LOCUS       NM_010568               9355 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus insulin receptor (Insr), transcript variant 1, mRNA.
ACCESSION   NM_010568 XM_621862
VERSION     NM_010568.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9355)
  AUTHORS   Warmke,N., Bridge,K.I., Ozber,C.H., Smith,J., Platt,F.,
            Haywood,N.J., Skromna,A., Makava,N., Yuldasheva,N.Y.,
            Wheatcroft,S., Kearney,M.T., Cubbon,R.M. and Griffin,K.J.
  TITLE     Insulin receptor signalling in PDGFRbeta-expressing cells
            influences systemic metabolism and negatively impacts lipid storage
  JOURNAL   Biochem Biophys Res Commun 735, 150799 (2024)
   PUBMED   39406023
REFERENCE   2  (bases 1 to 9355)
  AUTHORS   Ardanaz,C.G., de la Cruz,A., Minhas,P.S., Hernandez-Martin,N.,
            Pozo,M.A., Valdecantos,M.P., Valverde,A.M., Villa-Valverde,P.,
            Elizalde-Horcada,M., Puerta,E., Ramirez,M.J., Ortega,J.E.,
            Urbiola,A., Ederra,C., Ariz,M., Ortiz-de-Solorzano,C.,
            Fernandez-Irigoyen,J., Santamaria,E., Karsenty,G., Bruning,J.C. and
            Solas,M.
  TITLE     Astrocytic GLUT1 reduction paradoxically improves central and
            peripheral glucose homeostasis
  JOURNAL   Sci Adv 10 (42), eadp1115 (2024)
   PUBMED   39423276
REFERENCE   3  (bases 1 to 9355)
  AUTHORS   Goedeke,L., Strober,J.W., Suh,R., Paolella,L.M., Li,X.,
            Rogers,J.C., Petersen,M.C., Nasiri,A.R., Casals,G., Kahn,M.,
            Cline,G.W., Samuel,V.T., Shulman,G.I. and Vatner,D.F.
  TITLE     High-fat-diet-induced hepatic insulin resistance per se attenuates
            murine de novo lipogenesis
  JOURNAL   iScience 27 (11), 111175 (2024)
   PUBMED   39524330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9355)
  AUTHORS   Kim,H.R., Jeong,J.K. and Young,C.N.
  TITLE     Cellular Profile of Subfornical Organ Insulin Receptors in Mice
  JOURNAL   Biomolecules 14 (10), 1256 (2024)
   PUBMED   39456189
  REMARK    GeneRIF: Cellular Profile of Subfornical Organ Insulin Receptors in
            Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9355)
  AUTHORS   Zhang,W., Wang,X., Tian,S., Wang,J. and Zhou,A.
  TITLE     Fetuin-B Interacts With Insulin Receptor-beta and Promotes Insulin
            Resistance in Retina Cells
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 16 (2024)
   PUBMED   39382879
  REMARK    GeneRIF: Fetuin-B Interacts With Insulin Receptor-beta and Promotes
            Insulin Resistance in Retina Cells.
REFERENCE   6  (bases 1 to 9355)
  AUTHORS   Rappolee,D.A., Sturm,K.S., Behrendtsen,O., Schultz,G.A.,
            Pedersen,R.A. and Werb,Z.
  TITLE     Insulin-like growth factor II acts through an endogenous growth
            pathway regulated by imprinting in early mouse embryos
  JOURNAL   Genes Dev 6 (6), 939-952 (1992)
   PUBMED   1317321
REFERENCE   7  (bases 1 to 9355)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   8  (bases 1 to 9355)
  AUTHORS   Weiland,M., Bahr,F., Hohne,M., Schurmann,A., Ziehm,D. and
            Joost,H.G.
  TITLE     The signaling potential of the receptors for insulin and
            insulin-like growth factor I (IGF-I) in 3T3-L1 adipocytes:
            comparison of glucose transport activity, induction of oncogene
            c-fos, glucose transporter mRNA, and DNA-synthesis
  JOURNAL   J Cell Physiol 149 (3), 428-435 (1991)
   PUBMED   1660482
REFERENCE   9  (bases 1 to 9355)
  AUTHORS   Howard,T.A., Rochelle,J.M., Saunders,A.M. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 8: further definition of
            homologous linkage relationships between mouse chromosome 8 and
            human chromosomes 8, 16, and 19
  JOURNAL   Genomics 10 (1), 207-213 (1991)
   PUBMED   1675193
REFERENCE   10 (bases 1 to 9355)
  AUTHORS   Sibley,E., Kastelic,T., Kelly,T.J. and Lane,M.D.
