of in-frame exons from each
            individual gene. The resulting fusion protein is thought to be a
            component of the multimolecular complexes of axon initial segments
            and nodes of Ranvier, and it may play a role in calcium-mediated
            responses. [provided by RefSeq, Oct 2010].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference genome strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU163409.1, SRR7652917.456338.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 30953, 208426
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC124370.3         146866-146967
            103-167             AC093360.7         156781-156845       c
            168-248             AC093360.7         150721-150801       c
            249-384             AC093360.7         142641-142776       c
            385-1068            AC122913.4         160242-160925
            1069-1187           AC121306.12        132942-133060       c
            1188-1305           AC121306.12        112653-112770       c
            1306-1503           AC121306.12        111402-111599       c
            1504-1627           AC121306.12        110491-110614       c
            1628-1721           AC121306.12        108144-108237       c
            1722-2397           AC121306.12        102728-103403       c
FEATURES             Location/Qualifiers
     source          1..2397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3"
     gene            1..2397
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /note="Iqcj and Schip1 fusion protein"
                     /db_xref="GeneID:100505386"
                     /db_xref="MGI:MGI:5439400"
     exon            1..102
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1773
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /note="IQ motif containing J-schwannomin interacting
                     protein 1 readthrough; IQ motif containing J-schwannomin
                     interacting protein 1 fusion protein"
                     /codon_start=1
                     /product="IQCJ-SCHIP1 readthrough transcript protein"
                     /protein_id="NP_001106890.1"
                     /db_xref="GeneID:100505386"
                     /db_xref="MGI:MGI:5439400"
                     /translation="MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQ
                     PLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPDYRED
                     GMDLGSDAGSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQ
                     KKVIDEWAPEEDGEEEEEEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSP
                     MPNGNLHPHDPQDLRHNGNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCL
                     QPPDGGTRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESI
                     RQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSK
                     TETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPM
                     AKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHS
                     QIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK"
     exon            103..167
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..248
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..384
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1068
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1187
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1305
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1503
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1627
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1721
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..2397
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /note="hexamer: AATAAA"
     polyA_site      2379
                     /gene="Iqschfp"
                     /gene_synonym="Gm21949; Iqcj-schip1; Schip-1-iqcj; Schip1"
                     /note="major polyA site"
ORIGIN      
        1 acagtgacac cgggctctgt gcttccgagg aacaccgtgc gccagcctct gattcagtct
       61 cctctcacct gcaggtgctc tagaaacttc aaaatgcgac tggaagaact aaagagacta
      121 cagaatcctt tagaacaagt tgacgatgga aaatatttgc ttgagaatca ccagctggcc
      181 atggatgtgg agaataacat tgagaactat cccctcagcc tacagccctt ggaatcaaag
      241 gtgaaaatca tccagcgagc atggcgagag tacttgcaga ggcaggaccc cctggagaag
      301 cggagcccat ccccaccttc tgtctcttca gacaagctga gcagctctgt cagcatgaac
      361 accttctccg acagcagcac acccgattac cgagaggatg ggatggatct aggcagtgac
      421 gccggcagca gcagcagcag ccgcgccagc tcacaatcca actccaccaa agtgacccct
      481 tgctccgagt gcaaatcctc atcgtcgccg gggggtagct tggacttggt gtctgctctg
      541 gaagactatg aagagccctt cccggtctac cagaagaagg tgattgatga gtgggctccg
      601 gaggaggacg gggaggagga ggaagaggag gacgatcgag ggtatcggga tgacggctgt
      661 ccggcccggg agccggggga cgtgagcgcc aggatcggca gcagcggcag cgggagcagg
      721 agcgccgcca ccaccatgcc gtccccgatg cctaacggca acctccatcc gcacgaccct
      781 caagacctca ggcacaatgg caacgtggtg gtagctggcc ggccgaacgc ctctcgggtt
      841 ccccggcgac ccatccagaa gacccagcct ccagggagcc ggcgcggagg ccgaaaccgg
      901 gcatctgggg gcctctgcct tcagccaccg gacggcggga cgcgggtccc ggaagaaccc
      961 cctgcgcccc caatggactg ggaggcattg gaaaagcatc tggccgggct gcagttccgg
     1021 gagcaggagg tgcgaaacca gggtcaggcg aggaccaact ccacctctgc acagaagaat
     1081 gagagagagt ctatcagaca gaagttggca ctcggaagct tctttgacga tggcccagga
     1141 atctatacca gctgcagcaa aagtgggaag ccaagccttt ctgcaagact acagagcggg
     1201 atgaacctcc agatatgctt tgtcaatgac agcggcagtg acaaggacag cgatgcagat
     1261 gacagtaaga cggaaaccag cttggacacg cccttgtccc ccatgagcaa gcagagttct
     1321 tcctattcgg atagagacac aactgaggag gagtctgaat ccctggatga catggacttc
     1381 ctcacaaggc aaaagaagct acaagctgaa gccaaaatgg ctctggccat ggccaaacca
     1441 atggccaaaa tgcaagtaga agtggaaaaa cagaacagga aaaagtctcc cgtcgctgat
     1501 cttctcccac acatgcctca cataagcgaa tgtttgatga aaagaagctt aaagcccacc
     1561 gacctgagag acatgactat cgggcagcta caagtgatcg tcaatgacct ccactcccag
     1621 attgaaagtt tgaatgaaga gttggtccag ctgctcctta ttcgagatga gctgcacaca
     1681 gaacaagatg ccatgctggt ggacattgaa gacttgacta gacacgctga gagtcagcag
     1741 aagcacatgg ctgagaaaat gcccgcgaag tgaaagagag ccatccacca gagaacaagc
     1801 tagaatttat tttgcttctg tggtcgtaaa aattgctgtt gctaaaggtg gttccgaaac
     1861 agacatcagt gttagtcatt ggtaacgtcc gagcttactg tcccgtgact ggccttcgct
     1921 tcttaattta ttttaatttc tttctttcct tttttttttt ttttttttta ctcttgccac
     1981 ttactatcag gccttttaat aaaacattgt tacaagaact gtacagtact taaaccacca
     2041 acaaccgtgg ataagcagag ggtagttttg actttgtttt tgtttagaga ctttaagttg
     2101 gagcagtatt ttaccattga ctgtttcatt cttcactgta gctttgaaga ggaactgtaa
     2161 atgacggtgc tatacaagtc aaaatacatg cctgcctcgt agtgaagtcg tagctctcca
     2221 tactacgtat attttaatca gttttcaaca ttttgtgaat gttgactacc tgaggtttat
     2281 tcttagatgt gctattaaca ttctgtcgga tccacatggt tccttgggag ttttatgtat
     2341 aaatatgtaa aataaaaatt aaaactttgt ttcatatgat acgtcctttt gctcact
//
