LOCUS       NM_153774               6236 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus importin 9 (Ipo9), transcript variant 1, mRNA.
ACCESSION   NM_153774 XM_129442 XM_898793 XM_898801 XM_898824 XM_915728
            XM_923899 XM_923904 XM_923916 XM_983357 XM_983389 XM_983428
            XM_983504
VERSION     NM_153774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6236)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6236)
  AUTHORS   You,P., Peng,Z., Wang,Y. and Tao,T.
  TITLE     Expression and subcellular distribution of imp13 are regulated in
            brain development
  JOURNAL   In Vitro Cell Dev Biol Anim 49 (5), 346-353 (2013)
   PUBMED   23605716
REFERENCE   3  (bases 1 to 6236)
  AUTHORS   Mukhopadhyay,P., Brock,G., Webb,C., Pisano,M.M. and Greene,R.M.
  TITLE     Strain-specific modifier genes governing craniofacial phenotypes
  JOURNAL   Birth Defects Res A Clin Mol Teratol 94 (3), 162-175 (2012)
   PUBMED   22371338
REFERENCE   4  (bases 1 to 6236)
  AUTHORS   Dopie,J., Skarp,K.P., Rajakyla,E.K., Tanhuanpaa,K. and
            Vartiainen,M.K.
  TITLE     Active maintenance of nuclear actin by importin 9 supports
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 109 (9), E544-E552 (2012)
   PUBMED   22323606
  REMARK    GeneRIF: the active maintenance of nuclear actin levels by importin
            9 is required for maximal transcriptional activity
REFERENCE   5  (bases 1 to 6236)
  AUTHORS   Lin,W., Ye,W., Cai,L., Meng,X., Ke,G., Huang,C., Peng,Z., Yu,Y.,
            Golden,J.A., Tartakoff,A.M. and Tao,T.
  TITLE     The roles of multiple importins for nuclear import of murine
            aristaless-related homeobox protein
  JOURNAL   J Biol Chem 284 (30), 20428-20439 (2009)
   PUBMED   19494118
REFERENCE   6  (bases 1 to 6236)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 6236)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 6236)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   9  (bases 1 to 6236)
  AUTHORS   Jakel,S., Mingot,J.M., Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Importins fulfil a dual function as nuclear import receptors and
            cytoplasmic chaperones for exposed basic domains
  JOURNAL   EMBO J 21 (3), 377-386 (2002)
   PUBMED   11823430
REFERENCE   10 (bases 1 to 6236)
  AUTHORS   Muhlhausser,P., Muller,E.C., Otto,A. and Kutay,U.
  TITLE     Multiple pathways contribute to nuclear import of core histones
  JOURNAL   EMBO Rep 2 (8), 690-696 (2001)
   PUBMED   11493596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD347972.1, BC056469.1 and AC016814.14.
            
            On or before Aug 19, 2006 this sequence version replaced
            XM_129442.7, XM_898824.2, XM_898801.2, XM_898793.2, XM_915728.2,
            XM_923916.2, XM_923904.2, XM_923899.2, XM_983504.1, XM_983428.1,
            XM_983389.1, XM_983357.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.121723.1,
                                           SRR1660817.183383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CD347972.1         1-33
            34-1916             BC056469.1         1-1883
            1917-3349           BC056469.1         2065-3497
            3350-6236           AC016814.14        129626-132512       c
FEATURES             Location/Qualifiers
     source          1..6236
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.6 cM"
     gene            1..6236
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /note="importin 9"
                     /db_xref="GeneID:226432"
                     /db_xref="MGI:MGI:1918944"
     exon            1..224
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..3184
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /note="isoform 1 is encoded by transcript variant 1; Ran
                     binding protein 9; ran-binding protein 9"
                     /codon_start=1
                     /product="importin-9 isoform 1"
