LOCUS       NM_013785               4429 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus inositol hexaphosphate kinase 1 (Ip6k1), mRNA.
ACCESSION   NM_013785
VERSION     NM_013785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4429)
  AUTHORS   Haykir,B., Moser,S.O., Pastor-Arroyo,E.M., Schnitzbauer,U.,
            Radvanyi,Z., Prucker,I., Qiu,D., Fiedler,D., Saiardi,A.,
            Jessen,H.J., Hernando,N. and Wagner,C.A.
  TITLE     The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular
            Function
  JOURNAL   J Am Soc Nephrol 35 (4), 441-455 (2024)
   PUBMED   38317282
  REMARK    GeneRIF: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal
            Tubular Function.
REFERENCE   2  (bases 1 to 4429)
  AUTHORS   Jin,H., Liu,A., Chin,A.C., Fu,C., Shen,H. and Cheng,W.
  TITLE     Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and
            suppresses excitability
  JOURNAL   Mol Brain 17 (1), 8 (2024)
   PUBMED   38350944
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4429)
  AUTHORS   Bhat,S.A., Malla,A.B., Oddi,V., Sen,J. and Bhandari,R.
  TITLE     Inositol hexakisphosphate kinase 1 is essential for cell junction
            integrity in the mouse seminiferous epithelium
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119596 (2024)
   PUBMED   37742721
  REMARK    GeneRIF: Inositol hexakisphosphate kinase 1 is essential for cell
            junction integrity in the mouse seminiferous epithelium.
REFERENCE   4  (bases 1 to 4429)
  AUTHORS   Li,H., Datunashvili,M., Reyes,R.C. and Voglmaier,S.M.
  TITLE     Inositol hexakisphosphate kinases differentially regulate
            trafficking of vesicular glutamate transporters 1 and 2
  JOURNAL   Front Cell Neurosci 16, 926794 (2022)
   PUBMED   35936490
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4429)
  AUTHORS   Ghoshal,S., Mukherjee,S., Chakraborty,M., Msengi,E.N., Haubner,J.
            and Chakraborty,A.
  TITLE     Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight
            Gain, Insulin Resistance and Metabolic Dysfunction
  JOURNAL   Int J Mol Sci 23 (4), 2059 (2022)
   PUBMED   35216174
  REMARK    GeneRIF: Whole Body Ip6k1 Deletion Protects Mice from Age-Induced
            Weight Gain, Insulin Resistance and Metabolic Dysfunction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4429)
  AUTHORS   Bhandari,R., Juluri,K.R., Resnick,A.C. and Snyder,S.H.
  TITLE     Gene deletion of inositol hexakisphosphate kinase 1 reveals
            inositol pyrophosphate regulation of insulin secretion, growth, and
            spermiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (7), 2349-2353 (2008)
   PUBMED   18268345
  REMARK    GeneRIF: Defects in the mutants indicate important roles for IP6K1
            and inositol pyrophosphates in several physiological functions
REFERENCE   7  (bases 1 to 4429)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (bases 1 to 4429)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4429)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
REFERENCE   10 (bases 1 to 4429)
  AUTHORS   Saiardi,A., Erdjument-Bromage,H., Snowman,A.M., Tempst,P. and
            Snyder,S.H.
  TITLE     Synthesis of diphosphoinositol pentakisphosphate by a newly
            identified family of higher inositol polyphosphate kinases
  JOURNAL   Curr Biol 9 (22), 1323-1326 (1999)
   PUBMED   10574768
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059006.1.
