LOCUS       NM_001081113            5357 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus importin 8 (Ipo8), transcript variant 1, mRNA.
ACCESSION   NM_001081113 XM_132974
VERSION     NM_001081113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5357)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5357)
  AUTHORS   Van Gucht,I., Meester,J.A.N., Bento,J.R., Bastiaansen,M.,
            Bastianen,J., Luyckx,I., Van Den Heuvel,L., Neutel,C.H.G.,
            Guns,P.J., Vermont,M., Fransen,E., Perik,M.H.A.M., Velchev,J.D.,
            Alaerts,M., Schepers,D., Peeters,S., Pintelon,I., Almesned,A.,
            Ferla,M.P., Taylor,J.C., Dallosso,A.R., Williams,M., Evans,J.,
            Rosenfeld,J.A., Sluysmans,T., Rodrigues,D., Chikermane,A.,
            Bharmappanavara,G., Vijayakumar,K., Mottaghi Moghaddam Shahri,H.,
            Hashemi,N., Torbati,P.N., Toosi,M.B., Al-Hassnan,Z.N., Vogt,J.,
            Revencu,N., Maystadt,I., Miller,E.M., Weaver,K.N., Begtrup,A.,
            Houlden,H., Murphy,D., Maroofian,R., Pagnamenta,A.T., Van Laer,L.,
            Loeys,B.L. and Verstraeten,A.
  CONSRTM   Genomics England Research Consortium
  TITLE     A human importin-beta-related disorder: Syndromic thoracic aortic
            aneurysm caused by bi-allelic loss-of-function variants in IPO8
  JOURNAL   Am J Hum Genet 108 (6), 1115-1125 (2021)
   PUBMED   34010605
REFERENCE   3  (bases 1 to 5357)
  AUTHORS   Nganou,G., Silva,C.G., Gladwyn-Ng,I., Engel,D., Coumans,B.,
            Delgado-Escueta,A.V., Tanaka,M., Nguyen,L., Grisar,T., de Nijs,L.
            and Lakaye,B.
  TITLE     Importin-8 Modulates Division of Apical Progenitors,
            Dendritogenesis and Tangential Migration During Development of
            Mouse Cortex
  JOURNAL   Front Mol Neurosci 11, 234 (2018)
   PUBMED   30042658
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5357)
  AUTHORS   Wei,Y., Li,L., Wang,D., Zhang,C.Y. and Zen,K.
  TITLE     Importin 8 regulates the transport of mature microRNAs into the
            cell nucleus
  JOURNAL   J Biol Chem 289 (15), 10270-10275 (2014)
   PUBMED   24596094
  REMARK    GeneRIF: Importin 8 plays a critical role in mediating the
            cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated
            nuclear transport of mature miRNAs is also dependent on the
            association of IPO8 with the Argonaute 2 complex.
REFERENCE   5  (bases 1 to 5357)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 5357)
  AUTHORS   Buttitta,L., Tanaka,T.S., Chen,A.E., Ko,M.S. and Fan,C.M.
  TITLE     Microarray analysis of somitogenesis reveals novel targets of
            different WNT signaling pathways in the somitic mesoderm
  JOURNAL   Dev Biol 258 (1), 91-104 (2003)
   PUBMED   12781685
REFERENCE   7  (bases 1 to 5357)
  AUTHORS   Kao,H.H., Huang,J.D. and Chang,M.S.
  TITLE     cDNA cloning and genomic organization of the murine MRP7, a new
            ATP-binding cassette transporter
  JOURNAL   Gene 286 (2), 299-306 (2002)
   PUBMED   11943485
REFERENCE   8  (bases 1 to 5357)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 5357)
  AUTHORS   Wright,E., Hargrave,M.R., Christiansen,J., Cooper,L., Kun,J.,
            Evans,T., Gangadharan,U., Greenfield,A. and Koopman,P.
  TITLE     The Sry-related gene Sox9 is expressed during chondrogenesis in
            mouse embryos
  JOURNAL   Nat Genet 9 (1), 15-20 (1995)
   PUBMED   7704017
REFERENCE   10 (bases 1 to 5357)
  AUTHORS   Salles,F.J., Darrow,A.L., O'Connell,M.L. and Strickland,S.
  TITLE     Isolation of novel murine maternal mRNAs regulated by cytoplasmic
            polyadenylation
  JOURNAL   Genes Dev 6 (7), 1202-1212 (1992)
   PUBMED   1628827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134542.3.