                     /protein_id="NP_722469.1"
                     /db_xref="CCDS:CCDS35719.1"
                     /db_xref="GeneID:226432"
                     /db_xref="MGI:MGI:1918944"
                     /translation="MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAE
                     EQIKVLEVTEEFGVHLAELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETT
                     ERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDL
                     NAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTC
                     AHMICNMEELEKGAAKVLIFPVVQQFTEAFVQALQMPDGPTSDSGFKMEVLKAVTALV
                     KNFPKHMVSSMQQILPIVWNTLTESAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVF
                     SIFEFVHALLENSKFKSTVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDD
                     TFSYTVRIAAQDLLLAVATDFQNESAVALATAATRHLQEAEQTKASGTEHWWKIHEAC
                     MLALGSVKSIITDSVKNGRIHFDMHGFLTNVILVDLNLSASPFLLGRALWAASRFTVA
                     MSPELIQQFLQATVSGLHETQPPSVRISAVRAIWGYCDQLKVSESTHVLQPFLPSILD
                     GLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTASVENKICPFTIAIFLKYSNDPVVAS
                     LAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPADKIPAGLCATAIDILTTVVRNTK
                     PPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAYVSVTLEQVAQWHDEQGHNGL
                     WYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGENLDQILRAILSKMQQAET
                     LSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVMAEWTSRQHLFYGQYEG
                     KVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSKSAKNPERWTNIPLL
                     VKILKLIINELSNVMEANAARQATPAEWNQDDSNDMWEDQEEEEEEEDGLAGQLLSDI
                     LATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPCYIMFSCHLNDN
                     ERRVLQTIGI"
     exon            225..286
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            287..373
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            374..575
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            576..664
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            665..751
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            752..871
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            872..972
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1031
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1183
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1282
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1389
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1529
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1689
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1916
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2065
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2194
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2470
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2637
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2771
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2894
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2996
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3073
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..6236
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4055..4060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /note="hexamer: AGTAAA"
     polyA_site      4078
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /note="major polyA site"
     polyA_site      4869
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
     regulatory      6214..6219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
                     /note="hexamer: AATAAA"
     polyA_site      6235
                     /gene="Ipo9"
                     /gene_synonym="0710008K06Rik; Imp9; Ranbp9"
ORIGIN      
        1 cgggagccgt cattcggtgg cgggtcccgg ccgcggggct ggcgggctga ggggaggaaa
