LOCUS       NP_951011                489 aa            linear   ROD 30-APR-2025
DEFINITION  inositol-pentakisphosphate 2-kinase isoform a [Mus musculus].
ACCESSION   NP_951011 XP_283126
VERSION     NP_951011.1
DBSOURCE    REFSEQ: accession NM_199056.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Franco-Echevarria,E., Sanz-Aparicio,J., Troffer-Charlier,N.,
            Poterszman,A. and Gonzalez,B.
  TITLE     Crystallization and Preliminary X-Ray Diffraction Analysis of a
            Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase
  JOURNAL   Protein J 36 (4), 240-248 (2017)
   PUBMED   28429156
  REMARK    GeneRIF: Crystallization and preliminary x-ray diffraction analysis
            of a mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase has been
            reported.
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Franco-Echevarria,E., Sanz-Aparicio,J., Brearley,C.A.,
            Gonzalez-Rubio,J.M. and Gonzalez,B.
  TITLE     The crystal structure of mammalian inositol
            1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding
            site and key features for protein function
  JOURNAL   J Biol Chem 292 (25), 10534-10548 (2017)
   PUBMED   28450399
  REMARK    GeneRIF: findings have uncovered distinct features of a mammalian
            IP5 2-K and set the stage for investigations into protein-protein
            or protein-RNA interactions important for IP5 2-K function and
            activity
REFERENCE   4  (residues 1 to 489)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (residues 1 to 489)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (residues 1 to 489)
  AUTHORS   Verbsky,J., Lavine,K. and Majerus,P.W.
  TITLE     Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate
            2-kinase gene, associated lethality, and tissue distribution of
            2-kinase expression
  JOURNAL   Proc Natl Acad Sci U S A 102 (24), 8448-8453 (2005)
   PUBMED   15939868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123954.4.
            
            On Jan 1, 2004 this sequence version replaced XP_283126.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the shorter isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167467.1, AK160092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.25 cM"
     Protein         1..489
                     /product="inositol-pentakisphosphate 2-kinase isoform a"
                     /EC_number="2.7.1.158"
                     /note="inositol-pentakisphosphate 2-kinase; insP5
                     2-kinase; ins(1,3,4,5,6)P5 2-kinase"
                     /calculated_mol_wt=55797
     Region          13..450
                     /region_name="Ins_P5_2-kin"
                     /note="Inositol-pentakisphosphate 2-kinase; pfam06090"
                     /db_xref="CDD:461826"
     Region          136..140
                     /region_name="EXKPK motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P1C1.1)"
     CDS             1..489
                     /gene="Ippk"
                     /gene_synonym="1810043M15Rik; InsP6"
                     /coded_by="NM_199056.4:145..1614"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26500.1"
                     /db_xref="GeneID:75678"
                     /db_xref="MGI:MGI:1922928"
ORIGIN      
        1 meegkmdene wsyhgegnks lvvahaqrcv vlrflkfppn kkktseeilq hlqnivdfgk
       61 nvmkdflgen yvhcgevvql plefvkqlcl kiqcerpesr cdkdldtfsg yamclpnltr
      121 lqtfhfaehr pilcveikpk cgfipfsndv themkhkvcr ycmhqhlkva tgkwkkisky
      181 cpldlysgnk qrmhfalrsl lqetqnnlri fkngeliygc gdarspvadl kelahhlkpf
      241 ffpsnglasg phctkavire lvhvitrvll sssekaraga lrlglqgprv ceaspfsrsl
      301 hnqgkntseh sglpkgclly ktlqvqmldq ldieglyply krveqyleef peerktlqid
      361 gpydevfyqk lldlsteddg tvafaltkvq qyrvamtakd csimialspc lqgtssdqrp
      421 vipssrsrla fsvsvldldl kpyesiphqy kldskivnyy sktvhakddt vrstrfkehe
      481 dctlvlhkv
//