            
            On Mar 18, 2023 this sequence version replaced NM_001081113.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151052.1, SRR9219381.152623.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC134542.3         101767-102067       c
            302-383             AC134542.3         95007-95088         c
            384-540             AC134542.3         92198-92354         c
            541-699             AC134542.3         88567-88725         c
            700-856             AC134542.3         87088-87244         c
            857-946             AC134542.3         82670-82759         c
            947-1041            AC134542.3         81271-81365         c
            1042-1126           AC134542.3         80483-80567         c
            1127-1261           AC134542.3         76988-77122         c
            1262-1361           AC134542.3         75225-75324         c
            1362-1438           AC134542.3         72516-72592         c
            1439-1555           AC134542.3         72090-72206         c
            1556-1645           AC134542.3         70784-70873         c
            1646-1811           AC134542.3         70330-70495         c
            1812-1972           AC134542.3         69226-69386         c
            1973-2098           AC134542.3         67244-67369         c
            2099-2165           AC134542.3         62044-62110         c
            2166-2291           AC134542.3         60400-60525         c
            2292-2389           AC134542.3         59674-59771         c
            2390-2485           AC134542.3         57298-57393         c
            2486-2706           AC134542.3         55105-55325         c
            2707-2912           AC134542.3         53201-53406         c
            2913-3113           AC134542.3         47806-48006         c
            3114-3230           AC134542.3         45580-45696         c
            3231-5357           AC134542.3         41286-43412         c
FEATURES             Location/Qualifiers
     source          1..5357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.57 cM"
     gene            1..5357
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /note="importin 8"
                     /db_xref="GeneID:320727"
                     /db_xref="MGI:MGI:2444611"
     exon            1..301
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3250
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 10;
                     oocyte maturation 1; imp8; ran-binding protein 8"
                     /codon_start=1
                     /product="importin-8 isoform 1"
                     /protein_id="NP_001074582.1"
                     /db_xref="CCDS:CCDS39719.1"
                     /db_xref="GeneID:320727"
                     /db_xref="MGI:MGI:2444611"
                     /translation="MDLNRIIQALKGTIDPKLRIAAETELNQSYKIINFAPSLLRIIV
                     SDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEVIFPFNIHENDRQQIRDNIVEGIIR
                     SPDLVRVQLTMCLRVIIRHDFPGHWPAVVDKIDYYLQSPNSGSWLGSLLCLYQLVKTY
                     EYKKAEEREPLLAAMQIFLPRIQQQILQLLPDASHYSVLLQKQILKIFYALVQYALPL
                     QLVNHQTMTTWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVARLFERY
                     GSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYIAPRVLQQAFNYLNQGV
                     VHAVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTT
                     AAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLF
                     KDQIELFLQNHVFPLLMSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIE
                     DEEMPVKVEAALALQSLISNQAQAKEHMKPYVRFIMQELLHIVRETENDDVTNVIQKL
                     ICEYSQDVASIAVDTTQHLAEIFGKVLQSDEYEEIEDKTVMAMGILHTIDTILTVVED
                     HPEIIQQLENICLRIIDLVLQKHVIEFYEEILSLAYNLTCHTISPQMWQLLGILYEVF
                     QQDCFEYFTDMMPLLHNYVTVDTNALLSNPKHLEVLFTMCRKVLCGEAGEDAECYAAK
                     LLEVIILQCKGRGIDQCIPLFIQLVLERLTRGVKTSELRTMCLQVAIAALYYSPELLF
                     HTLEQVQLPHNPGPVTSQFINQWMNDTDYFLGHHDRKMCIIGLSVLLELQNRPPAVDA
                     VAAQILPSILFLFLGLKQVCATRQTVNRENHSKAEKVDIEENEEISSEEEEETSVSAQ
                     AMQSQIGRSEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDA
                     AWYQLLVAPLSEDQKRKLQEVYTLAEHRRTLAAGQFHI"
