LOCUS       NM_145540               4460 bp    mRNA    linear   ROD 11-JAN-2024
DEFINITION  Mus musculus integrator complex subunit 3 (Ints3), transcript
            variant 1, mRNA.
ACCESSION   NM_145540
VERSION     NM_145540.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4460)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY132895.1, AK146699.1, BC055344.1 and AI836764.1.
            
            [WARNING] On Jan 12, 2024 this sequence was replaced by
            NM_145540.4.
            
            On Mar 23, 2011 this sequence version replaced NM_145540.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146699.1, SRR1660815.20176.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               BY132895.1         5-298
            295-3801            AK146699.1         189-3695
            3802-4456           BC055344.1         3337-3991
            4457-4460           AI836764.1         19-22               c
FEATURES             Location/Qualifiers
     source          1..4460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.22 cM"
     gene            1..4460
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /note="integrator complex subunit 3"
                     /db_xref="GeneID:229543"
                     /db_xref="MGI:MGI:2140050"
     exon            1..833
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             687..3812
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /note="SOSS complex subunit A; sensor of ssDNA subunit A;
                     sensor of single-strand DNA complex subunit A"
                     /codon_start=1
                     /product="integrator complex subunit 3"
                     /protein_id="NP_663515.2"
                     /db_xref="CCDS:CCDS17528.1"
                     /db_xref="GeneID:229543"
                     /db_xref="MGI:MGI:2140050"
                     /translation="MELQKGKGTVAAAASGAAGGGGGGAGAGAPGGGRLLLSTSLDAK
                     DELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGPPQHEEICLGLFTLVLTEPAQ
                     AQKCYRDLALVSRDGMNIVLNKINQLLMEKYLKLQDTCRTQLVWLVRELVKSGVLGAD
                     GVCMTFMKQIAGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDH
                     HGTAQLQTLRQKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHN
                     PQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQ
                     YLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKL
                     ALFYDWLFFSPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGH
                     VRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRSMLREKFPEFCSSPSPPVEVKIE
                     EPVSMEMDNHLSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDV
                     TPYLDQLDESLRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQEL
                     FKAHFRGEVLPEEVTEESLEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQKQ
                     PKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHL
                     TPSIYTEFPDETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQS
                     LDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMV
                     KMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKALLIKNNSLPRKRQSLRSSSSKL
                     AQLTLEQILEHLDNLRLNLANTKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLA
                     EEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPTKRKR
                     KGSSAVGSDSD"
     exon            834..917
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1001
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1115
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1200
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1267
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1412
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1542
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1640
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1832
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1920
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2000
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2092
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2199
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2319
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2449
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2504
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2608
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2653
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2773
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2927
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..2996
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3072
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3186
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3235
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3403
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3504
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3577
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3734
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..4460
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4456
                     /gene="Ints3"
                     /gene_synonym="int3; SOSS-A"
ORIGIN      
        1 attggcagcc cgggaaaagg ccagtccgcc gtcgtcggct tactccttag agacctggcg
       61 ccaccgcgga agccgctatt ggcggacgcc cgggaccgcg actgctcact tccggcgccg
