LOCUS       NM_175515               6390 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus inturned planar cell polarity protein (Intu),
            transcript variant 1, mRNA.
ACCESSION   NM_175515 XM_358350 XM_484332
VERSION     NM_175515.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6390)
  AUTHORS   Zeng,H., Ali,S., Sebastian,A., Ramos-Medero,A.S., Albert,I.,
            Dean,C. and Liu,A.
  TITLE     CPLANE protein INTU regulates growth and patterning of the mouse
            lungs through cilia-dependent Hh signaling
  JOURNAL   Dev Biol 515, 92-101 (2024)
   PUBMED   39029571
  REMARK    GeneRIF: CPLANE protein INTU regulates growth and patterning of the
            mouse lungs through cilia-dependent Hh signaling.
REFERENCE   2  (bases 1 to 6390)
  AUTHORS   Wang,S., Liu,A., Su,Y. and Dong,Z.
  TITLE     Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney
            Repair and Suppresses Renal Fibrosis after Acute Kidney Injury
  JOURNAL   Am J Pathol 193 (3), 275-285 (2023)
   PUBMED   36586478
REFERENCE   3  (bases 1 to 6390)
  AUTHORS   Langousis,G., Cavadini,S., Boegholm,N., Lorentzen,E., Kempf,G. and
            Matthias,P.
  TITLE     Structure of the ciliogenesis-associated CPLANE complex
  JOURNAL   Sci Adv 8 (15), eabn0832 (2022)
   PUBMED   35427153
REFERENCE   4  (bases 1 to 6390)
  AUTHORS   Wang,S., Liu,A., Wu,G., Ding,H.F., Huang,S., Nahman,S. and Dong,Z.
  TITLE     The CPLANE protein Intu protects kidneys from ischemia-reperfusion
            injury by targeting STAT1 for degradation
  JOURNAL   Nat Commun 9 (1), 1234 (2018)
   PUBMED   29581513
  REMARK    GeneRIF: propose a role for Intu in protecting cells and tissues
            after injury by targeting STAT1 for degradation and maintaining
            primary cilia
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6390)
  AUTHORS   Agbu,S.O., Liang,Y., Liu,A. and Anderson,K.V.
  TITLE     The small GTPase RSG1 controls a final step in primary cilia
            initiation
  JOURNAL   J Cell Biol 217 (1), 413-427 (2018)
   PUBMED   29038301
REFERENCE   6  (bases 1 to 6390)
  AUTHORS   Dai,D., Li,L., Huebner,A., Zeng,H., Guevara,E., Claypool,D.J.,
            Liu,A. and Chen,J.
  TITLE     Planar cell polarity effector gene Intu regulates cell
            fate-specific differentiation of keratinocytes through the primary
            cilia
  JOURNAL   Cell Death Differ 20 (1), 130-138 (2013)
   PUBMED   22935613
  REMARK    GeneRIF: Targeting Intu in the epidermis resulted in almost
            complete loss of primary cilia in epidermal and follicular
            keratinocytes, and a suppressed hedgehog signaling pathway.
REFERENCE   7  (bases 1 to 6390)
  AUTHORS   Heydeck,W. and Liu,A.
  TITLE     PCP effector proteins inturned and fuzzy play nonredundant roles in
            the patterning but not convergent extension of mammalian neural
            tube
  JOURNAL   Dev Dyn 240 (8), 1938-1948 (2011)
   PUBMED   21761479
  REMARK    GeneRIF: Data show that the functions of both Inturned and Fuzzy in
            neural tube patterning are dependent on the presence of cilia.
REFERENCE   8  (bases 1 to 6390)
  AUTHORS   Zeng,H., Hoover,A.N. and Liu,A.
  TITLE     PCP effector gene Inturned is an important regulator of cilia
            formation and embryonic development in mammals
  JOURNAL   Dev Biol 339 (2), 418-428 (2010)
   PUBMED   20067783
REFERENCE   9  (bases 1 to 6390)
  AUTHORS   Singla,V. and Reiter,J.F.
