LOCUS       NM_027184               5447 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus inositol polyphosphate multikinase (Ipmk), transcript
            variant 1, mRNA.
ACCESSION   NM_027184 XM_125641
VERSION     NM_027184.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5447)
  AUTHORS   Hong,S., Kim,K., Shim,Y.R., Park,J., Choi,S.E., Min,H., Lee,S.,
            Song,J.J., Kang,S.J., Jeong,W.I., Seong,R.H. and Kim,S.
  TITLE     A non-catalytic role of IPMK is required for PLCgamma1 activation
            in T cell receptor signaling by stabilizing the PLCgamma1-Sam68
            complex
  JOURNAL   Cell Commun Signal 22 (1), 526 (2024)
   PUBMED   39478550
  REMARK    GeneRIF: A non-catalytic role of IPMK is required for PLCgamma1
            activation in T cell receptor signaling by stabilizing the
            PLCgamma1-Sam68 complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5447)
  AUTHORS   Jung,I.R., Ahima,R.S. and Kim,S.F.
  TITLE     Time-Restricted Feeding Ameliorates Methionine-Choline Deficient
            Diet-Induced Steatohepatitis in Mice
  JOURNAL   Int J Mol Sci 25 (3), 1390 (2024)
   PUBMED   38338668
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5447)
  AUTHORS   Jung,I.R., Ahima,R.S. and Kim,S.F.
  TITLE     Inositol polyphosphate multikinase modulates free fatty
            acids-induced insulin resistance in primary mouse hepatocytes
  JOURNAL   J Cell Biochem 124 (11), 1695-1704 (2023)
   PUBMED   37795573
  REMARK    GeneRIF: Inositol polyphosphate multikinase modulates free fatty
            acids-induced insulin resistance in primary mouse hepatocytes.
REFERENCE   4  (bases 1 to 5447)
  AUTHORS   Reilly,L., Semenza,E.R., Koshkaryan,G., Mishra,S., Chatterjee,S.,
            Abramson,E., Mishra,P., Sei,Y., Wank,S.A., Donowitz,M., Snyder,S.H.
            and Guha,P.
  TITLE     Loss of PI3k activity of inositol polyphosphate multikinase impairs
            PDK1-mediated AKT activation, cell migration, and intestinal
            homeostasis
  JOURNAL   iScience 26 (5), 106623 (2023)
   PUBMED   37216099
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5447)
  AUTHORS   Lee,H., Kim,E. and Kim,S.
  TITLE     miRNA-Induced Downregulation of IPMK in Macrophages Mediates
            Lipopolysaccharide-Triggered TLR4 Signaling
  JOURNAL   Biomolecules 13 (2), 332 (2023)
   PUBMED   36830701
  REMARK    GeneRIF: miRNA-Induced Downregulation of IPMK in Macrophages
            Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5447)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 5447)
  AUTHORS   Frederick,J.P., Mattiske,D., Wofford,J.A., Megosh,L.C., Drake,L.Y.,
            Chiou,S.T., Hogan,B.L. and York,J.D.
  TITLE     An essential role for an inositol polyphosphate multikinase, Ipk2,
            in mouse embryogenesis and second messenger production
  JOURNAL   Proc Natl Acad Sci U S A 102 (24), 8454-8459 (2005)
   PUBMED   15939867
  REMARK    GeneRIF: Inositol polyphosphate multikinase (Ipk2) plays a major
            role in the synthesis of inositol polyphosphate messengers derived
            from inositol 1,4,5-trisphosphate in embryogenesis and normal
            development.
REFERENCE   8  (bases 1 to 5447)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 5447)
  AUTHORS   Chang,S.C., Miller,A.L., Feng,Y., Wente,S.R. and Majerus,P.W.
  TITLE     The human homolog of the rat inositol phosphate multikinase is an
            inositol 1,3,4,6-tetrakisphosphate 5-kinase
  JOURNAL   J Biol Chem 277 (46), 43836-43843 (2002)
   PUBMED   12223481
REFERENCE   10 (bases 1 to 5447)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156270.5.
            
            On Jul 30, 2020 this sequence version replaced NM_027184.2.
