LOCUS       NM_013754                660 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus insulin-like 6 (Insl6), mRNA.
ACCESSION   NM_013754
VERSION     NM_013754.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 660)
  AUTHORS   Yi,X., Liu,X., Kenney,H.M., Duan,R., Lin,X., Schwarz,E. and Yao,Z.
  TITLE     TNF-Polarized Macrophages Produce Insulin-like 6 Peptide to
            Stimulate Bone Formation in Rheumatoid Arthritis in Mice
  JOURNAL   J Bone Miner Res 36 (12), 2426-2439 (2021)
   PUBMED   34585777
  REMARK    GeneRIF: TNF-Polarized Macrophages Produce Insulin-like 6 Peptide
            to Stimulate Bone Formation in Rheumatoid Arthritis in Mice.
REFERENCE   2  (bases 1 to 660)
  AUTHORS   Maruyama,S., Wu,C.L., Yoshida,S., Zhang,D., Li,P.H., Wu,F., Parker
            Duffen,J., Yao,R., Jardin,B., Adham,I.M., Law,R., Berger,J., Di
            Marchi,R. and Walsh,K.
  TITLE     Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac
            Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure
            Models
  JOURNAL   J Am Heart Assoc 7 (12), e008441 (2018)
   PUBMED   29887522
  REMARK    GeneRIF: Endogenous Insl6 protein inhibits cardiac systolic
            dysfunction and cardiac fibrosis in angiotensin II- and
            isoproterenol-induced cardiac stress models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 660)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 660)
  AUTHORS   Zeng,L., Akasaki,Y., Sato,K., Ouchi,N., Izumiya,Y. and Walsh,K.
  TITLE     Insulin-like 6 is induced by muscle injury and functions as a
            regenerative factor
  JOURNAL   J Biol Chem 285 (46), 36060-36069 (2010)
   PUBMED   20807758
  REMARK    GeneRIF: Data indicate that Insl6 is an injury-regulated myokine
            that functions as a myogenic regenerative factor.
REFERENCE   5  (bases 1 to 660)
  AUTHORS   Burnicka-Turek,O., Shirneshan,K., Paprotta,I., Grzmil,P.,
            Meinhardt,A., Engel,W. and Adham,I.M.
  TITLE     Inactivation of insulin-like factor 6 disrupts the progression of
            spermatogenesis at late meiotic prophase
  JOURNAL   Endocrinology 150 (9), 4348-4357 (2009)
   PUBMED   19520787
  REMARK    GeneRIF: results suggest that INSL6 modulates two different
            processes related to fertility, spermatogenesis, and sperm
            motility.
REFERENCE   6  (bases 1 to 660)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Insl6 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   7  (bases 1 to 660)
  AUTHORS   Brailoiu,G.C., Dun,S.L., Yin,D., Yang,J., Chang,J.K. and Dun,N.J.
  TITLE     Insulin-like 6 immunoreactivity in the mouse brain and testis
  JOURNAL   Brain Res 1040 (1-2), 187-190 (2005)
   PUBMED   15804440
  REMARK    GeneRIF: The presence of immunoreactive INSL6 in discrete
            populations of hypothalamic and brainstem neurons and in Leydig
            cells of the testis suggests a diverse biological function of this
            novel peptide.
REFERENCE   8  (bases 1 to 660)
  AUTHORS   Kasik,J., Muglia,L., Stephan,D.A. and Menon,R.K.
  TITLE     Identification, chromosomal mapping, and partial characterization
            of mouse InsI6: a new member of the insulin family
  JOURNAL   Endocrinology 141 (1), 458-461 (2000)
   PUBMED   10614671
REFERENCE   9  (bases 1 to 660)
  AUTHORS   Hsu,S.Y.
  TITLE     Cloning of two novel mammalian paralogs of relaxin/insulin family
            proteins and their expression in testis and kidney
  JOURNAL   Mol Endocrinol 13 (12), 2163-2174 (1999)
   PUBMED   10598589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF143807.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF143807.2, BC028752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.82 cM"
     gene            1..660
                     /gene="Insl6"
                     /gene_synonym="RIF1"
                     /note="insulin-like 6"
                     /db_xref="GeneID:27356"
                     /db_xref="MGI:MGI:1351595"
     exon            1..274
                     /gene="Insl6"
                     /gene_synonym="RIF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..579
                     /gene="Insl6"
                     /gene_synonym="RIF1"
                     /note="insulin-like peptide INSL6; insulin-like peptide 6;
                     relaxin/insulin-like factor 1"
                     /codon_start=1
                     /product="insulin-like peptide INSL6 precursor"
                     /protein_id="NP_038782.1"
                     /db_xref="CCDS:CCDS29732.1"
                     /db_xref="GeneID:27356"
                     /db_xref="MGI:MGI:1351595"
                     /translation="MKQLCCSCLLWLGLLLTPFSREEEEESRPRKLCGRHLLIEVIKL
                     CGQSDWSRFEMEEQSPMTQFFPHYSRKGKAFNPHPSSSAWRRFTNPVPAGVSQKKGTH
                     TWEPQSLPDYQFEKTELLPKARVFSYHSGKPYVKSVQLQKKSTNKMNTFRSLFWGNHS
                     QRKRRGFADKCCVIGCTKEEMAVACLPFVDF"
     exon            275..660
                     /gene="Insl6"
                     /gene_synonym="RIF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatgaagc agctgtgctg ttcttgtctg ttgtggcttg gactcctact gactcctttc
       61 tccagggaag aggaagagga atccagaccc aggaagctgt gcggcaggca cctgctgata
      121 gaagttataa aactctgtgg ccaaagtgac tggagccggt tcgagatgga ggagcaaagt
      181 cctatgacac agttctttcc ccactactca cgcaagggca aagccttcaa ccctcaccct
      241 tcttcctccg cctggagaag attcacaaac ccagtccctg caggcgtctc tcagaagaaa
      301 ggaacacaca cttgggagcc tcagtcactg cccgactatc agtttgaaaa gacggagttg
      361 cttcctaagg caagagtgtt ttcataccac agtggcaagc cctatgttaa gagcgtacaa
      421 cttcagaaga aaagcacgaa caaaatgaat accttcagaa gtttattttg ggggaatcat
      481 tcccaaagga aacgcagagg ctttgcagat aagtgctgtg tgataggatg caccaaagaa
      541 gagatggccg tcgcgtgcct cccctttgtt gatttttaaa ccttaacgat taatcaaaca
      601 tcactggtga tagagatgta caaactgtcg taggaactat gctcgcttaa taaaagctta
//