  TITLE     The primary cilium as the cell's antenna: signaling at a sensory
            organelle
  JOURNAL   Science 313 (5787), 629-633 (2006)
   PUBMED   16888132
  REMARK    Review article
REFERENCE   10 (bases 1 to 6390)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163023.4 and AC146980.9.
            
            On Apr 25, 2022 this sequence version replaced NM_175515.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132387.1, SRR10223969.3660.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC163023.4         9609-9854           c
            247-794             AC146980.9         157419-157966       c
            795-880             AC146980.9         147327-147412       c
            881-1084            AC146980.9         138898-139101       c
            1085-1203           AC146980.9         136328-136446       c
            1204-1293           AC146980.9         132700-132789       c
            1294-1371           AC146980.9         132063-132140       c
            1372-1561           AC146980.9         128126-128315       c
            1562-1615           AC146980.9         123843-123896       c
            1616-1678           AC146980.9         120914-120976       c
            1679-1900           AC146980.9         119736-119957       c
            1901-2371           AC146980.9         118703-119173       c
            2372-2469           AC146980.9         117414-117511       c
            2470-2659           AC146980.9         113999-114188       c
            2660-2817           AC146980.9         111876-112033       c
            2818-6390           AC146980.9         106898-110470       c
FEATURES             Location/Qualifiers
     source          1..6390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 19.46 cM"
     gene            1..6390
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /note="inturned planar cell polarity protein"
                     /db_xref="GeneID:380614"
                     /db_xref="MGI:MGI:2443752"
     exon            1..246
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2929
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /note="isoform 1 is encoded by transcript variant 1; PDZ
                     domain-containing protein 6; protein inturned; inturned
                     planar cell polarity effector homolog"
                     /codon_start=1
                     /product="protein inturned isoform 1"
                     /protein_id="NP_780724.3"
                     /db_xref="CCDS:CCDS84619.1"
                     /db_xref="GeneID:380614"
                     /db_xref="MGI:MGI:2443752"
                     /translation="MAGLARGDSRGRPPELPGDLSSQEEEEEEGDSDAGASSLGSYSS
                     ASSDTDVEPEWLDSVQKNGELFYLELSEDEEESLLPETQTANHVNHVRFSDKEVIIEE
                     DDSRERKKSEPKLRRFTKILKSKSLLPRRHHKKSSSNNGPVSILKHQSSQKTGVTVQQ
                     RYKDVTVYINPRKLTAIKAREQVKLLEVLVGIIHQTKRSWKRSAKQADGERLVVHGLL
                     PGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKRETA
                     QPQKKKAQSSTQDLVKLLCGSEADAVQHSTLSIPHISMYLTLQLQSEAAREEQEILYH
                     YPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHLNGKQIHVAYLKESDKLLLI
                     GLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENAPRLDHFFSLFFERALRPG
                     KLHLSGSPSAQQYAAASAVLLDNLPGVRWLVLPQELKVELDTALSDLEAADFEELSED
