LOCUS       NM_010569               5674 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus inversin (Invs), transcript variant 1, mRNA.
ACCESSION   NM_010569
VERSION     NM_010569.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5674)
  AUTHORS   Niborski LL, Paces-Fessy M, Ricci P, Bourgeois A, Magalhaes P,
            Kuzma-Kuzniarska M, Lesaulnier C, Reczko M, Declercq E, Zurbig P,
            Doucet A, Umbhauer M and Cereghini S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   2  (bases 1 to 5674)
  AUTHORS   Ru J, Guo D, Fan J, Zhang J, Ju R, Ouyang H, Wei L, Liu Y and Liu
            C.
  TITLE     Malformation of Tear Ducts Underlies the Epiphora and Precocious
            Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for
            Tear Duct Genesis
  JOURNAL   Invest Ophthalmol Vis Sci 61 (13), 6 (2020)
   PUBMED   33141892
REFERENCE   3  (bases 1 to 5674)
  AUTHORS   Flasse L, Yennek S, Cortijo C, Barandiaran IS, Kraus MR and
            Grapin-Botton A.
  TITLE     Apical Restriction of the Planar Cell Polarity Component VANGL in
            Pancreatic Ducts Is Required to Maintain Epithelial Integrity
  JOURNAL   Cell Rep 31 (8), 107677 (2020)
   PUBMED   32460029
REFERENCE   4  (bases 1 to 5674)
  AUTHORS   Shigeta M, Kanazawa H and Yokoyama T.
  TITLE     Tubular cell loss in early inv/nphp2 mutant kidneys represents a
            possible homeostatic mechanism in cortical tubular formation
  JOURNAL   PLoS One 13 (6), e0198580 (2018)
   PUBMED   29889867
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5674)
  AUTHORS   Nakajima Y, Kiyonari H, Mukumoto Y and Yokoyama T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   6  (bases 1 to 5674)
  AUTHORS   Biben C and Harvey RP.
  TITLE     Homeodomain factor Nkx2-5 controls left/right asymmetric expression
            of bHLH gene eHand during murine heart development
  JOURNAL   Genes Dev 11 (11), 1357-1369 (1997)
   PUBMED   9192865
REFERENCE   7  (bases 1 to 5674)
  AUTHORS   Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS,
            Overbeek P and Kuehn MR.
  TITLE     Conserved left-right asymmetry of nodal expression and alterations
            in murine situs inversus
  JOURNAL   Nature 381 (6578), 158-161 (1996)
   PUBMED   8610013
REFERENCE   8  (bases 1 to 5674)
  AUTHORS   Collignon J, Varlet I and Robertson EJ.
  TITLE     Relationship between asymmetric nodal expression and the direction
            of embryonic turning
  JOURNAL   Nature 381 (6578), 155-158 (1996)
   PUBMED   8610012
REFERENCE   9  (bases 1 to 5674)
  AUTHORS   Meno C, Saijoh Y, Fujii H, Ikeda M, Yokoyama T, Yokoyama M, Toyoda
            Y and Hamada H.
  TITLE     Left-right asymmetric expression of the TGF beta-family member
            lefty in mouse embryos
  JOURNAL   Nature 381 (6578), 151-155 (1996)
   PUBMED   8610011
REFERENCE   10 (bases 1 to 5674)
  AUTHORS   Yokoyama T, Copeland NG, Jenkins NA, Montgomery CA, Elder FF and
            Overbeek PA.
  TITLE     Reversal of left-right asymmetry: a situs inversus mutation
  JOURNAL   Science 260 (5108), 679-682 (1993)
   PUBMED   8480178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040307.1, BX528321.1, AK158766.1, BC126929.1 and AL807247.10.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_010569.5.
