LOCUS       NM_181517               4722 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus importin 7 (Ipo7), transcript variant 1, mRNA.
ACCESSION   NM_181517
VERSION     NM_181517.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4722)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4722)
  AUTHORS   Ding,N., Li,H., Zhang,Z. and Jia,H.
  TITLE     Inhibition of importin-7 attenuates ventilator-induced lung injury
            by targeting nuclear translocation of p38
  JOURNAL   Inflamm Res 72 (5), 971-988 (2023)
   PUBMED   37004548
  REMARK    GeneRIF: Inhibition of importin-7 attenuates ventilator-induced
            lung injury by targeting nuclear translocation of p38.
REFERENCE   3  (bases 1 to 4722)
  AUTHORS   Zhang,Y., Zhang,H., Xiao,Z., Yuan,G. and Yang,G.
  TITLE     IPO7 Promotes Odontoblastic Differentiation and Inhibits
            Osteoblastic Differentiation Through Regulation of RUNX2 Expression
            and Translocation
  JOURNAL   Stem Cells 40 (11), 1020-1030 (2022)
   PUBMED   35922041
  REMARK    GeneRIF: IPO7 Promotes Odontoblastic Differentiation and Inhibits
            Osteoblastic Differentiation Through Regulation of RUNX2 Expression
            and Translocation.
REFERENCE   4  (bases 1 to 4722)
  AUTHORS   She,Y., Zhang,Y., Xiao,Z., Yuan,G. and Yang,G.
  TITLE     The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by
            importin7 in dental mesenchymal cells
  JOURNAL   Cells Dev 169, 203763 (2022)
   PUBMED   34995814
  REMARK    GeneRIF: The regulation of Msx1 by BMP4/pSmad1/5 signaling is
            mediated by importin7 in dental mesenchymal cells.
REFERENCE   5  (bases 1 to 4722)
  AUTHORS   Zhang,Y., Zhang,H., Yuan,G. and Yang,G.
  TITLE     Effects of transforming growth factor-beta1 on odontoblastic
            differentiation in dental papilla cells is determined by IPO7
            expression level
  JOURNAL   Biochem Biophys Res Commun 545, 105-111 (2021)
   PUBMED   33548622
  REMARK    GeneRIF: Effects of transforming growth factor-beta1 on
            odontoblastic differentiation in dental papilla cells is determined
            by IPO7 expression level.
REFERENCE   6  (bases 1 to 4722)
  AUTHORS   Loebel,D.A., O'Rourke,M.P., Steiner,K.A., Banyer,J. and Tam,P.P.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   7  (bases 1 to 4722)
  AUTHORS   Muhlhausser,P., Muller,E.C., Otto,A. and Kutay,U.
  TITLE     Multiple pathways contribute to nuclear import of core histones
  JOURNAL   EMBO Rep 2 (8), 690-696 (2001)
   PUBMED   11493596
REFERENCE   8  (bases 1 to 4722)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
REFERENCE   9  (bases 1 to 4722)
  AUTHORS   Cichutek,A., Brueckmann,T., Seipel,B., Hauser,H., Schlaubitz,S.,
            Prawitt,D., Hankeln,T., Schmidt,E.R., Winterpacht,A. and Zabel,B.U.
  TITLE     Comparative architectural aspects of regions of conserved synteny
            on human chromosome 11p15.3 and mouse chromosome 7 (including genes
            WEE1 and LMO1)
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 277-283 (2001)
   PUBMED   11528126
REFERENCE   10 (bases 1 to 4722)
  AUTHORS   Smitherman,M., Lee,K., Swanger,J., Kapur,R. and Clurman,B.E.
  TITLE     Characterization and targeted disruption of murine Nup50, a
            p27(Kip1)-interacting component of the nuclear pore complex
  JOURNAL   Mol Cell Biol 20 (15), 5631-5642 (2000)
   PUBMED   10891500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140235.3 and AC121995.2.
