LOCUS       NM_001412588            5316 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus inositol polyphosphate phosphatase-like 1 (Inppl1),
            transcript variant 3, mRNA.
ACCESSION   NM_001412588 XM_036152700
VERSION     NM_001412588.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5316)
  AUTHORS   Fernandes,S., Srivastava,N., Pedicone,C., Sudan,R., Luke,E.A.,
            Dungan,O.M., Pacherille,A., Meyer,S.T., Dormann,S., Schurmans,S.,
            Chambers,B.J., Chisholm,J.D. and Kerr,W.G.
  TITLE     Obesity control by SHIP inhibition requires pan-paralog inhibition
            and an intact eosinophil compartment
  JOURNAL   iScience 26 (2), 106071 (2023)
   PUBMED   36818285
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5316)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5316)
  AUTHORS   Michael,M., McCormick,B., Anderson,K.E., Karmakar,U., Vermeren,M.,
            Schurmans,S., Amour,A. and Vermeren,S.
  TITLE     The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and
            Recruitment
  JOURNAL   Front Immunol 12, 671756 (2021)
   PUBMED   33953730
  REMARK    GeneRIF: The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and
            Recruitment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5316)
  AUTHORS   Vande Catsyne,C.A., Sayyed,S.A., Molina-Ortiz,P., Moes,B.,
            Communi,D., Muller,J., Heusschen,R., Caers,J., Azzi,A., Erneux,C.
            and Schurmans,S.
  TITLE     Altered chondrocyte differentiation, matrix mineralization and
            MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model
            of opsismodysplasia
  JOURNAL   Adv Biol Regul 76, 100651 (2020)
   PUBMED   31519471
  REMARK    GeneRIF: Altered chondrocyte differentiation, matrix mineralization
            and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse
            model of opsismodysplasia.
REFERENCE   5  (bases 1 to 5316)
  AUTHORS   Pal Singh,S., de Bruijn,M.J.W., Velaso Gago da Graca,C.,
            Corneth,O.B.J., Rip,J., Stadhouders,R., Meijers,R.W.J.,
            Schurmans,S., Kerr,W.G., Ter Burg,J., Eldering,E., Langerak,A.W.,
            Pillai,S.Y. and Hendriks,R.W.
  TITLE     Overexpression of SH2-Containing Inositol Phosphatase Contributes
            to Chronic Lymphocytic Leukemia Survival
  JOURNAL   J Immunol 204 (2), 360-374 (2020)
   PUBMED   31836657
REFERENCE   6  (bases 1 to 5316)
  AUTHORS   Hori,H., Sasaoka,T., Ishihara,H., Wada,T., Murakami,S., Ishiki,M.
            and Kobayashi,M.
  TITLE     Association of SH2-containing inositol phosphatase 2 with the
            insulin resistance of diabetic db/db mice
  JOURNAL   Diabetes 51 (8), 2387-2394 (2002)
   PUBMED   12145149
  REMARK    GeneRIF: Association with the insulin resistance of diabetic db/db
            mice.
REFERENCE   7  (bases 1 to 5316)
  AUTHORS   Marion,E., Kaisaki,P.J., Pouillon,V., Gueydan,C., Levy,J.C.,
            Bodson,A., Krzentowski,G., Daubresse,J.C., Mockel,J., Behrends,J.,
            Servais,G., Szpirer,C., Kruys,V., Gauguier,D. and Schurmans,S.
  TITLE     The gene INPPL1, encoding the lipid phosphatase SHIP2, is a
            candidate for type 2 diabetes in rat and man
  JOURNAL   Diabetes 51 (7), 2012-2017 (2002)
   PUBMED   12086927
REFERENCE   8  (bases 1 to 5316)
  AUTHORS   Clement,S., Krause,U., Desmedt,F., Tanti,J.F., Behrends,J.,
            Pesesse,X., Sasaki,T., Penninger,J., Doherty,M., Malaisse,W.,
            Dumont,J.E., Le Marchand-Brustel,Y., Erneux,C., Hue,L. and
            Schurmans,S.
  TITLE     The lipid phosphatase SHIP2 controls insulin sensitivity
  JOURNAL   Nature 409 (6816), 92-97 (2001)
   PUBMED   11343120
  REMARK    Erratum:[Nature. 2004 Oct 14;431(7010):878]
REFERENCE   9  (bases 1 to 5316)
  AUTHORS   Schurmans,S., Carrio,R., Behrends,J., Pouillon,V., Merino,J. and
            Clement,S.