            
            On Aug 13, 2013 this sequence version replaced NM_010569.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034860.3, AJ010902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AK040307.1         2-426
            426-564             BX528321.1         407-545
            565-865             AK158766.1         640-940
            866-5077            BC126929.1         703-4914
            5078-5674           AL807247.10        111444-112040
FEATURES             Location/Qualifiers
     source          1..5674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.11 cM"
     gene            1..5674
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /note="inversin"
                     /db_xref="GeneID:16348"
                     /db_xref="MGI:MGI:1335082"
     exon            1..216
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..346
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..3429
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nephrocystin 2; inversion of embryo turning protein"
                     /codon_start=1
                     /product="inversin isoform 1"
                     /protein_id="NP_034699.3"
                     /db_xref="CCDS:CCDS18166.1"
                     /db_xref="GeneID:16348"
                     /db_xref="MGI:MGI:1335082"
                     /translation="MNISEDVLSTGSSLASQVHAAAVNGDKGALQRLIVGNSALRDKE
                     DRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLT
                     RRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYN
                     NPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQD
                     YEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE
                     RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGN
                     DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHT
                     PLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN
                     VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL
                     LDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVY
                     KGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSS
                     SAPVLPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSID
                     LQGTASRKPSETPIEHCRGPSACVHPRSWEGGNSSKNQGTSSVEKRRGETNGKHRRCE
                     EGPSSARQPLCTGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKRR
                     THQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTE
                     ASRSGCKQLYEDICASPETGVAHGPPPGQCMNIHLLPVEQRLLIIQRERSRKELFRRK
                     NKAAAVIQRAWRSYQLRKHLSRLLHLKQLGAREVLRCTQVCTALLLQVWRKELELKFP
                     KSISVSRTSKSPSKGSSATKYARHSVLRQIYGCSQEGKGHHPIKSSKAPAVLHLSSVN
                     SLQSIHLDNSGRSKKFSYNLQPSSQSKNKPKL"
     exon            347..513
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..687
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..855
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1036
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1146
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1318
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1474
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1704
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1811
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2024
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2317
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..3020
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3250
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3325
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..5674
