LOCUS       NM_001159595            4676 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus integrator complex subunit 8 (Ints8), transcript
            variant 1, mRNA.
ACCESSION   NM_001159595
VERSION     NM_001159595.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4676)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4676)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4676)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134643.1 and AK140829.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140829.1, BC057618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CJ134643.1         4-9
            7-4676              AK140829.1         2-4671
FEATURES             Location/Qualifiers
     source          1..4676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.08 cM"
     gene            1..4676
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /note="integrator complex subunit 8"
                     /db_xref="GeneID:72656"
                     /db_xref="MGI:MGI:1919906"
     exon            1..279
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3137
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /note="int8"
                     /codon_start=1
                     /product="integrator complex subunit 8"
                     /protein_id="NP_001153067.1"
                     /db_xref="CCDS:CCDS17967.1"
                     /db_xref="GeneID:72656"
                     /db_xref="MGI:MGI:1919906"
                     /translation="MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKACPD
                     PAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRVLKLLALKVAAHLKWDLDILEKS
                     LSVPVLNMLLNELLCISKVPPGTKHVDMDLSALPPTTAMAILLYNRWAIRTIVQSSFP
                     VKQAKPGPPQLNVMNQMQQEKELTENILKVLKEQAADCILVLEAALRLNKDLYVHTMR
                     TLDLLAVEPGTVNGETENSTAGLKIRTEEMQCQVCYDLGAAYFQQGSTDSAIYENARE
                     KFFRTKELLAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDNNSQQLTPYSQVHICLR
                     SGSYQEVVQIFIEDNLTFTLPVQFRQSVLRELFQKAQQGNEALDEICFKICVCNTVRD
                     VLEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSINVEKASDSLKGNMAAFLKNVCLGL
                     EDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVN
                     IGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSSVILGIKDNLT
                     RDLVYILMAKGLHCSTVKDFPHSKQLFTACLELVTEFSPKLRQVMLNEMLLLDIRTHE
                     AGVGQSGERPPSDLISRVRGYLEMRLPDIPLRQVVAEECVAFMLNWRENEYLTLQVPA
                     FLFQNNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSNQHKRGNDGRVS
                     LIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISI
                     WPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHAWLIIQADIYFATNQHSAALHYY
                     LQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFK
                     SLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPE
                     EVLQLAAQRRKKKFLQAMAKLYF"
     exon            280..454
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            455..595
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            596..667
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..719
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..902
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1010
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1166
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1267
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1409
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1480