      121 gcgacgactc tgcccgctcg ggcactctca gcctcccccg cccttccacc atggccgcct
      181 ctgtgtggtg tggggagaag ctggtcctcc catagcgctc ctgctgcatc ctcacccgct
      241 aggggccgga ttccaaggaa ccgcgtttcc caatcccgcc gggaaggttt cccactccca
      301 attcagggcc aggactcctt cccacgcctc gagaggcaga aacttagggt ttcccctcct
      361 ttcaggataa gaagccagag ggtttccccc tccacttctg caagggtggc agccttgcct
      421 atctccctgc aggacacaag acccttagtc taccatactt ctgcgcaaaa gctttgcccc
      481 agcccggcca ctcctgaggg agcatctaga gaacccgcgc cttccccctc cgcaggagag
      541 gaggcaagag tgcggaaagc caggcctgtc ggcctccctc ccacttgttc ctcttgctcc
      601 tcgtccttgg caagccagag ttctccattt ctaggactta acacccgtct actcccttga
      661 cctcttctgg tctcttggct gcagccatgg agttacagaa gggaaagggg accgtagcag
      721 ctgctgcatc aggagcagcg ggaggtggag gaggaggagc gggagcagga gccccaggag
      781 gggggaggct gctactttca accagtttgg atgccaagga tgagttagag gagaggttgg
      841 aaaggtgcat gagtattgtc acatcgatga ccgctggtgt ctccgagaga gaggccaatg
      901 atgctctcaa tgcctatgtg tgcaaaggac ctccccagca tgaggagatc tgcctaggcc
      961 tgtttactct tgtcctcact gagcctgccc aagcccagaa gtgttaccgg gacttggctc
     1021 tggtgagtcg tgatggtatg aacatcgtcc tgaacaagat caaccagcta cttatggaga
     1081 agtacttgaa gctgcaagat acctgccgta ctcagttggt gtggttggtt cgggaactag
     1141 taaagagtgg agttctggga gctgatggcg tttgcatgac atttatgaag cagattgcag
     1201 gtggcgatgt tacagccaaa aatatctggt tggcagaaag tgtcctggat atcctgacgg
     1261 agcagaggga gtgggtgctg aagagcagca tcctcattgc catggctgtg tacacgtacc
     1321 tccgacttat tgtggaccac catgggactg cccagctcca gacccttcgg cagaaggaag
     1381 ttgacttctg catctccttg cttcgggaac ggttcatgga atgtttgatg attggccggg
     1441 accttgtaag attacttcag aatgttgcta ggataccaga atttgaacta ctgtggaaag
     1501 atatcatcca taaccctcag gccttgagtc ctcagtttac aggtatccta cagctacttc
     1561 agtcaagaac atcccgaaaa tttctagcct gtcgtctaac cccagacatg gaaacgaagc
     1621 tcctcttcat gacatcccgg gtgcggtttg gccagcaaaa gcggtaccag gactggttcc
     1681 agcgccagta cctctcaacc cctgacagtc agtctctgcg ctgtgacctc attcgataca
     1741 tctgtggggt agtccacccc tctaacgaag tgctgagttc tgatatcttg ccccggtggg
     1801 ccatcattgg ctggctcctg acaacatgca cgtccaacgt tgctgcctcc aatgccaagc
     1861 tggctttgtt ttatgactgg ctgttcttca gcccagaaaa ggatagtatt atgaacatag
     1921 agccagctat cctggtcatg catcactcca tgaagcccca cccagccatc actgccacgc
     1981 tcctggactt catgtgccga atcattccta acttctaccc accattggaa ggccacgttc
     2041 ggcagggtgt cttttcttcc ctcaaccaca ttgtggagaa acgagtcttg gcacacttgg
     2101 ctcccctgtt tgacaaccct aaattggata aagagcttcg gtccatgctt cgggagaagt
     2161 ttcctgagtt ctgcagctcg ccctcccctc ctgtggaagt caaaattgaa gagcctgttt
     2221 ccatggaaat ggacaaccac ctctcagata aggatgagag ttgctatgac aatgcagagg
     2281 cagccttcag tgatgatgag gaggatctta atagcaaagg gaagaagaga gagtttcgct
     2341 tccaccccat caaggagact gtcgtggagg agccggttga tgtcacccct taccttgatc
     2401 agttggacga gtccctgagg gacaaagtgc tacagctaca gaagggaagt gatacagagg
     2461 cccagtgtga ggttatgcag gaaattgtgg atcaggtcct ggaggaagac tttgactcgg
     2521 agcaactgtc tgtcctggct tcctgcctac aggagctctt caaggcccac tttcgagggg
     2581 aggtgttgcc tgaagaggtc actgaagagt ccctggagga gtcagtaggg aaaccactgt
     2641 acctaatatt taggaacctg tgccagatgc aggaggacaa cagcagcttc tcgctgcttc
     2701 tggaccttct ctccgagctg tatcaaaagc aacccaagat cggctaccac ctgctctact
     2761 acttgagggc aagcaaagcc gccgcaggga agatgaacct gtatgagtcg tttgcccagg
     2821 ctacccagct gggtgatctg cacacctgtc taatgatgga catgaaggcc tgccaagagg
     2881 atgatgtgcg actgctatgc cacctcacac cttccatcta cacagagttt ccagatgaaa
     2941 ctttgaggag tggggagctg ctgaacatga ttgtggctgt tattgactct gcacagctcc
     3001 aggagctggt ctgccatgtg atgatgggga acctggtcat gtttcggaag gactcagtcc
     3061 tcaacatact cattcagagc ctagactggg aaacgtttga gcagtactgt gcctggcagc
     3121 tcttcctggc ccacaacatc cccttggaga ccattattcc tattctccag cacctcaaat
     3181 acaaggagca cccagaggcc ctgtcctgtc tcctgcttca gctacggaga gagaagccga
     3241 gtgaggagat ggtgaagatg gtgctgagca ggccctgcca tcctgatgac cagttcacca
     3301 ccagcatcct gaggcactgg tgcatgaagc acgacgagct gctggcagag cacatcaagg
     3361 cgctgctcat caagaacaac agcctgcccc gcaagaggca gagcctaaga agctctagca
     3421 gcaagctggc ccagctgacc ctggaacaga tcctggaaca cttggacaac ctaaggctca
     3481 acctagccaa caccaagcag aacttcttta gccagacacc aatcctccag gcgctgcagc
     3541 atgtccaggc aagctgtgac gaagctcaca agatgaagtt cagtgacctc ttctccctgg
     3601 cggaggaata tgaggactct tccactaagc cacccaagag ccggcggaag gcagctctgt
     3661 ccagccctcg aagtcgaaag aatgctaccc agccccccaa tgctgaagag gagtcaggct
     3721 ccagcagtgc ctcggaggaa gaagatacaa agcctaagcc taccaaacga aaacgaaaag
     3781 gctcctctgc tgtgggttct gacagtgact gaggcctgga tccccaccct gccccagcct
     3841 gagaaaggtc catgcagccc cacctctcct ctcctcccag ggcctccagc tcttttcacc
     3901 ccctcttcac tgctgctccc actggtaggt tctcacagca accagaagct gtgcagaagc
     3961 agatcatggt ggaagtcctt tgccgccggc tcctccccaa gtctccgaag agccatttgg
     4021 acagagaaag gagtgatgaa gaggctgctg ggcagaggag ctggggtgac agcagatgct
     4081 gtgtgagtgg gcatttcccc ctgcttcctg tcagtctgca tttgtagtct gtggacggtg
     4141 gtcattacac cagtgtgaag tgggcatctg acctggtgtg ggcggtgccc atctgggcag
     4201 atgccacagc cttcagaaaa gaacccaatg gcagcgtgag aggctcttgc tgcacctggg
     4261 atgcttgggt tggcccggca ttggcacttc aagctgagcc agagcccagg ggagtcctgg
     4321 aggcaagttc ctcagaactg tcagatggcc tgattttctg tggttctgtt tttgcttttt
     4381 cttttggcaa agataatcga gttttaaatt gtttttaagt gataatgaaa caagccagaa
     4441 catcttttgt gcctgagttg
//
