LOCUS       NM_146152               3588 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus importin 13 (Ipo13), transcript variant 1, mRNA.
ACCESSION   NM_146152
VERSION     NM_146152.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Gajewska,K.A., Haynes,J.M. and Jans,D.A.
  TITLE     Nuclear Transporter IPO13 Is Central to Efficient Neuronal
            Differentiation
  JOURNAL   Cells 11 (12), 1904 (2022)
   PUBMED   35741036
  REMARK    GeneRIF: Nuclear Transporter IPO13 Is Central to Efficient Neuronal
            Differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Gajewska,K.A., Lescesen,H., Ramialison,M., Wagstaff,K.M. and
            Jans,D.A.
  TITLE     Nuclear transporter Importin-13 plays a key role in the oxidative
            stress transcriptional response
  JOURNAL   Nat Commun 12 (1), 5904 (2021)
   PUBMED   34625540
  REMARK    GeneRIF: Nuclear transporter Importin-13 plays a key role in the
            oxidative stress transcriptional response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Fatima,S., Wagstaff,K.M., Lim,S.M., Polo,J.M., Young,J.C. and
            Jans,D.A.
  TITLE     The nuclear transporter importin 13 is critical for cell survival
            during embryonic stem cell differentiation
  JOURNAL   Biochem Biophys Res Commun 534, 141-148 (2021)
   PUBMED   33333437
  REMARK    GeneRIF: The nuclear transporter importin 13 is critical for cell
            survival during embryonic stem cell differentiation.
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Zohud,B.A., Guo,P., Zohud,B.A., Li,F., Hao,J.J., Shan,X., Yu,W.,
            Guo,W., Qin,Y. and Cai,X.
  TITLE     Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear
            translocation and hTERT expression upregulation
  JOURNAL   Cell Death Dis 11 (10), 879 (2020)
   PUBMED   33082305
  REMARK    GeneRIF: Importin 13 promotes NSCLC progression by mediating RFPL3
            nuclear translocation and hTERT expression upregulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Fatima,S., Wagstaff,K.M., Lieu,K.G., Davies,R.G., Tanaka,S.S.,
            Yamaguchi,Y.L., Loveland,K.L., Tam,P.P. and Jans,D.A.
  TITLE     Interactome of the inhibitory isoform of the nuclear transporter
            Importin 13
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (3), 546-561 (2017)
   PUBMED   27993670
  REMARK    GeneRIF: Interactome of the inhibitory isoform of the nuclear
            transporter Importin 13 has been reported.
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Lin,W., Ye,W., Cai,L., Meng,X., Ke,G., Huang,C., Peng,Z., Yu,Y.,
            Golden,J.A., Tartakoff,A.M. and Tao,T.
  TITLE     The roles of multiple importins for nuclear import of murine
            aristaless-related homeobox protein
  JOURNAL   J Biol Chem 284 (30), 20428-20439 (2009)
   PUBMED   19494118
REFERENCE   7  (bases 1 to 3588)
  AUTHORS   Cui,C.Y., Kunisada,M., Esibizione,D., Grivennikov,S.I., Piao,Y.,
            Nedospasov,S.A. and Schlessinger,D.
  TITLE     Lymphotoxin-beta regulates periderm differentiation during
            embryonic skin development
  JOURNAL   Hum Mol Genet 16 (21), 2583-2590 (2007)
   PUBMED   17673451
REFERENCE   8  (bases 1 to 3588)
  AUTHORS   Yamaguchi,Y.L., Tanaka,S.S., Yasuda,K., Matsui,Y. and Tam,P.P.
  TITLE     Stage-specific Importin13 activity influences meiosis of germ cells
            in the mouse
  JOURNAL   Dev Biol 297 (2), 350-360 (2006)
   PUBMED   16908015
  REMARK    GeneRIF: IPO13 has a stage-specific role in nuclear-cytoplasmic
            translocation of cargoes that accompanies meiotic differentiation
            of the mouse germ cells
REFERENCE   9  (bases 1 to 3588)
  AUTHORS   Kahle,J., Baake,M., Doenecke,D. and Albig,W.
