LOCUS       NM_001416271            4770 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus importin 5 (Ipo5), transcript variant 4, mRNA.
ACCESSION   NM_001416271 XM_030248018
VERSION     NM_001416271.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4770)
  AUTHORS   Li,M., Li,X., Chen,S., Zhang,T., Song,L., Pei,J., Sun,G. and Guo,L.
  TITLE     IPO5 Mediates EMT and Promotes Esophageal Cancer Development
            through the RAS-ERK Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 6570879 (2022)
   PUBMED   36120598
  REMARK    GeneRIF: IPO5 Mediates EMT and Promotes Esophageal Cancer
            Development through the RAS-ERK Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4770)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4770)
  AUTHORS   Miriyala,S., Thippakorn,C., Chaiswing,L., Xu,Y., Noel,T.,
            Tovmasyan,A., Batinic-Haberle,I., Vander Kooi,C.W., Chi,W.,
            Latif,A.A., Panchatcharam,M., Prachayasittikul,V.,
            Butterfield,D.A., Vore,M., Moscow,J. and St Clair,D.K.
  TITLE     Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial
            stress signaling
  JOURNAL   Free Radic Biol Med 91, 68-80 (2016)
   PUBMED   26689472
REFERENCE   4  (bases 1 to 4770)
  AUTHORS   Mihalas,B.P., Western,P.S., Loveland,K.L., McLaughlin,E.A. and
            Holt,J.E.
  TITLE     Changing expression and subcellular distribution of karyopherins
            during murine oogenesis
  JOURNAL   Reproduction 150 (6), 485-496 (2015)
   PUBMED   26399853
REFERENCE   5  (bases 1 to 4770)
  AUTHORS   Sutherland,J.M., Sobinoff,A.P., Fraser,B.A., Redgrove,K.A.,
            Davidson,T.L., Siddall,N.A., Koopman,P., Hime,G.R. and
            McLaughlin,E.A.
  TITLE     RNA binding protein Musashi-1 directly targets Msi2 and Erh during
            early testis germ cell development and interacts with IPO5 upon
            translocation to the nucleus
  JOURNAL   FASEB J 29 (7), 2759-2768 (2015)
   PUBMED   25782991
  REMARK    GeneRIF: nuclear import protein IPO5 facilitates the nuclear
            translocation of MSI1 to the transcriptionally silenced XY
            chromatin domain in meiotic pachytene spermatocytes, resulting in
            the release of MSI1 RNA-binding targets
REFERENCE   6  (bases 1 to 4770)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 4770)
  AUTHORS   Anway,M.D., Li,Y., Ravindranath,N., Dym,M. and Griswold,M.D.
  TITLE     Expression of testicular germ cell genes identified by differential
            display analysis
  JOURNAL   J Androl 24 (2), 173-184 (2003)
   PUBMED   12634303
REFERENCE   8  (bases 1 to 4770)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4770)
  AUTHORS   Plafker,S.M. and Macara,I.G.
  TITLE     Ribosomal protein L12 uses a distinct nuclear import pathway
            mediated by importin 11
  JOURNAL   Mol Cell Biol 22 (4), 1266-1275 (2002)
   PUBMED   11809816
REFERENCE   10 (bases 1 to 4770)
  AUTHORS   Muhlhausser,P., Muller,E.C., Otto,A. and Kutay,U.
  TITLE     Multiple pathways contribute to nuclear import of core histones
  JOURNAL   EMBO Rep 2 (8), 690-696 (2001)
   PUBMED   11493596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154283.1.
