LOCUS       NM_153414               2429 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus integrator complex subunit 9 (Ints9), transcript
            variant 1, mRNA.
ACCESSION   NM_153414
VERSION     NM_153414.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141425.3 and AC155172.4.
            
            On May 21, 2019 this sequence version replaced NM_153414.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077634.1, AK136992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC141425.3         51950-52024         c
            76-203              AC141425.3         22068-22195         c
            204-264             AC141425.3         15954-16014         c
            265-327             AC141425.3         11723-11785         c
            328-467             AC141425.3         9204-9343           c
            468-554             AC141425.3         7249-7335           c
            555-675             AC155172.4         161525-161645
            676-810             AC155172.4         162270-162404
            811-922             AC155172.4         170809-170920
            923-1103            AC155172.4         174595-174775
            1104-1164           AC155172.4         180684-180744
            1165-1336           AC155172.4         183165-183336
            1337-1461           AC155172.4         186499-186623
            1462-1629           AC155172.4         188207-188374
            1630-1728           AC155172.4         190677-190775
            1729-1866           AC155172.4         191625-191762
            1867-2429           AC155172.4         193552-194114
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.81 cM"
     gene            1..2429
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /note="integrator complex subunit 9"
                     /db_xref="GeneID:210925"
                     /db_xref="MGI:MGI:1098533"
     exon            1..75
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2043
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /note="isoform 1 is encoded by transcript variant 1; int9"
                     /codon_start=1
                     /product="integrator complex subunit 9 isoform 1"
                     /protein_id="NP_700463.3"
                     /db_xref="CCDS:CCDS27210.1"
                     /db_xref="GeneID:210925"
                     /db_xref="MGI:MGI:1098533"
                     /translation="MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLV
                     QSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILIS
                     NYHCMMALPYITEHTGFTGTVYATEPTMQIGRLLMEELVNFIERVPKAQSASLWKNKD
                     IQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGY
                     ALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIPTANPDG
                     MVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSNIPFYFISPVAN
                     SSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYRSIHGDFSNDFRQPCV
                     LFTGHPSLRFGDVVHFMELWGKSSLNTIIFTEPDFSYLEALAPYQPLAMKCIYCPIDT
                     RLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQAHRMDLMIDCQPPAMSYRRAEVLALP
                     FKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHVLQPPPKPTQPTSSK
                     KRKRVNEDIPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAET
                     LIQIEEDSTHIICDNDETLRVRLRDLVLRFLQKF"
     exon            76..203
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            204..264
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            265..327
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            328..467
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            468..554
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            555..675
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            676..810
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            811..922
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1103
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1164
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1336
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1461
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1629
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1728
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1866
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2429
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /note="hexamer: AATAAA"
     polyA_site      2426
                     /gene="Ints9"
                     /gene_synonym="D14Ertd231e"
                     /note="major polyA site"
ORIGIN      
        1 aaaccggaag atccttccct gtctttagaa gtgaagagac tggtactgaa caaccaaaag
       61 tccgatatga aactgtattg cctgtcaggg cacccaactt taccatgcaa cgtactcaaa
      121 ttcaaatcca ctactattat gttggactgt ggactggaca tgacttccac cctcaatttc
      181 ctccctttgc ctcttgttca aagccccagg ctatctaatc ttcccggatg gtctctaaaa
      241 gacggaaatg cttttttgga caaggagcta aaagagtgct ccggtcatgt atttgtggat
      301 tctgtgcctg aattctgctt accagagacc gagctaatag acctgtctac agtcgatgtg
      361 atcctcatct ctaactacca ctgcatgatg gcgctgccct acatcaccga gcacacagga
      421 ttcacaggca cagtgtatgc cacagaaccc accatgcaga tcggcaggct tctcatggaa
      481 gagctggtga atttcatcga aagagtgcca aaggcccagt ctgcctcctt gtggaagaat
      541 aaggatatac agcggctgct gccttctccc ctcaaggatg cagtggaagt gtcaacctgg
      601 agaagatgct acacgatgca ggaggtgaac tcggccctca gtaaaatcca gctggtggga
      661 tattcccaga aaatcgagct gtttggtgct gtccaggtga cccctctgag ctctggctat
      721 gcccttggaa gctccaactg gattatccag tcacattatg agaaagtatc ttacgtctct
      781 ggatcctcct tgcttaccac acaccctcag cccatggacc aagcttctct caaaaacagt
      841 gacgttctga ttctcacagg gctgacacag atccctactg caaacccgga cggcatggtg
      901 ggcgagttct gcagcaacct cgctctgaca gttcggaatg gaggaaacgt gttggtccct
      961 tgctatcctt caggcgtgat ctatgacctc ctggagtgct tatatcaata cattgactcc
     1021 gctggcctct ccaacatccc tttctacttc atctcccccg ttgccaacag ttcactcgag
     1081 ttttcccaga tttttgctga gtggctttgt cacaacaaac agagtaaagt ttacctccca
     1141 gaaccacctt tcccacatgc agagctcatt cagacgaata agctgaagca ctaccgcagc
     1201 atccacggtg acttcagcaa tgacttcaga cagccgtgtg tgctgttcac cggacatcct
     1261 tccctccgct ttggggacgt cgtccacttc atggagctct gggggaagtc cagcctcaac
     1321 accatcatat tcacagaacc cgatttctcc tacctggagg ccttggctcc ttaccagccg
     1381 ctggccatga agtgcatcta ctgcccaatt gacactcgac tgaatttcat ccaggtgtca
     1441 aagctgctta aagaagtaca gcccctgcac gtggtctgtc ctgagcagta cacccagcca
     1501 ccgccagccc aggcccacag gatggacctc atgatcgact gccagccacc agccatgtcc
     1561 tatcgacggg ctgaggtcct tgccctgccc ttcaaacgac gctatgagaa aattgaaatc
     1621 atgccagagc tggcagactc cctggtgccc atggaaatca agcctggcat ctccttggcg
     1681 actgtctcag ctgtgctgca tacgaaggat aacaaacatg tgcttcagcc ccctcccaag
     1741 cccacccagc ccaccagcag taagaagagg aagcgggtga acgaggacat tcctgactgc
     1801 aaagtactga agcctctgct gagtggctcc atccccgtag agcagtttgt gcagaccctg
     1861 gagaagcatg gcttcagtga cattaaggtg gaagacacag ccaagggaca tattgtcctg
     1921 ctgcaggaag ccgagacact catccagatt gaagaagact ccactcacat catctgtgac
     1981 aatgacgaga cactgagggt ccgactgcgg gaccttgtcc tcaggttcct gcagaagttc
     2041 tgagtggcat ccgtgacatc ctaggccctt cacccagaga cagtctggtg gtgtcctatg
     2101 acttccggag aggagaggtg tctccagcta ggatctgcca gtgtgacttc ctcgtactgc
     2161 tgaccccaag aacgtttaga ggcctgttct tttcagttct gggctcctga gcagctatgg
     2221 gtgacaacat gacagacatc ctttcctaag ggaaatgaaa aaaaaaaaat gcctggcctg
     2281 tgtttttggg gctcacaggg ggtgactctc ggacttaccc tcctacagtg ctacaccgta
     2341 taaaggtcag cccccaaatt agaaggcaaa cctatctcgc tgttctgtgg cccgttttgc
     2401 taaaaataaa cattattttt ataaaagtg
//