  TITLE     Subunits of the heterotrimeric transcription factor NF-Y are
            imported into the nucleus by distinct pathways involving importin
            beta and importin 13
  JOURNAL   Mol Cell Biol 25 (13), 5339-5354 (2005)
   PUBMED   15964792
REFERENCE   10 (bases 1 to 3588)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052257.1.
            
            On Apr 5, 2007 this sequence version replaced NM_146152.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052257.1, AK149978.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3588              AK052257.1         2-3589
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.76 cM"
     gene            1..3588
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /note="importin 13"
                     /db_xref="GeneID:230673"
                     /db_xref="MGI:MGI:2385205"
     exon            1..712
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..3520
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="importin-13 isoform 1"
                     /protein_id="NP_666264.1"
                     /db_xref="CCDS:CCDS18542.1"
                     /db_xref="GeneID:230673"
                     /db_xref="MGI:MGI:2385205"
                     /translation="MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIDNKNL
                     AQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLK
                     AQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQ
                     GRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGTVFPLLEQLLQQPSSPSCV
                     RQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYV
                     NTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFL
                     ALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQ
                     LVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKL
                     GRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADT
                     VMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYA
                     ANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKL
                     AEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGPELRKLPVPQGPNPVVVVLQ
                     QVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQ
                     ASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDHPDIVDSFMQLLA
                     QALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGK
                     VVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFP
                     SARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY"
     exon            713..1449
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1590
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1732
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1899
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2020
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2168
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2350
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2377
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2512
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2656
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2737
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2875
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2972
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3025
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3092
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3151
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3241
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3423
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3588
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Kap13; Ranbp13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcactggg gcggaggcag cgaccgtagc ggggccaacg ccgggaggcg aacagatcgc
       61 gggccaggcg aacggagggg acctatctca gtcccccaac tctaccgact ctgccccaga
      121 ctcacgaaac tgcaatcccg tgcttccttg gacgtctccg tatctcgcga agggctctct
      181 cccgggtgat ctcccagccc ccctgacctc atagcatcta gaagctcgtc cagactgggg
      241 tgttatgggt acaggccgtt gattctgtga cccctcacgg gccagggcct ctgtttcccc