            
            On Jan 24, 2023 this sequence version replaced XM_030248018.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC052392.1, SRR17784648.209354.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384, SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC154283.1         73924-73976         c
            54-133              AC154283.1         73522-73601         c
            134-238             AC154283.1         62763-62867         c
            239-332             AC154283.1         59492-59585         c
            333-413             AC154283.1         53399-53479         c
            414-606             AC154283.1         50720-50912         c
            607-709             AC154283.1         48607-48709         c
            710-806             AC154283.1         47699-47795         c
            807-911             AC154283.1         47250-47354         c
            912-1034            AC154283.1         44512-44634         c
            1035-1155           AC154283.1         44302-44422         c
            1156-1243           AC154283.1         42290-42377         c
            1244-1350           AC154283.1         41428-41534         c
            1351-1475           AC154283.1         37867-37991         c
            1476-1565           AC154283.1         37695-37784         c
            1566-1739           AC154283.1         37432-37605         c
            1740-1958           AC154283.1         35588-35806         c
            1959-2042           AC154283.1         34330-34413         c
            2043-2175           AC154283.1         32138-32270         c
            2176-2297           AC154283.1         31938-32059         c
            2298-2394           AC154283.1         31279-31375         c
            2395-2567           AC154283.1         29841-30013         c
            2568-2679           AC154283.1         29092-29203         c
            2680-2735           AC154283.1         28950-29005         c
            2736-2858           AC154283.1         28064-28186         c
            2859-3078           AC154283.1         26936-27155         c
            3079-3307           AC154283.1         26274-26502         c
            3308-3449           AC154283.1         24617-24758         c
            3450-4770           AC154283.1         22796-24116         c
FEATURES             Location/Qualifiers
     source          1..4770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 64.81 cM"
     gene            1..4770
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="importin 5"
                     /db_xref="GeneID:70572"
                     /db_xref="MGI:MGI:1917822"
     exon            1..53
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            54..133
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            134..238
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            239..332
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..3536
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="isoform 1 is encoded by transcript variant 4;
                     karyopherin (importin) beta 3; RAN binding protein 5;
                     karyopherin beta-3; importin subunit beta-3; importin beta
                     3"
                     /codon_start=1
                     /product="importin-5 isoform 1"
                     /protein_id="NP_001403200.1"
                     /db_xref="GeneID:70572"
                     /db_xref="MGI:MGI:1917822"
                     /translation="MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGRSKITF
                     LLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQ
                     SSMRKKICDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNMGLREAALHIFWNFPG
                     IFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLL
                     PGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTNLNNMQR
                     QLALEVIVTLSETAAAMLRKHTSLIAQTIPQMLAMMVDLEEDEDWANADELEDDDFDS
                     NAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQ
                     MEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTM
                     EDQGNQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLV
                     LEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGL
                     AVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLP
                     VVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTAC
                     QMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPE
                     YLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILK
                     AKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEK
                     VLPWFEQLLPLIVNLICPQRPWPDRQWGLCIFDDIVEHCSPASFKYAEYFISPMLQYV
                     CDNSPEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENVNATENC
                     ISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDLIESNHPIVLGP
                     NNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQA
                     AIQELLNSA"
     exon            333..413
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..606
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            607..709
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            710..806
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            807..911
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1034
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1155
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1243
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1350
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1475
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1565
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1739
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1958
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2042
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2175
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2297
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2394
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2567
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2679
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2735
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2858
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3078
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3307
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3449
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..4770
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4125..4130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="hexamer: AATAAA"
     polyA_site      4147
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="major polyA site"
     regulatory      4709..4714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="hexamer: ATTAAA"
     polyA_site      4730
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
     regulatory      4747..4752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="hexamer: ATTAAA"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
                     /note="hexamer: AACAAA"
     polyA_site      4766
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
     polyA_site      4770
                     /gene="Ipo5"
                     /gene_synonym="1110011C18Rik; 5730478E03Rik; IMB3; imp5;
                     Kpnb3; Ranbp5"
ORIGIN      
        1 agtgccatcc tgtgactgac gcaagcatag ggctgagaac agccttgact actgtggttc
       61 cggggagaaa gcttaccagg gcccatgtgt gagcacagcc actcttcctg accaggacct
      121 ttgcaccacc caacaaggaa aggaaattcc gaagcaagga acaccggtca gaaagcgctg
      181 tgccatgtct ccaaatccct gagaatcaag tcaaaaactg ggagcgacag aaaacactcg
      241 caatggcggc ggccgcggcg gagcagcaac agttctacct gctcctggga aacctgctca
      301 gccccgacaa tgtggtccgg aaacaggcgg aggaaaccta tgagaatatc ccaggccggt
      361 ccaagatcac attcctctta caagccatca gaaacacaac cgctgccgag gaggctagac
      421 aaatggctgc tgttctccta agacgtcttt tgtcctctgc atttgatgaa gtctacccag
      481 ctcttccatc agatgtccag actgccatca agagtgaatt gctaatgatc attcagatgg
      541 aaacacaatc cagcatgagg aagaaaatct gtgatattgc tgcagaattg gccaggaatt
      601 taatagatga ggacggcaac aaccagtggc ctgaaggttt gaagttcctc tttgattcag
      661 tcagctcaca aaacatggga ctccgggaag ctgcccttca catattttgg aactttcctg
      721 gaatttttgg gaaccaacaa cagcactatt tggacgtcat caaacggatg ttagttcagt
      781 gtatgcaaga tcaggagcat ccttcgatca ggacactgtc tgccagagct actgctgcct
      841 tcatacttgc caatgagcat aatgtcgctc tgttcaaaca ctttgcagac ttgctgcctg
      901 gattcttaca ggctgtcaat gactcatgct accagaatga tgactcggtc ctaaaatccc
      961 ttgttgagat tgcagacacc gtaccaaagt acttgcgccc tcacttagaa gcaactctgc
     1021 agttgagtct gaagttgtgt ggagacacta acctcaataa tatgcagcgc cagcttgccc
     1081 ttgaagtgat tgtgacactg tcagagactg cagctgctat gttaagaaag cataccagtc
     1141 tcatcgcaca gacgattcct cagatgttgg caatgatggt tgacctagaa gaagatgagg