       61 gatggcggca gcggcggcag ctggtgcggc ttctgggctg ccgggtccag tggcacaggg
      121 attgaaggag gcgttggtgg ataccctcac cggaatcctg tccccggtgc aggaggtgcg
      181 ggcggctgca gaggagcaga ttaaggtgct ggaggtgaca gaggaatttg gtgttcacct
      241 ggcagagctg actgtagatc ctcagggggc actggcaatc cgtcagctgg cgtcagtcat
      301 cttgaaacag tatgtggaaa ctcactggtg tgcccaatca gagaagttca gacctccgga
      361 aactacagaa agggcaaaaa ttgtcatccg ggagctgtta cccaatgggt taagagaatc
      421 aataagcaaa gtgcgctcca gtgtggccta tgctgtgtcc gccattgccc actgggattg
      481 gcctgaagcc tggccccagc tcttcaacct gcttatggaa atgttggtga gcggagactt
      541 aaatgccgtc catggagcca tgcgtgtgtt gacagagttt actcgagaag tgacagacac
      601 acagatgcca cttgttgctc ctgtcattct gccagagatg tataagatat tcaccatggc
      661 cgaggtgtat ggtattcgaa ctcgttcccg agcagtggag atttttacta cttgtgcgca
      721 tatgatctgt aacatggagg aactggaaaa gggtgcagcc aaagtcctga tcttccccgt
      781 ggtgcagcag ttcacagagg cctttgttca ggcactccag atgcccgatg gccccacatc
      841 tgacagtggc tttaagatgg aggtcctgaa ggcagtgaca gccttggtga aaaacttccc
      901 aaagcacatg gtgtcctcca tgcaacagat cctgcccatt gtttggaaca ctctaactga
      961 aagtgctgcc ttttatgtga ggacggaagt gaattacaca gaggaagtgg aagatcctgt
     1021 ggattcggat ggagaagtcc tgggctttga gaacctcgtc tttagcattt ttgagtttgt
     1081 ccatgcccta ctggagaaca gcaagttcaa aagcaccgtt aagaaggctc tgcccgagct
     1141 catttactac atcatcctgt acatgcagat caccgaggag cagattaaag tgtggacagc
     1201 taacccacag cagtttgtag aagacgagga tgatgacacg ttctcctaca ctgttaggat
     1261 tgccgctcaa gacttgttgc tggctgtggc cacagatttc cagaatgaga gtgcagtggc
     1321 cctggctact gcagccacac ggcatttaca agaagcagag cagacaaaag ccagtggcac
     1381 tgagcactgg tggaagatcc acgaggcctg catgcttgct ctaggctctg tgaagtctat
     1441 catcactgac agtgtgaaaa atggcaggat ccattttgat atgcatgggt tcctgaccaa
     1501 tgtcatcctt gtagacctca acctgtcagc atctcctttc ctcttgggcc gggcactgtg
     1561 ggctgccagt cgcttcactg tcgctatgtc ccctgaactg attcagcagt tcctacaggc
     1621 aacagtcagt ggtcttcatg agacacagcc cccatcagtt cgcatctctg ctgtgagagc
     1681 catctggggt tattgtgatc aactgaaagt ctcagagagt acgcatgtgc ttcagccctt
     1741 cctacccagc atccttgatg gcctaattca cctagcagcc cagttcagct cagaggtcct
     1801 caacctggtg atggagacgc tgtgcattgt ttgtactgtt gacccagaat tcacagcaag
     1861 cgtggaaaac aagatctgtc ccttcaccat cgctattttc ctcaagtaca gtaatgatcc
     1921 tgttgtggcc tcgctggctc aggacatctt caaggagctt tcgcaaattg aagcctgtca
     1981 aggtcccatg cagatgaggc tgattcccac gctggtcagc ataatgcagg ccccagcaga
     2041 caagatccct gcggggctct gtgcgacagc cattgacatc ttgactacag tagttcgaaa
     2101 taccaagcct cccctttccc agctcctcat ttgccaggct ttccctgctg tggcgcagtg
     2161 cacccttcac acagatgaca atgccaccat gcagaatggt ggtgagtgtt tgcgggccta
     2221 tgtgtcagtg acactggaac aggtagccca gtggcatgac gaacaaggcc acaatggact
     2281 gtggtacgtg atgcaagtag tgagccagct ccttgaccca cgaacctcag agtttactgc
     2341 agcttttgtg ggccgcctgg tctccaccct catctccaag gcagggcggg agctggggga
     2401 gaatctggac cagattcttc gtgccatcct cagtaagatg cagcaggcag agacactcag
     2461 tgtcatgcag tctctcatca tggtgtttgc tcatctggtg cacactcagc tggaacctct
     2521 attggagttc ctatgtagcc tcccaggacc aactgggaag cctgccctgg agttcgtgat
     2581 ggctgagtgg acgagtcggc agcacctgtt ctatggacag tatgaaggca aagttagctc
     2641 tgtggcactg tgtaaactgc ttcagcatgg catcaatgca gacgacaagc ggctacaaga
     2701 tattcgtgtg aagggagagg agatctacag catggacgag ggcatccgca cccgctctaa
     2761 gtcagccaaa aacccggagc gctggacgaa cattcctctg ttggtcaaga tcctaaagct
     2821 gattatcaac gagctttcca atgtcatgga ggccaatgct gctcgccagg ccactcctgc
     2881 tgagtggaac caagatgatt ccaatgatat gtgggaggac caggaggaag aggaggagga
     2941 ggaggatggt ttagctggcc agcttttatc tgacattctt gctacaagta aatacgagga
     3001 ggattactat gaagacgatg aggaagatga ccccgatgcc ctgaaggatc ctctctatca
     3061 gattgatctg caggcgtatc tcacagactt cctttgccag tttgctcagc agccctgtta