                     YYDMRRLYTILGSSLFYKGYMVCSHLPKDDVIEIAAYCRQHCLLPLAAKQRIGQLIIW
                     REVFPRHHLQPPSDSDPEAFQEPEGRYFLLVVGLRHYLLCVLLEAGGCASKATGNPGP
                     DCIYVDQVRATLHQLEGVDSRIEEQLATSPGPCLSCADWFLAAPREKADSLTTSPILS
                     RLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPTEGEESAGLSPHATPDAV
                     RKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYDIMKLTSGPENT
                     LFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHQCCLSIRAFFQQTLKEEKKK
                     ALSDGEHSEPTNSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKP
                     QELYVCFHDSVSEIAIEMAFKLFFGLTL"
     exon            247..794
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            795..880
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1084
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1203
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1293
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1371
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1561
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1615
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1678
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1900
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2371
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2469
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2659
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2817
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..6390
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6370..6375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /note="hexamer: AATAAA"
     polyA_site      6390
                     /gene="Intu"
                     /gene_synonym="9230116I04Rik; 9430087H23Rik; mKIAA1284;
                     Pdzd6; Pdzk6"
                     /note="major polyA site"
ORIGIN      
        1 gtcacgtggc ccgacctggc aaaatggcgg cgctgctgga ggcgcggctg gcgggctctg
       61 gcgtctgagc ttctgccccg gagctctcgc gacccagagg atggcgggcc ttgcgagggg
      121 agactcgcgt gggcgcccgc ccgagctccc tggagacctg tcctcacagg aagaggaaga
      181 ggaggaaggc gactccgacg ccggggccag cagcttgggc tcctactcct cagccagcag
      241 tgacactgat gtggagcctg agtggctgga cagtgtgcag aagaacggag aactgttcta
      301 cctggagctg agtgaggacg aggaggagag cctccttccg gagacccaga cagcgaacca
      361 cgtgaaccac gtgaggttca gcgacaagga ggtcatcatc gaagaggacg attccagaga
      421 gaggaagaag tccgagccca agctcaggcg cttcaccaag atcttgaaaa gcaaaagcct
      481 tttacccagg cgtcaccaca aaaagagcag cagcaacaat gggcccgtgt ccattctgaa
      541 acatcagtcc tcccagaaga cgggagtcac cgtgcagcag cggtacaagg atgtgaccgt
      601 ctacatcaac cccagaaagc tgacggccat caaggccagg gagcaggtca aactcctgga
      661 agtactggtg gggatcatcc atcagaccaa gaggagctgg aaaaggagcg cgaagcaggc
      721 agacggagag aggctcgtgg tgcatggcct gttgccagga ggctcggcta tgaagagcgg
      781 tcaggtcctg gttggcgatg tccttgttgc tgtgaatgat gtagatgtga cttctgaaaa
      841 catagaaaga gttctgtcct gcatccctgg gccaatgcag gtgaagctga catttgaaaa
      901 cgcatatgct gtgaaacggg aaacagctca accccaaaag aaaaaggcac agtcgagcac
      961 ccaagatttg gtgaaactcc tctgcgggtc agaggctgat gctgtccagc acagtaccct
     1021 gagcatccca cacatctcca tgtacctcac actgcagctc cagtcagagg cagccaggga
     1081 ggagcaggaa attctttacc attatccagt gtctgaagca tctcagaaac tcaagagcgt
