LOCUS       NM_028833               4359 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus IQ motif containing E (Iqce), transcript variant 1,
            mRNA.
ACCESSION   NM_028833
VERSION     NM_028833.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4359)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4359)
  AUTHORS   Pusapati,G.V., Hughes,C.E., Dorn,K.V., Zhang,D., Sugianto,P.,
            Aravind,L. and Rohatgi,R.
  TITLE     EFCAB7 and IQCE regulate hedgehog signaling by tethering the
            EVC-EVC2 complex to the base of primary cilia
  JOURNAL   Dev Cell 28 (5), 483-496 (2014)
   PUBMED   24582806
REFERENCE   4  (bases 1 to 4359)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110253.10.
            
            On Nov 17, 2006 this sequence version replaced NM_028833.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059223.1, SRR17784644.1088277.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC110253.10        36051-36247
            198-245             AC110253.10        38697-38744
            246-291             AC110253.10        41376-41421
            292-420             AC110253.10        44886-45014
            421-555             AC110253.10        45501-45635
            556-626             AC110253.10        46759-46829
            627-740             AC110253.10        48360-48473
            741-791             AC110253.10        48566-48616
            792-862             AC110253.10        50574-50644
            863-935             AC110253.10        52029-52101
            936-985             AC110253.10        52335-52384
            986-1149            AC110253.10        54890-55053
            1150-1205           AC110253.10        55972-56027
            1206-1435           AC110253.10        57484-57713
            1436-1540           AC110253.10        60251-60355
            1541-1631           AC110253.10        60923-61013
            1632-1802           AC110253.10        63181-63351
            1803-1826           AC110253.10        64069-64092
            1827-1946           AC110253.10        66503-66622
            1947-2068           AC110253.10        66964-67085
            2069-2169           AC110253.10        67862-67962
            2170-2370           AC110253.10        72221-72421
            2371-4359           AC110253.10        72936-74924
FEATURES             Location/Qualifiers
     source          1..4359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.2 cM"
     gene            1..4359
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /note="IQ motif containing E"
                     /db_xref="GeneID:74239"
                     /db_xref="MGI:MGI:1921489"
     exon            1..197
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2498
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein E"
                     /codon_start=1
                     /product="IQ domain-containing protein E isoform 1"
                     /protein_id="NP_083109.2"
                     /db_xref="CCDS:CCDS39358.1"
                     /db_xref="GeneID:74239"
                     /db_xref="MGI:MGI:1921489"
                     /translation="MSLGTTDIASETGDDSLSAITFESDIESKTKRKSFHKPPSTSPK
                     SPYYSKPRKVTSWRSLKTAGSMPLSSRMSLTPQKLWLGSSKQGSVAQPPSPTLTSEHA
                     WTHPPSCTPDYLTEAVRAKRADLRRSGSHGHVSGTSVYREKEDMYDEIIELKKSLHMQ
                     KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGPDFVRTLAEKKPDTGWVITGLKQR
                     IFRLEQQCKEKDNTINKLQTDMKTTNLEEMRIAMETYYEEIHRLQTLLASSEATGKKP
                     MVEKKLGVKRQKKMSSALLNLTRSVQELTEENQSLKEDLDRMLSNSPTISKIKGYGDW
                     SKPRLLRRIAELEKKVSSSESPKQSTSELVNPNPLVRSPSNISVQKQPKGDQSPEDLP
                     KVAPCEEQEHLQGTVKSLREELGALQEQLLEKDLEMKQLLQSKIDLEKELETAREGEK
