LOCUS       NM_024267               3846 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus importin 4 (Ipo4), transcript variant 1, mRNA.
ACCESSION   NM_024267
VERSION     NM_024267.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3846)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3846)
  AUTHORS   Young,J.C., Major,A.T., Miyamoto,Y., Loveland,K.L. and Jans,D.A.
  TITLE     Distinct effects of importin alpha2 and alpha4 on Oct3/4
            localization and expression in mouse embryonic stem cells
  JOURNAL   FASEB J 25 (11), 3958-3965 (2011)
   PUBMED   21840941
REFERENCE   3  (bases 1 to 3846)
  AUTHORS   Wang,J., Sarkar,T.R., Zhou,M., Sharan,S., Ritt,D.A., Veenstra,T.D.,
            Morrison,D.K., Huang,A.M. and Sterneck,E.
  TITLE     CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated
            nuclear import of FANCD2 by IPO4 augments cellular response to DNA
            damage
  JOURNAL   Proc Natl Acad Sci U S A 107 (37), 16131-16136 (2010)
   PUBMED   20805509
  REMARK    GeneRIF: report a function of IPO4 and nuclear import in the
            Fanconi anemia pathway of DNA repair
REFERENCE   4  (bases 1 to 3846)
  AUTHORS   Pradeepa,M.M., Manjunatha,S., Sathish,V., Agrawal,S. and Rao,M.R.
  TITLE     Involvement of importin-4 in the transport of transition protein 2
            into the spermatid nucleus
  JOURNAL   Mol Cell Biol 28 (13), 4331-4341 (2008)
   PUBMED   17682055
REFERENCE   5  (bases 1 to 3846)
  AUTHORS   Wesselkamper,S.C., McDowell,S.A., Medvedovic,M., Dalton,T.P.,
            Deshmukh,H.S., Sartor,M.A., Case,L.M., Henning,L.N., Borchers,M.T.,
            Tomlinson,C.R., Prows,D.R. and Leikauf,G.D.
  TITLE     The role of metallothionein in the pathogenesis of acute lung
            injury
  JOURNAL   Am J Respir Cell Mol Biol 34 (1), 73-82 (2006)
   PUBMED   16166738
  REMARK    GeneRIF: Metallothionein deficient mice have a marked decrease in
            Importin 4 transcripts during acute lung injury
REFERENCE   6  (bases 1 to 3846)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   7  (bases 1 to 3846)
  AUTHORS   Jakel,S., Mingot,J.M., Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Importins fulfil a dual function as nuclear import receptors and
            cytoplasmic chaperones for exposed basic domains
  JOURNAL   EMBO J 21 (3), 377-386 (2002)
   PUBMED   11823430
REFERENCE   8  (bases 1 to 3846)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030490.1 and AK147086.1.
            
            On Jan 26, 2018 this sequence version replaced NM_024267.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147086.1, AK030490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3497              AK030490.1         2-3498
            3498-3841           AK147086.1         3449-3792
            3842-3846           AK147086.1         3794-3798
FEATURES             Location/Qualifiers
     source          1..3846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..3846
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /note="importin 4"
                     /db_xref="GeneID:75751"
                     /db_xref="MGI:MGI:1923001"
     exon            1..155
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..3335
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     importin 4a; imp4; ran-binding protein 4"
                     /codon_start=1
                     /product="importin-4 isoform 1"
                     /protein_id="NP_077229.4"
                     /db_xref="CCDS:CCDS27121.1"
                     /db_xref="GeneID:75751"
                     /db_xref="MGI:MGI:1923001"
                     /translation="MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDL
                     LATATDSQIRQFAAVLTRRRLNNRWRRLAPEQRESLKSLVLTALQKETVHSVSVSLAQ
                     LSATIFRKEGLQGWPQFMNLLQHSTHSSHSPEKEVGLLLLSVVVSSQPEAFHAHQHEL
                     LQLLNETLSDVSFPGVLFYSLRTLTAIARYVRPDDVSLARMLVPKVVTALRTLIPLDE
                     VKACEALEALDEMLETELPIINPHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVK
                     VKSKALLKNRLVPPLLHALFPLMAAEPPMGQLDPEDQDSDDDDLEIGLMGETPKHFAV
                     QVVDMLALHLPPEKLCPHVMPMLEEALRSEDPYQRKAGFLVLAVLSDGAGDHIRQRLL
