LOCUS       NM_001370847            6090 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus IQ motif containing N (Iqcn), transcript variant 2,
            mRNA.
ACCESSION   NM_001370847 XM_006509816
VERSION     NM_001370847.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6090)
  AUTHORS   Li,Q., Wang,Y., Zheng,W., Guo,J., Zhang,S., Gong,F., Lu,G.X.,
            Lin,G. and Dai,J.
  TITLE     Biallelic variants in IQCN cause sperm flagellar assembly defects
            and male infertility
  JOURNAL   Hum Reprod 38 (7), 1390-1398 (2023)
   PUBMED   37140151
  REMARK    GeneRIF: Biallelic variants in IQCN cause sperm flagellar assembly
            defects and male infertility.
REFERENCE   2  (bases 1 to 6090)
  AUTHORS   Wang,Y., Chen,G., Tang,Z., Mei,X., Lin,C., Kang,J., Lian,J., Lu,J.,
            Liu,Y., Lan,F., Huang,W. and Zhang,D.
  TITLE     Loss-of-function mutations in IQCN cause male infertility in humans
            and mice owing to total fertilization failure
  JOURNAL   Mol Hum Reprod 29 (7) (2023)
   PUBMED   37184908
  REMARK    GeneRIF: Loss-of-function mutations in IQCN cause male infertility
            in humans and mice owing to total fertilization failure.
REFERENCE   3  (bases 1 to 6090)
  AUTHORS   Dai,J., Li,Q., Zhou,Q., Zhang,S., Chen,J., Wang,Y., Guo,J., Gu,Y.,
            Gong,F., Tan,Y., Lu,G., Zheng,W. and Lin,G.
  TITLE     IQCN disruption causes fertilization failure and male infertility
            due to manchette assembly defect
  JOURNAL   EMBO Mol Med 14 (12), e16501 (2022)
   PUBMED   36321563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162446.2.
            
            On Jun 6, 2019 this sequence version replaced XM_006509816.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189685.149960.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1547              AC162446.2         54237-55783
            1548-1672           AC162446.2         59831-59955
            1673-5041           AC162446.2         60342-63710
            5042-6090           AC162446.2         68814-69862
FEATURES             Location/Qualifiers
     source          1..6090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..6090
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /note="IQ motif containing N"
                     /db_xref="GeneID:637079"
                     /db_xref="MGI:MGI:3708784"
     exon            1..1547
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1672
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..5041
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /inference="alignment:Splign:2.1.0"
     CDS             1694..6007
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /codon_start=1
                     /product="IQ domain-containing protein N"
                     /protein_id="NP_001357776.1"
                     /db_xref="GeneID:637079"
                     /db_xref="MGI:MGI:3708784"
                     /translation="MAAMQPAAQLQFQNLMSPSGPSLPQPTPIHQEKVAKLCPQLQHD
                     FYPSEELAVLPSQEVPRLRAVVESQAFRNILVDEMDMMVSRAATVIQASWKGYRLRQK
                     LISQMTAAKAIQEAWRRFSTRRLMHSNRLTVKKAKREDEEDIPYHQPQQVRFHAPEDQ
                     PPVMVTKETQFPSFDNLVPSQATAGPCASRVPGGGLHPQYVINRLTVPKYQPCMLTKT
