LOCUS       NM_011832               5102 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus insulin receptor-related receptor (Insrr), mRNA.
ACCESSION   NM_011832
VERSION     NM_011832.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5102)
  AUTHORS   Gantsova,E.A., Gavrilenkova,A.A., Serova,O.V. and Deyev,I.E.
  TITLE     Changes in the Expression of the gapdh Gene in the Organs of insrr
            Knockout Mice
  JOURNAL   Dokl Biol Sci 505 (1), 113-118 (2022)
   PUBMED   36038798
  REMARK    GeneRIF: Changes in the Expression of the gapdh Gene in the Organs
            of insrr Knockout Mice.
REFERENCE   2  (bases 1 to 5102)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   3  (bases 1 to 5102)
  AUTHORS   Deyev,I.E., Popova,N.V., Serova,O.V., Zhenilo,S.V., Regoli,M.,
            Bertelli,E. and Petrenko,A.G.
  TITLE     Alkaline pH induces IRR-mediated phosphorylation of IRS-1 and actin
            cytoskeleton remodeling in a pancreatic beta cell line
  JOURNAL   Biochimie 138, 62-69 (2017)
   PUBMED   28438671
  REMARK    GeneRIF: The activation of IRR by alkali might be part of a local
            loop of signaling between the exocrine and endocrine parts of the
            pancreas where alkalinization of the juice facilitate insulin
            release that increases the volume of secreted juice to control its
            pH and bicabonate content.
REFERENCE   4  (bases 1 to 5102)
  AUTHORS   Zubkov,E.A., Morozova,A.Y., Chachina,N.A., Shayahmetova,D.M.,
            Mozhaev,A.A., Deyev,I.E., Chekhonin,V.P. and Petrenko,A.G.
  TITLE     [Behavioral Phenotype of Mice with Alkali Sensor IRR Gene Knockout]
  JOURNAL   Zh Vyssh Nerv Deiat Im I P Pavlova 67 (1), 106-112 (2017)
   PUBMED   30695555
  REMARK    GeneRIF: The obtained data suggest that the IRR gene inactivation
            results in disturbances of the aggressive-defensive behavior
            typical of the parental mouse strain c57bl.
REFERENCE   5  (bases 1 to 5102)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 5102)
  AUTHORS   Nef,S., Verma-Kurvari,S., Merenmies,J., Vassalli,J.D.,
            Efstratiadis,A., Accili,D. and Parada,L.F.
  TITLE     Testis determination requires insulin receptor family function in
            mice
  JOURNAL   Nature 426 (6964), 291-295 (2003)
   PUBMED   14628051
  REMARK    GeneRIF: the insulin receptor tyrosine kinase family, comprising
            Ir, Igf1r and Irr, is required for the appearance of male gonads
            and thus for male sexual differentiation
REFERENCE   7  (bases 1 to 5102)
  AUTHORS   Kitamura,T., Kido,Y., Nef,S., Merenmies,J., Parada,L.F. and
            Accili,D.
  TITLE     Preserved pancreatic beta-cell development and function in mice
            lacking the insulin receptor-related receptor
  JOURNAL   Mol Cell Biol 21 (16), 5624-5630 (2001)
   PUBMED   11463843
REFERENCE   8  (bases 1 to 5102)
  AUTHORS   Tsuji,T., Katoh,H. and Kunieda,T.
  TITLE     The insulin receptor-related receptor (Insrr) gene maps to mouse
            chromosome 3
  JOURNAL   Exp Anim 50 (4), 359-360 (2001)
   PUBMED   11515104
REFERENCE   9  (bases 1 to 5102)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   10 (bases 1 to 5102)
  AUTHORS   Hirayama,I., Tamemoto,H., Yokota,H., Kubo,S.K., Wang,J., Kuwano,H.,
            Nagamachi,Y., Takeuchi,T. and Izumi,T.