            
            On Jun 17, 2019 this sequence version replaced NM_181517.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY316153.1, SRR9219382.125274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC140235.3         27458-27651         c
            195-276             AC140235.3         18814-18895         c
            277-430             AC140235.3         16122-16275         c
            431-589             AC140235.3         14200-14358         c
            590-746             AC140235.3         8866-9022           c
            747-836             AC140235.3         6713-6802           c
            837-931             AC140235.3         5266-5360           c
            932-1016            AC140235.3         5069-5153           c
            1017-1151           AC140235.3         3851-3985           c
            1152-1251           AC140235.3         3081-3180           c
            1252-1328           AC140235.3         1481-1557           c
            1329-1445           AC140235.3         1232-1348           c
            1446-1535           AC121995.2         103959-104048
            1536-1701           AC121995.2         104475-104640
            1702-1862           AC121995.2         104784-104944
            1863-1991           AC121995.2         105926-106054
            1992-2058           AC121995.2         106591-106657
            2059-2184           AC121995.2         106742-106867
            2185-2282           AC121995.2         107393-107490
            2283-2378           AC121995.2         108577-108672
            2379-2599           AC121995.2         108810-109030
            2600-2805           AC121995.2         109119-109324
            2806-3012           AC121995.2         110508-110714
            3013-3129           AC121995.2         111797-111913
            3130-4722           AC121995.2         112814-114406
FEATURES             Location/Qualifiers
     source          1..4722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.7 cM"
     gene            1..4722
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /note="importin 7"
                     /db_xref="GeneID:233726"
                     /db_xref="MGI:MGI:2152414"
     exon            1..194
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3227
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /note="isoform 1 is encoded by transcript variant 1; RAN
                     binding protein 7"
                     /codon_start=1
                     /product="importin-7 isoform 1"
                     /protein_id="NP_852658.2"
                     /db_xref="CCDS:CCDS40085.1"
                     /db_xref="GeneID:233726"
                     /db_xref="MGI:MGI:2152414"
                     /translation="MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITM
                     SEQLDLPVRQAGVIYLKNMITQYWPDREATPGDIAPYTIPEEDRHCIRENIVEAIIHS
                     PELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYE
                     YKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLE
                     LINQQNLTEWVEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYG
                     SPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVS
                     HALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTA
                     AQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYK
                     DQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDD
                     REMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMI
                     CEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVED
                     HKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVF
                     QQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAK
                     LLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLL
                     NTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQ
                     VSGQILPAFILLFNGLKRAYACHAEHENDSDDDEDAEDDDETEELGSDEDDIDEDGQE
