LOCUS       NM_153526               2667 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus insulin induced gene 1 (Insig1), mRNA.
ACCESSION   NM_153526
VERSION     NM_153526.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Zheng,L., Song,H., Li,Y., Li,H., Lin,G. and Cai,Z.
  TITLE     Insulin-Induced Gene 1-Enhance Secretion of BMSC Exosome Enriched
            in miR-132-3p Promoting Wound Healing in Diabetic Mice
  JOURNAL   Mol Pharm 21 (9), 4372-4385 (2024)
   PUBMED   39136964
  REMARK    GeneRIF: Insulin-Induced Gene 1-Enhance Secretion of BMSC Exosome
            Enriched in miR-132-3p Promoting Wound Healing in Diabetic Mice.
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Azzu,V., Vacca,M., Kamzolas,I., Hall,Z., Leslie,J., Carobbio,S.,
            Virtue,S., Davies,S.E., Lukasik,A., Dale,M., Bohlooly-Y,M.,
            Acharjee,A., Linden,D., Bidault,G., Petsalaki,E., Griffin,J.L.,
            Oakley,F., Allison,M.E.D. and Vidal-Puig,A.
  TITLE     Suppression of insulin-induced gene 1 (INSIG1) function promotes
            hepatic lipid remodelling and restrains NASH progression
  JOURNAL   Mol Metab 48, 101210 (2021)
   PUBMED   33722690
  REMARK    GeneRIF: Suppression of insulin-induced gene 1 (INSIG1) function
            promotes hepatic lipid remodelling and restrains NASH progression.
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z. PMID: 33712809]
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Zhou,Z.S., Li,M.X., Liu,J., Jiao,H., Xia,J.M., Shi,X.J., Zhao,H.,
            Chu,L., Liu,J., Qi,W., Luo,J. and Song,B.L.
  TITLE     Competitive oxidation and ubiquitylation on the evolutionarily
            conserved cysteine confer tissue-specific stabilization of Insig-2
  JOURNAL   Nat Commun 11 (1), 379 (2020)
   PUBMED   31953408
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Engelking,L.J., Liang,G., Hammer,R.E., Takaishi,K., Kuriyama,H.,
            Evers,B.M., Li,W.P., Horton,J.D., Goldstein,J.L. and Brown,M.S.
  TITLE     Schoenheimer effect explained--feedback regulation of cholesterol
            synthesis in mice mediated by Insig proteins
  JOURNAL   J Clin Invest 115 (9), 2489-2498 (2005)
   PUBMED   16100574
  REMARK    GeneRIF: Results define Insig proteins 1 and 2 as essential
            elements of the feedback inhibition system of cholesterol synthesis
            in mouse liver.
REFERENCE   7  (bases 1 to 2667)
  AUTHORS   Kast-Woelbern,H.R., Dana,S.L., Cesario,R.M., Sun,L., de
            Grandpre,L.Y., Brooks,M.E., Osburn,D.L., Reifel-Miller,A.,
            Klausing,K. and Leibowitz,M.D.
  TITLE     Rosiglitazone induction of Insig-1 in white adipose tissue reveals
            a novel interplay of peroxisome proliferator-activated receptor
            gamma and sterol regulatory element-binding protein in the
            regulation of adipogenesis
  JOURNAL   J Biol Chem 279 (23), 23908-23915 (2004)
   PUBMED   15073165
  REMARK    GeneRIF: the regulation of Insig-1 by PPARgamma agonists could in
            turn regulate SREBP processing and thus couple insulin sensitizers
            with the regulation of lipid homeostasis
REFERENCE   8  (bases 1 to 2667)
  AUTHORS   Li,J., Takaishi,K., Cook,W., McCorkle,S.K. and Unger,R.H.
  TITLE     Insig-1 'brakes' lipogenesis in adipocytes and inhibits
            differentiation of preadipocytes
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9476-9481 (2003)
   PUBMED   12869692
  REMARK    GeneRIF: insig-1 expression restricts lipogenesis in mature
            adipocytes and blocks differentiation in preadipocytes
REFERENCE   9  (bases 1 to 2667)
  AUTHORS   Yabe,D., Komuro,R., Liang,G., Goldstein,J.L. and Brown,M.S.
  TITLE     Liver-specific mRNA for Insig-2 down-regulated by insulin:
            implications for fatty acid synthesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (6), 3155-3160 (2003)
   PUBMED   12624180
REFERENCE   10 (bases 1 to 2667)
  AUTHORS   Yabe,D., Brown,M.S. and Goldstein,J.L.
  TITLE     Insig-2, a second endoplasmic reticulum protein that binds SCAP and
            blocks export of sterol regulatory element-binding proteins
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 12753-12758 (2002)
   PUBMED   12242332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079559.1 and AK151186.1.