                     FRSSCLMRHLEGDSLKIRHVASKTIKVGALEAAATGRYGQAMHGSLKTQTQAHTESDV
                     PKAPLRIYPVNKTHTKVCPMAAAVPESSATMSTAPRSAPQARPTSPATVMKMQATTSP
                     TSPVIRLPAPVGPNSSLSNTTPQMQVRYMMPGARIQPPGSAVASTIKALPHFGAPVMK
                     VPLQTGPGFTMTKTSLQMRPMTRSQAQTYTVSTSSKTSPSSPTVKPSPQTRLAAMLTK
                     TPAQLRSVAAVFRTLCGGTTEAVASSPRCSPQSPVVAGNTPSQVHLNSTRTKVTVSTK
                     QATTVVKVNSQSYLGRCGSQGNLDTIVPKPPATYPLEVEKMKSCPARSPKKEAALKTN
                     TTIAARALSWTKMMEDRSKALTQIKQRAEIIKVHFRVYMPEEIPVTLTQAQLAVPLTK
                     SSSQIQPPPCHARTQPTSPFCKAVSQSCMPSGLAHGTPEGQRPPVGLSASLSSSPLAA
                     HLMSLTAQLQPACEQARSVSRDHLTRSCPASASLQARSSGTIVPPEVYPNTYSPTSAP
                     QHHMASLLAKSSSQLHPPAEHAKTMNTKTTKAACQVCPSTKLSKAPSLAQLITCLAKV
                     PSQAQLATETAKCLLAAHPTTDHRSKTQSQTFLSSSKASVQLWQHLGTLSTGSRAKPD
                     DRSVAQPQLHSHAPNKTMQNPRSVVTDSQGMLIPLMTPSGHPVCNAESWGDSGRAQTP
                     PPSPVPNQAVPCHDDLAASVASLCADLVAMLGSPEDLRTLLVKTLSQGEVRTALSQAL
                     SREVLGPSVVKALPQGMLGMALMKALSWGELGISLSRALSRGELRPELNKATQGKLAE
                     VLCKALTEEERATLSQALCQGELGAVFTQSLAQMAQRTGTFLPKATSKTVGSRMTTAP
                     APVEVTCSGSLSVAWGPAMGPVGARCSKGPVDAGLASGQSWNSKVPNVSVRATAHAGA
                     PQGVWYPSRGHKPWDPIGAEAELDRKPSAELLMSVQGMEKVVVQAVVTIQACARGYLV
                     RRTVKVWHQWATIIQATWRGYRVRRNLERLFRATTIIQAAWRGYCIRRARARQVLLPI
                     AWPEHSGRTKGTLDNRNSSEHRCFLSCQPDVCSVCQSLGPPVESPPSVVMLVGSQPRT
                     CHVCGHTLSTRVVQGFGQGISGQPVSRWASASQQNTLLSQQHRACTIIQAAWKGYRTR
                     RQLSQKQSAAKMVQAVWRGHYTRSCLTTDALLGTGGPWSISRDTSRHSSRAYSLHWPG
                     V"
     exon            5042..6090
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6069..6074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /note="hexamer: AATAAA"
     polyA_site      6090
                     /gene="Iqcn"
                     /gene_synonym="Gm16486"
                     /note="major polyA site"
ORIGIN      
        1 cagggttttt ctcctgtagc cttggctatc ctggaactca ctttatagac caagctgacc
       61 tcaaactcag aaatcctcct gcctctgcct cccaagtgct gggatcaaag gtgtgtgcca
      121 ccactgccca gctgggccaa gattattgta cccctattac acagcagtgg cccagaaacc
      181 tgttctacag gctgtgaaca gcatagtaga aatttgaact ctgacctctc ctttggccct
      241 tgaaatgttg ggataccatg tacaccagtg tctgcagtgt tctgcttttg tagtgttaga
      301 tggaatctgg atctttataa agatttgtgt tgtttgagat gatgtcttac tgtatagccc
      361 agactggcct cgaactcagt ttttcccacc tctgggacta aaggcatgtg ccaccacagc
      421 ggcccaatga ggttttgttg atgttgggag tgtttccagt cagctgatca gagccaggct
      481 gggccctgca agcctgtgac ttaagcactt gcaatgtaga ggcagaaggg ccatgagttt
      541 cagtccagcc tggggtatat aaggagccta tctcaaaaca ccaaggactc ttgacagagc
      601 acatcatgtg cccagggggc ctgggctcag agttctgttc cccagcattg aaaggctggc
      661 tctgcaattc aagtacattt ctttccctga gtctcatcta gcacatgggc taagaccacc
      721 atatctaggt gcccaaagaa acaaaaggct cactagaagt gctcacaaca gctaaaggac
      781 agaggagaga ggcagggaaa agccacaggg ttgtatgtct gctctttgca tagaggcctt
      841 gttctagtag ccccttggcc aggcgaagtg gttctggctt gagcctgctg tgcataggcc
      901 aaggtgtgtg tcagccttgg ctggagcatc tatgactcac actgggtatg agcccagcct