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1656
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1790
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1901
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2103
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2225
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2410
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2444
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2501
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2563
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2682
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2786
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2837
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2911
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..2976
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3020
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..4676
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3197..3202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3221
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /note="major polyA site"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3677
                     /gene="Ints8"
                     /gene_synonym="2810013E07Rik; D130008D20Rik"
ORIGIN      
        1 ggatccgggg ccggactctg gccgactact acgccatctt gggctgtgcg agctgactag
       61 aggttccggg cggtttcgct ggataaaggg actgggcgag ggtcaggttg gagcccggag
      121 gcggcgggag cagcggcggc gggggcagga tgagcgcgga ggcggcggac cgggaggcgg
      181 ccacctccag ccggccctgc accccgccgc agacttgctg gttcgagttc ctgctggagg
      241 agtcgctgtt ggagaagcat ctgcgcaaag cctgtccgga tcctgcacca gttcagctta
      301 tagttcagtt tttggagcag gcttccaaac cttcagttaa tgagcaaaac caagtccagc
      361 ctccacctga taacaagaga aatcgcgtcc taaagcttct tgctcttaaa gttgctgcac
      421 atttgaagtg ggatttagac atactggaga aaagcctgtc tgttccggtg ctgaacatgc
      481 tgctgaatga gctcctgtgc atcagtaagg tccctcccgg gaccaagcac gtggacatgg
      541 atctgtcagc cctgccccca accactgcca tggccatcct gctctacaac cgatgggcaa
      601 ttaggacaat tgttcaaagt agttttcctg tcaaacaggc taaacctgga ccccctcaac
      661 taaatgtcat gaatcagatg caacaggaaa aagaactgac agaaaacatt ttgaaagtgc
      721 taaaagaaca agctgctgat tgtattttgg tcctggaagc agctctgaga ttaaacaagg
      781 atctgtatgt tcacacgatg agaactctag acttgctggc cgtggagcca ggcacggtga
      841 atggggagac tgagaactct acggctgggt tgaaaatcag aactgaggag atgcagtgcc
      901 aggtgtgtta tgacttgggt gcagcatact tccagcaagg ctccacagat tcagccatct
      961 atgaaaacgc aagagagaag ttttttagaa ctaaagaact acttgcagag ataggttcat
     1021 tatctcttca ttgtaccata gatgagaagc ggttagctgg ctattgtcaa gcgtgtgatg
     1081 ttcttgtacc ttcttctgat aataactctc aacaattgac tccatacagt caagtccata
     1141 tttgtttacg atctggcagc tatcaggaag tagtgcagat tttcattgaa gataacttaa
     1201 ctttcacttt accagtccag ttccgacaat cggtattaag ggaacttttt cagaaagctc
     1261 aacagggaaa tgaagctcta gatgaaatct gttttaaaat ttgtgtctgc aacacagtac
     1321 gagatgtact ggaaggcaga acaattagtg tccagttcaa tcaactattt cttagaccaa
     1381 acaaagaaaa aatagatttt ctccttgagg tatgttcaag atcaataaac gtagaaaaag
     1441 cttcagattc tctgaaagga aacatggctg cttttctaaa gaatgtgtgt ctggggttgg
     1501 aagatctgca gtatgtcttc atgatttcgt ctcatgagct tttcattaca ctgttgaaag
     1561 atgaagaacg aaagctgctt gttgatcaaa tgagaaagag atccccgaga gtaaatctgt
     1621 gcattaaacc tgtgacttca ttttatgata tcccagcctc agcaagtgtc aacattggcc
     1681 agttggaaca tcagcttata ttatcagtgg atccctggcg gattagacag attttaattg
     1741 aattgcatgg tatgacttca gagcgacaat tttggactgt gtcaaataag tgggaagtac
     1801 cttctgtata tagtagtgtt atcctaggaa ttaaggacaa tttaacaaga gatttggttt