                     YPLLQIVCKGLDDPSQIVRNAALFALGQFSENLQPHISSYSEEVMPLLLSYLKSVPMG
                     NTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTKELAVSAIGAIA
                     TAAQDSLLPYFPTIMDLLREFLLTGHEDFHLVQIQSLETLGVLARALGESMKPLAEEC
                     CQLGLGLCIHIDDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTEGIVP
                     QYDGISSFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALG
                     EISMNTCVAFLPFMDATFDEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDP
                     SSSPVLQTSLARVMPAYMQAVKVERERPVVMAVLESLTGVLRTCGSLALQPPGRLSEL
                     CNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAIPVLAATAGGHAFAPFF
                     ATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAREADP
                     EVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMA
                     SPVGKTEPQVLATLLRALPLKEDMEEWLTIGHLFSFLHQNNPEQVVDVASELLRICSL
                     ILPDNRIPPDTKAALLLLLTFLAKQHTDSFHTALGSLPNDKAQELQAMMGLT"
     exon            156..242
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            243..322
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            323..364
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            365..494
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            495..674
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            675..740
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            741..842
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            843..926
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1091
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1145
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1255
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1364
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1494
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1608
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1722
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1843
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1955
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2074
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2152
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2210
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2319
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2513
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2561
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2687
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2896
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3029
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3134
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3204
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3846
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3472..3477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /note="hexamer: AATAAA"
     regulatory      3501..3506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /note="hexamer: AATAAA"
     polyA_site      3525
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /note="major polyA site"
     polyA_site      3535
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
     regulatory      3586..3591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
                     /note="hexamer: AATAAA"
     polyA_site      3618
                     /gene="Ipo4"
                     /gene_synonym="8430408O15Rik; Imp4a; RanBP4"
ORIGIN      
        1 gctgtcggag tctccacgtg ccgatcctcc ccctccccac ccggccctgt agcagcggcg
       61 gcgtcggcgg cggctcggca gctgccatgg agcctgcggg tttggaacag atcctgaagg
      121 agctgctgct gcccgacacg gagcgcatcc gccgggctac ggagcagctc cagaccatcc
      181 ttcgggaccc tgctgccttg cccgcactct tcgatctgct ggcaacagcg accgactctc
      241 agatccgcca gtttgcagcg gtcctgaccc gcagaaggct gaacaatcgc tggcgacgcc
      301 tggcacctga gcagagggag agcctcaagt ccctggtcct gacagcactg cagaaagaga
      361 cagtgcattc tgtgagtgtc agcttggccc agctctcagc caccattttt cgaaaggaag
      421 gcctacaagg atggcctcag ttcatgaacc ttcttcagca cagcactcat agttcccata
      481 gccccgagaa agaggtggga cttctgctgc tgagtgtggt ggtgtcttcc cagcccgagg