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052463.1, AK036084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC156270.5         105577-105904       c
            329-414             AC156270.5         90132-90217         c
            415-511             AC156270.5         87562-87658         c
            512-684             AC156270.5         80787-80959         c
            685-766             AC156270.5         76881-76962         c
            767-5447            AC156270.5         67782-72462         c
FEATURES             Location/Qualifiers
     source          1..5447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.89 cM"
     gene            1..5447
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /note="inositol polyphosphate multikinase"
                     /db_xref="GeneID:69718"
                     /db_xref="MGI:MGI:1916968"
     exon            1..328
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1380
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /EC_number="2.7.1.153"
                     /EC_number="2.7.1.151"
                     /EC_number="2.7.1.140"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inositol 1,3,4,6-tetrakisphosphate 5-kinase"
                     /codon_start=1
                     /product="inositol polyphosphate multikinase isoform 1"
                     /protein_id="NP_081460.1"
                     /db_xref="CCDS:CCDS23918.1"
                     /db_xref="GeneID:69718"
                     /db_xref="MGI:MGI:1916968"
                     /translation="MAAEPPALRLRPPGSTGDSPPVPRLLGGCVPLSHQVAGHMYGKD
                     KVGILQHPDGTVLKQLQPPPRGPRELEFYTMVYAADCADAVLLELRKHLPKYYGVWSP
                     PTAPNDVYLKLEDVTHKFNKPCIMDVKIGRKSYDPFASSEKIQQQVSKYPLMEEIGFL
                     VLGMRVYHLHSDSYETQNQHYGRGLTKETLKEGVSKFFHNGFCLRKDAIAASIQKVEK
                     ILQWFENQKQLNFYASSLLFVYEGSSQPATTKANDRTLAGRFLSKGPLTDADGLECNN
                     NFHLFGAPPNGMSVGKSLSKAYSRHRKLYAKKHQSQTSLKVETLEQDNGWRSMSQEHL
                     NGNVLAQLEKVFYHLPAGRPEIPEAEVRMIDFAHVFPSNTVDEGYVYGLKHLIAVLRS
                     ILDS"
     exon            329..414
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /inference="alignment:Splign:2.1.0"
     exon            415..511
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /inference="alignment:Splign:2.1.0"
     exon            512..684
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /inference="alignment:Splign:2.1.0"
     exon            685..766
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /inference="alignment:Splign:2.1.0"
     exon            767..5447
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3690..3695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /note="hexamer: AATAAA"
     polyA_site      3717
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
     regulatory      5426..5431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /note="hexamer: ATTAAA"
     polyA_site      5447
                     /gene="Ipmk"
                     /gene_synonym="2410017C19Rik; Impk"
                     /note="major polyA site"
ORIGIN      
        1 ggccggagcg cacagggggc gggcagaggc ggggccgcgg cgcccttatc ccgggcgcgg
       61 gcggccgggg ttcagagtgc gggccgcgga gcgggcagcg cggtctcggc atgggtccgc
      121 gcgctgggcc tgcgcgggcg atgccgcccc ggtcctccct gacgcctgac gccgagtgtc