     1141 gagggggatt tttctcacgc tctgtgacat gctggaaagc gtaacgggga cacaagtcac
     1201 tagctcatcc ctccatctaa atgggaaaca aattcatgtt gcttacttga aagagtctga
     1261 caagttgctg ttaattggcc tgcctgctga agaagttcct cttcctcagt taaggaacat
     1321 gatagaagat gtggcccaaa ccctaaagtt catgtatggt tctttagaca gcgccttctg
     1381 ccaggttgag aacgcacctc gtctggatca tttcttcagt ttgttcttcg aacgagctct
     1441 tcggcccggc aagttgcatc tcagcggcag ccccagcgcc cagcagtatg ccgcagccag
     1501 tgccgtgctt ttggacaatc tcccgggagt ccgttggctc gtgcttccac aggaactcaa
     1561 ggtggaactg gacacagcac tgagtgacct tgaggccgct gacttcgaag aactgtctga
     1621 ggattattat gacatgagac ggctgtatac aattttgggt tcttctctgt tttacaaggg
     1681 ttacatggtg tgcagccatc tgcctaagga tgatgttatt gagatcgctg catactgtcg
     1741 ccagcactgc ctgctgcctt tagcagcaaa gcaaaggatt ggccagctga taatatggag
     1801 agaggtgttc ccaagacacc acctccagcc cccttcagac tcagaccccg aggccttcca
     1861 ggaacctgaa gggagatatt tcttactagt tgtcggattg cgacattatt tgttgtgcgt
     1921 gctgttagaa gctggaggct gtgcatctaa agctactggg aaccctggtc ccgattgtat
     1981 ctatgtagat caggtcagag cgacccttca tcagctggaa ggagtagact cccgcataga
     2041 ggaacagcta gccacatccc cggggccctg cttgtcttgt gctgactggt tccttgctgc
     2101 tccacgtgaa aaggcagata gtttgactac ttcacctatc ctcagtcggc tgcaggggcc
     2161 ttccaaaaca gcagcctctc caacatgcag gagaaccttt ttcagtgact attccttcaa
     2221 ggcacggaag cccagtccct ccaggatcgg tggaggacgt gaacccactg aaggggaaga
     2281 aagtgctggt ctgagcccac atgctacccc agatgcagta cggaagcaaa gagaatccga
     2341 aggctcggac gacaatgtgg ccttgcttaa gcttgctaga aagaagtcaa cacttccaaa
     2401 tccgtttcat ttgggaactt cgaaaaaaga actttcagaa aaagagttgg aagtctatga
     2461 cataatgaaa ttgacctccg gtcctgagaa tacactcttc cactatgttg ccttggaaac
     2521 agtgcaaggc atcttcatca cccccaccca tgaagaggtg gctcagctag gtggttccgt
     2581 tcactctcaa ctgataaaga atttccatca atgttgtctc tctatccgtg catttttcca
     2641 gcagacgctg aaggaagaga aaaagaaagc gctaagtgat ggagagcatt cggagcctac
     2701 aaattcagtg tcttctctga gccctgtgaa agaacatggt gtgctgtttg aatgctcacc
     2761 tgaaaactgg actgatcaga aaaagactcc accagtcatg tcatactggg tagtagggcg
     2821 gctctttctt aacccaaaac ctcaggaact atatgtctgt tttcacgact cagtctcaga
     2881 aattgccatt gaaatggcat ttaaattgtt ctttgggtta acgttgtagc tgtgtttgta
     2941 agatgcaaag caacacaccg atggaccaca ggacattgtc agaatgacag aaatcatcat
     3001 acagagataa ggctcagtac attcactatt cactatagta ctcgttaaat actgagatgc
     3061 aatcctattg ggttggtcca tcagttcatg tgtggtatta tacaagactc tgagctggta
     3121 cttgatcaaa atatagacac aagattgtta atttattgcc attttggtat accttgctaa
     3181 tttattgaat agttttaaat aatgtgaatt ctttaataaa aaattaatat agatggtttt
     3241 ttagggttca tattttaatc attgtttgtt ttcataaaac ccaatactga atgactgaaa
     3301 cctggtgaag aagtcatgac ttgaagagat ggcaaggttc tgtagctggt tagtgctgtg
     3361 ttgtgagcaa gcgcttgcat cagttagacc tcagagtatg tgtagactaa tcacattatt
     3421 attgcattag gattttgaaa caccctgtta agaaaaatgt gttgtttgct tattgatcag
     3481 tatataaatt tacaaaacct atgttctagt ttcttagcaa atcaaaagcc tgtgcactga
     3541 tttaagtatt ttagtagata cctcactaca gaggcagagg gagaggatgg cagttaaagt
     3601 taatgtatat ttatttgatt ctctttattg tttatttgga ttaggataca catctgcaat
     3661 catctgtaaa ctccccctgc tttctttctg gttcacatac atttatgtca gctctatcga
     3721 atcatattaa aggcactgaa gtgggggctg gatcaatggc tcagaggtca ggaacaagta