                     GRQEQEQALREEVEALTKKCQELEEAKREEKNSFVAVTHEAHPELHAPSPCSRHSEPD
                     SDNSAGEEGSSQPPAPCSEERREAAIRTLQAQWKAHRRKKREAALDEAATVLQAAFRG
                     HLARSKLVRSKVPDSRSPSLPGLLSPLNQSSPAPRVLSPISPAEENPTQEEAVIVIQS
                     ILRGYLAQARFIASCCREIAASSQRETVSLTPSGSASPPSLRASPGVIRKELCASEEL
                     RETSASEPAPSVPYSAQGGHGDCPSSSSLEAVPSMKDAMCEERSSSPRSAGPSLAEPS
                     PPELQPLSPPPVEDICSDDSDDIIFSPFLPRKKSPSPF"
     exon            198..245
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            246..291
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            292..420
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            421..555
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            556..626
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            627..740
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            741..791
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            792..862
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            863..935
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            936..985
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1149
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1205
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1435
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1540
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1631
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1802
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1826
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1946
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2068
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2169
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2370
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..4359
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4337..4342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /note="hexamer: AGTAAA"
     polyA_site      4359
                     /gene="Iqce"
                     /gene_synonym="1700028P05Rik; mKIAA1023"
                     /note="major polyA site"
ORIGIN      
        1 gcacactttg cgcgtgcaca agattcgtcg ggctccggag gaaggaccac atccggggct
       61 ctgtggccgc ggcacggttg ccatggtacc agggcggctg gcaggcctcc caagccgagg
      121 gcagagctcg caggacccgg aggccgcgca gcgctgccgc tatgagcctg ggcaccacag
      181 atatagcctc ggagacggga gatgacagtc tgtctgctat tacctttgaa tctgacattg
      241 agtcgaaaac aaaaaggaaa agtttccaca aacctccttc cacatcacca aagtcgccct
      301 actactccaa acccagaaaa gtgacctcct ggcgatctct gaagacggca gggagcatgc
      361 ctctgagtag cagaatgtcc ttgaccccac agaagctgtg gctgggatcc tcgaaacagg
      421 gtagtgtggc ccaacccccg agccccacgc ttacctcgga gcacgcgtgg acccaccccc
      481 ccagctgcac tcccgactac ctgacagaag ccgtgagagc gaagagggca gacctcaggc
      541 gttctggcag ccatggtcac gtctctggga cttccgtcta cagagagaag gaggacatgt
      601 acgacgagat catcgagttg aagaagtcct tacatatgca gaaaagtgat gtggatctga
      661 tgagaacaaa gcttcggcgc ttggaagagg agaacagcag aaaggatcgg cagatagaac
      721 agcttctgga tccaagtcga ggcccagact tcgtgcgaac cttggcagag aagaagcctg
      781 acacgggctg ggtcatcacc gggctcaaac aaaggatctt caggctggag cagcaatgca
      841 aggagaagga caacactatc aacaaactgc agacggacat gaagaccacc aacctggagg
      901 agatgcgcat tgccatggaa acatactacg aagagatcca tcgtctgcag accctcctgg
      961 cgagttctga agccacagga aagaagccca tggtggagaa gaaactgggt gtgaagaggc
     1021 agaagaagat gagcagtgcc ctgctgaacc taacacggag tgtgcaggag ctgaccgagg
     1081 agaaccagag cctgaaggag gacctggacc gcatgctgag caattcaccc accatctcca
     1141 aaataaaggg ttacggggac tggagcaagc cccggctgct gagacgcatc gcagagctag
     1201 aaaagaaagt gagttcctca gaaagcccaa agcaatcgac ttcagagctg gtgaatccga
     1261 atcccctggt ccgctcccca tccaacatct cagtgcaaaa gcagccgaaa ggggaccagt
