LOCUS       NM_008715               5019 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus integrator complex subunit 6 (Ints6), mRNA.
ACCESSION   NM_008715
VERSION     NM_008715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5019)
  AUTHORS   Lachke,S.A., Alkuraya,F.S., Kneeland,S.C., Ohn,T., Aboukhalil,A.,
            Howell,G.R., Saadi,I., Cavallesco,R., Yue,Y., Tsai,A.C., Nair,K.S.,
            Cosma,M.I., Smith,R.S., Hodges,E., Alfadhli,S.M., Al-Hajeri,A.,
            Shamseldin,H.E., Behbehani,A., Hannon,G.J., Bulyk,M.L., Drack,A.V.,
            Anderson,P.J., John,S.W. and Maas,R.L.
  TITLE     Mutations in the RNA granule component TDRD7 cause cataract and
            glaucoma
  JOURNAL   Science 331 (6024), 1571-1576 (2011)
   PUBMED   21436445
REFERENCE   2  (bases 1 to 5019)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   3  (bases 1 to 5019)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 5019)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   5  (bases 1 to 5019)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   6  (bases 1 to 5019)
  AUTHORS   Hoff,H.B. 3rd, Tresini,M., Li,S. and Sell,C.
  TITLE     DBI-1, a novel gene related to the notch family, modulates
            mitogenic response to insulin-like growth factor 1
  JOURNAL   Exp Cell Res 238 (2), 359-370 (1998)
   PUBMED   9473344
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059263.1.
            
            On Aug 20, 2004 this sequence version replaced NM_008715.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059263.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.23 cM"
     gene            1..5019
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /note="integrator complex subunit 6"
                     /db_xref="GeneID:18130"
                     /db_xref="MGI:MGI:1202397"
     exon            1..565
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..3106
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /note="int6; DBI-1; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide 26"
                     /codon_start=1
                     /product="integrator complex subunit 6"
                     /protein_id="NP_032741.2"
                     /db_xref="CCDS:CCDS27191.1"
                     /db_xref="GeneID:18130"
                     /db_xref="MGI:MGI:1202397"
                     /translation="MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPA
                     SRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLN
                     RLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKE
                     PFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQ
                     CLESLVQKVQSGVVINFEKAGPDPPPAEEGQPDISRPFGSQPWHSCHKLIYVRPNPKT
                     GVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPL
                     TQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPL
                     LDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSY
                     SVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQVLQGIS
                     EDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKST
                     RKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKG
                     MMIDEADEFVAGPQNKHKRPGEPSMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPP
                     APMTQAQPGLIKPLPLHKEATNDSIVDDVVENHVADQLSSDMTPNAMDTEFLTSPPNL
                     LEPSTNHTEALGHEHLGNNDLTVGGFLENHEEPRNKEQSAEENIPASSLNKGKKLMHC
                     RSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKK
                     RMLIEQLENFLDEIHRRANQINHINSN"
     exon            566..643
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            644..793
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            794..883