      181 gccgccccga tggccgccga gcccccagcg ctgcgcctgc ggccgccggg aagcaccgga
      241 gacagcccgc cggtgccgcg cctgctcgga ggctgcgtgc cgctgtcgca tcaggtggct
      301 ggccacatgt acggcaagga caaagtgggc atactccagc acccagatgg tacagttctg
      361 aaacagctac agccaccgcc acggggccca agagagctgg aattttatac catggtttac
      421 gctgctgact gtgccgatgc tgttctcctg gagctgcgaa aacacctgcc caaatactac
      481 ggcgtctggt cccctcccac cgcaccaaac gatgtgtacc taaaactgga agatgtgact
      541 cataagttta acaaaccctg tataatggac gtgaagattg ggcggaagag ctacgacccc
      601 tttgcgtcat cagagaagat tcagcagcag gtcagcaagt accctctgat ggaggagatc
      661 gggttcctgg tgctcggcat gagggtttat catcttcact ctgacagcta cgagacacaa
      721 aaccagcact atggaagagg cctaacgaaa gagaccctga aggaaggcgt ctccaagttt
      781 ttccacaatg gcttctgttt aagaaaagat gcgattgccg ccagtattca gaaggtagag
      841 aagattctcc agtggtttga aaatcagaag cagcttaact tttacgcaag ttctttactg
      901 tttgtttatg aaggttcatc tcagccagct actacaaaag caaacgatag aactttggcg
      961 gggaggtttc tctccaaagg acccctgacg gatgcggacg gcctggagtg caataacaac
     1021 ttccacctgt tcggcgcccc gcccaacggg atgtcggtgg gcaagagctt atcgaaggcg
     1081 tactcgaggc acagaaagct gtatgcaaaa aagcaccaga gtcagacttc cctgaaagtc
     1141 gaaacgctgg agcaagacaa cgggtggaga agcatgtccc aggaacactt aaacggaaac
     1201 gtgcttgccc aactggaaaa ggtgttctac caccttcccg cgggtcgtcc ggagatcccg
     1261 gaagcggaag tacggatgat agactttgct cacgtgttcc ctagcaacac agtcgatgag
     1321 gggtatgttt acggtctgaa gcatctaatt gccgtgcttc ggagtatttt agacagttga
     1381 gtcttgctgc agtctgtgaa ggagcgggcc aatcaccatg gagagctgca ggcgttagcc
     1441 gagcacctgt actgctctgt aaaaaatttg tattgtgagt cagcgtttta tttgtcttta
     1501 tacttttggt agatggttaa cttttttata ttcttactca ggaatactaa tttgttcatt
     1561 agaaaactat gaagaataaa gaaaaaggaa tgtcgagcag ggagtgtgtg gaacacggag
     1621 caaacagctg taacactcgc aaatcattac gcagtcattt agaggtcaca tagctttctg
     1681 tagccagtca ccatgaaatc tgtccaccca accttgccag tgagccgacc ctaaactatg
     1741 actttatcag accatcctaa gatctagaaa ggtccctaaa actggagaag attttacacg
     1801 gaaacgaggc tctgtgggtt ctatattaaa ggcagagtgc agcgcagcga atgaaagaaa
     1861 ggtgcttaag ccagcagggc tccctcccgg tcctgtctgc tctgtgctga gcatcatggg
     1921 aaggggagtg tcaggtggcc ggcagcagct aacagcacaa attttcctcc ctagggtcaa
     1981 gagaagagag atatttgtaa agaacatatt acccttttct ttcttttgtt ttaaagaatt
     2041 tcatttatgg aaaagtcttc atttactatg ttgtgaaagc tgtcataaaa caccctcttt
     2101 ttattaccag tgaggctccc gagaggtgaa tggtggaaac tttgttttat ctcttcttta
     2161 atttttgaga gtcttccatt ttagaaaatc cattctttaa aatgtatccc cattgacttt
     2221 ttaagcctta gcataaacat tatctctcag aatttggtta agcatccaca gaacgctgtg
     2281 cccagtgcac tggaggaacc ctgcttaggt ctcacaacag aacgctgtgc ccagtgcact
     2341 ggaggaaccc tgcttaggtc tcacaacaga acgttgtgcc cagtgcactg gaggaaccct
     2401 gcttaggtct cactcccgtg gtgtctaaca gagaggtcct agttaatttc actcggagca
     2461 acaggcaggc aacttttcct tgaaaaaaaa gatatttata agtgtcatgt ttattttacc
     2521 actaccacct ttttcaaagc tgtcgttaaa gtgttttcaa aactgaaatt aaatttgcaa
     2581 atctttttgc tgtgcttgct tgccctttga cccgctgatg tgataaaata actgaacagc
     2641 ttgtcctttt tagacaagct ttgagtcacg acctgacctt tttttccttt tcacctcttt
     2701 tttccttgag gtttacaaat caaactgcaa aatccaagaa ccattttctg taatgtggag
     2761 gaacttttac agtccaaatg tagtttgcaa atgcccacgc tcaaatgtga gccggaaagg
