LOCUS       NM_027711               5771 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus IQ motif containing GTPase activating protein 2
            (Iqgap2), mRNA.
ACCESSION   NM_027711
VERSION     NM_027711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5771)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5771)
  AUTHORS   Sen,A., Youssef,S., Wendt,K. and Anakk,S.
  TITLE     Depletion of IQ motif-containing GTPase activating protein 2
            (IQGAP2) reduces hepatic glycogen and impairs insulin signaling
  JOURNAL   J Biol Chem 299 (11), 105322 (2023)
   PUBMED   37805137
  REMARK    GeneRIF: Depletion of IQ motif-containing GTPase activating protein
            2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
REFERENCE   3  (bases 1 to 5771)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5771)
  AUTHORS   Lupu,D.S., Orozco,L.D., Wang,Y., Cullen,J.M., Pellegrini,M. and
            Zeisel,S.H.
  TITLE     Altered methylation of specific DNA loci in the liver of Bhmt-null
            mice results in repression of Iqgap2 and F2rl2 and is associated
            with development of preneoplastic foci
  JOURNAL   FASEB J 31 (5), 2090-2103 (2017)
   PUBMED   28179424
  REMARK    GeneRIF: found a hypomethylated region mapping to Iqgap2 (IQ
            motif-containing GTPase activating protein 2) and F2rl2
REFERENCE   5  (bases 1 to 5771)
  AUTHORS   Leoni,C., Montagner,S., Rinaldi,A., Bertoni,F., Polletti,S.,
            Balestrieri,C. and Monticelli,S.
  TITLE     Dnmt3a restrains mast cell inflammatory responses
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1490-E1499 (2017)
   PUBMED   28167789
  REMARK    GeneRIF: The exacerbated mast cell responses observed in the
            absence of Dnmt3a were recapitulated or enhanced by treatment with
            the demethylating agent 5-aza-2'-deoxycytidine as well as by
            down-modulation of Dnmt1 expression. These effects were in part
            mediated by the dysregulated expression of the scaffold protein
            IQGAP2.
REFERENCE   6  (bases 1 to 5771)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   7  (bases 1 to 5771)
  AUTHORS   Cupit,L.D., Schmidt,V.A., Miller,F. and Bahou,W.F.
  TITLE     Distinct PAR/IQGAP expression patterns during murine development:
            implications for thrombin-associated cytoskeletal reorganization
  JOURNAL   Mamm Genome 15 (8), 618-629 (2004)
   PUBMED   15457341
REFERENCE   8  (bases 1 to 5771)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5771)
  AUTHORS   Natale,D.R. and Watson,A.J.
  TITLE     Rac-1 and IQGAP are potential regulators of E-cadherin-catenin
            interactions during murine preimplantation development
  JOURNAL   Mech Dev 119 Suppl 1, S21-S26 (2002)
   PUBMED   14516655
REFERENCE   10 (bases 1 to 5771)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142813.1, AK147360.1 and CJ201339.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147360.1, BC150958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4036              AK142813.1         2-4037
            4037-4100           AK147360.1         4031-4094
            4101-4551           AK142813.1         4102-4552
            4552-5768           AK147360.1         4546-5762
            5769-5771           CJ201339.1         402-404
FEATURES             Location/Qualifiers
     source          1..5771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.26 cM"
     gene            1..5771
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /note="IQ motif containing GTPase activating protein 2"
                     /db_xref="GeneID:544963"
                     /db_xref="MGI:MGI:2449975"
     exon            1..259
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..4941
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP2"
                     /protein_id="NP_081987.1"
                     /db_xref="CCDS:CCDS36753.1"
                     /db_xref="GeneID:544963"
                     /db_xref="MGI:MGI:2449975"
