LOCUS       NM_016721               7377 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus IQ motif containing GTPase activating protein 1
            (Iqgap1), mRNA.
ACCESSION   NM_016721
VERSION     NM_016721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7377)
  AUTHORS   Wen,X., Li,D., Wang,H., Zhang,D., Song,J., Zhou,Z., Huang,W.,
            Xia,X., Hu,X., Liu,W., Gonzales,J., Via,L.E., Zhang,L. and Wang,D.
  TITLE     IQGAP1 domesticates macrophages to favor mycobacteria survival via
            modulating NF-kappaB signal and augmenting VEGF secretion
  JOURNAL   Int Immunopharmacol 138, 112549 (2024)
   PUBMED   38944950
  REMARK    GeneRIF: IQGAP1 domesticates macrophages to favor mycobacteria
            survival via modulating NF-kappaB signal and augmenting VEGF
            secretion.
REFERENCE   2  (bases 1 to 7377)
  AUTHORS   Akter,T., Atanelishvili,I., Silver,R.M. and Bogatkevich,G.S.
  TITLE     IQGAP1 Regulates Actin Polymerization and Contributes to
            Bleomycin-Induced Lung Fibrosis
  JOURNAL   Int J Mol Sci 25 (10), 5244 (2024)
   PUBMED   38791282
  REMARK    GeneRIF: IQGAP1 Regulates Actin Polymerization and Contributes to
            Bleomycin-Induced Lung Fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7377)
  AUTHORS   He,Y., Jiang,L., Liu,H., Bu,Q., Kuang,W., Zhao,Y., Chen,Y.,
            Zhang,N., Xiao,Y., Li,S., Chen,R., Han,S., Zhou,Y., Zhang,J.,
            Wan,X., Xu,R., Wang,S., Zhang,H., Gu,H., Wei,Q., Qin,F., Zhao,Y.,
            Li,H., Wang,L., Wang,X., Wang,Y., Dai,Y., Li,M., Chen,Y., Wang,H.,
            Tian,J., Zhao,Y. and Cen,X.
  TITLE     Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and
            Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in
            Mice
  JOURNAL   Biol Psychiatry 95 (9), 896-908 (2024)
   PUBMED   37913973
  REMARK    GeneRIF: Hippocampal circAnk3 Deficiency Causes Anxiety-like
            Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1
            Pathway in Mice.
REFERENCE   4  (bases 1 to 7377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 7377)
  AUTHORS   Elenbaas,J.S., Pudupakkam,U., Ashworth,K.J., Kang,C.J., Patel,V.,
            Santana,K., Jung,I.H., Lee,P.C., Burks,K.H., Amrute,J.M.,
            Mecham,R.P., Halabi,C.M., Alisio,A., Di Paola,J. and Stitziel,N.O.
  TITLE     SVEP1 is an endogenous ligand for the orphan receptor PEAR1
  JOURNAL   Nat Commun 14 (1), 850 (2023)
   PUBMED   36792666
  REMARK    Erratum:[Nat Commun. 2023 Mar 17;14(1):1511. doi:
            10.1038/s41467-023-37005-x.. PMID: 36932061]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7377)
  AUTHORS   Mataraza,J.M., Briggs,M.W., Li,Z., Entwistle,A., Ridley,A.J. and
            Sacks,D.B.
  TITLE     IQGAP1 promotes cell motility and invasion
  JOURNAL   J Biol Chem 278 (42), 41237-41245 (2003)
   PUBMED   12900413
  REMARK    GeneRIF: IQGAP1 has a fundamental role in cell motility and
            invasion
REFERENCE   7  (bases 1 to 7377)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7377)
  AUTHORS   Mbele,G.O., Deloulme,J.C., Gentil,B.J., Delphin,C., Ferro,M.,
            Garin,J., Takahashi,M. and Baudier,J.
  TITLE     The zinc- and calcium-binding S100B interacts and co-localizes with
            IQGAP1 during dynamic rearrangement of cell membranes
  JOURNAL   J Biol Chem 277 (51), 49998-50007 (2002)
   PUBMED   12377780
  REMARK    GeneRIF: IQGAP1 is a potential target protein of S100B during
            processes of dynamic rearrangement of cell membrane morphology
REFERENCE   9  (bases 1 to 7377)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   10 (bases 1 to 7377)
  AUTHORS   Li,S., Wang,Q., Chakladar,A., Bronson,R.T. and Bernards,A.