     2821 aatgggtcat taaccagagt gggtctggtt aacgtgcctt ttaggggttt tctctgggag
     2881 gctgcaggtg ttctcagacc tgcaagaacg acacattctc tgcccaggtg tggactggct
     2941 atacctattt ttgtttctct cattttgtgg gagtgaattt taagtgataa ttattagaaa
     3001 actttcagtt tgactgtttt tcttacaata ttgacttgtt atctgggtgt gattcaggaa
     3061 ctctcaagcc catctgctga acactatttt ggctcttaag aggcagtttg agatggtatc
     3121 agcctatata tgaggaattg ggaaacttga gtattcgaag ctttgggcac acttcagctt
     3181 agtaaagtct ctgatctaca gctgtttcaa acatttcgga agccagcatc ctgccttttc
     3241 gacaagtagg ttttgtctga ataaaacagg aagtgattct tccccctgct tctcagggaa
     3301 ggggtgagca tccagttctt ctcgtttaca gtttcccaac tgctggccac tttgtgttac
     3361 tttgtgctcc ttgatgccat gatcaacatg ttcgtgatgt aagcaacctg tggtgggtgt
     3421 ttcccggtct gtcctgtctt taaaaatgat gctgagattt gccactttgg ggaagaggca
     3481 tctgtcacta accatgcata tgtgaacaca cggatattta agaaatgagc aaatgaggag
     3541 gtggtttgaa ctggtggtga tgctagccgc cccctcttag cccccccaac atgatttgag
     3601 tgtgttcctt atgggatgca ctcatggaaa ggacttgtgg gtgtgaatac atttctcaaa
     3661 taaaagttta aattgtaaaa tagttttata ataaagtatt tacattaatt attttaatat
     3721 ggatggaagt tgcataaatt ataattgtga actatttagt ctttcaagag agttttgaaa
     3781 aatgtatgta agtggctctg atggctgtgg tgttaaatta gtatgcgatg ctttgttctg
     3841 tgtgtttgga gggggctggg cactctacct gtccacacta cagacagaca gttactgcgg
     3901 gccgagtgag aaccgattcc tgaatgcctg ccggcgtcct gtgatgcagt tgcccgagat
     3961 ctccacagtg ttgccctcgc tgtcaggcct ctgaactgtc gaatttataa catttggggg
     4021 gaaatgaatt tctataatta cctctgttgc aatcttttta ttgctgttag gatttggaat
     4081 gtgtaggcag gaggaagggc tgaactggga actgactggc tctgactgtt aataccactc
     4141 cccttgaggt ctgatgtcca gacgtgcttg gttgaaccag ccgtttacac agctgtcctt
     4201 ctcttgcaga ccctcaaccg accgtggctt ttgtgtatcc atagcttccg ttgccctttg
     4261 tcttgccccc tacaatggtt cagttaccca gaaacatcaa gtccctttta agaatagtcc
     4321 atttggttac tctcagggta gtgtctgggg gccttggcct ctcagttcac tcagactcaa
     4381 gtctgcacct caccaagtat tttcaacccc tctccctgac gtgtgcgttg gtgaagcagt
     4441 caggactgat cgtctccagc accctgtcta ggtggagagg ctcacgagga cgactttaaa
     4501 acagagacac accaacacct gtatttcaag ctgttaaagc tagtgtttgg gtaaagatga
     4561 agtgctaagt attgagctac aacagaggca gatgattggg ggctgagatc aagggaaccg
     4621 ctgactctcc agctggggca gttacagaca gcctaaaaca gcctgaaaaa gagcgctctt
     4681 aagacatgct tgtaaaggta cattcagccg tcgcctttgg aataataaat agcacagtgt
     4741 gactatggtt gctcctcgct ggtgcaaacc ttttaaatct caagttttca gattgctggg
     4801 atttcagact tgtcagcgga catgaaggta tttcttgact tcagagcaac tctgttgtta
     4861 taacatccaa tactgatatc tggagacaga ttcagcctct tggctgtcga tagtgtgtct
     4921 tcccacttgc ttcgatagct tctatcaaaa accaccatga ttcgtgccag taaatcagac
     4981 agtcaaatta aaaaaaaaca aaaacaaaac caaaaacagt agaaacgtgt ggtgtggtga
     5041 aactttggcc tggtgtccac ttaaaagatt aaaaggttag ttattgaaga tagggtttct
     5101 ggtcccctgt agcgaaaggc acacatagac acttggctgt gggatctgtg gtggaagatg
     5161 ggaaatcaca cccagttgtg tccttagtaa catccaggca gcagtgccag tccccgcccc
     5221 ctgttacttg atgaatgaat gtatccctgt actttggtgg aaatgtctct agctttcttt
     5281 ttctcagtgt ttgtaatttg tactattgat gggatagtct tggagtgcaa ggctcatcac
     5341 tgtgtttgta gaatcatcta atgtgatata ccaattttta taagcgatat ttagataact
     5401 ctaataactg tacattcaac aacttattaa aatgttttgc attggaa
//
