LOCUS       NM_016889               2920 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus insulinoma-associated 1 (Insm1), mRNA.
ACCESSION   NM_016889 XM_992511
VERSION     NM_016889.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Zhang,Y., Karagiannis,D., Liu,H., Lin,M., Fang,Y., Jiang,M.,
            Chen,X., Suresh,S., Huang,H., She,J., Shi,F., Liu,J., Luo,D.,
            Angel,J.C., Lin,G., Yang,P., El-Rifai,W., Zaika,A., Oro,A.E.,
            Liu,K., Rustgi,A.K., Wang,T.C., Lu,C. and Que,J.
  TITLE     Epigenetic regulation of p63 blocks squamous-to-neuroendocrine
            transdifferentiation in esophageal development and malignancy
  JOURNAL   Sci Adv 10 (41), eadq0479 (2024)
   PUBMED   39383220
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Tao,W., Ye,Z., Wei,Y., Wang,J., Yang,W., Yu,G., Xiong,J. and Jia,S.
  TITLE     Insm1 regulates mTEC development and immune tolerance
  JOURNAL   Cell Mol Immunol 20 (12), 1472-1486 (2023)
   PUBMED   37990032
  REMARK    GeneRIF: Insm1 regulates mTEC development and immune tolerance.
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Givony,T., Leshkowitz,D., Del Castillo,D., Nevo,S., Kadouri,N.,
            Dassa,B., Gruper,Y., Khalaila,R., Ben-Nun,O., Gome,T., Dobes,J.,
            Ben-Dor,S., Kedmi,M., Keren-Shaul,H., Heffner-Krausz,R., Porat,Z.,
            Golani,O., Addadi,Y., Brenner,O., Lo,D.D., Goldfarb,Y. and
            Abramson,J.
  TITLE     Thymic mimetic cells function beyond self-tolerance
  JOURNAL   Nature 622 (7981), 164-172 (2023)
   PUBMED   37674082
  REMARK    Erratum:[Nature. 2023 Dec;624(7991):E4. doi:
            10.1038/s41586-023-06881-0.. PMID: 38036683]
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Prescott,K., Ivins,S., Hubank,M., Lindsay,E., Baldini,A. and
            Scambler,P.
  TITLE     Microarray analysis of the Df1 mouse model of the 22q11 deletion
            syndrome
  JOURNAL   Hum Genet 116 (6), 486-496 (2005)
   PUBMED   15778864
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Breslin,M.B., Zhu,M. and Lan,M.S.
  TITLE     NeuroD1/E47 regulates the E-box element of a novel zinc finger
            transcription factor, IA-1, in developing nervous system
  JOURNAL   J Biol Chem 278 (40), 38991-38997 (2003)
   PUBMED   12890672
  REMARK    GeneRIF: IA-1 gene is developmentally expressed in the nervous
            system and the NeuroD1/E47 transcription factors up-regulate IA-1
            gene expression through the proximal E-box element of the IA-1
            promoter
REFERENCE   8  (bases 1 to 2920)
  AUTHORS   Xie,J., Cai,T., Zhang,H., Lan,M.S. and Notkins,A.L.
  TITLE     The zinc-finger transcription factor INSM1 is expressed during
            embryo development and interacts with the Cbl-associated protein
  JOURNAL   Genomics 80 (1), 54-61 (2002)
   PUBMED   12079283
  REMARK    GeneRIF: isolation, characterization, and identification of an
            interacting protein, Cbl-associated protein (CAP)
REFERENCE   9  (bases 1 to 2920)
  AUTHORS   Wu,J., Duggan,A. and Chalfie,M.
  TITLE     Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans
  JOURNAL   Genes Dev 15 (6), 789-802 (2001)
   PUBMED   11274062
REFERENCE   10 (bases 1 to 2920)
  AUTHORS   Tateno,M., Fukunishi,Y., Komatsu,S., Okazaki,Y., Kawai,J.,
            Shibata,K., Itoh,M., Muramatsu,M., Held,W.A. and Hayashizaki,Y.