      961 ggggaggtgg cccagaacat tggcttcact ccatctgccc cctcctaggg ctgtggctca
     1021 cactgcatga ccttttattt ttttctacac agggtctcca tatgcagccc aggctggcct
     1081 ggaactcacc aaaatccata aactctcggt gcttgactgt tgcaggccat atgaagcttt
     1141 gcacgtgtct tttcatgccc tccaggagat gtctccagga catcttggag gctcagcagc
     1201 tatgtcaggt ggtgacagaa ctccctccaa acacaaggca agagggggga aggctagctc
     1261 tatgctcaga gccctaattt tccttccctg ttggaccatc aggacagctc agatcctctt
     1321 gtcctgtcag gggccccagt tccaagctct agaacccttt cccctaaatg ctgctgggga
     1381 ttggtcggaa ctcacctgga gtcataaaga catttgggtg ccccggttcc caaggctggc
     1441 tgtcagggct ggtggcttca gctctgggga taggtgagtg ggctggtggg ggtaccacac
     1501 tctgtcaccc agctcttgcc aagaatgtct gcattctctg gactgcgaac cagcccagag
     1561 cactgctgtg tacatttctt ggaatgaaga actgaagaca gcctccccgt acaggctggc
     1621 ttccaagatt acatcttctt ctgctccttt gccaactcta tgaccctcca agacttttct
     1681 gcctggctca ggaatggcag caatgcagcc ggcagctcag ctccagttcc agaacctcat
     1741 gtcacctagc gggccaagcc tccctcagcc tacccccatt caccaagaga aagtggccaa
     1801 gctatgtcct cagctccagc atgacttcta tccatccgag gagctagcag tgttaccatc
     1861 acaagaagtg cctcgcctgc gggcagtggt ggagagccag gccttcagga acatcctggt
     1921 agatgagatg gacatgatgg tgtcacgggc agccactgtc atccaagcca gctggaaggg
     1981 ctaccggctg cggcagaaac tcatctccca gatgacagca gccaaggcca tccaggaggc
     2041 ctggcgacgc ttcagcacgc gccggctgat gcactccaac aggctgactg ttaagaaagc
     2101 gaagagggag gatgaagagg acatccctta ccaccagcca cagcaggtgc gctttcatgc
     2161 cccagaggac cagccaccag tcatggtgac taaagagact cagttcccgt cctttgacaa
     2221 tctggtcccc tcacaagcca cagcaggtcc ctgtgccagc agagtccccg gaggtggtct
     2281 ccatccacag tatgtgatca acagactcac agttcccaag tatcaaccct gcatgttgac
     2341 caagactttt cggagctctt gtctcatgag acacttggag ggggacagtc tgaagatcag
     2401 gcatgtggct tccaagacta tcaaagtggg ggccctagag gcagcagcaa cagggagata
     2461 tggccaggcc atgcatggat ccctgaagac ccagacccag gctcacacag aatcagatgt
     2521 ccccaaggcc ccattgcgta tatatccagt caacaagacc cacaccaagg tgtgtccaat
     2581 ggctgctgcc gtccctgaat cctcagccac aatgtccaca gcaccaagga gtgcacccca
     2641 ggcacgcccc acatccccag caactgtcat gaagatgcaa gcaacaacca gcccgacctc
     2701 cccagtgatc aggctcccag ctcctgtggg acccaattct tcactctcta acaccacacc
     2761 acagatgcag gtgcgttaca tgatgcctgg ggccagaata cagcccccag gttctgctgt
     2821 ggcctctaca atcaaggcct taccacactt tggagcgcct gtcatgaagg tcccactgca
     2881 aactggccct gggttcacaa tgacaaagac ctcactccag atgagaccaa tgaccagaag
     2941 ccaagctcag acatacacgg tgtccacttc atccaaaacc tccccgtcaa gccccacggt
     3001 caagccttca ccccagacac gcctggcagc tatgctaacc aagaccccgg ctcagttacg
     3061 ctccgtagct gctgtgttca ggaccctgtg tggtggtaca actgaggcag tagcctcaag
     3121 tcccaggtgt tcaccccaaa gtccagtggt tgctggcaac actccatccc aggtccactt
     3181 gaatagcaca aggaccaagg tcaccgtgag caccaagcag gccaccacag ttgtcaaggt
     3241 gaactctcag tcatacttgg gcaggtgcgg gtcccagggg aatctagaca ccatagttcc
     3301 taagcctcca gccacgtatc cactggaagt agaaaagatg aagtcatgtc ccgcaaggtc
     3361 ccccaagaag gaagcagctc tcaaaactaa cacaaccatt gcagccagag ctctgtcttg
     3421 gacaaaaatg atggaagatc ggagcaaggc cctgactcag atcaagcaga gggcggagat
     3481 cataaaggtt cacttcagag tgtacatgcc tgaagagatt cctgtgaccc tgacccaggc