                     /translation="MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHL
                     EEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKK
                     SGLHFRHTDNTVQWLRAMEAIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLG
                     IAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPAFSKIGGILANELSVDEAALHAAV
                     IAINEAIEKGVAKQTIITLRNPNAVLTCVDDSLSQEYQKELWEAKKKKEESAKLKNSC
                     ISEEERDAYEELLTQAEIQSNISTVNRMAAVDHINAVLQEGDPENTLLALKKPEAQLP
                     AVYPFAAVMYQNELFNLQKQNTSNYLAHEELLIAVEMLSAVALLNQALESSDLVAVQN
                     QLRSPTIGFNNLDEAHVDRYADALLSVKQEALSQGQDTLSWNEIQNCIDMINNQIQEE
                     NDRMVVLGYINEAIDAGNPLKTLDTLLLPTANIRDVDPDCAQHYQDVLFYTKSQKLGD
                     PKNVSKVLWLDEIQQAINEANVDENRAKQWVTLVVDVNECLDRKQSDHILTALKSSPS
                     NIHNILPECANKYYDTLVKAKESKTDNESSEGSWVTLNVQEKYNYYYNTDSKEGSWVP
                     PELCLSKESWLTGEEIEDIVEEVTSDYIREKLWSASEDLLVRFEATTLGPALREEFEA
                     RKAFLYEQTESVVKIQAFWKGFKQRQEYLHRQQVFAGNVDSVVKIQSWFRMVTARKSY
                     LSRLRYFEDHKNEIVKIQSLLRASKARDDYKALVGSENPPLTVIRKFVYLLDQSDLDF
                     QEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHRKKLNKKK
                     GGEIEILNNTDNKGIKSLSKERRKTLETYQQLFYLLQTKPSYLAKLIFQMPQNKSTKF
                     MDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFN
                     RGARGQNTLRQLLAPVVKEIIEDKALVINTNPVEVYKAWVNQLETQTGEASKLPYDVT
                     TEQALTYPEVKNKLEASIENLRKVTDKVLGSIISSLDLLPYGLRYIAKVLKNSIREKF
                     PDATEEELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSNQRRNLGSVAKVLQ
                     HAASNKLFEGENEHLSSMNNYLSETYQEFRKYFQEACDVPEPEEKFNMDKYTDLVTVS
                     KPVIYISIEEIINTHLLLLEHQDAIATEKSDLLNELLESLGEVPTVESFLGEGAVDPN
                     DPNKENTLNQLSKTEISLSLTSKYDVKDGEAVDGRSLMIKTKKLIIDVTRNQPGSTLT
                     EILETPATGQQELEHAKDMESRAVVDSRTPEEGKQSQAVIEDARLPLEQKKRKIQRNL
                     RTLEQTGHVSSKNKYQDILNEIAKDIRNQRIHRKLRKAELSKLQQTLNALNKKAAFYE
                     DQINYYDTYIKTCVDNLKRKNSRRSIKLDGKAEPKGTKRVKPVRYTAAKLHDKGVLLG
                     IDDLQTNQFKNVMFDIIATEDMGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMK
                     MFDKVKVNVNLLIYLLNKKFYGK"
     exon            260..359
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            360..516
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            517..594
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            595..671
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            672..739
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            740..853
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1032
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1120
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1284
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1445
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1570
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1734
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1825
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1993
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2136
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2307
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2391
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2463
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2533
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2742
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2892
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3056
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3281
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3422
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3507
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3740
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3873
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..3976
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            3977..4118
