LOCUS       NM_001379600            1762 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus inositol hexaphosphate kinase 2 (Ip6k2), transcript
            variant 3, mRNA.
ACCESSION   NM_001379600 XM_006511852
VERSION     NM_001379600.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Haykir,B., Moser,S.O., Pastor-Arroyo,E.M., Schnitzbauer,U.,
            Radvanyi,Z., Prucker,I., Qiu,D., Fiedler,D., Saiardi,A.,
            Jessen,H.J., Hernando,N. and Wagner,C.A.
  TITLE     The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular
            Function
  JOURNAL   J Am Soc Nephrol 35 (4), 441-455 (2024)
   PUBMED   38317282
  REMARK    GeneRIF: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal
            Tubular Function.
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Ito,M., Fujii,N., Kohara,S., Hori,S., Tanaka,M., Wittwer,C.,
            Kikuchi,K., Iijima,T., Kakimoto,Y., Hirabayashi,K., Kurotaki,D.,
            Jessen,H.J., Saiardi,A. and Nagata,E.
  TITLE     Inositol pyrophosphate profiling reveals regulatory roles of
            IP6K2-dependent enhanced IP7 metabolism in the enteric nervous
            system
  JOURNAL   J Biol Chem 299 (3), 102928 (2023)
   PUBMED   36681123
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Nagpal,L., Kornberg,M.D. and Snyder,S.H.
  TITLE     Inositol hexakisphosphate kinase-2 non-catalytically regulates
            mitophagy by attenuating PINK1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2121946119 (2022)
   PUBMED   35353626
  REMARK    GeneRIF: Inositol hexakisphosphate kinase-2 non-catalytically
            regulates mitophagy by attenuating PINK1 signaling.
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Nagpal,L., Kornberg,M.D., Albacarys,L.K. and Snyder,S.H.
  TITLE     Inositol hexakisphosphate kinase-2 determines cellular energy
            dynamics by regulating creatine kinase-B
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33547244
  REMARK    GeneRIF: Inositol hexakisphosphate kinase-2 determines cellular
            energy dynamics by regulating creatine kinase-B.
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Chin,A.C., Gao,Z., Riley,A.M., Furkert,D., Wittwer,C., Dutta,A.,
            Rojas,T., Semenza,E.R., Felder,R.A., Pluznick,J.L., Jessen,H.J.,
            Fiedler,D., Potter,B.V.L., Snyder,S.H. and Fu,C.
  TITLE     The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump
            degradation by relieving an autoinhibitory domain of PI3K p85alpha
  JOURNAL   Sci Adv 6 (44) (2020)
   PUBMED   33115740
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Koldobskiy,M.A., Chakraborty,A., Werner,J.K. Jr., Snowman,A.M.,
            Juluri,K.R., Vandiver,M.S., Kim,S., Heletz,S. and Snyder,S.H.
  TITLE     p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 20947-20951 (2010)
   PUBMED   21078964
REFERENCE   7  (bases 1 to 1762)
  AUTHORS   Morrison,B.H., Haney,R., Lamarre,E., Drazba,J., Prestwich,G.D. and
            Lindner,D.J.
  TITLE     Gene deletion of inositol hexakisphosphate kinase 2 predisposes to
            aerodigestive tract carcinoma
  JOURNAL   Oncogene 28 (25), 2383-2392 (2009)
   PUBMED   19430495
  REMARK    GeneRIF: Gene deletion of inositol hexakisphosphate kinase 2
            predisposes to aerodigestive tract carcinoma.
REFERENCE   8  (bases 1 to 1762)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 1762)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
REFERENCE   10 (bases 1 to 1762)
  AUTHORS   Saiardi,A., Erdjument-Bromage,H., Snowman,A.M., Tempst,P. and
            Snyder,S.H.
  TITLE     Synthesis of diphosphoinositol pentakisphosphate by a newly
            identified family of higher inositol polyphosphate kinases
  JOURNAL   Curr Biol 9 (22), 1323-1326 (1999)
   PUBMED   10574768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC173341.1 and AC168054.4.