  TITLE     Gastric hyperplasia in mice lacking the putative Cdc42 effector
            IQGAP1
  JOURNAL   Mol Cell Biol 20 (2), 697-701 (2000)
   PUBMED   10611248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY107028.1, AK164482.1, CB519254.1, DV069947.1, AK160892.1 and
            BQ174517.1.
            
            On Jun 30, 2009 this sequence version replaced NM_016721.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF240630.1, BC046385.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY107028.1         87-123
            38-1893             AK164482.1         3-1858
            1894-2235           CB519254.1         250-591
            2236-2678           DV069947.1         66-508
            2679-7355           AK160892.1         214-4890
            7356-7377           BQ174517.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..7377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.68 cM"
     gene            1..7377
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /note="IQ motif containing GTPase activating protein 1"
                     /db_xref="GeneID:29875"
                     /db_xref="MGI:MGI:1352757"
     exon            1..191
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..5110
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /note="Cdc42-Rac1 effector protein"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP1"
                     /protein_id="NP_057930.2"
                     /db_xref="CCDS:CCDS40001.1"
                     /db_xref="GeneID:29875"
                     /db_xref="MGI:MGI:1352757"
                     /translation="MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYL
                     CHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTR
                     YKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLF
                     KLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALH
                     AAVIAINEAIDRRVAADTFTALKNPNAMLVNLEEGLAPTYQDVLYQAKQDKMTNAKNR
                     TENSDRERDVYEELLTQAEIQGNVNKVNTSSALANISLALEQGCAVTLLKALQSLALG
                     LRGLQTQNSDWYMKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANSAAQQYQRRLAAV
                     AAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPEL
                     TVAVEMLSSVALINRALESGDMTTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQA
                     HAENNAFITWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAA
                     KLEGVLAEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFA
                     LGISAINEAVDSGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNN
                     SKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQ
                     LWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDR
                     LAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYK
                     TLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMD
                     IKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAY
                     QHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTAL
                     QEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIK
                     TDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFL
                     SAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPD
                     AFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKF
                     RRFFQVACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
                     NDPIHELLDDLGEVPTIESLIGESCGNSNDPNKEALAKTEVSLTLTNKFDVPGDENAE
                     MDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPD
                     KMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRR
                     YRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMK
                     GKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGV
                     QMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK"