     1321 ccccagagga cctgcccaag gtggccccgt gtgaggaaca agagcatctc caaggaaccg
     1381 tgaagagcct gagagaggag ctgggtgcac tgcaggagca gctgctggag aaagacctgg
     1441 agatgaagca gctgctacag tccaagatcg acctggagaa ggagttggag acagccaggg
     1501 aaggcgagaa ggggaggcag gagcaggagc aggctttgag ggaggaagtt gaagcactca
     1561 ccaaaaaatg tcaagaactg gaagaagcta agagagaaga gaaaaactcc ttcgtagcag
     1621 tgactcatga ggctcatcca gagctccatg ccccctcgcc ctgcagcagg cactccgagc
     1681 cagactctga caatagtgct ggtgaggagg gtagctccca accccctgcc ccatgctctg
     1741 aagagaggag agaggctgcc attaggaccc tgcaggcgca gtggaaggcc cacaggcgca
     1801 agaaaagaga agcagctctg gatgaggcag cgactgtgct ccaggcagcc ttcaggggac
     1861 acctagctcg ttcgaagctt gtacgcagca aagtcccaga ctccaggtct cccagcctgc
     1921 cgggccttct cagccctctt aaccagagtt ctcctgcgcc ccgtgtccta agccccatct
     1981 ccccggctga agagaaccca acacaagagg aggctgtcat cgttatccag tccatcctcc
     2041 gtggatacct ggcccaggcc aggttcattg ccagctgctg tcgagagatt gcggcgtcct
     2101 ctcagaggga aactgtttca ttgacaccct caggatctgc ctccccaccc tccctcagag
     2161 cttctcccgg agtgatccgc aaggagctct gtgcctcgga ggagctgagg gagacctctg
     2221 catctgaacc tgccccctcc gtcccctact ccgcccaagg tggccacggg gactgcccgt
     2281 cctcatccag tctggaggct gtgcccagta tgaaggatgc catgtgtgag gaaaggagca
     2341 gcagccctag aagcgcaggg ccatccttgg ctgagccctc tcccccagaa ctgcagccct
     2401 tgtcaccacc acctgtggag gacatctgct cggatgactc agatgacatt atcttttcgc
     2461 catttctgcc caggaagaaa agcccctccc cgttctaaga ccccagccat tgcctccagg
     2521 tgaggtggct ggggacaagt cagaggactc taaatcttgc tagggaagag ccctgcctca
     2581 ctccagaaca cctcagccat ccattttctt atgtgtcgtg cctttgaggg gtgctggtgg
     2641 ctctgtactc tctggggacg gaggggggag ggtgggcaac tcccacttcc atttcccact
     2701 ttagcctgtg tgtttctagt gcccacagat aacgtccacc tcaaggccag ggcagcagac
     2761 agtcctgcaa agagaactct tacagagtct actacttgct cttaacatgg cactgttagc
     2821 tgtcatgttg gcctagcctt cctggtctgc tgctgcccag tgccttaaca ggtgctacag
     2881 ctaagcctcc cgagcccaca gcaagatgca gtcatagaag agccagcaag aacctatggc
     2941 catcagggtc cctaactgag tccttgtccc atgggctcct tgttcctccc ggttttctcc
     3001 cccactgcct ccatcacccg ccccaggagg atgaactctg ggaagaggta ccaggcagcg
     3061 tcatcacaga gtggtccagc cactaatgag aagcagcccg aggatggctc aggtcaccca
     3121 gacacaaggc aaggcagcag ggccaggagg caggcagccc attgtcccag aggagatatg
     3181 tctcagggaa ggacaaattc cagtacagcc ctgtaactgg gtgtgcagag gtacctgcag
     3241 gtgaccggtg ccatctggca ccctcagcat ctggcagctt gaggtgttgg tcccttgtct
     3301 gtgaaattag ctcctggcag tgggtgagaa tgagggactt tgggcttaga cagggtttta
     3361 ggagtatcca ggctccatgt aacttaggcc tgctgcccaa gtgtcccctc cagagtgcct
     3421 gttagactgg ctgctggtgg tctccatagg tcactggaga tggaacttcc tggtcccata
     3481 gaactgagat ttgtctcaag gaaaacctaa taaggttctt tcttggagta gaccagtggg
     3541 gacccccaag aggtttgctt ttggggacca tttagttcct ggcacccttc tctacaaaac
     3601 acttgcctga taggacgttc aggaagtgag ctgggcttgc cagttagaga ccaggaagag
     3661 ggagggccca gctttgtcta cctgctcctg gaaggtttaa gcacccctaa tactctgatg
     3721 ggaccaggga cagctgcctc ccatttttct ccaccagggg gcaaaacaca acgcagccat
     3781 ggcctggagg ctgcctgcca aggtagtttc tcagtgaact ggtggtaact ttactcacat
     3841 agcagccgcc tggagccctc tgtagatctg cttccttgtc agaacttggc tgtgttccct
     3901 gtgattgctg ccacccctta aagcctcaga caccacccac taagacacaa gacggcggct
     3961 acaggtggcc ctcatgtgcc tgtacctttc ccggggccag gagtgtccat gtgccactgc
     4021 tctgtcccct cccttattta actgcagcca tctgtgcatt gagtgttccg agtgagcaaa
     4081 cagtcagggt ggggtgtttt cacccccttc acctgggggg gggtgctcca cctcaggaag
     4141 gggttatgca agatggcact ctagctgcag ggccaacctg tgcacccagc ctggccagtg
     4201 ggcaatgagg tctgatcagc ccccgcactt gggttttcta agaacctgcc tctgaaacac
     4261 aggaaagctg tagccttccc atcctttggt gtagcagctc atctattaaa ggcaaagcct
     4321 gtcttgaagc tgccccagta aatgagggtg aagcctgaa
//
