LOCUS       NM_176921               2177 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus inhibitory synaptic factor 1 (Insyn1), mRNA.
ACCESSION   NM_176921 XM_976531
VERSION     NM_176921.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Uezu,A., Hisey,E., Kobayashi,Y., Gao,Y., Bradshaw,T.W., Devlin,P.,
            Rodriguiz,R., Tata,P.R. and Soderling,S.
  TITLE     Essential role for InSyn1 in dystroglycan complex integrity and
            cognitive behaviors in mice
  JOURNAL   Elife 8, e50712 (2019)
   PUBMED   31829939
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Uezu,A., Kanak,D.J., Bradshaw,T.W., Soderblom,E.J., Catavero,C.M.,
            Burette,A.C., Weinberg,R.J. and Soderling,S.H.
  TITLE     Identification of an elaborate complex mediating postsynaptic
            inhibition
  JOURNAL   Science 353 (6304), 1123-1129 (2016)
   PUBMED   27609886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031382.1 and BC096614.1.
            
            On Jan 18, 2019 this sequence version replaced NM_176921.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031382.1, SRR11927938.4064808.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1873              AK031382.1         3-1875
            1874-2177           BC096614.1         1298-1601
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.79 cM"
     gene            1..2177
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /note="inhibitory synaptic factor 1"
                     /db_xref="GeneID:319477"
                     /db_xref="MGI:MGI:2442108"
     exon            1..637
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            638..1361
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1206..2084
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /note="UPF0583 protein C15orf59 homolog"
                     /codon_start=1
                     /product="inhibitory synaptic factor 1"
                     /protein_id="NP_795895.1"
                     /db_xref="CCDS:CCDS23243.1"
                     /db_xref="GeneID:319477"
                     /db_xref="MGI:MGI:2442108"
                     /translation="MNIRGAPDLGQPSDDPNSGGERERIRQRMKMVIGQLEGILRELK
                     EVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGVGGPFDLGHLDFMT
                     ADILSDSWEFCSFLDVSTPSDSVDGPEAPRPGTGPDYQLMNGGLPIPNGPRVETPDSS
                     SEEAFSAGPAKGQVPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEGEEEEEGDLAP
                     ELPRVEPHTGPLKPSPAPYKTKRSPLTTRRLGPTLAPEQTRRVTRNSSTQTVSDKSTQ
                     TVLPYTATKQKAKGKN"
     exon            1362..2177
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="Insyn1"
                     /gene_synonym="6030419C18Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggactttccc caccgttgat ggagccgact gccgggctgg actgagcggt ttctgcggcc
       61 gctccagacg tcgcccgggc cggagcacgg acattctggg tcccggctga gtacaccccg
      121 gacacctagc agtgccagct cgggaagggc agagcaaggc aaaggcagga cagaccccgg
      181 aggggctcag acctgcccat ctagaatgga cagagagaat cgcgaaccct gtggagcccg
      241 gggaatgccg ggcgtgggct gaggggatcc cggcgccctc cccagccctc cgactttggc
      301 ttagtcgcct ggaccggacc ggtgtcacct cggctcgggt cacctgtggc ctcggggcct
      361 ccgagctcgc cggaccctcg cgaccgggag cctggcgagc gtggtgagga gatttttggg
      421 gatttttttt ttttgccccc ttccccggag cgcggaggcc ccgccccctc ccaccgccca
      481 gatgtctccg gtcaccgctc ggaagacctt cctgaggcca ggagccgaag ggtccagaga
      541 gagaagcccg ccctagggag ccttgggggc cccccaacct cgtcttgtgg ctcggccccg
      601 acactgctta gaggaaaggc cactgccccc acccttgggg gctgccctcc tccaatccag
      661 ttccctctcc agtgctgttc acatctggag ccccctccac atctggaaga tcctgatcac
      721 cgtccctgtg ctggttcagc tgcatctaga gacctctgcc tttgtaactg cctaggagtt
      781 gcgaggggat tgctgccttc ccccatccca agggcatctc ttacccttag tccttgcaga
      841 atcatccccc tgcctccgca tccagattcg ggcaaagatc agctctgtac accataggca
      901 cttcaagtcc tggaagctgt tcttgggccc taaggcccct ccccttgccc tcctgtgtcc
      961 tcaccttgac ccccctccca ccctgtcaga ctctgtctcc ctctgggtgc tccatccccc
     1021 acccagaggc gagtaggtgg agtggcaggc tgcaggggct gggtgagggc cgcccaaggc
     1081 cagggtaggc tggggggccg ttaaaatgtg gagctctgcc cggccgaggg gggctccgtg
     1141 gaggcagacg aagcgtgtgc cccgctgggg cgagtatggg caggcttgcg gccacgtggt
     1201 gaaggatgaa cattcggggt gccccggacc tcgggcagcc cagtgacgac cccaacagtg
     1261 gtggagagag agagcggatt cgacagcgca tgaagatggt catcgggcaa cttgaaggca
     1321 tcctgagaga actcaaagaa gtggctaagg agctgaggga ggtggtgagt cagatcgaca
     1381 agctaacctc tgactttgac tttgaactgg agccagatga ctggaccacg gccactgtga
     1441 gcagcacctc cagcagtgac aaggcaggtg tgggcggccc ctttgacctg ggccacctgg
     1501 acttcatgac ggctgatatc ctctcagaca gctgggagtt ctgttctttc ctggatgtct
     1561 ccaccccatc agactcggtg gatggccccg aggcgccacg gccaggcaca ggccctgact
     1621 accagctcat gaatggtggt ttgcccatcc ccaacgggcc acgagtggag acaccagact
     1681 cctccagtga agaggccttc agtgctggcc ctgcaaaggg ccaggtgccc cagcggactc
     1741 cagggacgag ggagagggta cggttcagtg acaaagtgct ctaccatgct ctgtgctgtg
     1801 acgatgaaga gggggatggt gaggagggag aggaggagga ggagggggac ctggccccag
     1861 agctgccccg cgtggagcca cacacaggcc ccctcaagcc ctccccagcc ccctacaaga
     1921 ccaagcgctc tccgttgacc acccgacgct tgggccccac gttggcccca gaacagaccc
     1981 ggagggtcac aaggaacagc agcactcaga cagtatcaga caagagcacg cagacagtgc
     2041 tgccctatac ggccaccaaa cagaaagcta agggcaagaa ctaggggctt gggggggggg
     2101 gcgggggatg catagaggta taaatatata tatatattta aacaaacaca gtcataataa
     2161 aattcataaa cacttaa
//