            
            On Apr 9, 2020 this sequence version replaced XM_006511852.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.329538.1,
                                           SRR11927932.3587329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC173341.1         148245-148303
            60-392              AC168054.4         73561-73893
            393-615             AC168054.4         75768-75990
            616-791             AC168054.4         76739-76914
            792-967             AC168054.4         82039-82214
            968-1762            AC168054.4         83036-83830
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..1762
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /note="inositol hexaphosphate kinase 2"
                     /db_xref="GeneID:76500"
                     /db_xref="MGI:MGI:1923750"
     exon            1..59
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..392
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1468
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /EC_number="2.7.4.21"
                     /note="isoform 2 is encoded by transcript variant 3;
                     inositol hexakisphosphate kinase 2; piUS; insP6 kinase 2;
                     p(i)-uptake stimulator"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 2 isoform 2"
                     /protein_id="NP_001366529.1"
                     /db_xref="GeneID:76500"
                     /db_xref="MGI:MGI:1923750"
                     /translation="MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPL
                     VPREHQFYETLPAEMRRFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGTVDIVDNS
                     DCEPKSKLLRWTNKKHHALETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYY
                     SVEKKGNVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVL
                     DLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHG
                     RKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIY
                     DGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYG
                     EDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE"
     exon            393..615
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..791
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..967
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1762
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /note="hexamer: AATACA"
     polyA_site      1762
                     /gene="Ip6k2"
                     /gene_synonym="1500005N04Rik; Ihpk2"
                     /note="major polyA site"
ORIGIN      
        1 attttggtgg aagagaaaca ataggacgga agcgtcgcgg gactgggctg tggccgcaga
       61 gtgtcctggc ctgcacaaac cgaggagctg agatcaaaca ggtggctgta aggacagaca
      121 gtgaacggag ggcaagccgg cctctggacc ccgctgcctc ccctttctcc ctgctgctcg
      181 tgtccagagg atgagcccag ccttcaggac catggacgtg gagccccgca ccaagggcat
      241 cctgctggag ccatttgtcc accaggttgg ggggcactca tgcgttctcc gattcaatga
      301 gacaaccctg tgcaaacccc tggttccgag ggagcatcag ttctacgaga ccctcccagc
      361 tgagatgcgc agattcactc cccagtacaa aggtgtggta tcagtacgct ttgaagaaga
      421 tgaagacagg aacttgtgtt taatagcata tccattaaaa ggggaccatg gaactgtgga
      481 tatagtagac aattcggact gtgaaccaaa aagtaagctg ctaagatgga caaacaaaaa
      541 gcatcatgcc ctagaaacag aaaagaatcc caaggactgg gtacgccagc accggaaaga
      601 ggagaagatg aagagccata agttagaaga agaatttgag tggctaaaga aatctgaagt
      661 cttatactac agtgtagaaa aaaagggaaa tgtaagttcc cagcttaaac actataaccc
      721 ttggagcatg aaatgtcatc aacaacagtt acagagaatg aaggagaatg ccaagcatcg
      781 aaaccagtac aaattcatct tactggagaa cctgacttcc cgctatgagg taccttgtgt
      841 cctggacctc aagatgggca cacgccagca tggcgatgat gcttcggagg aaaaagcagc
      901 taaccagatc cgaaaatgtc agcagagcac gtctgcggtc atcggtgttc gagtgtgcgg
      961 catgcaggtg taccaggcgg gcactgggca gctcatgttc atgaacaagt accatgggcg
     1021 gaagctttcg gtgcagggct tcaaggaggc gcttttccag ttctttcaca atgggcggta
     1081 cctgcgccgt gagctcctgg gccctgtgct caagaagcta actgagctca aggccgtgtt
     1141 ggagcgacag gaatcctacc gcttctattc aagttcccta ctggtcatct atgatggcaa
     1201 ggagtggcca gaagtgaccc tggactcaga tgctgaggac ttggaggacc tctccgaaga
     1261 gtcggctgat gagtctgccg gtgcctatgc ctacaagccc atcggtgcca gctcagtgga
     1321 cgtgcgcatg attgactttg cacacaccac ctgcaggctg tatggcgagg acagtgtggt
     1381 gcatgagggc caggatgctg gctatatctt tgggctgcag agcctgatag acattgtcac
     1441 agagataagt gaggagagtg gggagtgagc tttctggcta ttccaggacc tgagagactc
     1501 tttgtgtccc cctacagctg tgctgtcggg aagcaggcca gtatggctag gtgttggcct
     1561 ctgcagcctg gagctgatag acagtggccc ctgtgacccc ctcccccccc cccccccccg
     1621 cctccagcct gagccggccc cagacgtgct cagagccttt tatttatttt aactgtttct
     1681 tcaacattcc acatttgatg atgcagatac ctctttcttc cctgagtgta aatgttctaa
     1741 tacagatgtt ttgtttattg ta
//