  TITLE     Insulin receptor-related receptor is expressed in pancreatic
            beta-cells and stimulates tyrosine phosphorylation of insulin
            receptor substrate-1 and -2
  JOURNAL   Diabetes 48 (6), 1237-1244 (1999)
   PUBMED   10342810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142578.1 and AB007135.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011832.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007135.1, BC137855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1412              AK142578.1         2-1413
            1413-5102           AB007135.1         1302-4991
FEATURES             Location/Qualifiers
     source          1..5102
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.7 cM"
     gene            1..5102
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /note="insulin receptor-related receptor"
                     /db_xref="GeneID:23920"
                     /db_xref="MGI:MGI:1346037"
     exon            1..558
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..4376
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /EC_number="2.7.10.1"
                     /note="insulin receptor-related protein; IR-related
                     receptor"
                     /codon_start=1
                     /product="insulin receptor-related protein precursor"
                     /protein_id="NP_035962.2"
                     /db_xref="CCDS:CCDS17454.1"
                     /db_xref="GeneID:23920"
                     /db_xref="MGI:MGI:1346037"
                     /translation="MAVPALWPWGVHLLMSLLSLGSGLDTLEVCPSLDIRSEVTELRR
                     LENCSVVEGHLQILLMFAATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLT
                     VIRGTRLFLGYALIIFEMPHLRDVGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLLQP
                     APGTNHIVGNKLGEECADVCPGVLGAAGEPCSRTTFSGRTDYRCWTSSHCQKVCPCPR
                     GMACTAGGDCCHSECLGGCSQPEDPRACVACRHLYFQGVCLRACPPGTYQYESWRCVT
                     AELCAHLREVPGLATTFGIYEGSCLAQCPPGFTRNGSSIFCHKCEGLCPKECKVGTKT
                     IDSVQATQDLVGCTHVEGNLILNLRQGYNLEPELQRNLGLVETITGFLKIKHSFALVT
                     LGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQLGSWVTAGLTIPVGKIYFAFNPRLCL
                     EHIYQLEEVTGTRGRQSKAEINPRTNGDRAACQTRTLRFVFNLTEEDRILLRWERYEP
                     LEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLAPLK
                     PWTQYAVFVRAITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVR
                     WKPPVQRNGNITYYLVLWQRLAEDGDLYINDYCHRGLRLPTSSHDTRFDREDPALEAE
                     PEQGCCPCQHSPPGQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRD
                     SERHRREAGLLRLGKNNSDFEIQEDKVPRERAILSGLRHFTEYRIDIHACNHAAHTVG
                     CSAATFVFARTMPHREADGIPGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRL
                     GEEATVLCVSRLRYAKVGGVHLALLPPGNYSAKVRATSLAGNGSWTDGVTFYITDLEE
                     EDTGGMRIFLTVTPVGFMLLVTLAALGFFYSRKRNSTLYTSVNPEYFSASHMYVPDEW
                     EVPREQIAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKE
                     ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPA
                     LSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYY
                     RKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF
                     VMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQDELRPSFRLCSFYYS
                     PECQRGQASLLPTEAEPDSPPTLNGASDYSAPNGGPGH"
     exon            559..1110
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1414
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1557
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1702
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1917
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2044