                     /gene="Invs"
                     /gene_synonym="inv; Nphp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagggacc gcgtacctct gtgcctccgg gacgggaact acaattccca gagggctgtg
       61 cagcctggag ccccaggcta cttcttcaga gctcccgggc tctagtgtcc tggggtctgt
      121 tcctgtgggc gcagtggcct ggcttggcgg taggggcggc cccgtgaggg ttgtgcctcc
      181 tggggcggcc ccgggacgcc attcttggag tcaggggtca ctaggattgt ggagaaaact
      241 atgaacatat ccgaggatgt actctctacg gggtcctcat tagcatctca ggttcatgcc
      301 gctgcagtta atggagataa aggtgccctt cagagactca ttgttggaaa ctctgctctc
      361 agagacaaag aagaccggtt tgggagaaca ccacttatgt actgtgtgtt ggcagacaga
      421 gtggactgtg cagatgctct tctcaaagca ggagcagatg tcaacaaaac ggaccatagc
      481 cggagaacag ccctccacct tgcagctcaa aagggaaatt atcgctttat gaaactctta
      541 cttactcgaa gagcaaactg gatgcagaag gatctagaag agatgacacc tttgcacctg
      601 agcactcggc acaggagccc caagtgtcta gctcttctgc tgaagtttat ggcccctggg
      661 gaggtggata cacaggacaa aaacaagcaa acagctctgc actggagtgc ctactacaac
      721 aaccccgagc acgcgaagct actcatcaag cacgactcca acatcgggat tcccgacgtg
      781 gaaggcaaga tcccactcca ctgggcagcc aaccacaaag acccgagtgc cgtgcacaca
      841 gtgagatgta tcctggacgc tgccccgaca gagtctttac tgaactggca agactacgag
      901 ggccgcacac ctctgcactt tgctgtcgct gatggaaacc taacggtggt ggatgtcttg
      961 acctcctatg aaagctgcaa cataacgtct tacgataact tatttcgaac cccacttcac
     1021 tgggcagcct tactaggtca tgcacagatt gtccatctcc ttctagaaag aaacaagtct
     1081 ggaacgatcc cttcggacag ccagggagca acacccttgc actatgcagc tcagagtaac
     1141 tttgctgaaa cggtcaaagt gtttttgcag catccttcag tgaaggatga ttctgacctg
     1201 gaaggaagaa catctttcat gtgggcagca ggaaaaggca atgacgacgt gctcaggacg
     1261 atgctgagtc taaagtcaga catcgacatt aacatgtcgg acaagtacgg aggcacagct
     1321 ttacacgccg ctgccctttc tggccacgtc agcaccgtga agttattatt ggacaatgat
     1381 gctcaagtgg atgccactga cgtcatgaaa catactccac tgttccgagc ctgtgagatg
     1441 ggacacagag atgtgattca gacgcttatt aaaggtggag cacgagtaga tctggttgac
     1501 caggacggac attcgcttct acactgggca gcgctggggg gaaatgctga cgtctgccag
     1561 atactgatag aaaataagat caacccaaac gtgcaggatt atgcaggaag aacaccgctt
     1621 cagtgtgctg cgtacggagg gtacatcaac tgtatggctg tgctcatgga gaataatgca
     1681 gaccccaaca tccaagacaa agagggacga acagctttgc actggtcctg taacaatggc
     1741 taccttgatg ccattaaact actgctagat tttgctgctt tccctaatca gatggagaac
     1801 aatgaggaga ggtacacacc ccttgattat gcattgcttg gtgagcgcca tgaggtgatc
     1861 cagttcatgc tggaacatgg tgccctgtcc atcgcagcta tacaagacat cgctgccttc
     1921 aaaatccaag cagtctacaa aggatacaag gtcagaaaag ccttccgaga ccggaagaac
     1981 ctcctcatga agcacgaaca gctgaggaaa gacgctgcag ccaaaaaacg ggaagaggaa
     2041 aacaagagga aggaagctga acagcagaaa gggcagctgg acaccgatcc tcccagatcc
     2101 cactgcagtt catctgcacc tgtcctcccc tgtccaccca gcccccagaa tgaggccagc
     2161 aagcaggacg caacccctag caaacagcca cctgctagcc acacagtcca gagccctgac
     2221 ccagaacaca gcaggcctcc aggcagatgt ccaggcagag cctcccaagg ggattcttcc
     2281 atagaccttc agggaacggc ctccagaaag ccaagtgaaa cacccataga gcactgcaga
     2341 ggcccctctg cctgtgtgca ccccagatcc tgggaaggtg gcaacagctc caagaaccag
     2401 ggaacatcct ctgtggagaa gcgcagaggt gagaccaatg gcaaacaccg gaggtgtgag
     2461 gaggggccca gcagcgccag gcagcccttg tgcactgggt caggccggcc tgctgagaaa
     2521 ggagaggact ccagccctgc agttgcaagt gcttcccagc aggaccaccc caggaagccc
     2581 aataagagac aggacagggc agccaggccc agaggtgctt cgcagaaaag acgcacccat
     2641 cagctcagag acaggtgctc cccagctggg tccagccggc ctggcagtgc caagggggaa
     2701 gttgcctgtg ctgatcagag ttctctccac cgtcacacac caagaagcaa ggtgacccag
     2761 gacaagctta taggaggggt ctcctcaggt ttgccgctca gcacagaagc gtcgaggtca