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1067
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1193
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1348
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1501
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1634
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1729
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1840
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2053
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2180
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2323
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2555
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2918
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3012
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3155
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..4998
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3717..3722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /note="hexamer: AATAAA"
     polyA_site      3736
                     /gene="Ints6"
                     /gene_synonym="2900075H24Rik; Ddx26; DICE1; HDB; Notch2l"
                     /note="major polyA site"
ORIGIN      
        1 agtggtgaca ccgctggggt gcggagggag tctctcaaac ttctctcaac agccccaggg
       61 ccaatctccc ctcagcccac tcccctcttc gccagatccc tggtccccac tccctgcact
      121 gggggtgggg tggggaactg ggcccgtctc ccgcggggac acacacaggg tccgggagtg
      181 gggacgggac ccccaggccg ggggggacgg acggacagac ggccgcgcgg ccgccccagc
      241 gggcaggcag gccggaggcg ggggtacggc cgggaggacc tgggctgggg agtttcctct
      301 caactatcgg gggagaaact ccccatagct ggtgttttcc tcccgggggc cgcgttcccc
      361 gccccgcgta tcggcggttg ccgccgccgc cgccggtgct tccacctctg ccatctcttc
      421 accacctcgg gccccggtgt ccccggccag cactatgccc atcttactgt tcctgataga
      481 cacgtctgcc tctatgaacc agcgcagcca tctgggcacc acctacctgg acacggccaa
      541 aggcgcggta gagaccttca tgaagctccg tgcccgggac cctgccagca gaggagacag
      601 gtatatgctg gtcactttcg aagagccgcc ctatgctatc aaggctggat ggaaagaaaa
      661 ccatgcaacg tttatgaatg aactgaaaaa ccttcaggca gaaggactta cgactcttgg
      721 ccaatcccta aggacagctt ttgatttgtt aaatttaaat agattagtaa ctggcataga
      781 caactatggg cagggaagaa accccttttt cttggagcca gcaataataa ttacaatcac
      841 tgatgggagc aagttgacta ctactagtgg tgtccaggat gagcttcatt tacctctgaa
      901 ttcgccgttg cctggaagtg aattgaccaa ggaacctttt cgttgggatc agagactatt
      961 tgctttagtg ctgcggttgc ctggcaccat gtcggtggaa tcagaacagt tgacaggtgt
     1021 gcctttggat gattctgcta tcacaccaat gtgtgaagtg acaggaggcc ggtcatactc
     1081 tgtatgttct ccaagaatgc ttaatcagtg tctggaatcc ttggtgcaga aagtacaaag
     1141 tggggtggta ataaactttg aaaaggcagg accagatcct ccccctgctg aagaggggca
     1201 gccagatata tcaagacctt ttggatctca gccttggcat agctgtcaca agctcatata
     1261 tgtcagacca aatcctaaaa ctggggttcc tataggccat tggcctgttc cagagtcttt
     1321 ttggccagat cagaattctc caacactacc acctcgtaca tctcatcctg tagtgaagtt
     1381 ttcctgtaca gactgtgagc caatggttat tgacaaattg ccttttgaca aatatgagtt
     1441 ggaaccttca ccactgactc agtttattct agaaaggaaa tctcctcaaa cgtgttggca
     1501 ggtgtatgtg agcaatagtg caaagtataa tgaacttggc catccctttg gttacttgaa
     1561 agctagtaca gcactgacct gtgtcaactt atttgtgatg ccttacaatt acccagtcct
     1621 ccttcctcta ttagatgact tgttcaaagt gcacaaagca aaaccaactc tgaaatggag
     1681 acagtcattt gaaagttatt tgaagacaat gcctccctac tatcttgggc ccctgaagaa
     1741 agctgttaga atgatgggtg cacctaatct gatagcagac agtatggagt atggactcag
     1801 ttacagtgtc atttcatacc tcaaaaaatt gagtcaacag gccaaaattg aatctgatag
     1861 agtcatcgga tccgtaggca aaaaagtagt acaggaaact ggaattaaag tccgaagccg
     1921 gtcacatggg ttgtcaatgg cgcataggaa aggttttcaa gtgctgcagg gtatttcgga
     1981 ggatgtcccc cacaggttgc tagaccttaa tatgaaggag tacactgggt tccaggttgc