  TITLE     Identification of a novel member of the snail/Gfi-1 repressor
            family, mlt 1, which is methylated and silenced in liver tumors of
            SV40 T antigen transgenic mice
  JOURNAL   Cancer Res 61 (3), 1144-1153 (2001)
   PUBMED   11221845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935056.18.
            
            On Jan 13, 2022 this sequence version replaced NM_016889.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC082809.1, SRR7345562.4054865.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2920              AL935056.18        42624-45543
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.33 cM"
     gene            1..2920
                     /gene="Insm1"
                     /gene_synonym="IA-1"
                     /note="insulinoma-associated 1"
                     /db_xref="GeneID:53626"
                     /db_xref="MGI:MGI:1859980"
     exon            1..2920
                     /gene="Insm1"
                     /gene_synonym="IA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1731
                     /gene="Insm1"
                     /gene_synonym="IA-1"
                     /note="insulinoma-associated protein (IA-1); zinc finger
                     protein IA-1"
                     /codon_start=1
                     /product="insulinoma-associated protein 1"
                     /protein_id="NP_058585.2"
                     /db_xref="CCDS:CCDS16830.1"
                     /db_xref="GeneID:53626"
                     /db_xref="MGI:MGI:1859980"
                     /translation="MPRGFLVKRSKKSTPVSYRVRGGEDSDRALLLSPGCGGARAEPP
                     VPSPGPLPPPPPPALAERAHAALAAALACAPGPPPPPPPGPRAAHFGNPEAAHPAPLY
                     SPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLAGGGSGANGAGGGGGGTCGG
                     DALLFAPAELKMGTAFSAGAEAARGPGTGPPLSPAAALRPPGKRPAPPAAVATEPPAK
                     AAKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGATRPLGEFICQL
                     CKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPVPAAARAP
                     EPEAATRAEAREAAGGGSSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHL
                     LAHHQALQAKGAPPPPPPPPPPAEDILAFYAGPDEKAPQEASGDGEAAGVLGLSATAQ
                     CHLCPVCGETFPSKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENR
                     QVILLQVPVRPAC"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insm1"
                     /gene_synonym="IA-1"
                     /note="hexamer: AATAAA"
     polyA_site      2920
                     /gene="Insm1"
                     /gene_synonym="IA-1"
                     /note="major polyA site"
ORIGIN      
        1 gacagggacg cgcgtgcgga gcgcagagcc gggccagcag ccgcgggcac tgcgggagtc
       61 ccgaagccgc cgcgtgcagg cgatgggctg gggtcactga gggccgccag ggccgagcac
      121 ggaggtggga cccaaccagt gcgtcgccct tttcaccgcg ccaacatgcc ccgcgggttt
      181 ctggtgaagc gcagcaagaa gtccacgccc gtgtcctacc gggtccgcgg cggcgaggac
      241 agtgaccggg cgctgctgct gtcacccggc tgcgggggcg cccgcgccga gcccccggtg
      301 cccagccccg ggccgctgcc gccacctccg ccgccggcgc tcgcggagcg cgcccatgct
      361 gcgctcgccg ccgcgctcgc ctgcgcgcca ggcccgccgc cgccaccccc gccaggcccg