     exon            192..291
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            292..448
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            449..526
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            527..603
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            604..671
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            672..785
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            786..964
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1049
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1213
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1298
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1462
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1623
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1748
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1912
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2003
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2171
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2314
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2485
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2569
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2641
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2711
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2920
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3076
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3240
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..3465
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3606
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3691
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3924
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4057
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4160
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4296
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4384
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4385..4597
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4764
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4765..4887
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..4996
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     exon            4997..7359
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7336..7341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /note="hexamer: AATAAA"
     polyA_site      7359
                     /gene="Iqgap1"
                     /gene_synonym="D7Ertd237e; D7Ertd257e; mKIAA0051"
                     /note="major polyA site"
ORIGIN      
        1 gggtggggcc gatggcgcgg ggcggggctc tgaggacagc gacagcccgc gcactgggca
       61 ggagttactg ctgctacggt cgcccgcgtc ttcaaggtct ctgcgcttcc tcaccggaga
      121 cctggactcg gccgccatgt ccgccgcgga ggaggttgat ggcctgggtg tggtccggcc
      181 gcactatggc tccgtcctgg ataatgagag gctcactgca gaggagatgg atgagcggag
      241 acggcagaac gtggcttatg aatacctttg tcatctggaa gaagcaaaga ggtggatgga
      301 agcatgccta ggtgaggacc tgccgcccac cacagagcta gaggagggcc ttagaaacgg
      361 agtctacctt gccaagctag ggaacttctt ctctcccaaa gtggtgtccc tgaagaaaat
      421 ctatgatcga gaacagacca gatacaaggc taccggcctc cacttcagac acacggataa
      481 tgtgattcag tggctgaatg ccatggatga gattgggttg cctaagattt tttacccaga
      541 aaccacagat atctatgacc ggaagaacat gccaagatgc atctactgta tccacgccct
      601 cagtttgtac ctgttcaaac tgggcctggc tcctcagatt caagacctgt atggaaaggt
      661 tgatttcaca gaagaagaaa tcaacaacat gaagatcgag ctggagaagt acgggatcca
      721 gatgcctgcc ttcagcaaga tcgggggcat cctggctaat gagctctcag tggatgaagc
      781 tgcgctacat gctgctgtta ttgctattaa tgaagcgatt gatcgcagag ttgcagctga
      841 cacttttacg gctctaaaaa accccaatgc catgctcgtc aatcttgaag aaggcctggc
      901 tcccacgtac caagacgtgc tttaccaggc caagcaggac aagatgacaa acgctaaaaa
      961 caggacggaa aactctgaca gagaaaggga cgtttatgag gagctgctca cacaagctga
     1021 aatccaaggg aatgtaaaca aagtcaacac atcttctgcc ctggccaaca tcagcctggc
