LOCUS       NM_027927               3099 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus integrator complex subunit 12 (Ints12), mRNA.
ACCESSION   NM_027927
VERSION     NM_027927.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3099)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3099)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3099)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 3099)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY155830.1, BY273040.1, AK003874.1, BX521801.1, AK015941.1 and
            BQ174479.1.
            
            On Feb 26, 2016 this sequence version replaced NM_027927.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023801.1, SRR1660811.202931.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY155830.1         1-8
            9-80                BY273040.1         2-73
            81-1641             AK003874.1         3-1563
            1642-2065           BX521801.1         103-526
            2066-3080           AK015941.1         345-1359
            3081-3099           BQ174479.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.56 cM"
     gene            1..3099
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /note="integrator complex subunit 12"
                     /db_xref="GeneID:71793"
                     /db_xref="MGI:MGI:1919043"
     exon            1..122
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     exon            123..287
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1517
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /note="PHD finger protein 22"
                     /codon_start=1
                     /product="integrator complex subunit 12"
                     /protein_id="NP_082203.1"
                     /db_xref="CCDS:CCDS17848.1"
                     /db_xref="GeneID:71793"
                     /db_xref="MGI:MGI:1919043"
                     /translation="MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGID
                     SSYRPTQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLTAEKIKKEAEKRPAD
                     KMKDVTEGIDVPKKPRLEKPETRSSPITVQTSKDLSMADLSSFEETSADDFAMEMGLA
                     CVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRM
                     AQKTQKPPQKPAPTVVSVTPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNS
                     SSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSAAQNSSGKPAASSSNQKPVGLTG
                     LATSSKGGIGSKIGSGNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSL
                     VPGGSSQLSGNGNSATTGPSGSTTSKATSETSSSTSASLKGPTSQESQLNAMKRLQMV
                     KKKAAQKKLKK"
     exon            288..440
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     exon            441..625
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     exon            626..785
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     exon            786..932
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     exon            933..3086
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1626..1631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /note="hexamer: AATAAA"
     polyA_site      1644
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /note="major polyA site"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /note="hexamer: ATTAAA"
     polyA_site      1689
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
     regulatory      3059..3064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
                     /note="hexamer: AATAAA"
     polyA_site      3086
                     /gene="Ints12"
                     /gene_synonym="1110020M19Rik; 2810027J24Rik;
                     4930529N21Rik; A230056J18Rik; int12; Phf22"
ORIGIN      
        1 tcggaaacgt tccccttccg acctgttgcg ggaacctttg tttctctctt cttaaagctg