  TITLE     Characterization of the mouse insulin receptor gene promoter
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9732-9736 (1989)
   PUBMED   2602374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY733217.1, J05149.1,
            AK077054.1, AK164267.1 and AC168068.3.
            
            On Aug 16, 2016 this sequence version replaced NM_010568.2.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of transmembrane signaling proteins that play important
            roles in cell differentiation, growth and metabolism. The encoded
            preproprotein undergoes proteolytic processing to generate alpha
            and beta chains that form a disulfide-linked heterodimer which, in
            turn homodimerizes to form a mature, functional receptor. Mice
            lacking the encoded protein develop severe hyperglycemia and
            hyperketonemia, and die within a couple of days after birth as a
            result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05149.1, SRR10223970.10271.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               BY733217.1         3-443
            442-1862            J05149.1           1-1421
            1863-2599           AK077054.1         1290-2026
            2600-3754           J05149.1           2159-3313
            3755-4148           AK077054.1         3182-3575
            4149-5016           AK164267.1         145-1012
            5017-9355           AC168068.3         94697-99035         c
FEATURES             Location/Qualifiers
     source          1..9355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.82 cM"
     gene            1..9355
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /note="insulin receptor"
                     /db_xref="GeneID:16337"
                     /db_xref="MGI:MGI:96575"
     exon            1..589
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..4608
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /EC_number="2.7.10.1"
                     /note="isoform A preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="insulin receptor isoform A preproprotein"
                     /protein_id="NP_034698.2"
                     /db_xref="CCDS:CCDS22059.1"
                     /db_xref="GeneID:16337"
                     /db_xref="MGI:MGI:96575"
                     /translation="MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNL
                     TRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDL
                     FPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDW
                     SRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKV
                     CPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQ
                     DWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGP
                     CPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEIS
                     GFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQ
                     GKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTS
                     FDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQR
                     SNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNP
                     SVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKL
                     PSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHN
                     VVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLV
                     ISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNV
                     VHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR
                     VRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKR
                     QPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEG
                     NAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP
                     TLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFV
                     HRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFT
                     ASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMC
                     WQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLD
                     RSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS"
     exon            590..1141
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1463
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1612
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1757
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1972
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2099
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2356
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2524
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2726
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..3001
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3141
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3301
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3404
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3472
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3717
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3828
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..3988
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4118
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4253
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..9355
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7019..7024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /note="hexamer: AATAAA"
     polyA_site      7043
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /note="major polyA site"
     regulatory      9336..9341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /note="hexamer: AATAAA"
     polyA_site      9355
                     /gene="Insr"
                     /gene_synonym="4932439J01Rik; CD220; D630014A15Rik; IR;
                     IR-A; IR-B"
                     /note="major polyA site"
ORIGIN      
        1 gtcttaatcc gcgccacctt ttcccttggc ccgcgcgggc ccagctgacg ggctgcgttg
       61 tttacgggct ggagtcgagc cctagctccc gccgccacca ccagcccagg tgccctccag
      121 tgcgcgcgtc cctctgtctc agactccaca caacgcgacc cacccagagc tgcacggagg
      181 gcagaagcag gagacccgga caggagacgc accgcggtga gctctggact ctgggattgc
      241 gggcacggga ccgggcctgg gtgacctgcg ggccgcgcca cggtgttgct tgcggccgag
      301 gcctctgtgc tcttcccggg actgtcccca gggccctcta ggctggagag ctgcggcctg
      361 tgagccacgg gcgtggaaga gaaggacgtg cggccccgag cgcctctcca gagaccttct
      421 cacggagtat gtccccagta ggccggcgtg gcgtgctctg atcgccgggg tcccagcact
      481 cctactgcta tgggcttcgg gagaggatgt gagacgacgg ctgtgccatt gctggtggcc
      541 gtggccgcgt tgctggtggg cacagccggc cacctgtacc ctggagaggt gtgccctggt
      601 atggacatcc ggaacaacct gaccaggcta catgagctgg agaactgctc agtcattgag
      661 ggccatctgc agatcctcct gatgttcaag accagacccg aagatttccg agacctcagt
      721 ttccccaaac tcatcatgat cacagattac ctgcttctct tccgtgtcta tggtctggaa
      781 agtctgaaag acctcttccc aaatctcaca gtcatccgag gctcccgtct cttcttcaac
      841 tatgccctgg ttatcttcga gatggtccac ctgaaggagc tggggcttta taacctcatg