     2821 ggatgcaagc agctttatga ggacatctgt gcatctccag agactggcgt ggctcatggc
     2881 cccccacctg gacagtgtat gaatattcac cttcttcctg tagagcagcg cctgctgata
     2941 atccagaggg aacgaagcag gaaagagctg tttcgacgga aaaacaaggc agcggcggtc
     3001 atccagcgag cttggcgaag ctaccagctc aggaagcacc tgtctcggct tctgcatttg
     3061 aagcagcttg gagccagaga agtgctcaga tgtacccaag tgtgcacagc cctgctcctc
     3121 caggtttgga ggaaagaact ggaactcaaa ttcccaaagt ccatctcagt aagcaggaca
     3181 tcgaagagtc catccaaagg ctcgtcggcc acaaagtatg ccaggcactc agtgctcagg
     3241 cagatctacg gttgttctca agaagggaaa ggacatcatc ccatcaaatc ttctaaagcc
     3301 cccgctgtgc ttcatctcag ctcagtgaac agtttgcagt ctatacatct tgacaacagt
     3361 ggaagatcaa agaagttctc ttacaatctg caaccatcca gtcaatcaaa aaacaagcca
     3421 aagctttaac cctggaggaa gatcagaacc agtgtggaat tctgctctct gtaaactctt
     3481 actcatgaga acgctttact atttgcacct aaagacttgt tacccagcat atgtggtcaa
     3541 agacaaggtt caaatgtttt ctcctgggtt tactcagcgt tactttttat tcctctcagc
     3601 atgcactgaa aggaccagag cagggcgctc ggatggactg cctagctgtg tgcttcacct
     3661 caagccagca tggctggaaa tgagaactgc cacactcatc ctgacaacac ctgtactaag
     3721 gagctgctgg gctgggattt ctaacagcta cctggcatag gcctaggttt ctcactcgat
     3781 agaaccttct tcaatgagat aggaaacctg ggccacaaca accaccctca actctttact
     3841 tccctggaac atactgtaat gaaaatcaca agagacattt taaactttag atgcacacgg
     3901 tggcttagtg cacgcagtta gaaactgtcc agtgtactag agcggaactg agaagcacat
     3961 tgtgttgctt ccttaccgtg ctcagtttcc aggttggtcc agagagaaca gaagctcggc
     4021 tttcactgct gagtggcacc aatgctagca cagcaccaaa agtcagcaag acagggctta
     4081 cagcagaatg caccaaccaa ctcaggcttc tcttcccctc tgcatcttct gaccaacttg
     4141 caggaatagg tagcattccc caaaagcagt ttcttttgtg aaagtaaccc acactctaac
     4201 taagactact tggctcacat aaagtctagt gattacgggc ttttacagag gcagcgacga
     4261 cgtcaggtca gtactgtgct aacagtgaag gtcaggaagc aagtgtttac ctcacttaac
     4321 tacctagact tttggtttag taaattatat tcaaaatgat gaagacaggt ttatctagat
     4381 gagatcacaa agattcactg gtaagtgaat gaaggcatcg tagctcactc tatgtattgt
     4441 aaacatttag ctcctcagaa attcaaactg ttctatagcc tgtctttgca tctcgtacta
     4501 ttccaggcaa acagtgtgag agcactaaaa gctcttaaac tttattttcc cacttctgta
     4561 tgaaggaagc tcatgaactt ctttaaaagt tgaggtttaa tggcaaacat ctgttacatc
     4621 agtctttctt caaaataaaa tgaatgtgca tgaacaatta acttcaaaca ggaggtacca
     4681 tggtgcttct ttaatacaat gcattcaata tactaggccc ttggggatgg ccactgatgt
     4741 acacgctgaa gcagtaatgt aagtctgtaa gccactgctc ctgaacactg ccactcttta
     4801 aagtctgcag agaaaaacaa aaggcacttt agtttgagaa cctgacattt ttcatgcctc
     4861 cataagagta tattccccaa ccactagctg gagaatatac atgggctgga cctaaggcct
     4921 ccctgtgggt cctgaataac tggagcaagg gctatcccaa aagctgttgc ctatatgtaa
     4981 gatatgctct tctagctggg ctgccttgtc tggcctcagt gggactggat gagcacagcc
     5041 acatagaaat ctgaagtgcc agggtgggag aatacccaga gggtgcccac cctctccgag
     5101 gagagggggg tggggggagt ggattgagga ggggggtgac tgggaggtgg ggcagtaaaa
     5161 gtaaaaagtg agtaagtaaa gaaatagatt ttctttttta aaatcctctc ctataaacta
     5221 gaagaaatct taaaatacaa aaccaaccaa ccaactgttg ggagttactt aaccaatgaa
     5281 atttcctact ctttacaaaa ttttgaaatt atgaaatgga ccctaaaggc ataggtattt
     5341 gaacagttgg ttgccagcta gtgctgctgt tttggaaggt tctttggaca cagcctactt
     5401 ctggcccagg ctctctactt cctgaccgac tgagatgtaa atccccacag caaacaccca
     5461 ctgccataga agtaccctag cacagtgctt actccatgat aacagagtgc cctctcacac
     5521 tgtcaaatac agtaagtcct ttcttttaag ttggatctgt tatttggtta atgtgacaag
     5581 agaaacagta tgtaccctta ggagtaacaa gttctttgtg aatgtgttcc ctcctggaca
     5641 tgctggagac taataaaaaa atttatggac aatc
//
