LOCUS       NM_001368722            3272 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus IQ motif containing with AAA domain 1 (Iqca1),
            transcript variant 2, mRNA.
ACCESSION   NM_001368722
VERSION     NM_001368722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3272)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3272)
  AUTHORS   Sun,J., Lu,Y., Nozawa,K., Xu,Z., Morohoshi,A., Castaneda,J.M.,
            Noda,T., Miyata,H., Abbasi,F., Shawki,H.H., Takahashi,S.,
            Devlin,D.J., Yu,Z., Matzuk,R.M., Garcia,T.X., Matzuk,M.M. and
            Ikawa,M.
  TITLE     CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or
            epididymis-enriched genes individually dispensable for male
            reproductiondagger
  JOURNAL   Biol Reprod 103 (2), 183-194 (2020)
   PUBMED   32588039
REFERENCE   3  (bases 1 to 3272)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3272)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110261.25 and AC124227.21.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849381
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC110261.25        154790-155061       c
            273-597             AC110261.25        146446-146770       c
            598-714             AC110261.25        144301-144417       c
            715-906             AC110261.25        141508-141699       c
            907-978             AC110261.25        139776-139847       c
            979-1184            AC110261.25        131678-131883       c
            1185-1269           AC110261.25        105448-105532       c
            1270-1422           AC110261.25        99536-99688         c
            1423-1498           AC110261.25        91100-91175         c
            1499-1605           AC110261.25        82941-83047         c
            1606-1698           AC110261.25        82485-82577         c
            1699-1766           AC110261.25        79432-79499         c
            1767-1849           AC110261.25        75372-75454         c
            1850-1957           AC110261.25        72137-72244         c
            1958-2157           AC110261.25        68350-68549         c
            2158-2244           AC110261.25        54013-54099         c
            2245-2422           AC124227.21        2805-2982
            2423-2661           AC124227.21        4941-5179
            2662-3272           AC124227.21        8029-8639
FEATURES             Location/Qualifiers
     source          1..3272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.08 cM"
     gene            1..3272
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /note="IQ motif containing with AAA domain 1"
                     /db_xref="GeneID:74918"
                     /db_xref="MGI:MGI:1922168"
     exon            1..272
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2778
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /note="isoform 2 is encoded by transcript variant 2; IQ
                     and AAA domain-containing protein 1; dynein regulatory
                     complex protein 11"
                     /codon_start=1
                     /product="dynein regulatory complex protein 11 isoform 2"
                     /protein_id="NP_001355651.1"
                     /db_xref="GeneID:74918"
                     /db_xref="MGI:MGI:1922168"
                     /translation="MSNLMYNKMWHQTQEALNSLLDKEFQKMSEPQANKVLVFQMLAT
                     FYINYVQIFRNMENVYDQIVHPQKRMLIRKVLDGVMGRILELKNEMVELEMTEFHYFD
                     DILQDLKLSPQQLDVPIPRYFLKERLEVIKGREKILARILTECGLNLPVKYAAKSIAL
                     EEAVKLIQIAERARQGRLRALFMKQIFLQECRAKEMKLLGHRLLDTKLAALQIQKVWR
                     GFHQCKKTVKEREEEMVFLGMKPSPLFNEVSDAIVQSKQVTNLRDEVQLKHEQDYQEA
                     LVNIKEDLKMLEGPDIKEHLQDQIRQWFIECRNLTGTFPDYPNEEDGGSALIFSNKTP
                     EQVMGDIIATQEEEEKLKKKKKKEDKENKGKKGKKEKKEKKEKKVSLKEKAMKDEDEE
                     WKMSPSLFLQLMEEGNSLYKDIWLNKDESWNFPQDYDPELIKEEKRKELEMEIRVQVD
                     ELMRQELKNLKLAVNREMEIPPRQKKGKKKNKGRKGRRGKRGKKEKDLTADRTIESLY
                     QELVEKGLLIQALKVNLSDYIGEYSYLGTTLRQVAIEPMPSLLDVRQLITLYGILPLG
                     SAEVHERAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQ
                     MMIHLVFKVARQLQPSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLKLLKPDD
                     RILIVGTTHRPFDAELQPFCRVYQKIILVPRPDYASRYVLWKEIILRNGGKLTNSLNI
                     SCLSKVTDGFTQGQIVQVIKDVLTERRLRQQAHKPLTAIEFITMMTNMNPVYREEEES
                     FKNWYAKTPLGKKRVLSLTVGNKEKEKDKGKKGKRGKKKK"
     exon            273..597
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            598..714
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            715..906
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            907..978
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1184
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1269
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1422
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1498