     1081 tttagagcag ggctgtgcag tgaccctgct caaggctctg cagtcactgg ctctgggcct
     1141 ccgagggctg cagacccaga acagcgactg gtacatgaag cagctacaga gtgatctgca
     1201 gcaaaagaga cagagtggcc agactgaccc cctgcagaag gaggaggtac aggccggagt
     1261 ggatgctgcc aacagtgctg cccagcagta ccaacgacgg ttggcagcag tggcagcaat
     1321 caacgctgcc atccagaagg gcatcgctga gaagaccgtg ttggagctaa tgaatcctga
     1381 agcccagctg ccccaggtgt atccatttgc agctgatctc tatcagaagg agttggccac
     1441 cctgcagcag cagagccctg agcatagcct cacccatcct gagctcactg ttgctgtgga
     1501 gatgctgtca tccgtggccc tcatcaacag ggcgctggag tcaggagaca tgaccactgt
     1561 gtggaagcag ctgagcagct cagttacggg ccttaccaac atcgaggaag aaaactgtca
     1621 aaggtatctc gatgagctga tgaagctgaa ggctcaggca catgccgaga ataatgcatt
     1681 tattacatgg aatgacatcc aggcgtgtgt ggaccatgtg aacctggtgg tccatgagga
     1741 gcatgagcgg attttggcca tcggcttgat taatgaagcc ctggatgaag gggacgctca
     1801 gaagactctg caggccctgc agatccctgc agccaagctc gagggcgtcc ttgcagaagt
     1861 ggcacagcac tatcaagaca cgctgatcag agcaaagaga gaaaaggccc aggaaacaca
     1921 ggatgagtca gctgtgttat ggttggatga aattcaaggt ggaatctggc agtccaacaa
     1981 agacacccaa gaggcccaga ggtttgcctt aggaatctct gccatcaatg aagcagtaga
     2041 cagcggtgat gttggcagaa ccctgagtgc cctacgttct cccgacgttg gcttatatgg
     2101 agtgatcccc gaatgtgggg aaacgtacca gagtgacctt gctgaagcca agaagaagag
     2161 actggcagca ggagataata acagcaagtg ggtgaagcac tgggtgaaag gcgggtacca
     2221 ttactaccac aacctggaga cgcaagcagg aggatgggct gagcccccag actttgtgca
     2281 gaattctgtg cagctttctc gagaggagat ccagagctcc atctctggag taaccgctgc
     2341 atataaccga gagcagcttt ggctggccaa cgaaggcttg atcaccaagc tgcaagcctg
     2401 ctgccgtggg tacctcgttc gacaggaatt ccgatcccgg atgaattttc tgaagaaaca
     2461 gatccctgcc atcacctgca ttcagtcaca gtggagagga tacaaacaga agaaggcata
     2521 tcaagatcgg ctggcttacc tgcactccca taaagacgaa gttgtgaaga ttcagtccct
     2581 tgccaggatg catcaagctc gaaagcgcta tagagatcgc ctacagtatt tccgagacca
     2641 tataaatgac attatcaaaa tccaggcttt cattcgggcc aacaaagctc gtgatgacta
     2701 caagactctc atcaatgctg aggacccgcc tatgattgtg gtccgaaagt ttgtccacct
     2761 cctggaccaa agtgatcagg acttccagga ggaacttgat ctcatgaaga tgcgcgagga
     2821 ggtcatcacc ctcatccgtt ccaaccagca gctggagaac gacctcaacc tcatggatat
     2881 caaaatcgga ctgctggtga agaacaagat cacgctgcag gatgtggttt cccatagtaa
     2941 aaaacttacc aaaaaaaata aggaacagct gtccgacatg atgatgataa acaagcagaa
     3001 gggcgggctc aaggctttga gcaaagagaa gagggagaag ctggaggcct atcagcatct
     3061 cttttatctc ctgcagacca accctaccta tctggccaag ctgatctttc agatgccaca
     3121 aaacaagtcc accaaattca tggactctgt gatcttcacg ctgtacaact atgcatctaa
     3181 ccagcgggag gagtacctgc tgctgcggct cttccagaca gctctgcagg aggagatcaa
     3241 gtcaaaggtg gatcagattc aagaaatcgt gacaggaaac cctacggtta ttaagatggt
     3301 tgtaagtttc aaccgtggtg cccggggcca gaatgccctc cggcagatct tggcccctgt
     3361 cgtgaaggaa attatggatg acaagtctct caacatcaaa accgaccctg tggatattta
     3421 caagtcttgg gttaatcaga tggagtcgca gacaggagag gcgagcaaac tgccctatga
     3481 tgtgactcct gaacaagcct tgtctcatga agaagtgaag acgaggttag acaactccat
     3541 caggaacatg agggccgtga cagacaagtt cctctcagcc atcgtcagct ctgtggacaa
     3601 aatcccttat gggatgcgct tcattgccaa agtcctgaag gattccctgc acgagaagtt
     3661 ccctgacgct ggtgaggacg agctgctgaa gattatcggt aacctgcttt actaccgata
     3721 catgaaccca gccatcgtcg ctcccgatgc cttcgacatc attgacctgt cagcaggggg
     3781 ccagctcacc acagaccagc gcagaaacct gggctccatt gccaagatgc tccagcacgc
     3841 ggcgtccaac aagatgtttc tgggcgataa tgcccactta agcatcatta atgagtatct
     3901 ctcgcagtcc taccagaaat tcagacggtt tttccaagtg gcttgtgacg tcccagagct
     3961 gcaggataaa tttaacgtgg atgagtactc tgacctagtc accctcacta agccagttat
     4021 ctacatctcc attggcgaaa tcatcaacac ccacactctc ctgttggacc atcaggatgc
     4081 cattgctcca gagcataacg accccatcca cgaacttctg gacgaccttg gggaggtgcc
     4141 caccattgag tcccttatag gagaaagctg tggcaattca aacgacccca acaaggaggc
     4201 tctggctaag acggaagtgt ctctcacgtt gaccaacaag tttgacgtgc ctggtgacga