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2283
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2451
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2647
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2689
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2910
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3047
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3210
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3316
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3369
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3599
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3710
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3870
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4000
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4135
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..5102
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5074..5079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /note="hexamer: AATAAA"
     polyA_site      5097
                     /gene="Insrr"
                     /gene_synonym="Irr"
                     /note="major polyA site"
ORIGIN      
        1 gcggccggtc gaccgagagt ggaagtctgc atgtccagga ggtccgcgga gtgtctcggg
       61 gtggagtgct gcgggtgtct cgggaccccg ctgccgcccc ttggggcact cccggggctc
      121 accgggggct tccactctgc ctcccctcag gactgcctgg actgtctgga tctttgtgtt
      181 ctgaatcatc ctccctctgg atgcctctct gaggctcctc cactcctatc tgcatctctg
      241 tcccagtatc tgtctctgga ccacactgag gctgtctcta gctgcttgtc acaggctttg
      301 tttcctctgt tccgaaattc ttttctatct cccgcggtct ctatttgaga tctctaatcc
      361 ctttgccttt gtgtgtcgtc gtcgtcccca cccctgccac ttcacactgg aacctgggtc
      421 tgcatcctcc tttctccctg gaggatacct ggaagacaac cagggctgag gtcatggcag
      481 tgcctgctct gtggccctgg ggagtacact tgcttatgag cctgctgtcc ttgggatctg
      541 gcctggacac actagaggtg tgccccagcc tggatatccg ctcggaggtg accgagctcc
      601 gtcggctgga gaactgcagt gtggtggagg gtcacctgca gatccttctt atgtttgctg
      661 ccactggaga ggatttccga ggcctcagct ttcctcgcct tacccaggtg actgactacc
      721 tgctgttgtt ccgagtctat ggcctggaga gccttcgaga cctcttcccc aacctcactg
      781 tgatccgagg cacccggctc ttcctgggct acgcactcat tatctttgag atgccccacc
      841 tacgggacgt cgggctgccg tcgcttgggg ccgtgctgcg tggggccgtg cgtgtggaga
      901 agaaccagga actttgccat ctctccacca ttgactgggg tctgctgcag cctgcacctg
      961 gtaccaacca cattgtagga aacaagctgg gcgaggagtg tgcagacgtg tgccccggtg
     1021 tgctgggagc tgctggtgag ccctgttcga gaaccacctt cagcgggcgc actgactaca
     1081 ggtgctggac gtccagccac tgtcagaaag tgtgtccctg cccccgaggg atggcctgca
     1141 cagcaggcgg tgattgctgc cacagtgagt gtctgggggg ctgcagccag cctgaagacc
     1201 ctcgagcctg tgtagcttgc cgccacctct acttccaagg agtctgcctc cgagcctgcc
     1261 ctccgggcac ctaccaatat gagtcctggc gctgtgtcac cgcggagctc tgcgctcatc
     1321 tgcgtgaggt tcctggactt gccaccacct tcggcatcta cgagggcagc tgcctagctc
     1381 agtgccctcc aggcttcacc cgcaatggca gcagcatttt ctgccataag tgtgagggcc
     1441 tgtgccccaa agagtgcaag gttgggacaa agaccatcga ctctgtccaa gccacacagg
     1501 acctggtggg ctgcacccac gtggagggaa acctcatcct caaccttcgc caaggctaca
     1561 atctggagcc agagcttcaa cgcaacctgg gtctggtgga gaccatcact ggcttcctca
     1621 aaatcaagca ctcttttgca ctcgtgaccc tgggcttttt caagaacctc aaactaatcc
     1681 ggggagattc catggtggat gggaattaca ctctctacgt attggacaac cagaacctgc
     1741 aacagttggg atcctgggtg accgcggggc tcaccattcc cgtgggcaaa atatacttcg
     1801 ccttcaaccc acgcctctgc ttggagcaca tataccaact ggaggaggtg acgggaacca
     1861 gaggtcggca gagcaaggct gaaatcaacc cccggaccaa tggagatcgg gctgcctgtc
     1921 agactcgcac tctacgtttt gtgttcaacc tgacggagga agaccgcatc ctcctgcgct
     1981 gggagcgcta tgagccactg gaggcccgtg acctgctcag cttcattgtc tattacaagg
     2041 agtccccatt tcagaatgcc acagaacacg tgggtccaga tgcctgtgga acccagagct