            
            On Dec 20, 2003 this sequence version replaced NM_013785.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059006.1, AK088872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..4429
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /note="inositol hexaphosphate kinase 1"
                     /db_xref="GeneID:27399"
                     /db_xref="MGI:MGI:1351633"
     exon            1..175
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            176..523
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1602
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /EC_number="2.7.4.21"
                     /note="inositol hexakisphosphate kinase 6; insP6 kinase 1"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 1"
                     /protein_id="NP_038813.2"
                     /db_xref="CCDS:CCDS23514.1"
                     /db_xref="GeneID:27399"
                     /db_xref="MGI:MGI:1351633"
                     /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD
                     HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV
                     EQDDTPEREQPRRKHSRRSLHRSGSGSDHKEEKASLSFETSESSQEAKSPKVELHSHS
                     DVPFQMLDSNSGLSSEKISYNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK
                     YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCR
                     NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS
                     LLVIYDGKECRSELRLKHVDMGLPEVPPPCGPSTSPSSTSLEAGPSSPPKVDVRMIDF
                     AHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ"
     exon            524..734
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            735..916
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1092
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..4412
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /note="hexamer: AATAAA"
     polyA_site      4412
                     /gene="Ip6k1"
                     /gene_synonym="1200016D08Rik; Ihpk1; InsP6; InsP6k1;
                     Itpk6"
                     /note="major polyA site"
ORIGIN      
        1 gttgatccgt acccagtggg cagcgccagg agctggaccg agcggccggt gaggggccgc
       61 tgctgcgggg ctcagccacc agcgccgcct gccagggggg cgggccgaga cctggaggcc
      121 cggggggccc agctcccgtg gggagccttg ggcgcccgct gcccgagtcg ggccggacag
      181 aacagtaaac taagcagact gtgaccattg gcctcccact agccaggatc aacttagctc
      241 tccttttgtg gtccatgtgc tgcatcgtct gccatcagtg tgcaaccggc ccccaacgca
      301 atgtgtgttt gtcaaaccat ggaagtgggg cagtatggca agaacgcaag tcgggccgga
      361 gaccgaggag tcctcctgga gcccttcatc catcaggtgg gcgggcacag cagcatgatg
      421 cggtacgacg accacactgt gtgcaaacct ctcatctccc gggaacagcg cttctacgag
      481 tcactccctc ccgaaatgaa ggaattcacc ccagagtaca aaggcgtggt ttctgtctgt
      541 tttgagggag acagtgatgg ttacatcaac ttggtagcct atccttatgt ggagagtgaa
      601 actgtagagc aagatgacac accagagcgg gagcaacctc ggcgcaaaca ctcccgccgg
      661 agcctgcatc ggtctggcag tggtagtgac cacaaggagg agaaagccag cctgtccttt
      721 gagacctctg agagctccca ggaggcaaag agtccaaagg tggaactgca cagccactca
      781 gatgtccctt tccagatgct agacagcaat agcggtctga gctccgagaa gatcagctac
      841 aacccctgga gcctgcgctg ccacaagcag cagctgagcc gcatgcgctc cgagtccaag
      901 gaccgaaaac tctacaagtt cctcctgctt gagaacgtgg tacaccactt caagtacccc
      961 tgtgtgctgg acttgaagat gggtacccgg cagcatggcg atgatgcttc agctgaaaag
     1021 gctgcccggc agatgaggaa gtgtgagcag agcacgtcgg ccacgctggg ggtcagggtc
     1081 tgtggcatgc aggtgtacca gctggacaca ggtcattacc tctgcaggaa taagtactat
     1141 ggccgtggac tctccatcga gggcttccgc aatgcgctct atcagtacct gcacaatggc
     1201 ttggaccttc gacgtgacct ttttgagcca atcctgagca aactgcgggg cctcaaagcc
     1261 gtactggagc ggcaggcctc ctaccgcttc tactccagct ccctgcttgt catctatgat
     1321 ggcaaggagt gccggtctga gctacgtctc aagcacgtgg acatggggct ccctgaggtg