     4261 gaacgcagag atggacgctc ggaccatctt actgaataca aaacgtttaa ttgtggatgt
     4321 catccggttc cagccaggag agaccttgac tgaaattcta gaaaccccag ccaccaatga
     4381 acaggaagct gaacatcaga gggccatgca gagacgggct atccgcgatg ccaaaacccc
     4441 tgacaagatg aaaaaatcaa agcccatgaa ggaggataac aacctcagcc tccaggagaa
     4501 gaaagagaag atccagactg gcctaaagaa gctaacggag cttgggacgg tggacccaaa
     4561 gaacagatac caggaactca tcaacgacat tgccaaggat atccggaatc agcggagata
     4621 caggcagagg aggaaagctg aattggtaaa actgcagcag acgtactcgg cgctgaactc
     4681 taaggccacc ttttacggcg agcaggtgga ctactacaag agctacatca aaacctgctt
     4741 ggataacttg gccagcaagg gcaaggtctc caaaaagcct agggaaatga aaggcaagaa
     4801 aagcaaaaag atttctctga agtacacagc agcgaggctg catgagaagg gcgtccttct
     4861 ggagattgaa gaccttcagg caaaccaatt taaaaatgtt atcttcgaaa ttggtccaac
     4921 agaagaagtt ggagactttg aagtaaaagc caagttcatg ggagttcaga tggagacttt
     4981 catgttgcat tatcaggact tgctgcagct acagtatgaa ggagttgcag ttatgaaatt
     5041 atttgataga gctaaagtga atgtcaacct cctgatcttc cttctcaaca aaaagttcta
     5101 tgggaagtaa tgggtcgctc gccgcccaga agagttaaca aaaaacggca gcacctcacg
     5161 gctgtctttc taggatcctc cattattcct tagaagcaag gacctggtcc agtggcggtg
     5221 cctcagttca cactccctct gacggacgga cggacgtcag tgccctctcc cttctccttg
     5281 tgaagccata agcctgactt cccctcagcc ctgctccctc attttctctc atcatgtagg
     5341 aaagagtggg accccctccc aacccctttc tgttaaagcc tcctaagtgg tcattactac
     5401 tttgtagaca ttggtatttg ttttacttag caataagaat ggtgaaattc aaattctcgt
     5461 ttagaagtga aagctgtcag gttgatagca agcatgcaca tcaaattcac cagaagtaca
     5521 acccatcggc gcagtcagag gatggagtct gatgtcttcc ggctgctgcc tttgtgggca
     5581 gagctaatcc aagttactgt tctctgttca aatgaagcag cttcaggaga aaaagagcaa
     5641 ttacttttga attctccaat aaatctggac aatgccgtta gcgaagagcc cttcctggtg
     5701 aaggcaaacc catggtcaca gcaggccatt tagagactga gtgggcgggg cacttaccat
     5761 cccttccaca aaggatagct tcccccagct caaaatgtaa ctgtttctaa actgtattcc
     5821 aagagtgcct taccaaagta taaatttatt tcttaaaatg tgagtaatag gaattttaaa
     5881 gatttatata atgcttttga acactctgag aaagggttgt tttttttcat tgggttaatc
     5941 tgtatatctg aattcttgaa gcttttctct agcctacagt agggtcgatc tgccgagctg
     6001 ctgaataacc ctgcttgatt ttagcaacaa gagacaatcc atgccatgct tttatcctga
     6061 gaaacctgga cccttaggct ctgactaaca aagacagttc agctccagac actgaacttg
     6121 gaatcctttg tctttggatt aaaagtcata aacttaaaaa aaaaaatctc tttattcaaa
     6181 aagatagtta aatcatgcta ctgagcctat gatgtcgttg atgtttggtt cggtattctt
     6241 gcataaaact taaaaattaa acgaacgctg cagagtttac tgatgtatat caaaggccaa
     6301 taagctcttt taattggtga cagatcatgc ggtatgtccc tattacaaat gtaagtcttg
     6361 gagaagggtc cttcatggtg tccacatgtg caggctcagg tagaggtctc agtgagtgga
     6421 cacaggtagc tgtgggtgcc gagaaaggat ctgccaccac cctgacattg tgttttggaa
     6481 cagagttttc tgagaaaaca ttttcaagtt aaaggaaaat gctaagtctg gcatggtagt
     6541 caacacctat aatctctgca ctcagaggct gaggaagaaa gatcactgag tcacggccag
     6601 cctgggctac atagccccgc cctgtctcca aaaaagagag agaaagaaaa aggaaaaaaa
     6661 aaagaaaaag atcctgttac aaccctcatc acctcaaaaa caaggttaac agaggggtca
     6721 agtgagtctt tttttttttt tttttttaaa gacagaggtg atggggtctc tgtcgccttg
     6781 gctgtcctag aactctatgt agatcatgct ggtctagcgc tcacagagat cagaactctg
     6841 tgtagatcac actggtctag aactcagagt ctgcctgcat ctgtctccta gtgctgggat
     6901 taaaggtgtg agccattata cctggctttc aggtatgttt tcttaagact gccatcacaa
     6961 atgtcccggg gcctcctgca agacagtaat gaatccaggt tatagtgcct tcgacgtctc
     7021 ggttccccgg aaggatgctc cttccctgaa tatgcagtag agctgtgcca catgcccttt
     7081 gaagatcttc atggctgctg tgagaccctg ctttggcagc accgagtcac ctggtgagcc
     7141 tcaggctggc acaccgaagt tgtgccgtgc ttacgttatt tattagctgt agccatttct
     7201 gtcttggctc tcacttcctc tgcccttccc tctgagcagc catagtgaca tttactatga
     7261 atttacttcc tcccaagaat ttggactggc cgtcagactg ttgctacata caattgcctt
     7321 tgtatcttcg tatgaaataa aaggtcattt gttcctgtta aaaaaaaaaa aaaaaaa
//