      541 cattccatgc ccaccagcac gagctgcttc agcttctgaa tgagacgctc agtgacgtca
      601 gctttcccgg agtgctcttc tactccctgc gcactctgac tgccatcgcc cgctatgtca
      661 ggccggatga tgtgtctctt gcacggatgt tggtgcccaa agtcgttacg gcactgagga
      721 ctctgatccc cttagatgag gtaaaggcct gtgaggccct ggaggccctg gatgaaatgc
      781 tggagacaga gttgcccatc atcaaccccc acctctctga ggtcctcacg ttttgcctgg
      841 aggtggctaa gaatgtggcc cttggcgaac cactccgcgt acgtgttctc tgctgcctca
      901 ctttcttggt caaagtcaaa agtaaggcct tactaaagaa ccgcctcgtg cctcccttgc
      961 tgcacgccct tttccccctc atggctgctg agccacccat gggccaactg gatcctgaag
     1021 atcaagattc ggatgacgat gacttggaga tcgggctgat gggggagact cccaagcact
     1081 ttgctgtaca ggttgtggac atgctggcac tacatcttcc ccctgagaag ctctgtcccc
     1141 atgtgatgcc catgctggaa gaagccttgc ggagcgagga cccataccag cgcaaagcag
     1201 gattcctggt gttggctgtg ctgtctgatg gtgcaggcga ccacatcagg cagagactgc
     1261 tgtacccact gctacagatt gtgtgcaagg gcctggatga cccctcacag attgttcgta
     1321 atgctgctct gttcgccctg ggccagtttt cagagaactt acagccccat atcagcagct
     1381 actctgagga ggtgatgccc cttctcctct cctacctgaa gtcagtgccg atgggaaaca
     1441 cacaccacct ggccaaggcc tgctatgctc tggagaattt tgtggagaac ctagggccca
     1501 aagtgcagcc ctaccttccg gagcttatgg aatgtatgct gcagccattg aagaacccca
     1561 gcaaagcccg gaccaaggag ctagctgtga gcgccatagg ggccattgcc acagcggccc
     1621 aggattccct gctgccctac ttccctacca tcatggatct tctccgggag ttcttgttga
     1681 caggccacga agactttcat cttgtgcaga tccagagcct ggagaccctg ggagtgctag
     1741 cacgagccct gggagagtcc atgaagcccc tggctgagga atgctgtcag cttgggctag
     1801 ggttatgcat ccatatagat gaccctgacg tgaggcgctg cacgtacagc ctgtttgcag
     1861 ccttatcagg gttaatggga gagggcttgg gaccctacct gcctcagatt accacgctca
     1921 tgctgctgtc gctgcgctcc actgagggca ttgtgccaca gtatgacggg atcagctcct
     1981 tcctgctgtt tgatgacgac agcgaagcag aagaggagga ggagctcatg gatgaagata
     2041 tggaagagga gggggatgac tctgagatct cggggtatag tgtggagaat gccttctttg
     2101 atgagaaaga agacacctgc accgccctgg gggagatctc catgaacacc tgtgtggctt
     2161 ttctcccatt catggatgcc accttcgatg aagtatacaa actgctggag tgccctcata
     2221 tgaatgtgcg gaagtcagct tacgaagcgc tgggacagtt ctgctgtgca ctgcataagg
     2281 cctctcagag aagctcctca gatcccagca gcagtcccgt tctgcagacc tccctggctc
     2341 gagtgatgcc agcttacatg caggccgtga aagtagaaag ggagcgccca gtggtgatgg
     2401 ccgtgctgga gtccctgaca ggggtgctgc gcacctgcgg cagccttgca ctgcagcctc
     2461 ctgggcggct cagtgagctc tgcaacgtgc tcaaggctgt gctgcagaaa aagacggcct
     2521 gtcaggacgc cgaggaggat gatgacgaag atgatgacca ggcagagtat gacgccatgt
     2581 tactagaaca tgctggagag gccattcccg tcctggcagc cacagctgga ggacacgcct
     2641 tcgctccctt ctttgccacg ttcttgccat tgttgctgtg taagacgaaa cagagctgta
     2701 cagtggcaga gaagtccttt gctgtgggaa ccctggcaga gtccattcag ggtctaggga
     2761 ccgcctcagc ccagtttgtg tctcggctgt tccctgtgct gttaaacaat gcccgggaag
     2821 cagaccctga ggtgcggagc aatgccatct ttgggttggg cgtactggca gagcatggcg
     2881 gctgccctgc tcaggaccac ttccctaagc tactgggcct ccttttgccc ctgctggcaa
     2941 gggagcgaca tgatcgagtc cgtgataaca tctgcggggc tcttgcccgt gtactgatgg
     3001 ccagtccagt aggaaaaacg gagccccagg tgctggctac cctgctacgt gccctgcccc
     3061 tgaaggaaga catggaggag tggctcacta taggtcacct cttcagcttc ctgcaccaga
     3121 acaatcctga gcaggttgtg gatgtggctt cagaactcct gcgcatctgc agcctgatcc
     3181 tgccggacaa ccggatccct ccagacacca aggcggccct gctgctgctc ctgacgttcc
     3241 tggccaagca gcacaccgac agcttccaca cagccctggg ctctctgcca aatgataaag
     3301 ctcaggaact tcaggccatg atgggcctca cttaagacta taggccacag gggccagggg
     3361 tccgaagacc gaggtcagcc ctggtccagt tcaccttacc aaagactcta tccattgaag
     3421 tcaactgtgc tgttttaaca ggggtgtctc tggggctgga catcatacta taataaagca
     3481 gagctgtgac atcatactat aataaagcag agctgtgaca tcatactata aggaagcagc
     3541 tgtgacgtca tactataaga aagcagagct gtgacgtcat actataataa aggtggcctg
     3601 tcttctgctt ggacactagc tttctgcaca aaggctagag gtatgtgttc agagctgaga
     3661 ctgggaaggg aggggctgcg ctgaggacat actgtccctg cagaagtcag aatgcggtcc
     3721 acccccactg gacggctcag acagccttga gctccagagg tttaattccc tcattccctt
     3781 gcacatctgg ctggcacaca cacataattt aaaattaaaa ataaatcttg aaaaaaaaaa
     3841 agaggc
//