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4206
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            4207..4419
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4580
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            4581..4718
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4827
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..5771
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5751..5756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /note="hexamer: AATAAA"
     polyA_site      5771
                     /gene="Iqgap2"
                     /gene_synonym="4933417J23Rik; A630053O10"
                     /note="major polyA site"
ORIGIN      
        1 agttcacttt tgccccggtg tcagcgagac gcggccgccg caggcgcgag tgaaggagca
       61 ccgagggagc ggagcggtca gctccgagaa gccgggcgag ggcagcccag aggtgggatc
      121 ggagcgcgcc cgccgggcgc ggagcccgcg agcctggcca gcgagggaaa ccacgggggg
      181 cgctccccgg gagggccccc agagcagcgc aggatgccgc acgaagagct gccgtcgttg
      241 caacggcccc gctacggctc aatcgtggat gatgaaaggc tgtctgcaga ggagatggat
      301 gagaggaggc gacagaacat cgcctatgaa tacttgtgtc acctggagga agccaagaga
      361 tggatggaag tctgcttagt tgaagaattg ccaccaacca ctgaactgga agaagggctc
      421 cggaatgggg tctacctcgc caagttagcc aagttcttcg ctccaaaaat ggtatcagag
      481 aagaagatct acgatgtgga gcagacacgt tataagaaat ctggccttca ttttcgacac
      541 acagataaca ctgtgcagtg gttaagagct atggaagcca tcgggctgcc caagatattt
      601 tatccagaaa caacagatgt ctacgatcgg aaaaacatac caaggatgat ctattgcatt
      661 cacgcgctaa gtttgtatct gtttaaactg gggattgcgc cccagatcca ggatttgctg
      721 ggaaaagtgg atttcacaga ggaggagatc agtaacatga ggaaagaact ggagaagtac
      781 gggatccaga tgccggcttt cagcaaaatc ggtggcattc tggccaatga actgtctgtg
      841 gacgaagctg cactacatgc tgcagtcata gctattaatg aggctattga aaagggagtg
      901 gccaagcaga ccattataac actaagaaac cccaacgcag tgttaacttg tgtggacgac
      961 agcctctcac aggagtacca gaaagaactg tgggaagcca aaaagaaaaa agaggaaagc
     1021 gcaaaactga agaacagctg tatttcagag gaagagagag atgcgtatga ggagctgctg
     1081 acccaggcag aaattcaaag caacatcagt accgtcaaca ggatggctgc tgtggaccac
     1141 atcaatgctg tccttcagga aggtgacccc gagaacacac tgcttgcact gaagaaacca
     1201 gaagcccagc tgccagctgt ctatcccttt gctgctgtta tgtatcaaaa tgaactcttc
     1261 aacctccaga aacagaacac atcgaactac ttggcccacg aggagctcct gattgccgtg
     1321 gaaatgttgt ctgccgttgc tctgctaaac caggccttgg agagcagtga cctcgtggct
     1381 gtgcagaacc aactcagaag ccccaccata ggcttcaaca atctggatga ggcacacgtg
     1441 gaccgttatg cagacgcact actctctgtt aaacaagaag cattatccca agggcaagat
     1501 accttaagct ggaatgaaat tcagaattgt atcgatatga ttaataacca gattcaagaa
     1561 gaaaatgacc gaatggtagt tctcgggtac atcaatgaag ccatcgacgc agggaaccct
     1621 ctgaagactt tagatacctt gctgctgccc actgctaata tcagagatgt ggacccagac
     1681 tgcgcccaac actaccagga tgttctgttc tatacaaaat cccagaaact cggggatcct
     1741 aagaatgttt ctaaagttct ctggctggat gagatacagc aagccatcaa tgaggccaac
     1801 gtggatgaga acagagcaaa gcaatgggtt acactggtcg ttgacgtgaa tgagtgtttg
     1861 gatagaaaac aatcagatca catcttgact gcactcaagt cttctcctag caatatccat
     1921 aacatactcc cagaatgtgc caacaagtac tatgataccc ttgtgaaggc gaaagagtca
     1981 aagactgaca atgagtccag tgaaggttca tgggtcacac tcaacgtgca agagaaatat
     2041 aactactatt acaacacgga ttccaaagaa ggctcttggg ttccacccga attatgcttg
     2101 tctaaagaat catggctcac gggagaggaa attgaggaca ttgtggagga ggtcacatca
     2161 gattacatcc gggagaagct gtggtctgct tcagaagact tgcttgtccg cttcgaggcc
     2221 acaaccttgg gacctgccct tagggaggaa tttgaagcta ggaaagcatt cttatatgaa
     2281 caaacagaga gcgtggtcaa aatccaggct ttctggaagg ggttcaaaca acgccaggaa
     2341 tatctgcaca gacaacaggt gtttgctggt aacgttgatt ctgttgtgaa gattcagtcc
     2401 tggttccgaa tggtgacagc aaggaagagt tatctttcac gactgcggta ttttgaagat
     2461 cataaaaatg aaattgtgaa aatacaatcc ctgttacggg caagcaaagc cagagacgac
     2521 tacaaagcac tagttggctc cgaaaaccca ccattaacag taatccgaaa gttcgtgtac
