LOCUS       NM_020287               2607 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus insulinoma-associated 2 (Insm2), mRNA.
ACCESSION   NM_020287
VERSION     NM_020287.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2607)
  AUTHORS   Li,Z.M., Li,Y.Y., Fei,C.F. and Zhou,L.Q.
  TITLE     Insm2 deficiency results in female infertility by disturbing
            steroid pathway and decreasing ovarian reserve in mice
  JOURNAL   Cell Cycle 21 (21), 2255-2267 (2022)
   PUBMED   35786158
  REMARK    GeneRIF: Insm2 deficiency results in female infertility by
            disturbing steroid pathway and decreasing ovarian reserve in mice.
REFERENCE   2  (bases 1 to 2607)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   3  (bases 1 to 2607)
  AUTHORS   Wiwatpanit,T., Lorenzen,S.M., Cantu,J.A., Foo,C.Z., Hogan,A.K.,
            Marquez,F., Clancy,J.C., Schipma,M.J., Cheatham,M.A., Duggan,A. and
            Garcia-Anoveros,J.
  TITLE     Trans-differentiation of outer hair cells into inner hair cells in
            the absence of INSM1
  JOURNAL   Nature 563 (7733), 691-695 (2018)
   PUBMED   30305733
  REMARK    Erratum:[Nature. 2019 Jan;565(7737):E2. doi:
            10.1038/s41586-018-0795-6.. PMID: 30518865]
REFERENCE   4  (bases 1 to 2607)
  AUTHORS   Wang,L., Sun,Z.S., Xiang,B., Wei,C.J., Wang,Y., Sun,K., Chen,G.,
            Lan,M.S., Carmona,G.N., Notkins,A.L. and Cai,T.
  TITLE     Targeted deletion of Insm2 in mice result in reduced insulin
            secretion and glucose intolerance
  JOURNAL   J Transl Med 16 (1), 297 (2018)
   PUBMED   30359270
  REMARK    GeneRIF: Insm2 is important in glucose-stimulated insulin
            secretion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2607)
  AUTHORS   Zhang,Q., Huang,R., Ye,Y., Guo,X., Lu,J., Zhu,F., Gong,X.,
            Zhang,Q., Yan,J., Luo,L., Zhuang,S., Chen,Y., Zhao,X., Evans,S.M.,
            Jiang,C., Liang,X. and Sun,Y.
  TITLE     Temporal requirements for ISL1 in sympathetic neuron proliferation,
            differentiation, and diversification
  JOURNAL   Cell Death Dis 9 (2), 247 (2018)
   PUBMED   29445148
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2607)
  AUTHORS   Punia,S., Rumery,K.K., Yu,E.A., Lambert,C.M., Notkins,A.L. and
            Weaver,D.R.
  TITLE     Disruption of gene expression rhythms in mice lacking secretory
            vesicle proteins IA-2 and IA-2beta
  JOURNAL   Am J Physiol Endocrinol Metab 303 (6), E762-E776 (2012)
   PUBMED   22785238
  REMARK    GeneRIF: Data suggest that IA-2 and IA-2beta play important roles
            in regulation of circadian rhythms, likely through their
            participation in neurochemical communication among neurons of
            suprachiasmatic nucleus.
REFERENCE   7  (bases 1 to 2607)
  AUTHORS   Cai,T., Chen,X., Wang,R., Xu,H., You,Y., Zhang,T., Lan,M.S. and
            Notkins,A.L.
  TITLE     Expression of insulinoma-associated 2 (INSM2) in pancreatic islet
            cells is regulated by the transcription factors Ngn3 and NeuroD1
  JOURNAL   Endocrinology 152 (5), 1961-1969 (2011)
   PUBMED   21343251
  REMARK    GeneRIF: Results suggest that Insm2 plays an important role in the
            differentiation cascade of Ngn3/NeuroD1 signaling in pancreatic
            islets.