     1201 actgggcaaa tgctgatgag ctagaagatg atgatttcga tagcaatgca gttgctggtg
     1261 agagtgcatt agaccgaatg gcctgtggac ttggtggaaa gctcgttctg cccatgatta
     1321 aggaacacat tatgcaaatg cttcaaaacc ctgattggaa atacaggcat gcaggactga
     1381 tggccctatc cgccattggc gaaggatgcc accagcagat ggaaggaatt ctaaatgaga
     1441 ttgtaaattt tgtcttgctt ttcctccagg atcctcatcc gagagtccgg tatgcagcct
     1501 gcaatgctgt gggtcaaatg gctacagatt ttgcacctgg ttttcaaaag aaatttcatg
     1561 agaaggtgat tgcagctttg cttcagacca tggaagacca aggcaaccag cgggtgcagg
     1621 cccatgcagc ggctgccctc attaacttca ctgaagattg tcccaagtcg ctgcttattc
     1681 cctacttgga taacttggtg aagcacctgc actccattat ggtgctcaag ctccaggagc
     1741 tgattcagaa aggcaccaag ttagttttgg aacaagttgt gacatccatt gcatcagttg
     1801 cagatactgc agaagaaaag tttgtcccct actatgactt gtttatgcca tcactgaagc
     1861 acattgtcga gaacgcagtc cagaaggagc tgagactgct gcgagggaag accatcgagt
     1921 gcatcagcct catcgggctg gccgtcggga aggagaaatt catgcaggat gcttcagatg
     1981 tgatgcagct attgttgaag acacagacag acttcaatga tatggaagat gacgaccccc
     2041 agatttctta catgatctca gcatgggcca ggatgtgcaa aatccttggg aaagaattcc
     2101 agcagtacct tcccgtggtt atggggccgc tgatgaagac tgcttcaatt aagcctgaag
     2161 tggcccttct agacacccag gacatggaga atatgagtga tgatgacggt tgggaatttg
     2221 tgaacctcgg agatcagcaa agttttggta ttaaaactgc aggactggaa gaaaagtcaa
     2281 cggcttgtca gatgttggtt tgctatgcta aggaattaaa ggaaggtttt gtggaataca
     2341 ctgaacaggt tgtcaaactg atggtcccgc tgctgaaatt ttatttccac gatggggtcc
     2401 gagtggcagc agcagagtcc atgcctcttc tgcttgagtg tgcgagagtc cggggtcccg
     2461 agtaccttac acagatgtgg cacttcatgt gcgacgctct catcaaggcc atcggcacag
     2521 agcccgactc agatgtcctc tcggagatca tgcattcctt tgcaaagtgc attgaggtca
     2581 tgggagacgg gtgcctcaac aatgagcact ttgaggagct gggaggcatc ctgaaggcga
     2641 agcttgaaga acatttcaaa aatcaggagt tgcggcaagt taaaagacaa gatgaagact
     2701 atgacgagca ggttgaagag tcactacaag atgaggatga taatgatgtt tatatactga
     2761 ctaaagtgtc ggatatttta cactcaatat tcagtagcta caaagaaaag gtgttgccgt
     2821 ggtttgaaca gctgctccca ttaattgtca acctgatttg tccgcaaaga ccatggccag
     2881 acagacaatg gggattgtgc atcttcgatg atatcgtaga acactgtagt ccagcttcat
     2941 ttaagtatgc agaatatttc ataagtccaa tgctccagta tgtgtgtgac aacagcccag
     3001 aagtcaggca agctgcggca tatggcctcg gcgtcatggc gcagtttggt ggagataact
     3061 accgcccttt ctgtaccgat gcactcccgc tgcttgtaag agtcattcag gctccagagg
     3121 ctaagaccaa agaaaatgtc aacgccacgg agaactgcat ctcagcagtg ggaaagatca
     3181 tgaagttcaa gcccgactgt gtgaatgtgg aggaggtctt accacactgg ctgtcatggc
     3241 tgcccctaca cgaagataaa gaagaagctg tccagacctt cagttacctg tgcgacctga
     3301 ttgaaagtaa tcacccaatt gttcttggcc caaacaatac caatctaccg aaaatattca
     3361 gtataattgc agaaggagaa atgcatgagg ccattaaaca tgaagacccc tgtgccaaac
     3421 gcctggccaa tgtagttcgc caagtacaga cttctggagg attgtggact gaatgcatag
     3481 ctcaactcag tccggagcag caggcagcca tccaggagct cctgaactct gcctgaaggg
     3541 ccttaactac cacctgccag aagactaact ccaaataaac gtttaccctt ttgtttaggt
     3601 ttctttgttt tgtttttgag caagagagca gtagtgttgt gtgtaggccg ttcttctgga
     3661 gccgtgcaca ggaaaagtaa ccctgtgtgc agggtggact gccatggatc tcatcaaacc
     3721 cgcagaggag gtccctgtaa gcctgatggt agcactgcag agtatttttc tattgctgtg
     3781 tctgacccac aagaagggaa agaggaaacg attccttttt tctcatagac ctgcagaaac
     3841 gtaaggaacg cagctttcag atcagttcat ccacatagat gtgtgttaca cagactgggg
     3901 gacaacctag tgtttattct gtaaatggag tgagagtctg gggggatgga aagaagccaa
     3961 ccagctgctg acaagccaga agcaaagggc tgtcacttga tgtcacgctg gttctttgca
     4021 agaaggctca tgcagtgact cggtgtggag gctgtcccac tccctcccgg cccttgaatg
     4081 tgaagtgtcg ttggcatgtc tggcagtcgt ctcattcact cctcaataaa cagcattgaa
     4141 atacaaagag gcctgtgtag aacttcagta ctgtctgtcg ttgattcctt tcatgtttta
     4201 atagaagagt gatctgatat ttttttaagg tgatagttct ggctcagtgt tttacctcca
     4261 cgctctgcag tgcagccttg gaagtgtgtc tcctgtcttg gaaagcgcag ttataacaca
     4321 gctactctgt tcacaattgg tattctgaag gtttgcacat tcaaccggct tttttaaagc
     4381 ttagggttgt tctgtagatc caaacgtttt ggcttaggat ttccattgca gattgtaatt
     4441 gctttagaga cacacgcagc ttttgaattt ttttaatttt acaagtatta tggctaaact
     4501 tatttactga aaatttcagt aaaatgtgtg aaattttctt tatgtattaa cctcagagca
     4561 gtaactgatg agctgttgtt tcctttaagt aattttctaa gggatcttaa tagatttctg
     4621 ttgaaacctt ggtgttaacg ttttcatagt ttgtactaaa tttaactgtg atacaaaaat
     4681 gagttttatg cataaatcag aatttaaaat taaaaaattt tttctttaaa tgatttgcat
     4741 tacttcatta aaacaaaatt tggaatgaaa
//