      901 aacatcaccc ggggctctgt ccgcatcgag aagaataatg agctctgcta cctggccact
      961 atcgactggt cccgtatcct ggattctgtg gaggacaact acattgtact gaacaaagat
     1021 gacaacgagg aatgtgggga tgtctgtcca ggcaccgcca agggcaagac caactgtcct
     1081 gccactgtca tcaatgggca gtttgtggaa cggtgctgga cacacagtca ttgtcagaaa
     1141 gtttgcccaa ccatctgtaa gtcacatggc tgcacagctg aaggcctgtg ctgccacaaa
     1201 gagtgcctgg gcaactgttc ggaacctgat gaccccacca agtgtgtggc ctgtcgcaac
     1261 ttctatctgg atggtcagtg tgtggagacc tgcccgccac cctactatca cttccaggac
     1321 tggcgctgtg tgaacttcag cttctgccaa gaccttcact tcaaatgcag gaactctcgg
     1381 aagcctggct gccaccaata cgtcattcac aacaataagt gcatccccga gtgcccgtct
     1441 ggctatacca tgaattccag caacttgatg tgcaccccat gtctgggacc ctgccctaag
     1501 gtctgccaaa tcctcgaagg tgagaagacc attgattctg tgacatctgc ccaggagctc
     1561 cgaggctgca ctgtgatcaa cggtagcctg atcatcaaca tccgaggggg caacaacctg
     1621 gcagctgagc tggaggctaa ccttggcctc attgaagaaa tttcgggatt tctaaagatc
     1681 cgccgctcct atgctctggt atcactttct ttcttcagga agctacatct gattcgagga
     1741 gagaccttgg aaattgggaa ctattctttt tatgccttgg acaaccagaa cctgaggcaa
     1801 ctctgggact ggagcaaaca caacctcacc atcactcagg gcaagctctt cttccattac
     1861 aacccgaaac tctgcttgtc tgaaattcac aagatggaag aagtctccgg aactaagggc
     1921 cgtcaggaga ggaacgacat tgccctgaag accaatgggg accaggcatc gtgtgaaaat
     1981 gaattgctta aattttcttt cattcggaca tcttttgaca agatcctgtt gaggtgggaa
     2041 ccctactggc cccccgactt ccgagatctc ctgggattca tgttgttcta caaagaggcc
     2101 ccttatcaga atgtgacaga gtttgatggg caggatgctt gtggctccaa cagctggact
     2161 gtggtggata ttgacccgcc ccagaggtcc aacgacccca agtctcagac cccaagccac
     2221 cctgggtggc tgatgcgggg cctcaaaccc tggacccaat acgccatctt tgtgaagacc
     2281 ttggttacct tctctgatga acggcggacc tatggagcca aaagtgatat catctatgtg
     2341 caaacagatg ccactaatcc ttctgtcccc ctggatccca tatcagtttc taattcctca
     2401 tctcagatta tcttaaagtg gaagcccccc tctgacccca atggcaacat cacacactac
     2461 ctggtgtact gggagaggca agcagaggac agcgagctgt ttgagctgga ttattgtctc
     2521 aaagggctga agctcccttc acggacctgg tccccaccct ttgagtctga tgattctcag
     2581 aagcacaatc agagtgagta tgacgactcg gccagtgagt gctgctcatg ccctaagact
     2641 gactctcaga tcctgaagga gctggaggag tcttcattca ggaagacctt cgaggattac
     2701 ctgcacaacg tggtttttgt ccccaggcca tcccgaaagc gaagatccct tgaagaggtg
     2761 gggaatgtga cagccaccac actcacactt ccagatttcc ccaacgtctc ctctaccatt
     2821 gtgcccacaa gtcaggagga gcacaggcca tttgagaaag tggtgaacaa ggagtcactt
     2881 gtcatctctg gcctgagaca cttcactggg taccgcattg agctgcaggc atgcaatcaa
     2941 gattccccag atgagaggtg cagtgtggct gcctacgtca gtgcccggac catgcctgaa
     3001 gctaaggcag atgacatcgt tggccctgtg actcatgaaa tctttgagaa caatgttgta
     3061 cacttaatgt ggcaagagcc aaaggaacct aatggtctga ttgtgctata tgaagtgagc
     3121 tatcgccgat atggtgatga ggagctgcac ctctgtgtct cccggaagca ttttgccctg
     3181 gagcggggct gcaggctgcg agggctctcc ccaggaaact acagtgttcg agtccgggct
     3241 acctctctgg caggaaatgg ctcctggaca gaacccacct atttttatgt gactgattat
     3301 ttagatgtcc catcaaatat tgccaaaatt atcattggac ccctcatctt tgtcttcctc
     3361 ttcagtgttg tgattggaag tatttatcta tttctgagaa agaggcagcc ggatgggcca
     3421 atgggaccac tgtatgcatc ttcaaaccct gagtacctca gtgccagtga tgtgtttcca
     3481 tcttctgtgt acgtgccgga cgagtgggag gtgcctcgag agaagatcac ccttcttcga
     3541 gagctggggc agggatcctt tggtatggtg tatgaaggca atgccaagga tatcatcaag
     3601 ggtgaggcag agacccgtgt tgcggttaag actgtcaatg agtcagccag tcttcgagaa
     3661 cggatcgagt tcctcaatga ggcatcagtc atgaagggat tcacctgcca tcatgtggtc