REFERENCE   8  (bases 1 to 2607)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2607)
  AUTHORS   Tateno,M., Fukunishi,Y., Komatsu,S., Okazaki,Y., Kawai,J.,
            Shibata,K., Itoh,M., Muramatsu,M., Held,W.A. and Hayashizaki,Y.
  TITLE     Identification of a novel member of the snail/Gfi-1 repressor
            family, mlt 1, which is methylated and silenced in liver tumors of
            SV40 T antigen transgenic mice
  JOURNAL   Cancer Res 61 (3), 1144-1153 (2001)
   PUBMED   11221845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158398.2.
            
            On Dec 23, 2021 this sequence version replaced NM_020287.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7652917.1161062.1,
                                        SRR7345562.1166372.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2607              AC158398.2         165685-168291
FEATURES             Location/Qualifiers
     source          1..2607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.05 cM"
     gene            1..2607
                     /gene="Insm2"
                     /gene_synonym="Mlt1"
                     /note="insulinoma-associated 2"
                     /db_xref="GeneID:56856"
                     /db_xref="MGI:MGI:1930787"
     exon            1..2607
                     /gene="Insm2"
                     /gene_synonym="Mlt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1528
                     /gene="Insm2"
                     /gene_synonym="Mlt1"
                     /note="methylated in liver tumor 1; mlt 1"
                     /codon_start=1
                     /product="insulinoma-associated protein 2"
                     /protein_id="NP_064683.2"
                     /db_xref="CCDS:CCDS25919.1"
                     /db_xref="GeneID:56856"
                     /db_xref="MGI:MGI:1930787"
                     /translation="MPRGFLVKRTKRSGSSYRARPVEPLFPPPGPLAAQSSPEEPGRG
                     LLGSPCLAPPQDDAEWGAGGGDGPGPSPARPAGPELRRAFLERCLRSPVSAESFPSAT
                     AFCSAAPAAVTSGEELVPPQVPVSVPIPVPGPAPHGLQRRGKGAPVCASAPAAVRKPK
                     AVRRLSFADEVTTSPVLGLKIKEEEPGAPARALGGVRTPLGEFICQLCKHQYADPFAL
                     AQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPTPACAASKPPHAPLTPPDP
                     SLATGKENGRVPRTDDQHPQAPDSSGDGQHRDSAARPGLQALVYPEAARPQAPYPEVI
                     LGRHGPGSSGASAGATSEVFVCPYCHKKFRRQAYLRKHLGTHETGSARAPTPGFGSER
                     TAPLTFACPLCGAHFPSADIREKHRLWHAVREELLLPALVGAPSEAGPGGASDGSAQQ
                     IFSCKYCPSTFFSSPGLTRHINKCHPSESRQVLLLQMPLRPGC"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insm2"
                     /gene_synonym="Mlt1"
                     /note="hexamer: AATAAA"
     polyA_site      2607
                     /gene="Insm2"
                     /gene_synonym="Mlt1"
                     /note="major polyA site"
ORIGIN      
        1 gtccagccct cctagctccg gggctcgccc gggcacccga cccaccatgc cgaggggctt
       61 cctggtgaag cgaaccaagc gctccggcag ctcctaccgc gcgcgcccgg tggagccgct
      121 tttccctcct ccgggtcccc tcgcggcgca atcctcaccg gaggagcccg gtcggggact