     1381 ccaccaccct gtggccccag caccagtcct agcagcacca gtcttgaggc tggcccctct
     1441 tctccgccca aggtggatgt tcgcatgatt gactttgcac acagcacatt caagggcttc
     1501 cgggatgacc ccactgttca cgatgggcca gacagaggct atgtgtttgg cttggagaat
     1561 cttatcagca tcatggagca gatgcgggat gagaaccagt aggccctgtg ctgggcctag
     1621 gacccccctc ctctccaccc acaggcaggg accattgctc tgaacttgct gtgaggacac
     1681 acagacttgc ttttaaaggg ttatatttct ctttggtgta aactaaaaga aatgttttta
     1741 gctgtagcct ggaatccata tatataaagt agaggagggc agaacatttg tcctctcagc
     1801 caggctcctt agctctgtgg ctgtgactgc tgtgtccagg ctgtctcagg aaggaagagg
     1861 tggccccagt gggcttgaca gcaaagagaa tgaatgcctt gaactttggt ctcccttgcc
     1921 taaggcgttt gggatctgtg gctgtggggc tctgctgatg gtgaggtgaa gccctcggct
     1981 ggcacacggt ctccatgccc aatcatccct tatttcccag aactggggaa ggttaagtgc
     2041 ccacgtcctg agggccatct tagtttcgtg ccagtgctgt aacagatgcc tcagggcatt
     2101 agagggctag ctgcacagac ggactcaccc ttgggtctga ttttggcatg gggctagatc
     2161 ggtgaaactg agctaaggcc aactcagcag agggcaggcc ctgggctccc taggcaccca
     2221 ctggcatgta accctgttcc tctctccaca actcgagcca gcctcttgct gggatccctg
     2281 acctaaggag gcctcatagc ctcctatccc actaagatgg gcacagctgt ttgctgagga
     2341 gagccagtgt cccaggaggc ctaagggcgg gactttagtg gctctggccc agacagtatt
     2401 tgcagttctg ggctctgggt ggcatccctt cctcacctgg ggcagctgtg ctgcttgtgg
     2461 gtgggctgct gctcccaggg ctcaggaacc gtggtccgct cagggtcttg tcttctccag
     2521 gccaagctca aggcagcagc cctgtatgtg gtgctccagg ctctaggcct ggagggagaa
     2581 ctttaaactt gtttgctttt agggacatag ggccctgggc acaggtgccc agcgtctgct
     2641 gagagctttg attaatcctg gggtttgtca gtaagtccat ttgtccacct gctagcccct
     2701 gtctcatggt gagctttctg gagtatagcc ttgttggtta gtatatattg atttccttca
     2761 tgcttccccc agcagtcttc tcctttcctt ttctgaggtg agtctgctcc tgtgcccctc
     2821 ctcagcaggt tctgctgtta caaacctggt ggccaaatga ttcatagtgg tgtttacctg
     2881 ctagcccagt ggccttcttg tgggcctggg gtatggcctt cagcaccaac ggtgggtaat
     2941 gaaggctcag ggttgaccct gacctattgc ttttatttct gctaccagtc ctttcatggt
     3001 agagacctgc tgctgcctgt aacatagtgt ccgacaggtt acactacacc aatcattgcc
     3061 aaggtgagca acagtctcca agtctatcac ttctaacatg tctctgtttt ggcatttgaa
     3121 ggtaatcctg ccaacctttg agagaaactg ttaacgaatg gcataatttc caggttctta
     3181 gagatgcagc ctctgaaaag ggttctgtga cggatccaag tcagtcttct gaccctggtg
     3241 ccattggtgg gcaggttccc attccttagg gccgggaggc acggcttggc ccatctctgc
     3301 ttactaacac ctgtcttctg tccagtagta gtgttgcttg tgccatgcag gcagcaagtg
     3361 ttaattagcg tggacacctt ttctttggca ggatagaggt caagagagga gtttggggcc
     3421 agcagagacc tcctaggaat gtgctgtact tccgatttac cagattttgg gaggtgctgc
     3481 ccccattctg ctgcttctca agtagcaagg gagttggtag gcactgctcc tgccactgca
     3541 agcgaggaaa ggctgggatt tgccgctgct caagggcagg gcctcacttt tcagcacttt
     3601 tgatatctgg aggcccagct ctgttatctg ataggtggtg gcaagtgtgt gcgaacactt
     3661 ttaccactgc tcttctgcct gtcccaggct agagccctgt ctttttcctg acaggtcctg
     3721 ccttcccaat catcaatttg ggaccaaagt gcaactaggg atcatgggtt gggagctcac
     3781 attacccctt tccattgtat ttcccgggcc aagcccatac cagcccgggg agatgggtgg
     3841 gagtgaaatg ggatgggtgc tgctggaaga ggaagggacc agtagagcaa tgtccttgcc
     3901 tgggattcta cccctctcag ctgtgggccg tgcagtggtg tggggattca ttctctccta
     3961 ggggcaaggg acctgggctc ggacagtatc cgttcagtat ccgctgctca ttcgctcaca
     4021 tctggccacg tgcacgttcc ctagatgcaa actgctttga actttacagc tatataagtt
     4081 ggttgtgtgt gtgtgctcat tttaaaaact acattttaac gaggaaaaag gagaacctgg
     4141 ggaaatttcc tttgcttctg tggaggaaat gtaagacttg gaattctgga aattgttatc
     4201 tgctcctctt tcctggaagc tacacaccct aagacctgcg cctggatgca tacgtggctc
     4261 cactggcgct taggcgcgct tgcattttcc ccaggtcttc tgtgtggtgg agaggagtgc
     4321 ttggcccaag ccggcccttt tctgtacacc cagcgctatc cgcccgcttg tgtctggtcg
     4381 tatacgtcaa aataaagcct ctagaaactg aaaaaaaaaa aaaaaaaaa
//