     3541 ccagctggct gtccccctga ccaagagctc ctcccaaatc cagccgcccc cctgccatgc
     3601 ccgaactcag ccgacctcac ccttctgtaa agctgtgtcc cagtcttgca tgccctccgg
     3661 gctggcccac ggcacacctg aaggacagcg tccacctgta ggtctctctg cctccctgtc
     3721 ctcctcacca ctggccgcac acctgatgtc actcacagcc cagctccaac ctgcttgtga
     3781 acaggccaga tctgtgtctc gagatcatct gaccaggtca tgtccagcct cagcctctct
     3841 gcaggcaagg tcctcaggga ccatagttcc tcctgaagtg tacccaaaca catattcacc
     3901 tacctctgct ccccagcacc acatggcctc tctcctggca aaaagctcat ctcagctgca
     3961 tccacctgct gagcatgcca agaccatgaa cactaaaacc accaaggcag cgtgccaggt
     4021 ctgtccatcc actaagctca gcaaggcccc atccctggcc cagctcatca catgtctggc
     4081 taaggttccc tcccaggccc agctggccac tgaaacagcc aagtgcctct tggctgccca
     4141 ccctaccact gaccacagaa gcaagaccca gtcacagaca ttcctgagct cttccaaggc
     4201 atctgtccag ttgtggcaac atttggggac acttagcact ggatcccgtg ccaagccaga
     4261 tgacaggagt gtggcccagc cccagctcca tagccatgca ccaaacaaga ccatgcagaa
     4321 cccacgttca gtagtcacag atagccaagg catgctgata cctctgatga ctcccagtgg
     4381 acacccagtg tgcaatgcag aatcctgggg tgacagtgga cgggcacaga ctccacctcc
     4441 atcccctgtg cccaaccagg cagtgccctg ccacgatgac ctggcagcat ctgttgcatc
     4501 cctatgtgca gatctggtgg ccatgctggg ctcccctgaa gacctgcgga cactcctggt
     4561 caagacactt tctcaggggg aagtaaggac ggcgttgagt caggccctat cccgggaggt
     4621 cctggggcca tctgtggtca aggccctgcc ccaaggcatg ctgggaatgg cactgatgaa
     4681 ggctctgtcg tggggtgaac tgggtatctc cctgtcccgg gccctgtccc gaggtgagct
     4741 gcgtccagaa ctcaacaagg ccacacaggg caagctggct gaggtcctgt gtaaggcctt
     4801 gacagaagag gagagggcca cactcagcca ggcgctgtgc cagggtgaac tgggtgctgt
     4861 cttcactcag tccttggccc agatggccca gaggacaggc accttcctcc ctaaggccac
     4921 ctcaaaaaca gtggggagcc ggatgaccac agcgcctgcc ccagtggagg tgacttgcag
     4981 cgggagtctg tcggtggcgt ggggacctgc gatgggtcct gtaggagcac ggtgtagcaa
     5041 gggccctgtg gatgccggcc tggcttctgg ccagtcatgg aattccaaag tccccaacgt
     5101 atcggtcaga gccacagcac atgctggggc accccaaggc gtatggtatc ccagcagggg
     5161 ccacaagcca tgggacccca ttggtgcaga ggccgagctg gaccgcaagc cttcagctga
     5221 gctgctgatg tcagtacagg gcatggagaa agttgtcgtc caggccgttg tcaccatcca
     5281 agcgtgcgct cgtggctacc tagtgcgccg cactgtgaaa gtgtggcacc aatgggccac
     5341 catcatccaa gctacgtggc gtggttaccg tgtacgacgg aatctggaaa ggctgttcag
     5401 ggccaccacc atcatccagg ctgcctggcg cggctattgc attcgccggg cccgggcccg
     5461 ccaggtactg ctccctattg catggccaga gcacagtggt cgaaccaagg gaaccttgga
     5521 caacagaaat agctccgagc accgctgctt cctatcctgt caaccagatg tctgcagcgt
     5581 ctgtcaatcc ctgggtcccc cggtagagag tccgcccagc gttgtgatgc ttgtgggatc
     5641 ccagccacgc acttgccacg tgtgtggcca cacactctcc acgcgagtgg tgcagggctt
     5701 tggccagggc atctcaggtc agcctgtctc tcgatgggcc tcagcatccc agcagaacac
     5761 ccttcttagc cagcagcaca gagcatgcac catcatccag gccgcctgga agggctacag
     5821 gacccgccgg cagctcagcc agaagcagtc tgcagccaag atggttcagg ccgtgtggag
     5881 gggccattac actcgaagct gcctcaccac ggatgcactc ttgggaacag gaggcccgtg
     5941 gagcatctcc agggacactt cacgccatag ctcaagggct tactctttgc actggcctgg
     6001 cgtctagacc cctccctggc tgtgggcaag agacaccatc atggccatgt ggcctcatga
     6061 gtcttgtgaa taaagcatgc tacagcctga
//
