LOCUS       NM_027590               4201 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus integrator complex subunit 10 (Ints10), transcript
            variant 3, mRNA.
ACCESSION   NM_027590
VERSION     NM_027590.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   2  (bases 1 to 4201)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040574.1, AK014939.1 and AC123813.4.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_027590.5.
            
            On Sep 12, 2014 this sequence version replaced NM_027590.3.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (3) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040574.1, AK030974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AK040574.1         2-83
            83-2435             AK014939.1         59-2411
            2436-4201           AC123813.4         141588-143353
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..4201
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /note="integrator complex subunit 10"
                     /db_xref="GeneID:70885"
                     /db_xref="MGI:MGI:1918135"
     exon            1..220
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2224
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     int10"
                     /codon_start=1
                     /product="integrator complex subunit 10 isoform 3"
                     /protein_id="NP_081866.1"
                     /db_xref="CCDS:CCDS22342.1"
                     /db_xref="GeneID:70885"
                     /db_xref="MGI:MGI:1918135"
                     /translation="MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQY
                     EMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSL
                     FETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETI
                     EEQDSPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQSEN
                     QHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSHIVDPWERLFKILNVVGMRCEWQMDK
                     GRRSCSDLLHRMKELCRYMNSFDSEAHNNYKNQVLYSTMLVFFKSAFQYVSSIQPSLF
                     QGPNAPSQVPLILLEDVANVYGDVEIDRSKHIHKKRKLAEGREKTMSSDDEECSAKGR
                     NRHIVVSKADLSNSIEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRI
                     FLTDMIIYQGQYKKAIASLHHLAALQGSLSQPQITGQGTLEHQRALIQLATCHFALGE
                     YRMTCEKVLDLMCYMVLPIQDGGKPQEEPSKVKPKCRKGLDLKLLPCTSKAIMPYCLH
                     LMLACFKLRAFTDSRDDMALGHVIVLLQQEWPRGENLFLKAISKICQQGNFQYENFFS
                     YVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQ
                     VSRCGENLMAVLHRFCINEKILLLQTLT"
     exon            221..288
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..392
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            393..532
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..614
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            615..755
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..927
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1097
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1231
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1385
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1468
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1621
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1730
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1810
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1973
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2067
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..4201
                     /gene="Ints10"
                     /gene_synonym="4921521J11Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggttggct ggtctctggg catgcgcagt ggccacctgg gggttggcgg cgccctagtg
       61 tcgcctactg gaagggcaaa aacccgggac catgtcggcc cagggcgact gtgagtttct
      121 ggtgcagcga gcccgggaac tagtgcccca ggacctgtgg gcagccaagg catggctgat
      181 cacggcccgc agcctctacc cggccgactt caacatccag tatgaaatgt acaccatcga
      241 acggaatgcc gagaggactg ccaccgcagg gaggttgctg tatgacatgt ttgtgaattt
      301 cccggaccag ccggtggtat ggagagaaat cagcatcatc acgtcagcat tgaggaacga
      361 ctcacaagat aagcagaccc agttcttacg gagtttattt gaaacccttc ccggtcgggt
      421 ccagtgtgaa atgttgttga aggtgacaga gcaatgcttc aacacgctgg aacgatcaga
      481 aatgttgctg ctgctgctga ggcgtttccc tgagacagtg gtgcaacacg gggttggcct
      541 cggggaggcc ctgctggaag ctgaaaccat tgaagaacaa gactctcctg ttaactgctt
      601 tagaaagcta tttgtttgtg atgtccttcc tctaataatc aacaaccatg atgtccgctt
