LOCUS       NP_081024               2195 aa            linear   ROD 12-JUN-2024
DEFINITION  integrator complex subunit 1 [Mus musculus].
ACCESSION   NP_081024 XP_132471
VERSION     NP_081024.4
DBSOURCE    REFSEQ: accession NM_026748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2195)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   2  (residues 1 to 2195)
  AUTHORS   Hata,T. and Nakayama,M.
  TITLE     Targeted disruption of the murine large nuclear KIAA1440/Ints1
            protein causes growth arrest in early blastocyst stage embryos and
            eventual apoptotic cell death
  JOURNAL   Biochim Biophys Acta 1773 (7), 1039-1051 (2007)
   PUBMED   17544522
REFERENCE   3  (residues 1 to 2195)
  AUTHORS   Nakayama,M., Iida,M., Koseki,H. and Ohara,O.
  TITLE     A gene-targeting approach for functional characterization of KIAA
            genes encoding extremely large proteins
  JOURNAL   FASEB J 20 (10), 1718-1720 (2006)
   PUBMED   16807365
REFERENCE   4  (residues 1 to 2195)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167333.3.
            
            On Aug 31, 2021 this sequence version replaced NP_081024.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB257854.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2195
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.8 cM"
     Protein         1..2195
                     /product="integrator complex subunit 1"
                     /note="int1"
                     /calculated_mol_wt=245038
     Region          1..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            13
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N201; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            47
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q8N201; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            83
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8N201; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            87
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N201; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Region          267..297
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N201; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Region          352..432
                     /region_name="DUF3677"
                     /note="Protein of unknown function (DUF3677); pfam12432"
                     /db_xref="CDD:463578"
     Region          923..947
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            926
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N201; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            1165..1185
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Region          1313..1347
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            1320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            1328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     Site            1329
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4S8.2)"
     CDS             1..2195
                     /gene="Ints1"
                     /gene_synonym="1110015K06Rik"
                     /coded_by="NM_026748.3:286..6873"
                     /db_xref="CCDS:CCDS57399.1"
                     /db_xref="GeneID:68510"
                     /db_xref="MGI:MGI:1915760"
ORIGIN      
        1 mnrakpttvr rpsaaakpsg hpppgdfial gskgqasesk ttstllkpap sglpserkrd
       61 asaslsgtsa ltgltkrpkl sstpplsalg rlaeaavaek raispsikep svvpievlpt
      121 vlldeieaae legnddrieg vlcgavkqlk vtrakpdstl ylslmylaki kpnifategv
      181 iealcsllrr dasvnfkakg nslvsvlacn llmaayeede nwpeifvkvy iedslgeriw
      241 vdsphcrtfv dniqtafntk mppksvllqg egarsggelg agssphpslt eeedsqtell
      301 iaeeklspeq egqlmprpry deltesveey vldmlrdqln rrqpidnvsr nllrlltatc
      361 gykevrllav qrlemwlqnp kltrpaqdll msvcmncnsh gsedmdvish likirlkpkv
      421 llnhymlcir ellnahkdnl gttikfvifn elsnarnpnn mqilytvlqh sselapkfla
      481 mvfqdlltnk ddylrasral lreiikqtkh einfqafclg lmqerkepqy lemefkerfv
      541 vhitdvlavs mmlgitaqvk eagvawdkge krnlevlrtf qnqiaaiqrd avwwlhtvvp
      601 svsklapkdy vhclhkvlft eqpetyykwd nwppesdrnf flrlcsevpi ledtlmrvlv
      661 iglsrelplg padameladh lvkraaavqa ddvevlkver iqlidavlnl ctyhhpeniq
      721 lppgyqppnl aistlywkaw plllvvaafn peniglaawe eyptlkmlme mvmtnnysyp
      781 pctltdeetr teminrelqi sqrekqeila feghlaaast kqtitesssl llsqltsldp
      841 qgpprrppph ildqvkalnq slrlghllcr srnpdfllhi iqrqassqsm pwladlvqss
      901 egsldvlpvq clcefllhda adstasgeed degesreqka kkrqrqqkqr qllgrlqdll
      961 lgpkadeqtt cevldyflrr lgssqvasrv lamkglslvl segglrdkee keppmeedig
     1021 etdalqgyqw llrdlprlpl fdsvrtttal alqqaihmet dpqtisayli ylsqhtpvee
     1081 qgphsdlald varlvverst imahlfskps cstasdavls allsvfsryv rrmrkskege
     1141 evyswsesqd qvflrwssge tatmhilvvh amvilltlgp prsgdsefse lldiwfpekk
     1201 plptaflvdt seealllpdw lklrmirsev prlvdaalqd lepqqlllfv qsfgipvssm
     1261 skllqyldqa vaqdpqtleq nimdknymah lvevqherga sggqtfhsll taslpprrds
     1321 teapkpessp epppgqgrtr agtqvpvlgp eddlagiflq ifplspdprw qsssprplal
     1381 alqqalgqel arvrqgnpev pgitvrllqa mttllssphg gtlalamhhs hflscplmrq
     1441 lyqyqravpq dtgfsslflk vlmqilqwld spavedgplq aqlklfatry sarhrisdvr
     1501 sgllhladal sfhgdlevan staraviatl rsgekcpvep eliskvlrgl ievrsphlee
     1561 lltalfsatt etscpspasg pivvvsslll qekeellgps kqevegaste amrlgpasgl
     1621 lvdwletldp evvcscpdlq wkllfsrrkg kghisaqvls frpyllallt hqaswstlhc
     1681 cirvllgksr eqrldpsasl dflwacihvp riwqgrdqrt pqkrreelvl hvqgpellsl
     1741 velilseaet rsqdgdsaar tliqtrlpll lsccrsndes igkvtehlts ciqqwgdsvl
     1801 gqrcrdlllq lylqrpevrv pvpevllqse gatsssickl dglvhrfitl ladtsdsrss
     1861 esrvadanma crklavahpv lllrhlpmia allhgrthln fqefrqqnhl afflhvlgil
     1921 ellqprvfqs ehqgalwdcl rsfirlllny rkssrhlapf iskfvqfihk yvgcsapaav
     1981 aflqkhaepl hdlsfdnsdl vmlksllagl slpsrdgrtd qgldeegede rsagslplvs
     2041 vslstpltva dvaphmkrls rgravedvle tlsdidemsr rrpevlgffs tnlqrlmssa
     2101 eescrnlafs lalrsiqnnp siaadflptf myclgsrdfe vvqtalrnlp eytllcqeha
     2161 avllhraflv gvygqidtsa qisealkilh meavm
//