     3721 cgccttcttg gggtggtatc caaaggacag ccaacgctgg tagtgatgga attgatggct
     3781 catggagacc tgaaaagtca cctccgttct ctgaggccag atgctgagaa taacccaggc
     3841 cgccctcccc ctaccttgca agaaatgatt cagatgacag cagaaattgc tgatggcatg
     3901 gcatacttga acgccaagaa gtttgtgcac cgggacctgg cagctcgaaa ctgcatggtt
     3961 gcccatgatt ttactgtcaa aattggagac tttggaatga caagggacat ctacgagaca
     4021 gattactatc ggaaaggggg caagggactg cttcctgtga ggtggatgtc acctgagtcc
     4081 ctgaaggatg gagtctttac tgcttcttct gatatgtggt cctttggggt ggtcctttgg
     4141 gaaatcacta gcctggctga gcaaccttat caaggcctgt ctaatgaaca ggtgttgaag
     4201 tttgtcatgg atggaggcta tctggatccc cctgataact gtccagagag actcactgac
     4261 ctgatgcgca tgtgctggca gttcaacccc aagatgaggc caaccttcct ggaaatcgtc
     4321 aacctgctca aggatgacct ccaccccagc tttccagaag tttccttctt ctacagcgag
     4381 gagaacaagg ctcctgagag tgaggagctg gagatggagt ttgaagacat ggagaatgtc
     4441 ccgttggatc gttcctctca ctgtcagaga gaagaggctg ggggccggga gggagggtcc
     4501 tcactgagca tcaaacggac ctatgatgaa cacatcccct atacccacat gaatgggggc
     4561 aagaagaacg gacgtgtcct taccctgcca aggtcaaacc cttcctaaca gcgccttctc
     4621 cgggaaggat tcttttcttt ctttcttttt taaaactctt ctgtagtttg actgcctcca
     4681 ggaaactcag gattatcagg actctgccca gatgtgaaac tgagctcaga gatagttcat
     4741 acacatttct gtttgtcttt tgacctgaaa acacacaagc gtgatcgcca accctgtaag
     4801 cctgtggagg gctaactgtg aacctagagg ggttgggctg tccatgctcc cttccctgcc
     4861 tccaccgtat caaaccaaga ttttgttgtt ggtggtgttc ttttccccat agattggaag
     4921 aatgtacctg cttttttaca gatatttttc ttcttttctt ttcttttctt ttcttttctt
     4981 ttcttttctt ttcttttctt ttcttttctt ttctttcttt tttttccccg ttagtgtctg
     5041 agttacagtt agttgtcaaa gacagactat ttatggagca caagtcagaa agcaaagaag
     5101 aaacagacag aaaacagaac aaaacaaaac aaaaaccaaa cctgacctac agagcctggc
     5161 tctagaatta tatgctctgc agggttgggc tttgagaagg tttcattaat ctaagagaag
     5221 gattttattt tattttattt tacttttttt cctcattcac aaaatcagtt cctcaaattg
     5281 accaatagct gctgctttca tattttattt tgggaaaggg tgtgtattcc taagtgtgtg
     5341 ctcatctgca cacctgtgtg catttgtgtg tatgttgtgt ccaggttaga gatcacaggg
     5401 tggggtgggg tggggtgggg gtggggtgct gtgtaaaata gtctctggac tgatgcttgg
     5461 tgaattggct cccgaagctc ctgctgcttg gagtgggtga cctcatattg tcctcttcct
     5521 tctcatgaac tgagagtctg tgccctcgag agagtcttct cagtcacatc agaagtcttg
     5581 ctcaggtgtc ttcttcccct tccctttgat gatgttttcc gaaaacagag ggaggattat
     5641 ttggtctgga ttctttgagg atctttggaa gaccaaacaa agcaaagggg acacacacac
     5701 acacacacac acacacacac acacacacac acacactaga aggaagtaag gcaacaattt
     5761 tgagaatata tttgtaacat atttaaagct tatggaatct ctggtatgag cctaataagt
     5821 tagtatttct ttgggagcag tggtgggcac atctgcctgt gtggggacac aggacaatat
     5881 gtgagtggcc tctgggtttg gtctttgaaa cacatatttt tctgggaatt ataccacatt
     5941 agctgctagc cctttaggac tcggggagtt cttgtggagt ctgtgggtaa ctggatattc
     6001 gactgtttca gatagtaaca ttgactggat gtttcttgct tggatacact ggtggttacc
     6061 tggagctgag atggccttcc agaacacctg tgttcatctg gtttttctct gcttgtgtac
     6121 ctcacttctt caaggcctac actttgctca atcattgtat aaacatacta aactcagatc
     6181 ccgaagacca atgacacaga tggactttga gaacactaag caatatgtaa ggagatgtac
     6241 ccttccgatc cccgctggtc tcctccacct ttggggcatc tggctattct ctacactaaa
     6301 ctcccacagc tgctcttggc gtccagggac ctcagcttgg gccagatata gtgcctgagt
     6361 ttatttctca ggtgcttatg tttgagtctc tagagactaa agtctggagg agaaaacatc
     6421 agagactttc ttctcaccac caagaactcg tgaaaggatg tgaactcaca acttctcttt
     6481 gcataaaacc acagctgctc aagtaaaaga aacaactatg gtgaactcaa aatcctccca