      661 gcccgccaat ctcttatata aatacttgaa caaagcagct gaattttaca tcaactatgt
      721 cactcggtcc acacagtcag aaaatcagca tcaaggtgca caggatacat ctgatttaat
      781 gtcgcctagc aagcgtagct ctcagaagta cataatagaa ggactgactg agaaatcatc
      841 ccacatcgtc gacccctggg agaggttgtt taagattctg aatgttgttg gaatgagatg
      901 cgaatggcag atggataaag ggagacgaag ctgcagtgac ctgctgcacc ggatgaagga
      961 gctctgcaga tacatgaaca gctttgacag cgaagctcac aacaactata aaaaccaagt
     1021 gctctactcc acgatgctgg tgttcttcaa gagtgcgttc cagtacgtca gcagcataca
     1081 gccatctctc ttccaaggtc ctaacgcccc aagccaggtt ccactaattc ttctggaaga
     1141 tgtggccaat gtgtatggtg atgtagaaat tgatcgcagt aaacacatac acaagaagag
     1201 gaagctagct gagggaagag aaaaaaccat gagttcagat gatgaagagt gttcagcgaa
     1261 aggcagaaac cggcacattg ttgtcagcaa agctgacctc agcaactcca tcgaagtact
     1321 ggagagcttc aaactggcca gggaaagctg ggagttactc tactctctgg aattccttga
     1381 caaagaattt acaagaattt gcttggcttg gaagacagac acctggctgt ggctaagaat
     1441 cttcctcaca gatatgatca tctaccaggg tcaatataag aaggccatag ccagtctgca
     1501 tcacttagca gctctgcaag gatccctttc tcagccacag atcacaggac aggggacttt
     1561 agaacaccag agggcgctca tccagctggc aacgtgtcac tttgctctgg gggagtacag
     1621 aatgacgtgc gagaaagtcc tagatctgat gtgttacatg gtgctcccca tacaagatgg
     1681 cgggaagcca caggaagagc cgtccaaagt aaagcccaag tgtagaaaag gtttggatct
     1741 gaagcttctg ccctgtacca gtaaggctat catgccatac tgcctgcact tgatgctggc
     1801 ctgctttaag ctgagagctt ttacagacag cagagacgac atggcactgg gccatgtgat
     1861 tgtactgctc cagcaggagt ggccacgggg agagaacctt ttcctgaaag ccatcagtaa
     1921 gatttgccag caaggaaatt tccagtatga gaacttcttc agctatgtta caaacattga
     1981 tatgctggag gaatttgctt atttaagaac ccaagaagga gggaagattc atctggaatt
     2041 actcccaaat caaggaatgc tgatcaagca ccacacagtc actcgaggca tcaccaaagg
     2101 tgtgaaggag gacttccgcc tggccatgga gcgccaggtc tcccgctgtg gtgagaacct
     2161 gatggcggta ctacatcgct tctgcattaa tgagaagatc ttgctcctgc agactctgac
     2221 ctgatagacc tcctggccac cagcggctca gccatgacaa gcgctgccag accagggctg
     2281 atgaagaaga aaaacaccaa gttctaactc ccttagttgc ttaaaagtca atccgaagag
     2341 tataggaagt tatttctatt tttaagactt caggtttttt tagtttgtac aaaataagat
     2401 tcaatccatt ttgtaaataa aaacccgaaa gatttgaagt tttaaaaaaa aacttatttt
     2461 tagtttcaag tagggtacat ttgtcttcta tttttctaat catggcaaag gggcaaaaat
     2521 ccaacacaat taaatgcagg aatgaatttt ttgatatatt tacctaatgg aatatgtctt
     2581 ccatgacctc aggtgtgttt tattgatatg ctttggtaag tattacacat caggataaca
     2641 ttggaccttt cgttttattt atgcacagtt gaacttgggc ctgtcctgtc cctgctgaga
     2701 gcccattgca ggcatggtac tctatagtct ctgaaaagac aggatgagaa atatcggaga
     2761 cagcaaagtg caggggaccc tcctctctgc tggggcctct ggaagtcagt ctggctctgt
     2821 ggactctcct aggcccttgg ggccgtgcat cactgcttga cagccatctg gcaccctgcc
     2881 ctgccctgct ctgccctgcc ctgccctgcc ctgccctgcc ctgtacttgt ctgtgtgatc
     2941 aagaatgaac atgtgcaaac acagacacac acacacacac acacacacac acacagagca
     3001 actagaatta tgttttctag gtgctgccaa agactaggtt gttttacaga tattttctaa
     3061 aaagaacagg cattcttatt tcttccaaag gtcactctag tgtatgttct gggtcttaac
     3121 ttatggaggc ataggtctta ggtataaagg attttcttgt taaatcaact gtcataattt
     3181 gaatagtgtc acccaaaggt cattgtgttc aaactggccc taacttcaca ctagtttagt
     3241 gtgtcacaca tacatttaac gatggttact tatagacagt cagtaggggt ttctattttt
     3301 tttttaattt cacttattta tttcctgctt tatgggcccc agcaagctgg agaatagaca
     3361 gaagaaaaat aaagtgattt catgatttga gtgttattgt ccatattcca ttaataaaac
     3421 aaaggtaaaa aggtcacata gtagtttata tttaacggtt acattcctaa tggatgccaa
     3481 gttcagatgt gagtgacatg ccaggtcacc ttgagcccag tggagggctt ccctttcgtt
     3541 gagagcagct ttgtggcttg ttacccatga aaagaaatga ctggtgaaaa ccaaggtgct
     3601 aatgttttag ccagaactcc aagtcagcca gctgcccaga gccttgcttg tcaagggaga
     3661 cagctccaca cctccgagaa ccttgagtta atgttctggg ctacagtcaa cagtcacatg
     3721 ctgtgaccta tagtttggcc agtgtgctct ggaatgctgc ttgggccagt gtgagcagaa
     3781 atttttgtta gaaattcaac atagtgttga caccttatgg ttttgtgtat cttcttaagt
     3841 ttggaacttg agataatact aaagaatgcc tcagtggttt taagcaaaag taaaggaagt
     3901 aaggtttatc tgtgtgacct ttcccttcag cctgactctg cctcccttca aatcaagacc
     3961 tgagttgact ttttacctgg aatacacttc tgtgactcaa gactctgctg ggatggcttt
     4021 tctgagaaca ggaacctggt gtgcgggtgc tgggtctgag gtcagttcac cacaaatcgg
     4081 gtgaaaatta actttgatac actaaactgt agaaacagct gttagcttct gaatgacctg
     4141 tactctcact ggtcagttat tggtttacat aataaaataa ttctaacatt tgttaactct
     4201 a
//