      181 tttggggtcc ccctgcctcg cacctccgca ggacgacgcc gagtggggcg cgggtggcgg
      241 cgacggcccc ggccccagcc ccgcgaggcc ggcgggcccc gagctgcgcc gcgcgttcct
      301 ggagcgctgc ctgcgctctc cggtctctgc ggagtccttc cccagcgcca ccgccttctg
      361 ctccgcggcg cccgcggccg tgacctccgg ggaggagttg gtaccgccgc aggtccctgt
      421 atccgttcca attcccgtcc ccgggcccgc cccgcatggc ctccagcgcc gcggtaaggg
      481 tgccccagtc tgcgcctcag cgccggcagc cgtcaggaaa cctaaggcgg tgagaaggct
      541 gagcttcgca gatgaggtga ccacgtcccc ggtgctgggt ctgaagatca aagaggagga
      601 gcccggggct ccggcacggg ctctgggcgg cgtccgcacc ccgctggggg agttcatctg
      661 ccagctgtgc aagcaccagt acgcggaccc cttcgctctg gctcagcacc gctgctcccg
      721 catcgtgcgc gtcgagtacc gctgtcccga gtgcgacaag gtcttcagct gccccgcgaa
      781 cctcgcctcc caccgccgct ggcacaagcc acgtcccacg cctgcctgcg ccgcgagtaa
      841 acctccccac gcgcctctga cccctccgga cccttccctg gcgacgggca aggagaacgg
      901 ccgcgtgccg cggaccgacg atcagcaccc gcaggctccg gacagctccg gagacggtca
      961 gcaccgggac agcgccgcgc gcccgggcct acaggctcta gtgtacccgg aggccgcacg
     1021 accccaggct ccctaccccg aggtgattct agggcgccac gggccggggt cgagcggtgc
     1081 cagcgcagga gcgacgtccg aggtcttcgt gtgcccgtat tgtcacaaaa agttccgtcg
     1141 ccaagcctat ctgcgcaagc acctgggcac ccatgagacg ggctcggccc gtgcaccaac
     1201 tccgggtttt ggctcggagc gcacggcccc actcaccttt gcgtgcccgc tttgcggggc
     1261 gcacttcccg tccgcggaca ttcgagagaa gcaccggcta tggcacgctg tccgcgagga
     1321 gctgctactg cccgccttgg tcggggcacc ttcggaagca ggccccggag gggcatccga
     1381 tggtagcgct cagcagattt tctcctgcaa gtactgcccg tccacttttt ttagctcccc
     1441 cggcttgacc cggcacatca ataagtgcca cccctccgaa agccggcaag tgctgctgct
     1501 gcagatgcca ctgaggcctg gctgttgagg accgaggcct gtcgagattt cgagaatggc
     1561 ttggagaaaa catacgggaa ctcctgtggg actctcttca tcttgcaatt tccagtttcc
     1621 ttcccatacc ttccctctta aaactctcag tcatggtgcc tgaggagagg gcaacaagat
     1681 gtaaaacccc ctctctagag caggtatgta tttggcataa aaattcacgg tcaacgctga
     1741 cagcttcaag tcctcactcc cactacaatg agatttcccc ttccttaaaa cgctggagac
     1801 cccaatggat tcccttgggt ttgtagttcc tatggaaaat cgcagtgaac gcctgcaagt
     1861 ctgtctacac aagattctac ctaaagtggt agtcaccaac gtttttgttt ttgtttttgt
     1921 ttttcttttg ccaccacagg cacttaagtc gtttctgtct caatagggtc agactttttt
     1981 tttttttttt gtcttgtata ttctgtgaat caagctttgt gactgatgtc aaacctgaag
     2041 ggagggaaga cccacacccg cgtggatgga caggaaatct gaggctgttg ctgtctggtg
     2101 tgataatgtc cctgggactt tatttcctta actgaatgta tgtcccttct tttaagctag
     2161 gctttggagg cagggcaggt gttgcttact gagaaggagt tggtgaagtt cactacttca
     2221 cgtgctgcgt taggaggagc taaacatttt ctttacataa ctttaaaaaa atacaatact
     2281 cgttcctcaa gtgtgaatgt ttttatagca agatttcact taaattatgt aatgattatg
     2341 ctgtaagtct gctgcatatt acatcataaa ctgttcaacc taagggggat gttaacacct
     2401 gcaatctacc atgaactgaa tggcaattca ctcaatattt tatattttct tttcaggagc
     2461 aacttttgaa tttctttttg taaatcatac tcagtgtgta ttctgtaact attccctcaa
     2521 tagccagagt ctgggacact ggcagagtgc tctttgacaa atggatttgt aagaatggtt
     2581 ctgccaaata aatgtatgta gactgtg
//