     2101 ggaacctgtt ggatgtggaa ctacccctca gccgcaccca ggaaccaggg gtaaccctgg
     2161 ccccccttaa gccctggaca cagtatgctg tgtttgtgcg ggccatcaca ctgaccaccg
     2221 ctgaggacag tccccatcag ggagcccaga gccccattgt ctacctgcga acattgcctg
     2281 ctgcacccac ggtgccccaa gatgtcatct ccacctccaa ctcctcttcc cacctcctgg
     2341 tgcgctggaa gccaccggtc cagcgcaatg gaaacatcac ctactacctg gtgctgtggc
     2401 agcgcctggc ggaggacggt gacctctaca tcaatgacta ctgccaccgc ggtctgcggc
     2461 tgcccaccag cagccacgac acacgcttcg accgtgaaga cccggcgctg gaggctgagc
     2521 cggaacaagg ctgctgtcct tgccaacact cacctcctgg gcaggccctg cctgcactgg
     2581 aggctcaaga ggtcaccttc cagaaaaaat ttgaaaactt cctacaccat gccatcacca
     2641 tccccaaggc tccatggaaa gtgacatcca tcaacaagaa cccccaaagg gattcggaga
     2701 ggcaccgcag ggaagctgga cttctcagac tagggaaaaa caactcggat tttgagattc
     2761 aagaggacaa ggttccccgg gagcgagcga tattgagcgg cttacggcac ttcacagagt
     2821 acaggattga catccatgcc tgcaaccacg ctgcgcacac tgtgggctgc agcgccgcca
     2881 ccttcgtctt tgcacgcacc atgccacata gagaggccga tggcatcccg gggaaagtgg
     2941 cctggaaggc agctggcaag agcagtgtca ccttgcattg gcttgaacca cctgacccca
     3001 atgggctcat tctcaagtat gaaatcaagt accgacgtct gggagaggag gccacagtgc
     3061 tttgtgtgtc ccgtcttcga tatgccaaag tcggtggagt ccacctggct ctgctgcccc
     3121 ctggaaacta ctctgctaaa gttcgggcca cctcgttggc tggcaatggt tcctggactg
     3181 acggtgttac cttctacatc accgatctag aggaagagga taccgggggg atgcgcatct
     3241 tcctcactgt cacccctgtg gggttcatgc tgctcgtgac acttgctgcc ctcggtttct
     3301 tctacagcag aaagagaaac agcacgctgt acacatccgt gaaccccgag tatttcagtg
     3361 catcccacat gtatgtcccc gacgagtggg aggtgcctcg ggagcagata gccatcatcc
     3421 gggagctggg ccaaggctct tttgggatgg tctatgaggg actggcccga ggacttgagg
     3481 ctggagagga gtccacgcct gtagccctga agacagttaa tgagctggcc agcgctcggg
     3541 aacgcgttga attcctcaag gaagcatctg tcatgaaggc attcaagtgt caccatgtgg
     3601 ttcgtctcct gggtgtggtg tctcagggcc agccaactct ggtcatcatg gagttaatga
     3661 cccgtgggga cctcaagagc catctccgat ctctgagacc tgaggcagag aacaaccccg
     3721 gcctcccgca gcctgcactc agtgacatga ttcagatggc aggggaaatt gcagatggca
     3781 tggcctacct tgctgccaag aagtttgtgc accgggacct ggcggcccgc aactgcatgg
     3841 tgtcccagga tttcacagtc aaaattggtg actttggaat gactcgggat gtgtatgaga
     3901 cagactatta ccgcaagggt ggaaaagggt tactgccagt gcgctggatg gcccccgagt
     3961 ccctcaaaga tggaatcttc accactcact cagatgtctg gtccttcggt gtggtgctct
     4021 gggagattgt gaccctggcc gaacaaccat accagggtct atcaaatgag caggtgctga
     4081 aatttgtcat ggatggtgga gttctagagg agctggagaa ctgtccgatt cagctacaag
     4141 agctgatgag actctgctgg cagcatagtc cacgcctgcg cccgactttc gtccacatcc
     4201 tggatcgcat acaggatgag cttcggccct ctttccggct ctgctccttc tactacagcc
     4261 cagagtgcca gcggggtcag gcctccttgc tgcctactga ggcagaacct gattccccac
     4321 caaccttaaa tggagcttca gactatagtg ccccaaatgg gggcccagga cactgacgag
     4381 tcaacctttt cccacctgac tggcctccca cgggcagaga aggcagaacc caacctttat
     4441 ggccagctgt tcccctctca cctcgagtcc ccctcagacg agtcaagaat tagctcagca
     4501 ctcacagaga tcaggtgcca gaaagggagg catctgaact cacaaatgca cagactcaca
     4561 gagacagcgt gtgggagatc atgagaggct gcagcaggag ggactctcag gccatagggc
     4621 agaagtgctc tgccctcaga gagaaacact ggtcagactg agaaagctag ctcatgggag
     4681 gcagggtcca gagacacacg cctccaactt caggtggtta acagcttgaa agcaaatgag
     4741 tggccagaga caggcctggg aggtctctcc actcatgttg gggcctgggg acaaggattc
     4801 cttctttccc tgtggttggc tcctccccct ctgtcccaca taccaggaca aagcaggaac
     4861 cctaggaccc tcactcctct ccccctgctc tacccaggga ccccaagctt ggtgctcctc
     4921 cttcttttgc cttaagagca tccctcaatg tgcagtctcc ccatttccag ctgtcccctg
     4981 gattattagc cctggatgct agggctttga gagccttgtc tccctctctc ccatctccca
     5041 tgcagcctct ctggggaaga ctggagaaga ctcaataaat acggaggtct gtttgtatct
     5101 gg
//