     2041 tttactaaat aaggatttga agcctcagac ctttagaaac gcttatgata taccaagacg
     2101 gaaccttctg gatcatttaa caagaatgag atcgaacctt ttaaagagca cccgcaaatt
     2161 tcttaaaggc caggatgaag atcaagtgca cagtgtacct atagcacaaa tggggaatta
     2221 ccaggaatac ctcaagcaag taccttctcc attgagagaa cttgatcctg atcagcctcg
     2281 aaggttgcat acatttggca atccctttaa actggataaa aagggtatga tgatagatga
     2341 agcagatgaa tttgtggctg gacctcagaa taaacacaag cggcctggag agccaagcat
     2401 gcaagggatc ccaaaaagac gccggtgtgc ctctccactc ttgagaggcc gaaggcagag
     2461 ccctgctgtg aacagtcaca tcggagggaa aggaccacct gcacccatga cgcaagcaca
     2521 gccaggtctt attaaacccc ttcctctgca taaagaagcc actaatgatt caatagtaga
     2581 tgatgtggtt gaaaatcatg ttgctgacca actttcatca gacatgacac caaatgctat
     2641 ggatactgaa tttttaacat ctccccctaa tcttttggaa ccatcaacca atcatacaga
     2701 ggcccttggt catgaacatt taggaaacaa tgacctcact gttggtgggt ttttagaaaa
     2761 tcatgaggag ccaagaaata aagaacaaag tgccgaagag aatataccag catcttcact
     2821 caacaaagga aagaaattga tgcattgtag aagccatgaa gaggtcaaca ctgaactaaa
     2881 agcacaaata atgaaagaga tcagaaagcc aggaagaaaa tatgaaagaa tcttcacctt
     2941 actgaagcat gtgcaaggca gtttacaaac aaggctaata ttcttacaaa atgtcattaa
     3001 ggaagcatcc aggtttaaga aacgaatgct aatagaacaa ctggagaact tcttggatga
     3061 aattcatcga agagccaatc aaatcaacca tattaatagc aattaaaaga aaatagaatg
     3121 aggccactta tttcattgtc ttctccaaat acaaaattgg gcatccttcc actggcctgt
     3181 gagcagaaag ccctgatttc ctccgttttc cgaggctggt gacaggcact tggcttggac
     3241 gaccacaccc aaaacactca cggaggagag aaccgaagag aatggggaga aaaagctata
     3301 tcccatattt taaaaagaaa gtgaggaaat atccttgggg aaactgctgc actttatgat
     3361 aaccaggagg ctctccaagg aggagcaaga ctcactttgg atgtgtgagt tacatagttg
     3421 gggtattact tgagtgtttc cacaaagctt cttcttgtgt tggaagcttg gctccctggg
     3481 taagtggtat tgagtgggtg gggcctttgg aaagttgggc ctaatagaag gtgaccaatc
     3541 tggacagccc ttgggaggtt taaacatagt tctgctgttg gttctcatga gagtgggtct
     3601 ctatgcagac cctaaattct gtcacatccc ttcttgctct gtggctgctt ctgccactgt
     3661 gatgccacca tctgtgtcct gatacagagc agagagactt tcagaactgt gagctgaata
     3721 aaatgtgtat attatataat gtgtgtgtgt gtgtgtatat actatattct aacatattag
     3781 ggaataaact gaaaagcaaa ttgatttata tctggattga taccttggac catgttagac
     3841 acagccaggg ttttgttgtt tgtcttttag acagggtctc actatgcagc cttggctagc
     3901 ttgggttgtt ctatatttct aaacatactg ctttctaact tcaaacattg tttttccaac
     3961 caataaaatg caggctagta caatatcata atctaatttt gtgaatgttt tcagctttct
     4021 cctttctcta cccagaagca agcattttat tcattgagta tattacttga cagtgttaat
     4081 cttccctgga ctatggctgt gattgtagga ttatggatac aaatgtccta taaacaccca
     4141 ttcttgatta tttaacagat tacatgttct taatgaaaac taactatcct tgtgcattta
     4201 attttataaa aaataattac tctggaagat ggcttcatag gtcacctcag aatactgctt
     4261 ggtggtgttc aaactcaagc tcaccctctg ggctcgtgcc aagtaacatg taacattgca
     4321 ttggtctcta cattgggctg ccactcactg agacctgtat gatgagcaca gagcacggaa
     4381 aatgaataat ttgagagagc tagaggtaag ttcttactca aaagctggct gtggagtggg
     4441 atgtagtaac ccccactttt aatcctgcca caaaaggcag aggcaggagg atctctgtga
     4501 gtttgaggcc agcctagtct acatagcaag ttacaggcta gccagggcta catagtgagc
     4561 ctctgtctaa ggagcaaaca agcaagtgaa cgaacaaact cttgatcata tctactgtgg
     4621 ttcaagctat atgtctaaat ccaaacctaa agcagtatta gcttttcaga ttagtccctc
     4681 aaacttccta atgctgtgac cctttaacac agttcttcac gttatggtga cctccaacca
     4741 taaaattatt tttgttgcta cttcaaaact gtaattttgc tactattatg aatcataatg
     4801 taaatatctg ctatgcgatc cctaagcagt catgacccac aaattgataa ccactgctta
     4861 aagaatttat atcttggctt tttgtttgat tgggtttttt tctctttggt ctggtctgga
     4921 gtgactgagt gagtgtgtgt ttctgtttgt gtaagattcg ttttgcttat gaaataaatg
     4981 gctttatttt cctaaaaaaa aaaaaaaaaa aaaaaaaaa
//
