LOCUS       NM_011831                710 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus insulin-like 5 (Insl5), transcript variant 2, mRNA.
ACCESSION   NM_011831
VERSION     NM_011831.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 710)
  AUTHORS   Vahkal B, Yegorov S, Onyilagha C, Donner J, Reddick D, Shrivastav
            A, Uzonna J and Good SV.
  TITLE     Immune System Effects of Insulin-Like Peptide 5 in a Mouse Model
  JOURNAL   Front Endocrinol (Lausanne) 11, 610672 (2021)
   PUBMED   33519716
  REMARK    GeneRIF: Immune System Effects of Insulin-Like Peptide 5 in a Mouse
            Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 710)
  AUTHORS   Kay RG, Galvin S, Larraufie P, Reimann F and Gribble FM.
  TITLE     Liquid chromatography/mass spectrometry based detection and
            semi-quantitative analysis of INSL5 in human and murine tissues
  JOURNAL   Rapid Commun Mass Spectrom 31 (23), 1963-1973 (2017)
   PUBMED   28857318
  REMARK    GeneRIF: Mass spectral analysis of purified enteroendocrine cells
            and tissue homogenates identified the exact sequence of A and B
            chains of INSL5 endogenously expressed in L-cells.
REFERENCE   3  (bases 1 to 710)
  AUTHORS   Lee YS, De Vadder F, Tremaroli V, Wichmann A, Mithieux G and
            Backhed F.
  TITLE     Insulin-like peptide 5 is a microbially regulated peptide that
            promotes hepatic glucose production
  JOURNAL   Mol Metab 5 (4), 263-270 (2016)
   PUBMED   27069866
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 710)
  AUTHORS   Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers
            GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L,
            Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD,
            Aparicio S, Carlton MB, Coll AP, Reimann F, O'Rahilly S and Gribble
            FM.
  TITLE     Insulin-like peptide 5 is an orexigenic gastrointestinal hormone
  JOURNAL   Proc Natl Acad Sci U S A 111 (30), 11133-11138 (2014)
   PUBMED   25028498
  REMARK    GeneRIF: Insl5 is an orexigenic hormone released from colonic
            L-cells, which promotes appetite during conditions of energy
            deprivation.
REFERENCE   5  (bases 1 to 710)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 710)
  AUTHORS   Dun SL, Brailoiu E, Wang Y, Brailoiu GC, Liu-Chen LY, Yang J, Chang
            JK and Dun NJ.
  TITLE     Insulin-like peptide 5: expression in the mouse brain and
            mobilization of calcium
  JOURNAL   Endocrinology 147 (7), 3243-3248 (2006)
   PUBMED   16601133
  REMARK    GeneRIF: Insulin-like peptide 5 is expressed in mouse brain and has
            a role in mobilization of calcium
REFERENCE   7  (bases 1 to 710)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 710)
  AUTHORS   Hsu SY.
  TITLE     Cloning of two novel mammalian paralogs of relaxin/insulin family
            proteins and their expression in testis and kidney
  JOURNAL   Mol Endocrinol 13 (12), 2163-2174 (1999)
   PUBMED   10598589
REFERENCE   9  (bases 1 to 710)
  AUTHORS   Berger J, Kurahashi H, Takihara Y, Shimada K, Brock HW and Randazzo
            F.
  TITLE     The human homolog of Sex comb on midleg (SCMH1) maps to chromosome
            1p34
  JOURNAL   Gene 237 (1), 185-191 (1999)
   PUBMED   10524249
REFERENCE   10 (bases 1 to 710)
  AUTHORS   Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S
            and Jaspers S.
  TITLE     Identification of INSL5, a new member of the insulin superfamily
  JOURNAL   Genomics 60 (1), 50-56 (1999)
   PUBMED   10458910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF133817.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_011831.3.
            
            On Apr 5, 2007 this sequence version replaced NM_011831.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and initiates translation at a downstream start
            codon, compared to variant 1. It encodes isoform 2, which has a
            shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF133817.1, BC010968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-710               AF133817.1         4-713
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 47.27 cM"
     gene            1..710
                     /gene="Insl5"
                     /gene_synonym="RIF2"
                     /note="insulin-like 5"
                     /db_xref="GeneID:23919"
                     /db_xref="MGI:MGI:1346085"
     exon            1..211
                     /gene="Insl5"
                     /gene_synonym="RIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..444
                     /gene="Insl5"
                     /gene_synonym="RIF2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; insulin-like peptide INSL5;
                     relaxin/insulin-like protein; relaxin/insulin-like factor
                     2"
                     /codon_start=1
                     /product="insulin-like peptide INSL5 isoform 2 precursor"
                     /protein_id="NP_035961.1"
                     /db_xref="CCDS:CCDS18406.1"
                     /db_xref="GeneID:23919"
                     /db_xref="MGI:MGI:1346085"
                     /translation="MKGPTLALFLLLVLLAVVEVRSRQTVKLCGLDYVRTVIYICASS
                     RWRRHLEGHFHSQQAETRNYLQLLDRHEPSKKTLEHSLPKTDLSGQELVRDPQAPKEG
                     LWELKKHSVVSRRDLQALCCREGCSMKELSTLC"
     exon            212..686
                     /gene="Insl5"
                     /gene_synonym="RIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insl5"
                     /gene_synonym="RIF2"
ORIGIN      
        1 gctgaccaca ttgcttctca tttgctctcc ggcaggatga agggccccac tcttgctctg
       61 tttctcctct tagttctgtt ggctgtggtg gaagtaagaa gcaggcagac tgtgaagctc
      121 tgtggcctgg actacgtgag aacagttatc tacatctgtg ccagctcacg gtggaggaga
      181 catctggagg ggcatttcca ctctcaacaa gctgagacaa gaaactacct ccagctccta
      241 gacaggcacg agccatccaa gaaaactctg gagcacagcc ttcccaagac ggatctctca
      301 ggacaggagc ttgttcgaga tccacaggca cccaaggaag gtctttggga actgaagaag
      361 cactcagtgg tatccagacg agatctgcaa gctctgtgct gcagggaagg ctgctccatg
      421 aaggaactca gcaccctctg ttaggatgcg cccaacccct tggcaggctt cagcatgcat
      481 ctcaatgttc taccatcgag ttccctgttc agcttctatc actacaacca cggcttttga
      541 tcctttcctt aaaggtctat tatggcttaa agccactctt ctccctgtgc tgaggtcaat
      601 ctacttttct ttctaaattc taactactgc tttgaagttt cgagtgctgt gcaaaattgc
      661 aataaaaaaa aatgcctgaa tccaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