       61 gtgagggcgg ggacggattc gaagagagct accgggaacc gaccgagtgg cggggcggag
      121 cggtgtttgc aatggctgct actgtgaact tggaacttga tcccattttt ctgaaagcac
      181 taggtttctt acattcaaag agtaaagatt ctgctgaaaa gctaaaagcg ttgcttgatg
      241 agtctttggc tcggggcatt gattccagtt accgtccaac tcaaaaggat gtggaaccac
      301 ccaaaatttc aagtacaaaa tcactttcta ttaagcaaga gcccaaaaca tcatctagcc
      361 tcccttccgg cagtagtaac ggcaaagtcc tcacagctga gaagataaag aaggaggctg
      421 agaagagacc tgctgataag atgaaagatg tcactgaagg aattgatgtt ccaaagaaac
      481 ctagactgga gaagccagag acacgatcct ctcccattac tgtccaaacc agcaaggatt
      541 tgagtatggc tgacctctcc agctttgagg agactagtgc tgatgacttt gccatggaga
      601 tggggttggc ctgtgttgtt tgtagacaaa tgaccgtggc atctggaaac caactggtag
      661 aatgtcaaga gtgccataac ctctaccacc aagactgcca taagccccag gtgacagaca
      721 aagaagtgaa tgaccctcgc ctggtgtggt actgtgcccg gtgcactaga cagatgaaga
      781 gaatggctca gaaaactcag aagccaccac agaaaccagc gcccactgtt gtttctgtga
      841 ctccaactgt caaggatcca ttagtcaaga agccagaaac caaacttaaa caagagacaa
      901 ccttcctagc attcaagaga accgaagtta agccatccac ggttatttca ggaaattctt
      961 ctagtaacaa cgtgtcctct tcagtaacta gtggcctaac tggatgggca gcttttgcag
     1021 ccaaaacttc ttcagctggt ccatcaacag caaaattgaa ttcagcagca caaaacagta
     1081 gtggaaaacc tgctgcctca tcctctaacc agaagcctgt gggtttgact ggtctggcaa
     1141 catcatccaa aggtggaata ggttccaaaa taggttctgg taacagcact agcccctctg
     1201 tcccgttgaa accgcttcca ccactaacct taggcaagac tggcctgagt cgctcagtga
     1261 gttgtgataa cgtcagcaaa gtgggtcttc ctagtcctag tagtttagtt cctggaggca
     1321 gcagccaatt gagtgggaat ggaaatagtg ctacaacggg gcccagtgga agtaccacca
     1381 gcaaagccac atcagagacc agcagcagta cctcagcatc tcttaaaggt ccaacttctc
     1441 aagaatcaca gctcaacgca atgaagcgat tacagatggt caagaagaaa gctgcccaaa
     1501 agaaactcaa gaagtaatat ggccagatag atttttatat catattactc taaaacttaa
     1561 aaaacaaaac aaaacaaaca aaataaaacc cttactggga caaaagttgt aatgtactgt
     1621 accttaataa aaatcttgat caaatctcta ttgtttgtta cattaaaatg ctaatattat
     1681 ttagccaaac ttggatctat ttatttcagt ctgtttagca tttttaattt ccatagtgtg
     1741 tgaaaatagt gattataatg actgatgcat gacaagagct tcaagaaatt gatggcgcat
     1801 acagatgaaa agaaatggct cacctggtac cttatgggtg gcagggacaa ctcaatagaa
     1861 agtgttccag cgttttataa aatctgaaat gttcagtgtc agtcattgtc ctcatgtcag
     1921 ctagtatctc tctccaatta cctcctcttt tatcaaaatt aattttgaaa gtgatttccc
     1981 atagctccct atcatgtctt tagctctcaa ccacccctta tcaattactt agggcgttat
     2041 ttattccagt agattatgaa tgctcataca gtatactttc tcacgttgcc cactttccgt
     2101 acctggccag tgtgtggata tgtgcagata tgtacattta ataaatgctg acttggctca
     2161 tcctggttgc acattctgag aatcattgag aagagtatcc atttccaaga ggcttggcag
     2221 atgggcattt atgactagtt tgcacccagc ttcttcctca tggtgaaagg acaagctgtt
     2281 tttaatactt caagaacgtt tggtgtggtt tatctttgta tgaaagaggc tcctacctaa
     2341 tgattagtcc ttgaggtttc tgtcagaacg tgctcatatg ctttgaatat tgttaggata
     2401 tggtttgtct taaggtttta tgtgttagga agcataatcc ccaatatggc aatggagttg
     2461 gtggttgaca ggtggagcct gttgggggaa gagtatgccc ttgggaagga ttaattagtc
     2521 ctcatatgtc cactgactaa ttctggccaa gagtggagtt ataaaaggct atcccagaat
     2581 tgacccttgg gcaaaatctc ctctgaactc ttgccgtgat gtgatcctat atacatggtc
     2641 caagccattg tcttgtaagc taatgaatta cccattagtt tacatatata tatgtatata
     2701 tgtacatacc ccaacagaga atactttctg tatctgacca gtaaatgtat tatagaaaaa
     2761 tagcttcctt tcttttttat aatcaatgaa tacctcatta tttcccaaaa atgaatcttg
     2821 tgatttccta tattcattga gtcaaattgc tttaaatcta atctcagtgt atctttatcc
     2881 ctagatgttc taacatcatt attctaaaaa taaattgata atcattgtaa aagagaaaac
     2941 ttttaaatta agcttggtct ttttctatgg aagtatttta aactgttaaa taatggcgtt
     3001 aaattgttca taataaatta gaaaccaata ttgaaataaa ctcaaaattt agagatggaa
     3061 taaatatcta tttatatact taaaaaaaaa aaaaaaaaa
//
