LOCUS       NM_173027               2305 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus inositol hexaphosphate kinase 3 (Ip6k3), mRNA.
ACCESSION   NM_173027
VERSION     NM_173027.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2305)
  AUTHORS   Li,H., Datunashvili,M., Reyes,R.C. and Voglmaier,S.M.
  TITLE     Inositol hexakisphosphate kinases differentially regulate
            trafficking of vesicular glutamate transporters 1 and 2
  JOURNAL   Front Cell Neurosci 16, 926794 (2022)
   PUBMED   35936490
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2305)
  AUTHORS   Rojas,T., Cheng,W., Gao,Z., Liu,X., Wang,Y., Malla,A.P., Chin,A.C.,
            Romer,L.H., Snyder,S.H. and Fu,C.
  TITLE     Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover
            via interactions with dynein intermediate chain 2
  JOURNAL   Proc Natl Acad Sci U S A 116 (8), 3278-3287 (2019)
   PUBMED   30718399
REFERENCE   3  (bases 1 to 2305)
  AUTHORS   Moritoh,Y., Oka,M., Yasuhara,Y., Hozumi,H., Iwachidow,K., Fuse,H.
            and Tozawa,R.
  TITLE     Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and
            Lifespan in Mice
  JOURNAL   Sci Rep 6, 32072 (2016)
   PUBMED   27577108
  REMARK    GeneRIF: High levels of IP6K3 mRNA were found in myotubes and
            muscle tissues. Expression was elevated under diabetic, fasting,
            and disuse conditions in mouse skeletal muscles. Ip6k3(-/-) mice
            had lower blood glucose, less insulin, decreased fat, lower weight,
            increased plasma lactate, enhanced glucose tolerance, lower glucose
            during an insulin tolerance test, and reduced muscle Pdk4
            expression. Ip6k3 deletion extended lifespan.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2305)
  AUTHORS   Fu,C., Xu,J., Li,R.J., Crawford,J.A., Khan,A.B., Ma,T.M., Cha,J.Y.,
            Snowman,A.M., Pletnikov,M.V. and Snyder,S.H.
  TITLE     Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and
            Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin
  JOURNAL   J Neurosci 35 (31), 11056-11067 (2015)
   PUBMED   26245967
  REMARK    GeneRIF: IP6K3 is highly expressed in cerebellar Purkinje cells.
            IP6K3-deleted mice display defects of motor learning and
            coordination. IP6K3-null mice manifest aberrations of Purkinje
            cells with a diminished number of synapses.
REFERENCE   5  (bases 1 to 2305)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK052857.1.
            
            On Apr 6, 2007 this sequence version replaced NM_173027.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052857.1, BC141263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2305              AK052857.1         2-2306
FEATURES             Location/Qualifiers
     source          1..2305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.77 cM"
     gene            1..2305
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /note="inositol hexaphosphate kinase 3"
                     /db_xref="GeneID:271424"
                     /db_xref="MGI:MGI:3045325"
     exon            1..125
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /inference="alignment:Splign:2.1.0"
     exon            126..402
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1394
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /EC_number="2.7.4.21"
                     /note="insP6 kinase 3"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 3"
                     /protein_id="NP_766615.1"
                     /db_xref="CCDS:CCDS28562.1"
                     /db_xref="GeneID:271424"
                     /db_xref="MGI:MGI:3045325"
                     /translation="MVVRHSSDKGKIGVGVPLEPFLHQVGGHLSVLQYDAYTVCKPLV
                     SQEQKFYESLPLAMKCFTPKYKGTITVRLRRDSRGHLGLVANPLKENLEPFQVSPESR
