LOCUS       NM_172726               2343 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus integrator complex subunit 15 (Ints15), mRNA.
ACCESSION   NM_172726
VERSION     NM_172726.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Azuma,N., Yokoi,T., Tanaka,T., Matsuzaka,E., Saida,Y., Nishina,S.,
            Terao,M., Takada,S., Fukami,M., Okamura,K., Maehara,K.,
            Yamasaki,T., Hirayama,J., Nishina,H., Handa,H. and Yamaguchi,Y.
  TITLE     Integrator complex subunit 15 controls mRNA splicing and is
            critical for eye development
  JOURNAL   Hum Mol Genet 32 (12), 2032-2045 (2023)
   PUBMED   36851842
  REMARK    GeneRIF: Integrator complex subunit 15 controls mRNA splicing and
            is critical for eye development.
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Wang,F., Tan,P., Zhang,P., Ren,Y., Zhou,J., Li,Y., Hou,S., Li,S.,
            Zhang,L., Ma,Y., Wang,C., Tang,W., Wang,X., Huo,Y., Hu,Y., Cui,T.,
            Niu,C., Wang,D., Liu,B., Lan,Y. and Yu,J.
  TITLE     Single-cell architecture and functional requirement of alternative
            splicing during hematopoietic stem cell formation
  JOURNAL   Sci Adv 8 (1), eabg5369 (2022)
   PUBMED   34995116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053801.1 and CJ315714.1.
            
            On Mar 21, 2008 this sequence version replaced NM_172726.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053801.1, AK087531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2207              AK053801.1         2-2208
            2208-2343           CJ315714.1         280-415
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.07 cM"
     gene            1..2343
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /note="integrator complex subunit 15"
                     /db_xref="GeneID:231868"
                     /db_xref="MGI:MGI:2442621"
     exon            1..458
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /inference="alignment:Splign:2.1.0"
     exon            459..680
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /inference="alignment:Splign:2.1.0"
     exon            681..846
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1371
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1411
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..2343
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /note="hexamer: AATAAA"
     polyA_site      2214
                     /gene="Ints15"
                     /gene_synonym="A630028N22; E130309D02Rik; Ents15"
                     /note="major polyA site"
ORIGIN      
        1 ccctgcgggc cgccgtcgcc attcagccgc cggttcggcc gagcggcgtc ggctcccgcg
       61 gctctgggcg gcgccgcagt cggaccccag gatactcgct ggcccgtggc ggcggcggca
      121 gcggcgacga tggtcccctg agcgggttgg cgcctgttag aggcgggcgg gcgccgcgac
      181 cctgcccgcg tcggggccca ggccggtcgc gcctctttgt ctccgggcgg aagtaggact
      241 cgcggcgggg acagggcggc cgcaccatga gcgacatccg ccactcgctg ctgcggcgcg
      301 acgcgctgag cgccgccaag gaggtgctgt accacctgga catctacttc agcagccagc
      361 tgcagagcgc gccgttgccc atcgtggaca agggctccgt ggagctgctg gaggagttcg
      421 tgttccaagt gcccaaggag cgcggcgcgc agcccaagag actgaattcc ctccaggagc
      481 tccagcttct tgaaatcatg tgcagttact tccaggagca aagcaaggac tctgtgcggc
      541 agatcatttt ctcctccctt ttcagccccc aagggaacaa agccgacgac agccgaatga
      601 gcttgttggg aaagctggtc tccatggccg tggccgtgtg tcggatcccc gtgttggaat
      661 gtgcggcctc ctggctccag cggacgcccg tggtctactg cgtgaggctt gccagagtgc
      721 ttgtggagga ctactgctgt ctggtgccgg gctccgttca gacactgaag cagatcttta
      781 gtgccagtcc tcgtttctgc tgccagttca taacgtccgt gaccgccctc tacgacctgt
      841 catcagatga cctcatccca cctttggact tgcttgaaat gattgtcagc tggattttcg
      901 aggacccgag gctgattctc atcacatttt taaatactcc catcgccgcc aacctgccca
      961 taggattttt agagctcaca cccctcattg ggctgatccg gtggtgcgtg aaggcccctc
     1021 tggcttacaa aaggaagaag ccttgcctat ccaatggcca catcagtcac aaggttgcca
     1081 aggactcggg tgccagcacg gacagagact cgcacttgct gtactcaaag ctccacctga
     1141 gcgtcctgca ggtcctcatg acgctccagc tgcacctcac agagaaaaac ctgtacgggc
     1201 gcctggggct catcctgttc gaccacatgg tcccgcttgt ggaggagatc aacagactag
     1261 cagatgaact gaaccccctc aatgcctccc aggagatcga gcttgccctg gaccgcttgg
     1321 cccaggcctt gcaggtggct atgacgtcgg gggccctgct gtgcacgaga gatgacctga
     1381 gaaccttgtg ctcccggctg ccccataaca acctgctcca gctggtgatc tcgggcccag
     1441 tgcagcagtc gccacacacc gctcttcccc ctgggttcta cccgcatatc catactcccc
     1501 cgctggccta tggggctgtg ccagcgcacc cagctgccca cccagccctg cctacgcacc
     1561 cagggcacac cttcatctca ggtgtgacct tcccgttcag gcccatccgc taggctggcc
     1621 cttccaagcc aagccgccaa gcggctgtgt gccttgctcc cagaccaagg aagcccttgg
     1681 agagagggat gctggccccg tggacaagga ccctgggagg cagcaggtgg tccttccagc
     1741 tggcagaacc atcttggtac tgatgtccca agttgctgtt tccggggtgc ctcctacctg
     1801 gtcatattaa atatccagat tggatgatga aagcgagtgg gctccaccct ctgcagagag
     1861 cactgtgggt gtttttagat atgccagtct gtgagtgaca gttgtcacac acagacactc
     1921 tcagctcgcc accagggtgt gctggtgggt aagccggtgc ctgcgggtcc atttgccctg
     1981 cctcaggaat gtgaagtgtc tctgccacca acagcgtttt ctgcagctcc atgagctcag
     2041 agtgcagagg gtgagaccca gctcgtacgc agtactgggc acagctcagg gacacctgtt
     2101 gggattcccc atcaccttgg agaggatctg tgtcttatgg ggggtgggga ggcgggtatc
     2161 taaattttcc tttcatgtgt tcaaaataaa tttttctaaa cagtttcata ggcattgtgg
     2221 ggttttcatt ttgtggtgct gagattcaag ctcatggcgt gcacctactt agcaggcgtg
     2281 ttttcagtga gctatacccc agccctatgg aacatacatc tttaattaaa ttttaaggat
     2341 ttg
//