     exon            302..383
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            384..540
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            541..699
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            700..856
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            857..946
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1041
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1126
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1261
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1361
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1438
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1555
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1645
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1811
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1972
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2098
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2165
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2291
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2389
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2485
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2706
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2912
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3113
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3230
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..5357
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5326..5331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /note="hexamer: AATAAA"
     polyA_site      5357
                     /gene="Ipo8"
                     /gene_synonym="6230418K12Rik; Abcc10; C130009K11Rik; MRP7;
                     OM-1; Om1; Ranbp8"
                     /note="major polyA site"
ORIGIN      
        1 gtaaaaggtg aatggagaga gagttgtcgg ggggaaggag ggaggacagg gggcgcggag
       61 tcagagtggc gcagcaagta gctgcaggcg gtggtggcag cggcaggggg tgggggtgag
      121 gtggtcccct gaggtagagg gggccaaaaa gggccaggag acatcccggc tgcaacccgg
      181 cctgctggct ctgggacccg agctcccgcc cgcggacatg gacctcaatc ggatcatcca
      241 ggcgctgaag ggcactatcg acccaaagct gagaattgca gctgagacgg agcttaacca
      301 gtcctacaag attattaatt ttgcccccag cttgcttcgg atcatagtct ctgaccatgt
      361 ggagttccct gtgcgtcagg cagctgccat ctacctgaag aacatggtga cacaatactg
      421 gccagacagg gagcctccac caggagaagt gatatttcca ttcaatattc atgagaacga
      481 ccggcagcag atccgtgaca acattgtgga agggataatt cggtctccag atttggtgag
      541 agtccagtta acaatgtgtc tccgagtcat cattagacac gattttcctg gtcactggcc
      601 tgcagtggtc gacaagatag actactactt gcagtcacca aacagtggga gctggcttgg
      661 cagtttactg tgcttatatc agctggtgaa gacatatgaa tataaaaaag cagaagaaag
      721 agaacctctc ctggcagcca tgcagatatt tctgcctaga attcaacagc aaatcctgca
      781 gctgcttccg gatgcctccc attactctgt gttgctgcag aaacagattc tgaaaatatt
      841 ctatgctctc gttcagtatg cactgcctct tcagctggtg aatcaccaga ccatgacaac
      901 gtggatggag atctttcgga ccatcattga taggacggtc cctccggaga ctcttcagat
      961 tgatgaggat gaccggccag agctggtgtg gtggaagtgt aagaagtggg ctctgcacat
     1021 tgtcgctcgt ctctttgaac ggtatggaag cccaggaaat gtcacaaaag aatacttcga
     1081 attttctgaa ttttttttga aaacctatgc agtgggaatt caacaggtac tactaaaaat
     1141 tttagaccaa tacagacaga aagagtatat agccccccgt gttcttcagc aagctttcaa
     1201 ctatctaaac caaggggttg tccatgctgt gacttggaag cagatgaagc cacatataca
     1261 gaatatctct gaagatgtga ttttttctgt gatgtgttat aaagacgagg atgaagagct
     1321 gtggcaagaa gatccgtatg aatacataag gatgaaattt gatattttcg aagattatgc
     1381 ttctcctacc acagcggccc agaccctctt gtatacagct gcaaagaaaa gaaaagaggt
     1441 gttgccaaaa atgatggcgt tctgttatca gatactaaca gacccgaact ttgaccctag
     1501 gaagaaagat ggagccctgc atgtgattgg ttccctggct gagattttgt tgaagaagag
     1561 tttattcaag gaccaaattg agctgttcct gcagaatcat gtatttccat tattaatgtc
     1621 taacctggga tatcttcgag ctagatcctg ctgggtgctg catgcattta gttctttgaa
     1681 gtttcacaat gagctcaacc tcagaaatgc agtagaatta gccaagaaga gcctgattga
     1741 agacgaggag atgcctgtca aggtggaagc tgcccttgca ctgcagtcgc tgatctccaa
     1801 ccaggcacaa gccaaggagc acatgaaacc gtacgtgaga ttcatcatgc aggagctgct
     1861 gcatatcgtc agagagacgg agaatgacga tgttaccaat gtcatccaga agctcatatg
     1921 tgagtacagt caggacgtgg cctccatcgc tgtcgacaca acccagcact tggctgagat