     2581 ctgttggacc agagtgactt ggatttccag gaggagctgg aggtagccag gctacgagaa
     2641 gaagtagtga cgaagatcag ggccaatcag cagctggaga aggacttgaa cctaatggac
     2701 atcaagattg gactgctggt gaagaacagg attacgctgg aggatgtaat ctcacacaga
     2761 aaaaagctga ataagaaaaa aggtggtgaa atagaaatac tgaataacac tgacaacaag
     2821 ggaattaaaa gcttgagtaa ggagagacgg aaaacactgg agacctacca gcaactgttc
     2881 tacctcctcc agaccaaacc ttcatacctg gctaagctga ttttccagat gccacagaac
     2941 aagtcgacga aattcatgga cacggttatc ttcactctat acaattacgc ctctaaccag
     3001 agggaagaat acctgttgct caagctcttc aaaactgcgc tggaggaaga aatcaaatca
     3061 aaggtggacc aggtacaaga catagtgaca ggcaacccta cagtcatcaa gatggttgtc
     3121 agcttcaaca gaggcgcccg gggacagaac accctgcgcc agctcctggc accagtggtg
     3181 aaagagatca ttgaggacaa ggccctggtc attaacacca accctgtgga ggtgtacaag
     3241 gcttgggtga accaactgga aacgcagact ggagaagcca gcaagctgcc ttacgacgtc
     3301 accacagagc aagccctgac atacccggag gtgaagaata aactggaggc atctattgaa
     3361 aacctgagga aggtcaccga caaagtcctg ggctccatca tttcttccct cgatctgctg
     3421 ccttatggat tgaggtatat agccaaagta ctgaagaact cgatccgtga gaaattcccc
     3481 gatgccacgg aagaagagct gttaaagatt gttggaaatc tcctatacta ccggtatatg
     3541 aacccagcca ttgtggctcc cgatggcttt gacatcattg acatgacagc cggaggtcag
     3601 atcaactcca accaaaggag aaacttggga tctgtggcaa aggttctgca acacgcagcc
     3661 tccaacaagc tgtttgaggg cgagaatgag catttgtcat caatgaacaa ttatttgtca
     3721 gagacctacc aggaattcag gaaatatttt caagaagcgt gtgatgtccc tgaaccggaa
     3781 gagaagttta atatggacaa atacacggat ttggtgaccg tcagcaagcc agttatttat
     3841 atctccatag aagaaatcat caatacacat ttactcctgc tggaacatca ggatgccatt
     3901 gccactgaaa agagtgacct actgaacgag ctgctggagt ctctggggga ggtgcccacg
     3961 gtggagtcct ttctcgggga aggagcagtt gaccccaatg accctaacaa ggaaaacaca
     4021 ttaaatcaac tctccaaaac cgagatttcc ctttccttga caagcaagta tgacgtcaaa
     4081 gatggcgagg ccgtcgatgg cagaagcctc atgataaaga ccaaaaagct gatcatcgat
     4141 gtgacccgga accagccagg gagcacgctg actgaaatct tagagacccc agcaactggg
     4201 cagcaggaac tagagcacgc caaagacatg gagagccgtg ccgttgtaga ctccaggacc
     4261 ccggaggaag ggaagcagag ccaagcagtg atagaagatg cacgcctgcc cctcgagcaa
     4321 aagaagagga agattcagag gaacctgcgg acgctggagc agactggaca cgtgtcctcc
     4381 aaaaacaagt accaagacat tctcaacgag attgccaagg atattcgaaa tcaaagaatc
     4441 caccgcaagc ttcgaaaagc tgagctgtcg aaacttcagc aaaccctgaa cgcacttaat
     4501 aagaaggcag cgttttatga agatcaaatt aattattacg acacctacat caagacctgt
     4561 gtagacaacc tgaaaagaaa aaattctcgg agatcaatta aactggatgg aaaagcagaa
     4621 cccaaaggaa cgaagagagt gaagccagtg aggtacacgg cagcaaagct acatgacaaa
     4681 ggcgtcctgt tgggcataga tgaccttcaa accaaccagt ttaagaatgt tatgttcgat
     4741 atcatagcta ctgaggacat gggcatcttt gacgtcagat ccaaattcct cggtgttgag
     4801 atggaaaagg tacaactcaa tattcaggac ttacttcaga tgcagtatga aggggtggcc
     4861 gtgatgaaaa tgttcgacaa ggtgaaagtg aacgtgaacc ttctcatata cctgctcaac
     4921 aagaagttct acggaaagtg acgtgccgtc tgccgaggga ctcgtggatt ctctattgcc
     4981 tgccttgaga aatgggcttg tctagtattt ttgtttgaaa acatgattgg aatcacggct
     5041 tataagtgtc tgaatttttt ttaagaccaa aactgttctg aagaatgtag ccatgtgcct
     5101 ttttgataat tggatactgc agcagaggga tagacaagat gggctgaggg gacacacaca
     5161 cacacacaca cacacacaca gtactgtggc acaggtactg cctcggaaag ttctgaatac
     5221 cctgtgatct attttaaagt aggggggaga aagtttagct gactagggac aaatgtataa
     5281 acctattttc ctatgaaaag aaattttaaa tgtcccactt aaatgattaa ttcttcatag
     5341 attgttttct atctgtggag aaatagagat ctaattaatt tgtaatgaat tatttagaca
     5401 tagagttcta agccctgtct tctgggaatt atcagtttta aagagaactt ttgtgcaatt
     5461 ccaaatgaag tttttataag taattgaaag tgatgataca ataacacttt ctgtataaaa
     5521 gtatatattt tatgtgattt attcaattta ctccaagtgc actactgcct catgggaagg
     5581 ctcctgtatg ggagtcacag gaaacacggt ggacagcagg tatagacccc caccttcacc
     5641 cgcaccattt atttgaatac ttcaattgtg cctctcaatt tttttgtaat gctatcaaat
     5701 cagtatccag atggttttta aatgtattct ttgaaaattg ttttatgtaa aataaatgtt
     5761 acttaattac a
//