                     YLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNR
                     NPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNF
                     GGPAPGMN"
     exon            195..276
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            277..430
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            431..589
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            590..746
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            747..836
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            837..931
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1016
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1151
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1251
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1328
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1445
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1535
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1701
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1862
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1991
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2058
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2184
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2282
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2378
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2599
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2805
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..3012
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3129
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..4722
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4208..4213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /note="hexamer: ATTAAA"
     polyA_site      4230
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /note="major polyA site"
     regulatory      4679..4684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
                     /note="hexamer: AATGAA"
     polyA_site      4722
                     /gene="Ipo7"
                     /gene_synonym="A330055O14Rik; C330016G14; Imp7; Ranbp7"
ORIGIN      
        1 cctttcgcgc cggttgccgc tgcggagcgc ggccggtcca tgtgcgcagt gagtggcgct
       61 atttctgcct cagtagcacc ggtgtcccgg gtctgaccga ccgcgcggcg atggatccca
      121 acaccatcat cgaggccctc cggggcacca tggacccagc cctgcgcgag gccgctgagc
      181 gccagctcaa tgaagcacac aagtctctga atttcgtttc aacactgctc cagattacta
      241 tgtcagaaca actggattta cctgtgagac aggcaggtgt tatttattta aaaaatatga
      301 taacacaata ttggcctgat cgggaagcca caccagggga catcgctcca tatactattc
      361 cagaagaaga ccggcattgt attcgagaaa atattgtaga agccattatc cactcacctg
      421 agcttatcag ggtacagctt actacgtgca tccatcatat catcaaacat gactatccaa
      481 gccgctggac tgccattgtg gacaagattg gcttttatct tcagtctgat aacagtgctt
      541 gttggctggg aatccttctt tgcctttatc agcttgtgaa aaattatgag tacaagaaac
      601 cagaagagcg aagtccgtta gtggcagcca tgcagcactt tctgccagtt ctgaaggatc
      661 gctttatcca gctgctttct gaccaatccg accagtctgt cctcattcaa aagcagatat
      721 tcaagatctt ctatgctctt gttcagtata cactacccct ggagctgata aaccaacaga
      781 atctaactga atgggtagaa attttgaaga cagttgtgaa tagggatgta cctaatgaaa
      841 cacttcaagt tgaagaagat gatagacctg agttaccctg gtggaaatgt aagaagtggg
      901 ccttacatat tttagcaaga ctttttgaaa gatatggaag ccctgggaat gtttctaagg
      961 agtataatga gtttgctgaa gtctttctga aggcctttgc tgttggtgtc cagcaagttt
     1021 tattgaaagt gttatatcag tacaaggaaa aacaatatat ggcgcctcga gttttacagc
     1081 agacattaaa ttatattaat caaggagttt cccatgcact tacgtggaag aacctgaagc
     1141 cccatataca aggcattatc caagatgtta tttttccatt gatgtgctat acagatgctg
     1201 atgaggagct ctggcaagaa gatccttatg aatatatacg catgaagttc gatgtgtttg
     1261 aagatttcat ttctcctact actgctgctc aaacactttt gtttacagcc tgtagcaaaa
     1321 ggaaagaggt actgcaaaag actatgggat tttgttacca aattcttact gaacccaatg
     1381 ctgatcctcg gaaaaaagat ggagccttgc atatgattgg ctctttagct gaaatacttc
     1441 taaagaaaaa gatctacaaa gatcaaatgg aatacatgtt gcaaaatcat gtatttcctc