  TITLE     The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic
            structure, promoter analysis, and gene expression in the embryo and
            adult mouse
  JOURNAL   Genomics 62 (2), 260-271 (1999)
   PUBMED   10610720
REFERENCE   10 (bases 1 to 5316)
  AUTHORS   Yamabhai,M. and Kay,B.K.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159005.3.
            
            On Oct 7, 2022 this sequence version replaced XM_036152700.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.7575.1,
                                           SRR10223970.9862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-662               AC159005.3         19156-19817
            663-1043            AC159005.3         20026-20406
            1044-1107           AC159005.3         23139-23202
            1108-1258           AC159005.3         23291-23441
            1259-1379           AC159005.3         24007-24127
            1380-1520           AC159005.3         24362-24502
            1521-1614           AC159005.3         24663-24756
            1615-1704           AC159005.3         24860-24949
            1705-1803           AC159005.3         25066-25164
            1804-1954           AC159005.3         25268-25418
            1955-2061           AC159005.3         25504-25610
            2062-2164           AC159005.3         25904-26006
            2165-2361           AC159005.3         26106-26302
            2362-2479           AC159005.3         26807-26924
            2480-2576           AC159005.3         27305-27401
            2577-2715           AC159005.3         27685-27823
            2716-2815           AC159005.3         27929-28028
            2816-2904           AC159005.3         28128-28216
            2905-2986           AC159005.3         28492-28573
            2987-3076           AC159005.3         28689-28778
            3077-3190           AC159005.3         29424-29537
            3191-3279           AC159005.3         29638-29726
            3280-3367           AC159005.3         30136-30223
            3368-3523           AC159005.3         30316-30471
            3524-3602           AC159005.3         30706-30784
            3603-3743           AC159005.3         30876-31016
            3744-4410           AC159005.3         32418-33084
            4411-4544           AC159005.3         33331-33464
            4545-5316           AC159005.3         33574-34345
FEATURES             Location/Qualifiers
     source          1..5316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.67 cM"
     gene            1..5316
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /note="inositol polyphosphate phosphatase-like 1"
                     /db_xref="GeneID:16332"
                     /db_xref="MGI:MGI:1333787"
     exon            1..662
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..1043
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             862..4635
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /EC_number="3.1.3.86"
                     /note="isoform a is encoded by transcript variant 3;
                     SHIP-2; INPPL-1; SH2 domain-containing inositol
                     5'-phosphatase 2; protein 51C; phosphatidylinositol
                     3,4,5-trisphosphate 5-phosphatase 2; ablSH3-binding
                     protein; SH2 domain-containing inositol phosphatase 2;
                     inositol polyphosphate phosphatase-like protein 1"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 2 isoform a"
                     /protein_id="NP_001399517.1"
                     /db_xref="GeneID:16332"
                     /db_xref="MGI:MGI:1333787"
                     /translation="MASVCGTPSPGGALGSPAPAWYHRDLSRAAAEELLARAGRDGSF
                     LVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLY
                     AQPNQGLVCALLLPVEGEREPDPPDDRDASDVEDEKPPLPPRSGSTSISAPVGPSSPL
                     PTPETPTTPAAESTPNGLSTVSHEYLKGSYGLDLEAVRGGASNLPHLTRTLVTSCRRL
                     HSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQSLPQTGEQELESLVLKLSVLKDFLS
                     GIQKKALKALQDMSSTAPPAPLQPSIRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFT
                     LSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRK
                     DFIFVSARKREAFCQLLQLMKNRHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSK
                     GLGKALDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWN
                     IKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSG
                     NEKTTRRNQNYLDILRLLSLGDRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYI
                     SRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGV
                     RTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGL
                     SKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQ
                     WSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTF
                     LSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDTGAKSKVPSVSRGSQEHR
                     SGSRKPASTETSCPLSKLFEEPEKPPPTGRPPAPPRAVPREEPLNPRLKSEGTSEQEG
                     VAAPPPKNSFNNPAYYVLEGVPHQLLPLEPPSLARAPLPPATKNKVAITVPAPQLGRH
                     RTPRVGEGSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSGGEARG
                     PPPPKAHPRPPLPPGTSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPGPGRSALL
                     PNPLELQPPRGPSDYGRPLSFPPPRIRESIQEDLAEEAPCPQGGRASGLGEAGMGAWL
                     RAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK"
     exon            1044..1107
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1258
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1379
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1520
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1614
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1704
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1803
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1954
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2061
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2164
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2361
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2479
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2576
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2715
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2815
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2904
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2986
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3076
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3190
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3279
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3367
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3523
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3602
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3743
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..4410
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4544
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..5316
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5274..5279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /note="hexamer: ATTACA"
     regulatory      5289..5294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /note="hexamer: AAGAAA"
     regulatory      5296..5301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /note="hexamer: AATAAA"
     polyA_site      5297
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
                     /note="major polyA site"
     polyA_site      5307
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
     polyA_site      5316
                     /gene="Inppl1"
                     /gene_synonym="51C; SHIP2"
ORIGIN      
        1 aggcgcgggg tgcgcggtgg cggcggatgg ccatcttaag tggccgcggg gagtccaggg
       61 aggcttcccc gggctaggag tcaacccgag tcgccctaga ggtggggcct gcgttcggta
      121 gttgaggctc tgagacttga gggaactttt tttctaggta gtcgaggggg tcctcctggt
      181 ctgggactgc aaaacctggg cctgcgggtg tggggcgtgg tgccaggcaa tttggtggag
      241 atgggggaag ggttttgcca ggctggaggg cctgcgggga ccggtgcgtg aaaggcacct
      301 cgagcgcgcg cgtatgtgtg gggtggggta tcggatctct ttgggatctt gtgggatgtg
      361 tcaggaatcg ttttgggggg ttcaggtctg aaggggcctc tgaccttata ggagttacga
      421 gaacttgttc tcttggatgt tgtagtagtt gtggatgtct atcctggagc cttgctttcc
      481 gaaccttgat cccgcaaggc tgtgggggtg ccgagtagaa gagatgtgtg tagtagaatc
      541 agatttgcat agggattagg ggtcatctca ttgcgaatcg ttggaaggat tgaattcacc
      601 agcgagaact tggactcaca agttgtcccg gagcgggtac cggggaactg gatcttcttg
      661 agttgaggcc ggcgctgcgg gcggcggcgg ctgcgcggag atccaggcgg ttggcgcggc
      721 caagcgtgga acccacatac tgggttctct cgggctggtg gatccttagt cccgggaccc
      781 gggcccaacc tcgacttcaa gcttccccgg gcggatggcg cggagcggca ggcatcggcg