     6541 gaggttcttt cctgcgtgca tttcccacaa atatttgatg cctttcttct cccttaggag
     6601 atatgagata aagacacact ggccaccctg attaagaaca caaggaaaca taaatcctgg
     6661 ttgtcaattg ctgtggaatt tatattataa aaattgcagc atgtaaaaat gttgccaggg
     6721 aactcaatga ttggcataag catcaagagt tacagttact tttacccaaa acactttgta
     6781 aatagaaggt ctgtgcatca atggaagaca ccgtaggtat ggatattttt tgtttatttt
     6841 tccttttcac agtaaatttg tagtgatgct atactagcag aaattttcac acctttctac
     6901 ttcaaaaggt tttcttatag taccggggaa agtatttatt ttaatatata agatcactct
     6961 tgaaaatcac ttttgtaaaa aaatgttatg aatgtaaatt ttttttttat caaggagaaa
     7021 taaaaacagg tgagtgtggg tcattttttt tttccttctt ctcagtacag tctacctcag
     7081 tgtcttatta ggatgtggtt cagtaacaga tgttgaggct tcaagattct ggctgaatca
     7141 ttctctgagt tggggagctg tgtaccattt gatttttaaa tgccagggac tagggagaac
     7201 tttgaaggag agagtttaga ttaaaaagtt agagccttcc tgtgaaccca aagtcttctt
     7261 gttggtgata ttcttcagag tatattctcc atacaaaaac ccatctgttg attgcacact
     7321 cctcacacac aagccacact tcaagtcatc atgatttagc tctttggagg cccctgatct
     7381 gaggtctttg aaaagtgggt gttcctttta ctgatgaggc tgtgagccag taccttcaga
     7441 agtcacatga aatcccccgg acatgaatgc aaagggaatc tgggttttct gaccatgatt
     7501 tctcaccctg tttagaccca tgaggctgtt tgtgggcacc tcttacacaa atagctgatg
     7561 caagggtatt tggagaaatc ctgctatgaa acctatcagt ttcctgaaca tatcttaaac
     7621 aataagatag gaaccctatg ctggggttgg gttgacttca agctgacact gtttggcctt
     7681 gtgcaatctt gagaactctg gaaatcaagg cggggccagc atggctccta gtttcaagct
     7741 ttgacatatt atttcacttt agaacactgt ccttaaaatt ttactctttt ccatcttttc
     7801 tggaaaggtg caccaacttg ggtgacccta ccaaaaagga ctccactaat tccatgttga
     7861 tatctactgt tgctgggaag gaaacaagta gctattgggt catgagactc attttggttt
     7921 cagaagatgt tagctttgtg agatctagaa aatcatggct atcctgggag ttcgtagtga
     7981 tggatgaaag agagagagaa aagaaaatag aaacaaaagc aagttacatt gatatttctt
     8041 gttgagtttt gggagatgtc tcatcatttt aaaactactt tcatgatcat gatgaaatgc
     8101 agttatttct tccaggatag cagcagacat gttgtctggt tcaatgatgt caagcataca
     8161 tcaggagatg ttcatgtact tggagccttt ctaaatgttt ccctgtcatt tgatgctagc
     8221 ttgaagggaa gagccttgat ggctttctgg atttaggctg agcacagttt gggagagtgg
     8281 agattggcag gaagagctga actgtattgt gtggcagctg ggtgtggtgc caccaacaca
     8341 agtaaaaact atccttacta tcttatcagg acagacgttc taccatgcac agtgattatt
     8401 gggttaaggg ctgtaatttt atttgaaacc taccataaca ctggctggtg ggcagtatca
     8461 ctgtgagagt ctggttcata ctggtgatct tggtaaatga atgatggttg ttctagtaat
     8521 ggttctattt tatgatagat ggatgtattc cagattctag ctaatgaatt cttgacaaca
     8581 taggctcttc aaaaattatg gttttgtcgg acatgcgaaa agaatagtgc tgattttgtg
     8641 taaatggtgc acatagcata tagtcatttt tagaaaaacc ttccagtatg ttcctcagaa
     8701 tatgaactta tacaaaagat gaagttgggc aatgggaata acagaatatc acttgtttaa
     8761 acgacacaaa ataatatgat ggtcttttaa gaggtaatga ctgaaggcat atgcatcctc
     8821 agatagtact caagaaatgg agatcaatga gtatttgagc taatttgata ccaatcagga
     8881 tacaaaaatc agtctctggt caaattttta tctgtatgtg ggccatttaa aaaacaaaca
     8941 aaatgaaaca aaaacatgtt aaaaatcaga tcatggttct ggaacccttg ttattatttg
     9001 agaagaaagg aaggtccctc agatgtgtgt gtgtctgttc acatgtgcag gaatggcttg
     9061 tttggtcttt atcctttgta tcaaagttgc tgcttctttc ccctttatgt gcctgggtgg
     9121 ttatatccca tgtgtcaaca gtgtgggatc aaatgtgcca tagcactgca gaaaacgcag
     9181 aaacacaaaa cccatccaaa gcacagtgac attttcctac aagagccaag tagcatcatg
     9241 tccagaatat gccttttttt gtgtggggag gagagggact gaaattgttc tgcatgtata
     9301 atacaggcta attacttgtt tatattaaaa tttggaataa attatcttga gacta
//