      421 cgggccgcgc acttcggcaa ccccgaggct gcgcacccgg cgcctctcta cagtcccacg
      481 cggccggtga gccgcgagca cgagaagcac aagtacttcg agcgcagctt caacctgggc
      541 tcgccggtgt ccgctgagtc cttccccacg cccgccgcgc tgctcgcagg gggaggcagc
      601 ggcgccaacg gcgctggcgg cggcggcggc ggcacctgcg gcggagacgc gctgctcttc
      661 gctcccgccg agctcaagat gggcactgcg ttctccgccg gcgccgaggc ggcccggggt
      721 cctgggaccg gtcctccact gtcccccgcc gcggccctgc ggcccccggg caagcgaccg
      781 gcgccccccg ccgctgtcgc tacagagccg cccgccaagg cagccaaggc cccgagcgcc
      841 aaaaagccga aggccatccg caagctgcac ttcgaggacg aggtgaccac gtcgccggtt
      901 ctggggctca agatcaagga gggcccggtg gaggcgccgc ggggtcgcgc ggggggcgcg
      961 acccgacccc tgggcgagtt catctgccag ctgtgcaagg aggagtacgc tgacccgttc
     1021 gcgctggcgc agcacaagtg ctcgcgcatc gtgcgcgtgg agtaccgctg cccagagtgc
     1081 gccaaggtct tcagctgccc ggccaacctg gcctcgcacc gccgctggca caaaccacgg
     1141 ccggtgcccg cggcggcccg cgcgccagag ccagaagccg ccaccagggc ggaggcgcgc
     1201 gaggctgcgg gcggcggcag cagcgatcgg gacacgccga gccctggcgg cgtatccgag
     1261 tcaggctccg aggacgggct ctacgagtgc caccactgcg ccaagaagtt ccgtcgccag
     1321 gcctatctgc gcaagcacct gctggcacat caccaggcgc tgcaggccaa aggcgcgccc
     1381 ccgcccccgc cgccgccgcc accccccgcc gaggacatcc tggctttcta cgcggggccc
     1441 gacgaaaagg cgccccagga ggcctcgggc gacggcgagg cggccggcgt gctgggcctg
     1501 agtgcgaccg cccagtgcca cctgtgccca gtgtgcgggg agaccttccc cagcaagggc
     1561 gcccaggagc gccacctgcg cctgctgcac gctgcccagg tgttcccctg caagtactgc
     1621 ccggccacct tctacagctc cccgggcctg acccggcaca tcaacaagtg ccacccgtct
     1681 gagaatagac aggtgatcct ccttcaggtg cctgtgcgtc cggcctgcta gagtgcgccc
     1741 tcggtccggg ggcccccaga actgtgcctt cactcggaga cccacaaaga gagagcgccc
     1801 cccatgcctg atctgggggt cccctactcc cattccaggg tgaaagtgtc ctcttcgctt
     1861 cgcttcggtg gagcatgacc acctggtctt ctcgctgtga ctcctttgga ccccaacccc
     1921 tttgcgttgt gccccccccc ccaagcccca tggcgcaaca ggagtccgtc tctttctgta
     1981 caggggagga aaaaaatgct gtatacgttt gtctcgtggt tggacgcctc cttttgaggg
     2041 gcaaagctgt ttttcttgct agtattcgct gtgttcatgg tctagaaaat gcggtttgct
     2101 ctgcctacca atctctgctc tctatgtctg tagcgtacgg gttgttttgg gtgaatcttg
     2161 aggaataaaa tgcctttata tttcacaggc tgtaaattga acttcccaca cgattagctt
     2221 tattatggct tgtgaactgc tggagtctgg ctttaccttt ttgtatgtga acaaatcaaa
     2281 ttgcttaaaa aagagttttc tttagtatag ccacaaatgc cttgacctgt tgtctgttgg
     2341 ggattgtttt ttgggggtgg gaggagttct aacgagatgc tgtagtaact gcctcagtat
     2401 atcccggaag acttttggtt taatcatctt tgttgaggta gggctattga gttcctttga
     2461 catgtatatg ttgattgatg cacaattgtt atttattctt tatttattta tattaattat
     2521 gaagattatg atattatttg attgcagatt ctctctctct ctctctcttt ctctctctct
     2581 ctctctctct ctctctctct ctctctctct ctctctgagc tttccccctg ccacttttga
     2641 catttcactg tgcattttag gaaagaatcg ttttttctag aggggtctgc tgaaagtttt
     2701 aacttttcta tctatcgagg gaattacaga caacatacca ttttattctg cttgaggggc
     2761 cccaaggccc ttgtacaacc gacagctctt acttttaaat gcaatctctt ttctacatac
     2821 attattttct taattgttag ctatttatag aaagcttcga tagaactgtt tcaactgtat
     2881 aaatatttac tattcaaata aaatattttc aaagtcaaaa
//