     3121 cataatgttt tcatgccacc ttaacgacaa cgagaggcgg gtcctacaga ctatcggcat
     3181 ctaaaaagga gagtcttcag cctgtgcttc ctctcctggc ccagccacag aacattctac
     3241 cgccctctct ggccttgaga tgcacttttt ctcagcctgg agtggcttct ggccgtcggc
     3301 ctggacagtg atactgacac tcagcccttg cttaccaggg ctggcatttt aaaagctaaa
     3361 gcaaagaaca tttatcaaag tcctgtgaag ataccccaaa tctggaactg tctttctccc
     3421 cagctctgcc cccttcattc ctagcatcct ctgttggcca gaccagaaac attgataccg
     3481 aggatgtggg ttcctggtta ttttgcccca cttcaggagc acaggaattc atttccatta
     3541 atactcagaa gcatatctgt ttctttcata ggacatctga tgtgttcagt taggagcccc
     3601 gtgagagatc attctgccta tgccttctgc cctcggccag tgatgctcta ggttttcagt
     3661 aaggagaagc tggagccgcc acgtactaag ccatttccag taacttcacc ttcatgcttt
     3721 cctcatgcaa cactaagggt cctctgtcaa aggctccata ttcccatctt tgcttcgttg
     3781 catgacacag cccctccccc aggctgttcc tatatataca tgcatacaca aagcaagcca
     3841 gacagacggc aacttgtctt tttttttttt ttttaagaaa aaaaatcagg aaagagattt
     3901 ttatttctaa atctgcttga cccatctata tttaatatgc ctcttctgca cataaccaca
     3961 gagtctgata ttcaaaggta tccctatccc tcaggaatcc tctgaagtgg ttgagttgta
     4021 gcccttgaat ttacaacatg tatttttcta ggacagtaaa gcgatcttta caaatgaatt
     4081 tagtctgcat actctaaggt gtctcaacac ctccaccttc tgtttcttcc ttccagaagc
     4141 aaagtaaaaa acagaagaaa gcatagcata ttttagcatc ctactgtgat ttggcaagca
     4201 gctcaaaaat cttagagaac tggtattttt catccaaata tgtttaaaga gtcagtggta
     4261 cagcgtgcgg aggatggccc agggttcggt ccccagtact acaaaaataa ggacatcctg
     4321 cagtggggtt ccctcgtatt atgagttgag aatgggtgaa gattaagagc agagtagttg
     4381 ccccatgctc cctttgtttg gtagtgcccg ggtctgctgc tccattttta atagctggag
     4441 ctttttcttt ggggtgatgc tttaacaaaa aggaaagggg atgtagtggt cttgagctcc
     4501 acttaagcag aaggcgtata aggcctttcc tgggaccaaa ggacttggca gcttgttact
     4561 gactgcgcca ccagatgtcc ttagtgctca accttgagtt cagaagcact aactaaagtt
     4621 tccactttta tttttaagag cctaagaaag tgtgtatagt tgtcttctgg ctggcggtgt
     4681 ggagaccagt attgcctctg cccttgctgc ttttcctcct gaagttgaag ttcctgataa
     4741 agagaaatga taacatacct gtccagtggt acccaaaaac accacagtaa gagctttgga
     4801 acctcgttct atagttgacc tcaaagtcaa ctggatttgg tgctaaaaac agtagaccat
     4861 tccacatgat taagttgtct aatggttttg tcacattaga gtggtaccag gttagcagca
     4921 ctggcctgct gagtttgagg aagcttggag accccagttc atatgccgac agtgatgtgg
     4981 gttcattcta agcctgcaca ttagaacagt tcccagtgtg tagtgccaaa attagtccaa
     5041 agggtctgtc ctgttctcat ggttcacttt tggtaggagg gctaagctcc tggcttaaga
     5101 aaacttgaaa agcaggtttg taggaagcca tcctggccaa catacataac tgattggaag
     5161 tggaggggct tctgcaccct ggtggacaga tgcttgtgtt ttcagagcaa ttaactcctg
     5221 caacagtgaa atctcccatc ctgccgagag actgttcctg agagcaagga gaaagttctg
     5281 ttggtgtgac gaagttgaac tctggctcat attttatctc ctatgaaagc caacttcatt
     5341 tgggaaaggg gtgaggcaga ccgttgaaga ctaagaaaag accagtgaac tcatgagagg
     5401 tgtgggctcc ctatgatcaa aggtttccag gttgtgggtg aaacactgga gagctagaaa
     5461 gcagatgaga ttccaagaaa gagttgttcc gctaacccct gactaagacg catgaaccta
     5521 caacagatgg ttcgaaagca gatgactgtc agcggggaaa gcagtggctg gggctgagag
     5581 aggtggtcat tgtgagctag gagctaaagt ggtgagctaa tgaaagcaag cctcagctct
     5641 tgttagctgt cctaagtacc ccagagaagt aaagtgagca ctgaccagcc gagcgacaag
     5701 tcagccttcg tgggagaacg ggggtgggtc tttactgtgg agatgagtgg gttgatttat
     5761 gccaggacat ttgaagccat ttgcaaaaga aactgaccta cacaaggaaa gaatgctcat
     5821 caaatcttag atgacaggaa acccctggga agggtgacat ttaggatcca agtagatcaa
     5881 gtataagaaa aggagtttgg cgacagtatt tatcgggaag attaaagatt tggagtactg
     5941 tgtacctcat taaaagtact gagtgttagg agtccaaaaa actccagtgt gggcccaggt
     6001 tatggtctag gatactgcag attttcctcc acctctgtcc ctctcaggga tcctgaccaa
     6061 tgacaatact ctgtaaaagg acatccaaga cctagactgt ttagaggaag tggtgacatg
     6121 gctgagaagg ctgggctcag gacagcctca gcactcatgg gtttgttcag acaagcgctg
     6181 cactgcacca ggccagctgt gccctgagga cggaataaaa agtgcatttc tggctc
//