                     AVALWQTLQQTTGSESSPCPLTQLARSLKESAAKVLLRSDCHLSTQASPLVESEDGSQ
                     VERKGFNPWGLHCHQAHLTRLCSQYPEDKRHRFLLLENVVSQYKQPCILDLKMGTRQH
                     GDDASEEKKARHMKKCAQSTSACLGVRICGMQVYQTDQKSFLCKDKYYGRKLSVEGFR
                     QALSQFLHDGTRLRAELLEPILRRLQALLTVIRSQSSYRFYSSSVLIIYDGEPPQTTQ
                     GSTSGGVTSGDPAKVDVRMIDFAHTTFKGSWNEHTTYEGPDPGYIFGLENLIGILRDI
                     QEGE"
     exon            403..601
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /inference="alignment:Splign:2.1.0"
     exon            602..777
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..953
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2305
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
                     /note="hexamer: AGTAAA"
     polyA_site      2164
                     /gene="Ip6k3"
                     /gene_synonym="D830007E07Rik; Ihpk3"
ORIGIN      
        1 acccgggccc cagcgggaga actgagctgg gccagacctt ttcctgtgct tgcagacaga
       61 ggagggcact gagagacaag agcccctact gcacactccc tgataccccc cagaaagagg
      121 ctctgagaag tcagctgccg gacaacccac ctggtgggga cagcagcttc tccctcttgc
      181 cttccttggg aggacttggt gccatggtgg tgcggcacag ctcggacaag gggaagatag
      241 gggtgggtgt gccactggag cccttcctgc accaggtcgg gggccacctg agtgtgctgc
      301 agtatgacgc ctacacagtc tgcaagcccc ttgtctccca ggaacagaaa ttctatgagt
      361 ccctgccact ggccatgaag tgcttcactc cgaagtacaa aggtaccatc acagtgcgtc
      421 tccggagaga cagcagaggc caccttggcc tggttgccaa cccactgaag gagaacctgg
      481 agcctttcca ggtctcccca gagtccagag cggtagctct ctggcagaca cttcagcaga
      541 caaccggcag cgagagcagc ccctgccccc tcacccagct ggctcgctca ctgaaggaga
      601 gtgcagccaa ggtgctcctg aggtccgact gccacctcag tacccaggcc tctccgctgg
      661 tggaaagtga agatgggagc caggtggaga gaaagggctt taacccatgg ggcctgcact
      721 gtcaccaagc ccacctgact cgtctgtgct cccagtaccc agaggacaag agacaccggt
      781 tcttgctgtt ggaaaatgtg gtgtcacagt acaagcagcc ctgcatcctg gatctgaaga
      841 tggggacccg ccagcatggg gacgatgcat ccgaggagaa gaaggcccgt cacatgaaga
      901 agtgcgcaca gagcacctcg gcctgtctgg gtgtgcgcat ctgtggcatg caggtttatc
      961 aaactgatca gaagagcttt ctctgcaaag ataagtacta tggaaggaag ctctcggtgg
     1021 agggattcag gcaagccctt tctcagttcc tccatgatgg aacccgcctc cgcgccgagc
     1081 tcctggagcc catcctgcgt aggctgcagg cgctgctcac tgtcatcagg agccagagtt
     1141 cttaccgctt ctactccagc tccgtcctca taatctatga tggggagcct ccccagacca
     1201 cccaaggcag cacttctggc ggcgtcactt ccggagaccc ggccaaagtt gatgtccgga
     1261 tgattgactt cgctcacacg acattcaagg gctcctggaa cgagcacacc acctacgagg
     1321 gaccagatcc tggctatatt tttggcctgg aaaacctcat tgggattctg cgggatatcc
     1381 aggaaggaga atgaagcttc ttggaacttt ctgggatttt tctctgggct gcagaatttt
     1441 gccaagggac ccaagctagg gtagtctaga tttcccctgt aggtgtcttt gtaataacca
     1501 tatctacctt caaaagccat ctctgcatgt ggcgggcggt gttgacaatt gctacagaaa
     1561 tctgctctgc aggcagccac cccccaccgg gcagcttgca cagtgcagtt acaaaatggg
     1621 gtgtcattgt caagtgcaca ggagggtgta gcctgggtca gaggctagca ctgtggtgct
     1681 gcagggtgcc tgcattccag actgcttctc tgttgtcagg ccatggtctt caacccctaa
     1741 aaaaaaaccc caggagggag aagaccctgg aagaagcctt gaagaatatt ctgcttgtgt
     1801 ggatcagccc ctccccaggt agacagagct gatgcctccc ccatgagtca taggtgggac
     1861 agggatgagt gatccccccc caactaaatg tgagggggag gatccctgca gcctagtgga
     1921 actagcaagt tttccacact gtgaccacgt gatgtccctg acctggaacc gcagcttcca
     1981 gaggaagcag agtgtaccca cagaggagcc cacagtgttg ggctgtattc tccatttcta
     2041 tttatttatt attttgggtg caggtggggg gtgtgcgttg gaagcagaga acctagaaga
     2101 ccaggaaccc caagacgatg tttacaagca tggtggacac aagtaaatga gaaaccagag
     2161 caaacaggtc taatgaattc cttcttctgc agcattgaag cttactacaa tgccctggag
     2221 cccagcgctg cgctatgctc cccaattagg gaaataaatt tgttaataaa attgctgagg
     2281 tcaccagtga ttactggtgc gcctt
//