     3781 cctcattggc agagacctga gttcagctcc cagcacccac attaggtagc tcaaaccccc
     3841 tgtaactcca gggactcctt tggcttttgc caggtgccca cacacacaat tagaaaataa
     3901 aaatcctttt taaaacactg ggggtcgggg tggtggtaag gaacaagcta aagctattgt
     3961 atgtaacttt ttctataaaa tactaatttc tgtcttacaa atcagcatca atctgcactg
     4021 ggtttttcca aaggagaggg gttgctttcc ccgactgtgg ctaatgtgag cttcagcggt
     4081 acagaaagct gacaagacag attttctttg gctgtgagaa tttggtgtgt tgaaaagtat
     4141 agtaaatgct aaatttatta ttgccatcta cccaggtgga catcccagag gctcaatatc
     4201 cccctacatt ttacagtcct gggtaatgtc tctttcaggg gttatatatg ttggaaggca
     4261 agctatctat cttagtcagg gtttctattc ctgcacaaac atcatggcca agaagcaagt
     4321 tggggaggaa agggtttatt tggcttacac ttccatactg ctgttcatca ccaaggaagt
     4381 caagactgga actcaagcag gtcaggaagc aggagctgat gcagaggcca tggagggatg
     4441 ttctttactg gcttgcctca cctggcttgc tcagcctgct ttcttataga accaagacta
     4501 ccagccctga gatggtccca cccacaaggg gcctttcccc cttgatcact aattgagaaa
     4561 atgcctgaca gttgtatctc atggaggcat ttcctcaact gaagctcctt cctctgtgat
     4621 aactccagct gtgtcaagtt gacacaaaac tagccagtac actatctaaa gccaatctaa
     4681 tgtttgtccc tacatttccc ctccctcaaa cactaaccct ccagcttaaa actagaaagc
     4741 atactagtgc acccctgagc cattcggtct tataaaacta ctgttgcctt ggccatcagt
     4801 gtaagattct catcaaggca taggtgacag ataccagctg tttacatcac tggtgacttc
     4861 tgggccttca ttgcggcttt caagtcagat aagaaaattg tgcaccttac aatgtagaga
     4921 acagtttgaa atatctcccc acgtaactga gtcaattagt taagactcac ttctgtctta
     4981 gacggcccgt gtgccgatgt gtgttccagc atttctaaaa gtgtactcat taaatgtctc
     5041 aagtttttgg atatagcctc aaatcccgag ctggttctag tgctgatcat tatgatgaat
     5101 gtagctgttg atgacctcag gtgttcaggc agaacaaact aagacttggg gttttaataa
     5161 agggaacttt tttccattta aattttgatc tgttcatgct ctcttcatgt cagatagcca
     5221 tgcacacatt attcaaaatg tggtgtgaag gacaagcaca gcacagatgt taaagatgag
     5281 ccactggcag tgcagtgagt gtgcatcata attccatact gaagagacac agcattttta
     5341 aggaaagaat attgtcttcc tttccatttc caagtgaaca ctgaaggcaa acatagctga
     5401 ccatgcccgt aaataaattc agactcacat ctgaaagtca atcagtctga ctgttggaca
     5461 gtagagtccc tgtctgtctt gttttcaggg agaggacaaa atatcaagtg cagatcccat
     5521 aaggatgggc ttcagagaaa cctccttgag tcaggtttta ttcacatcct ggtagtcgtg
     5581 ttctaaagaa cattactgta cgaaagtaaa atgcatggtc tgcctaacat tcttagaact
     5641 gttatgtctg gcttggtggc acatgcctag aatccagtgt tcaggaagct gaggcagagg
     5701 gcaggctggg ttctatctgt aacaaaaata aaaccacaag tgctttcttc ctactacctc
     5761 acgtttctta gccccaaaga aactccagac tcttgctttt tctttccctc ttctctctct
     5821 tctctctttc ctttgtttcg gtcttgtcag agaactgtac ctaggagggt acggtaggca
     5881 gtgtatcact ttttgtgcca agggacaata gatgatgata catacatacc taacaaaatg
     5941 gtgattgtaa aataatctct taaatatttc tgacacaaat cgaaaaaccg tgaaactagt
     6001 ctactaagtt ttgtctgctt taaccattgt tcgtttccat atgctctccc taaaccatgg
     6061 ttgtcataca ttgtcaatta tgaagcataa gctgtggcta ccatttatca tcattaagtg
     6121 gccccagctt gagaaacaaa agggtacagt taaatcatgc ccgttactgc ataacatgac
     6181 agcaacgatc tgagaaaatt actttgttgt atagttttga aaataaggat ttatattttg
     6241 gattttttta aatggtaagt tctattaaaa cctgaaccta cacaccaaac tgtatgaact
     6301 aacttaatta tgaagagttt tatttctgta tgtaattaaa gctatttttc tacattatcc
     6361 agagttttaa ataaaaatgt tttggaggtt
//