     1501 tcttcagcag tgagctaggt tacatgagag caagggcttg ctgggttctt cactattttt
     1561 gtgaagtgaa gttcaaaagt gatcaaaatc tccaaacagc tttagagctg acaagaagat
     1621 gtctgattga tgatcgagaa atgcctgtga aagtggaagc tgccattgca ctacaggtgt
     1681 tgatcagcaa tcaagaaaaa gctaaagagt acatcactcc atttatcaga cctgtcatgc
     1741 aggctcttct tcatattata agagaaacag aaaatgatga tcttacaaat gtaattcaga
     1801 aaatgatctg tgaatatagt gaagaagtta ctcctattgc tgtagaaatg acacaacatc
     1861 tggcaatgac atttaaccaa gtaatccaga ctgggccaga tgaggaagga agtgatgaca
     1921 aagcagttac tgctatggga attctgaaca caattgatac acttctgagt gtggttgaag
     1981 atcacaaaga gataacccag cagcttgagg gaatctgctt acaagtcatt gggaccgttc
     2041 tacaacagca tgtcttagaa ttctatgagg agatcttttc tttggcacat agtctgacat
     2101 gtcaacaagt gtctcctcag atgtggcagt tacttcccct tgtgtttgag gtatttcagc
     2161 aagatggctt tgattacttt acagacatga tgcctcttct acataactat gtaacagttg
     2221 atacagacac tcttctctct gataccaagt atctggagat gatatacagt atgtgtaaaa
     2281 aggttcttac tggagtcgca ggagaagatg cggaatgcca tgcggcaaaa ttgttagagg
     2341 tcattattct gcagtgcaaa ggccggggca ttgatcagtg tataccatta ttcgtggaag
     2401 cagctttaga aagactgacc agagaggtta aaacaagtga actcagaaca atgtgcctgc
     2461 aggttgcaat tgcagcattg tattataatc cacacctact gcttaatact ttagaaaatc
     2521 ttcgcttccc aaataatgtt gaacctgtta caaatcattt tatcacacaa tggcttaatg
     2581 acgttgactg ttttctgggg cttcatgaca ggaagatgtg tgttcttggc ctatgcgccc
     2641 ttattgatat ggaacaaata ccacaggttt taaatcaggt ttcaggacag attttgccag
     2701 cttttatcct tttatttaat ggattgaaaa gagcatatgc ctgccatgca gaacacgaga
     2761 atgacagtga cgatgatgag gatgcggaag atgatgatga aactgaagaa ctggggagtg
     2821 atgaagatga tattgatgaa gatggacaag aatatttgga gatcctggct aaacaagctg
     2881 gtgaggatgg agatgatgaa gattgggaag aagatgatgc tgaggagact gctctggaag
     2941 gctattccac aatcatcgat gatgaagaca accctgttga tgagtatcaa atctttaaag
     3001 ctatatttca aactattcaa aatcgcaatc ctgtatggta tcaggctttg actcacggtc
     3061 ttaatgaaga gcaaaggaaa cagttacagg acatagcaac tctagctgat caaagaagag
     3121 cagcccatga gtccaaaatg attgaaaagc atggaggata caaattcagt gcaccagttg
     3181 tgccaagttc tttcaatttt ggaggcccag caccggggat gaattgagtt tccactttct
     3241 ttcctgctgt gtgagtgtag tgaagagctt gtgttcctcc tagtagtggt tccagatccg
     3301 gttcatgtta actactaact gatcaataga aggacagaaa ccccaggagg tgggagctga
     3361 tcatgtaacc tggcactgga cgagaaacta gagggatttg gggaggggtt aacttggggg
     3421 gctattttct ttattttttg aagaaagtaa gatcctgact ctgaagcttc aagagacact
     3481 gtggaaatct gaaatgaggg gatgtcatga aggcagcttt tctttttctg aggaaaaaaa
     3541 taggcatggg ctacaggact atttaaaatg tctcatttac agtataaagt tcaaaggtag
     3601 atgtaatttt tacacctcta agtatttgtc ctatttctgt ctgttcctta ccattgggta
     3661 tcctttatat gtaaatatga taaggtaatc gatagcctta ttcggtcttt atcattttca
     3721 ttcaccagat tgttcctatg tagattggac atttattgta gcactacata actgatttta
     3781 aaatctgtaa atgaattagc actttcatat tgaaacaagc ctgctagcct atgtataaaa
     3841 gcaaaactgt ttgctgttta taaaaaggga tgtaatgggg tggggggcag gggtaatttc
     3901 aggtttaatt attaatttaa aaatgaacta gcaattttgt atctggtgac tttgtggtgc
     3961 actcacctct ggtagtgact tgaattcggt atgtaaaaag gggttagtga tgtttcattg
     4021 ctgctaaaaa tggcaactct ctctgtgtcc ttttttgttc ctaaagctct cagtgtacaa
     4081 gtggacattt ggatacaaga ccttatgtaa caaacagagg tgatatctga agcatgtaaa
     4141 ttggatataa aattctactc ttaaagagtt gatctagagt atggctaaac atctatatat
     4201 gcaatctatt aaaagaactt aattcggcaa ttatgtcttg atctgattgc aatttattcc
     4261 taattaatcc ttacccccat taacctgttt ttatcttgta ccagatagag tgcaaaatgt
     4321 atttataaga ttaatacctg cccattcccc tctcctcatt tctcctcccc tgtcttgatt
     4381 atggtatctt atcctaactc tgaagactga aggcacatgg ttccctctaa aaaccactat
     4441 tgataccact gcagaaataa gccagcaaca acagggcagc ggggtgggct tctcccctct
     4501 cttcctaaat gcatgttcaa agatgagacc ttattgatct taaacatctg tcagatgagt
     4561 catacattgg attatttttt atatacatgt atacacaata tttcaaattg aaagcaacat
     4621 ctcagtggat tcaaaactac tacatactgt tgtctaaaac aaaatttata attgtacaaa
     4681 tgaaatgcac atattgatat ttaaaatgca taattaagaa aa
//