     1981 atttggtaaa gttcttcaga gtgatgagta tgaagaaatt gaagacaaaa ctgtcatggc
     2041 catggggatt ttacacacca tcgacactat cttaacagtt gtggaagatc atccagagat
     2101 tatacagcag ttggagaaca tctgcctacg aatcattgat cttgttttac agaagcacgt
     2161 tattgaattc tatgaggaaa tcctttccct ggcatacaat ttaacctgcc ataccatctc
     2221 cccgcagatg tggcagctcc tgggcatttt atatgaagtt ttccagcagg attgcttcga
     2281 gtactttaca gacatgatgc ctctcctgca taattacgtg acagtagata ccaacgctct
     2341 gctgtcaaat ccaaagcatt tagaagtctt gttcacaatg tgcaggaagg tactgtgtgg
     2401 agaggcagga gaagatgccg agtgctatgc tgcaaaactc ttggaagtca tcattcttca
     2461 gtgcaaagga aggggaattg accagtgtat cccgctattc attcaacttg tcttggagag
     2521 attaacacgt ggggtcaaga ccagtgagct gcgcacaatg tgtctccagg tggccatcgc
     2581 agctctttac tacagccctg aactgctgtt ccatacactg gagcaagtcc agctgccaca
     2641 caacccagga cccgtcacgt cgcagttcat aaaccagtgg atgaatgaca ctgattactt
     2701 cctgggacac catgaccgga agatgtgtat aataggactg agtgtgctct tggagctgca
     2761 gaaccgacct cctgccgtgg atgctgtggc tgcacagatc ctcccctcca ttctcttcct
     2821 tttccttggc ctgaagcagg tctgtgctac acgacaaacg gtaaaccgtg aaaatcactc
     2881 aaaagcagag aaagtcgaca tagaggaaaa tgaggagatt tcaagtgagg aggaggaaga
     2941 gacaagtgtg agtgctcaag ctatgcagtc acaaattggc agaagtgagg aggaggatga
     3001 tgacgactgg gatgaagaag tgctggagga gacagccctc gagggcttca gcaccccact
     3061 ggacctggac aacagtgtgg atgaatacca gttttttaca caagctctgc tgactgtgca
     3121 gaatcgggat gctgcctggt accagctgct ggtggcacca ctcagtgagg atcagaaaag
     3181 aaagctgcag gaggtgtaca cgttggcaga gcaccgaagg acactggcag cagggcagtt
     3241 tcacatttga ggacaagagc atcttctcca cgtttaattt tggagtcgtg cccagcaaca
     3301 actggaaggc gcatccaccg ttcaccgatc ggcgtcaccg ctgctgctta gtacatgggt
     3361 tgagggccaa gaaggcaata agaggctgtg tcattggcat caggcggcca cgggcctgct
     3421 ctcccttcct tgacccttct taccctggag tatatatatt tttaacagct actgtaacgt
     3481 acgaaatttt gaaaaaagca gagtcattga ttggaaagga caaagcgtct gctcttaagg
     3541 ctgaacgctg aggggttaga gttgtgtatc ggcgcatgtc tcaggttttt gccatgaaga
     3601 atcagtggat ttatgcagat aacagtgcct tctgttgtac atgaataatc agaaaaaaat
     3661 ttttttggag tgcattgcaa tttttttaaa gcataaaaca tatttctaga tatcctgtaa
     3721 accttggtta tgtcatttca ttctgcattt tacttggtga gttgactgtc aggcaggtgg
     3781 tgcgggtctc tggcttcaga agcatccttg cttccttcaa ccaccctgtg ctcagaggct
     3841 tctttcaagg cttggaattt aggctctggt ttttcacaag acatctgtgg ttatcctaag
     3901 aactgttaag ttccgttttc catcactttt cccctcttga atgggatgat gtttctttca
     3961 ggatcataag tgtattgata atattgataa cctgctaagt tcagacttta cccacctctc
     4021 ggcagccagc agcagggact tgttggtcac taggcttagc agaaagactg aaggtcttat
     4081 gaatcatgtg cttaaatgat actacaggaa ttgtgggcat ccaaatatga aagcacaccg
     4141 aagttctaag cagaaggtga tttctgggtg ggggcttggt cagtagttac cattccaacc
     4201 atgttggaca gggcccaaaa cattttatat gttttctttt tttctttctc ctttcagccc
     4261 tcccttcttt ctttgtgaga tagagtctgt ctctgtatgc aacccaggtt ggcctcaaga
     4321 ttgcagtcct gactcagcct cctggccact gttaacacac ccagatgctg ggttttgtta
     4381 tgtagttctg gctggactgg aactcactct gtggcctagg ctgacctcag acttgtggca
     4441 gcccgtgctc agcttctaag gggttggaat tacagccacg acaaatggta gatatttttt
     4501 tatttagtaa caagacacaa cagatctaat ttaaccatct gcttttcaca gtctgaaatc
     4561 tctccagcct gatttagctt attagtcttt gttattgctc ggttgtcttt tttataaatt
     4621 cttcaagggt tggtctctcg gtcagctggg tgaataggtg actgatgatg tcagtattgc
     4681 agatggctct tcctgaactg ttcaagagca gaatatgaac cactgtgctt tcatctggca
     4741 aaatgaaaac atgttatcag gattggacat atttctggat gtgatacaga ttttgtttgt
     4801 gtgaaatacc tgcagcttaa atttccatca gcaactggca ggattttcta ggtgattcct
     4861 gaattacaaa tcttgtattt tttttttttt aatttaggtt atttaatttt tttgtcagaa
     4921 gtagctataa aaaagccata tgtttcagag agaaattacc ctgtattttg ccatctctca
     4981 tttttcaggg caccaaagct gcatgccccc cagcagttag aagggcaaga ttgcattgaa
     5041 ggggtttcag acctctgaag tagtcagttt tctcccatgt cttctatggt ttaattgtaa
     5101 cataggtagt atgccttcac actggatccc gggggcatgg gttttggaga tgttattttg
     5161 tggtgaattg tcatctgcag tattaaaggg aagacatatt cctgcacatc accatacctt
     5221 gtttttaaag ccagagtcat tgtatgattt ttattaccag aagtgctaac cggaatgtga
     5281 tctggttacc ttggaaatgc aggaactttt atgaatgtac tgtaaaataa aatgtgggct
     5341 aattcccaga aactgaa
//