      301 tataggcctc cctcccctat gacttttgat tcaagggaca gagctgtgac ctcccactag
      361 gacccttgtc tgggagtacc tcacggacgc ctcccttctg ggagccgcct tagcgggtcc
      421 ctttccgaag agcacatctt ttgacctctg caacccactc cccctccaaa cgaggtgggc
      481 aggcctcggc agccatgccc gccctgggca tcccctcatc ccaccacctc ccgggtactc
      541 aagccggggt ctagcagggg gccgacagcc aaagggctgg ggcaagaaag agatcagggt
      601 ccacctccct gccaggcagg gagcaaagat ggagcggcgg gaggagcagc tgggggctgc
      661 aggggctgga gcagcaccag ccttggactt cactgtggag aacgtggaga aggcgctgca
      721 ccagctctac tacgacccca atattgacaa caagaacctg gctcagaagt ggctgatgca
      781 ggcccaggtc tctccacagg cctggcactt cagctggcag ctactacagc cagacaaggt
      841 gcccgagatc cagtactttg gggccagtgc cctgcacatc aagatctctc gctactggag
      901 cgacatcccc accgaccagt atgaaagctt aaaggcacag ctcttcaccc agatcacccg
      961 ctttgccagc ggctccaaaa ttgtgctgac tcggctgtgc gtggcgctgg cctcactagc
     1021 tctcagcatg atgcctgacg cttggccatg tgctgtggca gatatggttc ggctcttcca
     1081 ggctgaggac tcgccggtgg atagccaggg ccgttgcctg gccctgctag agttgctgac
     1141 agtactgccc gaggagtttc agaccagccg cttgccccag taccgcaaag gtctggtgcg
     1201 gaccagcctg gctgtggagt gtgggactgt cttcccattg ctggagcaac tgctacaaca
     1261 gcccagctct cctagctgtg tgcgtcagaa ggtgctcaag tgcttctcca gttgggtgca
     1321 gctggaggta cccctgcagg actgtgaggc gctcattcag gctgccttcg ccgctctgca
     1381 ggactcagag ctctttgaca gcagcgtgga ggccattgtc aatgccatct cccaacctga
     1441 tgcccaaagg tacgtgaaca cactcctgaa actcattcct ctggtgctgg gactgcagga
     1501 acaactgcgg caggcagtgc agaatgggga catggagacc tcccatggca tctgccgtat
     1561 tgctgtggcc ctgggcgaga accactctcg ggccttgcta gaccaagtag agcactggca
     1621 gagcttcctg gcactcgtca acatgatcat gttctgcact ggcatccctg gccactatcc
     1681 tgtcaacgag accaccagct ccctcactct cactttctgg tacacactgc aggatgacat
     1741 tctgtccttt gaggcagaga agcaggctgt gtaccagcag gtgtaccggc cagtctactt
     1801 ccagctggtg gacgtgcttc tgcacaaggc ccagttccct tctgacgagg agtatggatt
     1861 ctggtcctca gacgaaaagg agcagttccg tatctacagg gtggacatct cagacacact
     1921 catgtatgtc tatgagatgc tgggggctga gctgcttagc aacctctatg acaagctggg
     1981 ccgtttgctc accagctcag aggagcccta ctcctggcag cacacagaag ccctgctcta
     2041 tggcttccag tccattgcag agaccatcga tgtcaactac tctgatgtgg taccagggct
     2101 cattggcctc atcccacgga tcagcatcag caacgtgcag ttggcggata ctgtcatgtt
     2161 caccattgga gctctgtctg aatggctggc tgaccacccc gtcatgatca acagcgttct
     2221 gccccttgtg ctgcatgccc taggcaatcc tgagctgtct gtgtcatctg tgtcgaccct
     2281 caaaaagatc tgccgagagt gcaagtatga cctgccgccc tatgctgcca acattgtagc
     2341 tgtctcccag gatgtgctga tgaagcagat tcacaagaca agccagtgca tgtggctgat
     2401 gcaggccctg ggcttcctgc tgtcagccct gcaggtggag gagatcctga agaacctgca
     2461 ctccctcatc tctccctaca tccaacagct ggagaagctg gcagaagaga tacctaatcc
     2521 ctctaacaag ctggccattg tccacatctt ggggcttctt tccaacctct ttaccacact
     2581 ggacgtcagt catcatgagg atgatcatga aggccctgaa ctccggaagt tgccagtgcc
     2641 acaaggaccc aacccggtgg tggttgtgct gcagcaggtc ttccagctca tccagaaggt
     2701 gctgagcaag tggctgaatg acgcccaggt ggttgaggcg gtatgcgcca tctttgagaa
     2761 gtctgttaag acactgctgg atgactttgc ccccatggtg ccgcagctct gtgagatgct
     2821 gggtcggatg tacagtactg ttccccaggc ctctgctctt gacctcaccc ggcagctggt
     2881 ccacatcttt gcccacgagc ctgcccactt tcccccaata gaggccctct tcctgctggt
     2941 gacttccgtc acactcagtc tcttccagca agggcccagg gatcatcctg atattgttga
     3001 ttcatttatg caactcctgg cacaggcttt gaagcggaag ccagatttgt tcctgtgtga
     3061 gcgactggat gtcaaagctg tgttccagtg tgccgtgctg gccctcaagt tccctgaggc
     3121 acctactgtc aaggcctcct gtggcttctt tactgagctg ctgcctcgat gtggggaaat
     3181 agagtctgtg gggaaagtgg tacaggaaga tggccgtatg ctgctcatag cagtgctgga
     3241 ggccatcggg ggccaggcct cccgtagcct catggactgt tttgccgaca tcctgttcgc
     3301 cctgaacaaa cactgcttca gcctcctgag catgtggatc aaggaggctc tgcagccacc
     3361 tggttttcca tctgcccgtc tcagccctga gcagaaggac acctttagcc agcagatact
     3421 tcgtgagcga gtaaacaaga gacgggtgaa ggagatggtg aaggaattta cactgctctg
     3481 ccgggggcta catggcacgg actacacagc tgactactga gggacatgtg tgtcccgcct
     3541 caccccttct taccccttcc tgttcccaaa gagtaaacct ggactctt
//