     1861 acattctcat ggccaaaggt ttacactgca gtactgttaa ggactttcct cactccaaac
     1921 agctctttac agcttgtttg gagctggtga cagagttctc accaaaactc cgccaggtta
     1981 tgctgaatga gatgctgctt ttagatattc gcactcacga ggctggagtg gggcagtcag
     2041 gagagagacc tccttctgac cttatcagta gggtacgagg atatttggaa atgaggcttc
     2101 ctgatattcc ccttcgtcaa gttgtagctg aagagtgtgt tgcttttatg ctaaactgga
     2161 gagaaaatga atatcttact ctgcaagttc ctgcattttt atttcagaat aacccatatg
     2221 taaagcttgg acagctttta gcagccacct gcaaagaact tccaggccct aaagagagta
     2281 gacggaccgc taaagacctc tgggaagttg ttgttcagat ctgcagtgtg tctaaccagc
     2341 acaaacgagg aaatgatggc agagttagtt tgataaagca gagggaatcc acattaggca
     2401 taatgtatcg gagtgaacta ctttctttta tcaaaaaact ccgggaacca ctggttttga
     2461 ctattatttt atcactcttt gtgaagcttc acaatgttcg ggaggacatt gtgaatgata
     2521 tcacagccga gcacatttct atctggccat cttccatacc taacctccaa tccgtggatt
     2581 ttgaagctgt agcaatcact gtgaaagagc tagttcgata tacactcagt ataaatccaa
     2641 acaaccatgc ttggctaatt attcaagcgg atatttattt tgcaacaaat cagcattcgg
     2701 cagctcttca ctattacctc caggcaggag ctgtgtgctc tgacttcttt aataaggctg
     2761 tgcctcctga tgtatataca gaccaagtga taaaacgaat gataaaatgc tgttctttgc
     2821 tgaattgtca tacacaggtg gcaattttat gtcagttcct cagagaaatt gactacaaaa
     2881 cagccttcaa gtcattgcag gaacaaaaca gccatgacgc tatggattcc tactatgact
     2941 acatttggga cgtcacaatc ttggagtact tgacttatct tcatcataaa agaggagaaa
     3001 cagataaaag acagattgca atcaaagcca ttggccaaac agaattgaat gcaagcaacc
     3061 ctgaagaagt attacagctg gcagcacaga gaaggaaaaa gaagtttcta caagcaatgg
     3121 caaaacttta cttttaagca gttagttaat tttttttcaa ttttattttt taaacagtgg
     3181 gctaaaagta aacagtatta aaagattaag tttatataat acatatgtac aatttagtgg
     3241 tgttttcttt ttagaccaaa acaaactgaa acaaattagt ttataaacaa attatacaaa
     3301 aacttcatat cttaacaata gtttataatt tcttcaaaga gagacaaggt tcatgcctgg
     3361 taccattttt tttctaatga aattaacttt tttaggccca aatttccttt tcaaaggcta
     3421 acttaaaata tttaatgtat aagtagctat tctatataca gcaagtttaa ataaataaat
     3481 ttctaggagt aagtatacat ttaatatttt ctgccataag aaaatagttt aggtcatatg
     3541 ttaaagtttt ttcatgttga cacagtcctc atctcataat atggggctta aaaatggacc
     3601 accagttttg caaacataaa gcgccttaga gatatcttag tgtgcaataa agtgactttc
     3661 ttatatagtt tgaaaaagtg tttaatttta cccaaattgt gatacacaaa aagattataa
     3721 agcaaccttt ctatcaagta aaacccccga gtagaagaag ccaaagcatt tatatcttgt
     3781 ttataatttc tttggttctc ccatttagag cacagtttaa acatttggtt cagtgcctta
     3841 ctgattaaga aatatggcaa ggcagacaaa ctagttcaaa acagattgaa ctttaccatt
     3901 cataaaattc aagttttatc gtttgttaca aactgcttta gataaattag tcactttatt
     3961 acaaaacaac ctttgtaaat aagcttaaaa tttattttca aaaacaaatt gcaccattca
     4021 agagtatagg aatttaagaa tataaaatct agattcaaag ttctgtgtca gctaatgtat
     4081 cctttaaggt agcactagtt tagtccatat tccaatgata aaattcctag ttcatcaaaa
     4141 gaaatacagt aacactgaat tttaaagaaa cacagtaaca aacagaaaca actgctatag
     4201 cttaaattgt tggcttccat ccactatcct tgggagtgaa gtcacctttg taaacaagtt
     4261 ctcttttata ggaaatactt ctttagtgcc aattttttga agtttttgtt ttgtttcctt
     4321 ttgtagtgct ggggattgaa cccaggattt tgtgcatcct aggcatttag tgccaaattg
     4381 atatagtttt taagtaaaag aatggcagtg taactcctta gacaaggata gttacagcac
     4441 tacttttctg taaaactcat ttatatgaaa ctatccatta tttgttcaat tccaggttgt
     4501 taacttcagt gttttcctgg tggtttttca gtactctttg gtggtgtcat aatgcctcca
     4561 ttacacactg gtgacagctg ccctcctttt ctgtagatgt tcacatagtt tacttcattc
     4621 tgtacatgtg aagaaattat tcagtaatta acagttaaga taaactaagt atgtag
//