            
            On Oct 24, 2007 this sequence version replaced NM_153526.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079559.1, AK151186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2529              BC079559.1         1-2529
            2530-2539           AK151186.1         2580-2589
            2540-2667           BC079559.1         2540-2667
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 13.94 cM"
     gene            1..2667
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /note="insulin induced gene 1"
                     /db_xref="GeneID:231070"
                     /db_xref="MGI:MGI:1916289"
     exon            1..384
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..509
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..676
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..776
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..2648
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2648
                     /gene="Insig1"
                     /gene_synonym="1810013C12Rik; Insig-1"
                     /note="major polyA site"
ORIGIN      
        1 accttccatg ctgtgcctgg acgccgatgc ccaggctgca cgaccacgtc tggaactatc
       61 caagcgcggg cgctgcgagg ccgtacagcc tcccgcgagg catgattgcg gcggccgctt
      121 gtccgcaggg ccccggagtc cccgaacccg agcacgcgcc ccggggccag cgagcgggaa
      181 ccacaggatg cagcgcgcgg ccgggcagct ggcaccacga cttggtgcag cggagcctag
      241 tgctcttctc atttggcgtg gtcctggccc tggtgctcaa cctgctgcag atccagcgga
      301 atgtcacgct cttccccgac gaggtgatag ccaccatctt ctcctccgcc tggtgggtgc
      361 ccccgtgctg tggcacggca gcggctgttg tcggtttact gtatccctgt attgacagtc
      421 acctgggaga accacacaag ttcaagagag aatgggccag cgttatgcgc tgtattgccg
      481 tgttcgttgg catcaaccac gccagtgcca aattagattt tgccaataat gtccagctgt
      541 ccttgacttt agcagccctc tctttgggtt tgtggtggac atttgatcgt tcccgaagcg
      601 gccttgggct tgggattacc atcgccttcc tagctacgct gatcactcag tttcttgtgt
      661 ataatggtgt ctaccagtac acgtcccctg atttcctcta tatccgttct tggctcccct
      721 gtatattttt ctcaggaggt gtcacagtgg gaaacatagg acgacagtta gctatgggtg
      781 ttccggaaaa gcctcacagt gactgagctt cagcacatgg ttcagagtgg aagcaggatg
      841 tagagacact ggtcctgggt gtgatgaaga tgatcttttt ctcaatgttc catttaggct
      901 gggctgacga taaatgactc ctaaagacat gttcacttag tctagactag caaatggagg
      961 caaggactgc ttacctaaaa gtcttacctt gctcccccac cctcacacct gtcttctttg
     1021 gaacattcca tcccaggctg tatgtgaaag tcgggtaagg ggggcagttt cccgagtatt
     1081 agagttcact catcattcaa agcaaatgcc atatttcaaa gccttgaatc aaaatgaatt
     1141 accaactagc agttttgtgt cagtgcccaa aggagggagg ttgatggtgc ttaacagaga
     1201 tgaagtgtgt gtagtaagaa tatttatcca gaattaaaat aaagggttgt gtaaagaggg
     1261 gttgagagca gcagtgagtt ggaggaagat catctcccag taggacctat agtgcagcca
     1321 tatctccagg tcacgctcag gctggcgctc acgtgtgggt ttcatcagtg tgggaacgat
     1381 gctttttact gccgggaggt ttgtagacga caatctcact gaaagccgag ggcagcacaa
     1441 agtcagggtt ctgcactgcg atgctggact tctcacctca gtttaagaga agttttatcc
     1501 gagctctgga ccatctaaga gtgagtcgct gtctgctgtt tcagtcataa tgagccgaaa
     1561 ttgtgtctct gtcactccag ggtggagagg actcttccac agccctgtgg agcttgcaat
     1621 ctgtgattgc ttcgtaacag gttgagtgtg cacgtcactg tgttaattac gcagtgtcct
     1681 atgtgcgttg gacagcatag aacacaacac gtgggaccta acttgcaagg attgggtctt
     1741 caacttcaag tgcaatgtgt atgaaaacca atctgagcct tgtattctcg taaatattta
     1801 ttttgtaatt tttgttaccg cacgagctat tccggagaag ggttctcggg tcatttcaga
     1861 ggtgcgtgga ggcacactca gcaatactgt gtcagccgtg acgtccctca gtcataccct
     1921 ccactgcaca ctagtcctct gacatactcc agctttgtga gttcagtgat ttttacttac
     1981 aaatttacca tttttgtatt ccaaaatgtg tttgttttaa gttatatgaa actgacctcc
     2041 tgacacagtc gttggtcccc aggcggggca gaagctctgt acctgtggac acctgggttt
     2101 gggttaaccc tcgcagggct cctcataggg ggttgctttt tttttttttt tttttttttt
     2161 ggagggaaat gtttgaagta aacctttgtt ttctgaaact actttggcta aaagaaaatg
     2221 ggttgtgcta gactttggga cggttcttaa agtttcctgg aaataaaaac aaatgattgg
     2281 tattttgaag acattcttca gctaagactg gagtgtcttg cacaagctac agtgactgga
     2341 agaaaaataa gtgatcttgg tgatgcactt gattgtatac aatgaggttt tttttttttt
     2401 ctcttaaact ggaaataaat gttagaaata atgtagccaa aaaaggtgaa tctgaaggat
     2461 gcttttgcca atagttatag cagttacaac aaaccaaagt gactgagttt gtacaaatgg
     2521 taactagtac caagcacact cactttcctg atctgaacac ccagcgaggt tcatgtccgt
     2581 gctaagtttg cagcattgtg ttcttttgca ttcttttttt ttttactttt attaaaggtt
     2641 caaaaccaaa aaaaaaaaaa aaaaaaa
//