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1605
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1698
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1766
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1849
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1957
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2157
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2244
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2422
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2661
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..3272
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /note="hexamer: AATAAA"
     polyA_site      3272
                     /gene="Iqca1"
                     /gene_synonym="4930465P12Rik; 4930585L22Rik; Iqca"
                     /note="major polyA site"
ORIGIN      
        1 agagcccgag gcagcaaccg gagcgaggga atcccagtca gagcctgctc tccaggaggg
       61 tggccacagg tcaccaaccc tgccaagcct ctccctgccc taagagacag gctgtcctca
      121 gtccctgttc ctccctccag aggaatcccc aacctctgaa aacctctagg gggagttccc
      181 ccaacttcgg cagtaggcca gcctttagag gccaaggaaa agctttcctg tgggtgaagg
      241 aaagacagaa agaggccaac catgtcgaac ctaatgtaca ataagatgtg gcaccagacc
      301 caagaagccc tcaattctct gcttgacaaa gagtttcaga agatgtccga accacaagca
      361 aacaaggtcc tagtctttca gatgttagcc accttctaca taaactatgt gcagatcttc
      421 aggaacatgg agaatgtcta tgatcagata gtccatccac agaaacgcat gctgatccgc
      481 aaggtcctgg atggagtgat gggtcgcatt ctggaactga agaatgagat ggtagagttg
      541 gaaatgacag agttccatta ttttgatgat atcttacagg acctgaagct gtctcctcaa
      601 cagttggatg tccccatacc caggtatttc ctgaaggaga ggttggaagt cataaaggga
      661 agagagaaga tcctggctcg gatcttaact gaatgcggac tgaacctccc tgtgaaatat
      721 gccgcaaaga gtatagcttt ggaagaggct gtgaaactga tccagatagc ggagcgtgca
      781 agacagggcc gcctcagggc tctgttcatg aagcagattt tccttcagga gtgcagagcc
      841 aaggagatga agctgttggg acatagatta ttagacacca agttggcggc actccagatc
      901 cagaaagttt ggcgaggttt ccatcaatgc aaaaaaacag tgaaggagcg ggaagaggag
      961 atggtcttcc tgggtatgaa accatcccct ctcttcaatg aagtcagtga tgccattgtc
     1021 cagtccaaac aagtgacaaa tctgcgggac gaggtgcagc taaaacacga acaggactac
     1081 caggaagcct tagtaaatat caaggaggac ctgaagatgc tggaaggccc ggacatcaag
     1141 gagcatcttc aggaccagat ccggcagtgg ttcattgagt gcaggaattt gacgggcaca
     1201 ttcccagact accccaatga ggaagacgga ggttcagctc tcatcttttc caataagacc
     1261 ccagaacagg ttatggggga tatcatagcc acccaagagg aggaagaaaa acttaagaag
     1321 aaaaagaaga aagaagacaa ggagaataag ggcaaaaaag gcaaaaagga gaagaaggag
     1381 aagaaggaga agaaggtcag cctgaaagaa aaggccatga aggacgaaga tgaggagtgg
     1441 aagatgtcac caagtctttt ccttcaattg atggaggaag gaaatagctt atacaaagac
     1501 atatggctga ataaagacga gtcttggaat ttccctcaag actatgaccc agaactgatc
     1561 aaggaggaaa aacgaaagga gttagaaatg gagataaggg ttcaggtgga tgagcttatg
     1621 agacaggaac tgaaaaacct taagctggct gtgaacagag agatggaaat cccaccccgg
     1681 caaaagaaag ggaaaaagaa aaataaaggg aggaaaggcc ggagagggaa acggggaaag
     1741 aaggaaaaag acctgacggc tgacaggacc atcgagtcgc tgtaccagga gctggttgaa
     1801 aaaggcctgc tgatccaggc tctgaaggtc aacctctcgg attacattgg tgagtacagc
     1861 tacctgggga caactctgcg ccaggtggcc atagaaccca tgccctccct cctggatgtc
     1921 agacagctca tcacactgta tggaatcttg cctctggggt ctgcagaagt gcatgagaga
     1981 gctcccttgg taaagtcact gcttttggct ggaccctcgg gagtagggaa gaaaatgctg
     2041 gtccatgcca tctgcacaga aacaggggct aaccttttca acctgtctgc cttgaacatc
     2101 gctgggaagt acccgggcaa aaccggcctg cagatgatga tacacttggt cttcaaggtg
     2161 gctcgccagc ttcagccttc cgtggtgtgg atccaagaca cagaaaaaac cttctacaaa
     2221 aaagtcccgc aggcagagaa acggtttgaa ccgaaacgcc taaaaagata cctccccaaa
     2281 ctcctgaagc tcctgaaacc ggatgacagg atcctgattg tggggaccac acaccgacct
     2341 ttcgacgcgg agctccagcc cttctgcaga gtgtaccaaa agatcatttt ggttcccaga
     2401 cctgactatg cttccagata tgttctgtgg aaagaaatca ttctacgcaa tggaggtaag
     2461 ctcaccaatt ccttgaacat cagctgccta tctaaagtca ctgatggctt cacacaagga
     2521 cagatcgtgc aagtgatcaa agacgtgctc acggaacgca gactccggca gcaggctcac
     2581 aagccactca ctgccatcga gtttatcacc atgatgacca acatgaaccc tgtgtaccga
     2641 gaggaggaag agagttttaa gaactggtat gccaaaaccc ctctggggaa aaagcgagtc
     2701 ttgtcactaa cagttggcaa caaagaaaag gaaaaggaca aaggaaagaa ggggaaaagg
     2761 ggcaaaaaga agaagtaatg tcttcctcag cagctacccc gagcatcttt gagatgatgt
     2821 cggccccagc ttgtcaggga gaggctcacc cctgctcacc tggggaagcc cacagagaag
     2881 ctaagcggag agcagccact ccaaggcact gtaccctgac cactgtgttc tgttatcctt
     2941 caggaggctg cacaccaagc aagatgtccc ttacagccat aaccattact tgccattatc
     3001 ccttaactca tgcaaagtct gtcaatatca agttggcttc ccttgtgctc cacactctac
     3061 ccagctctca cacttgccag tattagttag caccaagatt acaacataaa gggaggtctc
     3121 tctcatggca agagcaccgt agttctattg ttggtacact cgctctttat taacccatac
     3181 gcattgtata ttttgttgca catattttaa taaattattt gctgtagtca tgaatatcac
     3241 ataatgaaat aaagctgttg tccttgaact ga
//