      841 gcgctgagcc ctgcgtgggc catggcctca gtgtgtggga caccgagtcc cgggggtgcg
      901 ctaggcagcc cggccccagc ctggtatcac cgtgacctga gccgcgctgc tgcggaggag
      961 ctcctggctc gggcgggccg cgatggcagc ttcctggtgc gagatagcga gagcgtggcg
     1021 ggggccttcg cactctgcgt cctgtatcaa aagcacgtgc acacctaccg cattctgcca
     1081 gatggagagg atttcctggc tgtgcagacc tcacagggtg ttcctgtgcg tcgcttccag
     1141 accctgggtg agcttatagg cctatatgcc cagcccaacc agggtcttgt ttgtgccctg
     1201 ctgctgcctg tagaggggga gagagagcca gacccaccag atgaccgaga tgcctcagat
     1261 gtggaggacg agaagccccc actacccccg cgctctggct ctaccagcat ttctgcccct
     1321 gtggggccca gcagccccct gccgactccc gagactccca caactccagc agctgagagc
     1381 actcctaatg gactcagcac tgtgtcacat gagtatctga agggcagcta cgggctggac
     1441 ctggaggctg tacgaggtgg agccagcaac ttgccacatc tcaccagaac ccttgtcacc
     1501 tcgtgccgaa ggctacacag cgaggtggac aaggtcctgt caggcttgga gatcctgtcg
     1561 aaggtgtttg accagcagag ctcgcccatg gtgacccgcc ttttacagca gcagagctta
     1621 ccacagactg gagagcagga gctggagagc cttgtgctga agctatctgt gttaaaggac
     1681 ttcctgtcag gcatccagaa gaaggcccta aaggcactgc aggacatgag ctccacagcg
     1741 cctccggctc cattgcagcc ctccatacgc aaggccaaga ccatccccgt gcaggccttt
     1801 gaggtgaagc tggatgtaac actgggtgac ctgaccaaga ttgggaagtc ccagaagttc
     1861 acgctgagtg tggatgtcga gggtgggagg ctggttctgc tgaggagaca gcgtgactcc
     1921 caggaggact ggacaacctt cacacatgac cggatccggc agctcattaa atcccagcgt
     1981 gtgcagaaca agctgggtgt tgtgtttgaa aaggagaaag atcggaccca gcgcaaggac
     2041 ttcatctttg tcagtgcccg gaaacgagaa gccttctgcc agctcctgca gctcatgaag
     2101 aacaggcact ccaagcagga cgagcccgac atgatctctg tcttcatagg cacctggaac
     2161 atgggaagtg taccaccacc caaaaacgtg acatcttggt tcacatcaaa gggactgggg
     2221 aaagctctgg atgaggtcac agtgactata ccccacgata tctatgtctt tgggactcag
     2281 gagaactcag tgggtgacag agagtggctg gatctgctgc gtgggggcct caaggagctt
     2341 acagatctgg attaccgtcc gattgctatg cagtcactat ggaacatcaa ggtggctgtg
     2401 ttggtcaagc cagaacatga gaatcgcatc agccacgtca gtacgtccag tgtgaagact
     2461 ggtatcgcca acaccctggg gaacaaggga gccgtgggtg tgtccttcat gttcaatggc
     2521 acctcatttg gcttcgtgaa ttgccatctc acctcaggga atgagaagac tactcggcgg
     2581 aaccagaatt atctggacat tctgcgtctc ctctcgttgg gtgatcggca gctcagtgcc
     2641 tttgacatct ctttgcggtt cactcatctc ttctggtttg gggaccttaa ctaccgctta
     2701 gacatggata tccaggagat cctgaactac attagtagga gagagtttga gcctctgctc
     2761 agggtggacc agctcaacct ggagcgggag aagcataagg tcttccttcg atttagtgag
     2821 gaggagatat ctttcccacc cacctaccgc tacgagcggg gttcccggga cacatacgct
     2881 tggcacaagc agaagccaac tggggtccgg accaatgtgc cttcgtggtg tgaccggatt
     2941 ctatggaaat cctatcctga aacccacatc atctgcaatt cctatggttg cactgatgac
     3001 attgttacca gtgaccattc tcctgtgttt gggacatttg aggttggagt tacttcccag
     3061 ttcatctcca agaaaggtct ctctaagacc tcagatcaag cctacattga gtttgagagt
     3121 atcgaagcca ttgtgaagac agccagccgc accaagttct tcattgagtt ctattctacc
     3181 tgcttggaag agtataagaa gagcttcgag aatgatgctc agagcagcga caacatcaat
     3241 ttcctcaagg tgcagtggtc ctcccgccag ctacccacgc tcaagccaat tctggctgac
     3301 attgagtacc tgcaggatca gcatctcctg ctcacagtca agtccatgga tggctacgaa
     3361 tcatatgggg agtgtgtggt tgcactcaag tccatgattg gcagcacagc ccagcagttc
     3421 ctgaccttct tgtcccaccg tggagaggag acaggcaaca tccgtggctc catgaaggtg
     3481 cgggtgccca cagagcgcct gggcacccgt gagcggctct atgaatggat tagcattgat
     3541 aaggatgaca caggagccaa aagcaaggtt ccttcagtgt caagaggcag ccaggagcac
     3601 agatctggga gccgcaagcc agcttccaca gagacctcct gtccactgtc caagttgttt
     3661 gaagagcctg aaaagccacc accgactggc agacccccgg ccccaccacg ggcagttcct
     3721 agggaggagc ccttgaaccc aaggctgaag tcagaaggga catctgagca ggaaggagta
     3781 gcagcccccc cacccaagaa cagcttcaat aaccctgcct actacgtcct tgaaggggtc
     3841 ccacatcagc tgctgcccct ggagccaccc tcacttgcca gggcccctct cccacctgcc
     3901 accaagaaca aagtggccat cacagtgcct gctcctcagc ttgggcgcca ccggacccct
     3961 cgtgtggggg agggaagctc atcagatgag gactctgggg gcacgctgcc tcctccagat
     4021 ttcccacctc caccactgcc agactcagcc atcttcctgc cccctaacct ggatcctttg
     4081 tcaatgccag tggtcagggg ccgaagtggg ggtgaggccc gtggcccacc acctcccaag
     4141 gcccatccaa gaccaccact accgccaggc acctcacctg ccagtacttt tttgggagag
     4201 gtcgcaagtg gggatgaccg gtcttgttcg gtactgcaaa tggccaaaac actcagtgag
     4261 gtagattatg ctccagggcc tggacgctca gcactcctcc ccaacccctt ggaattgcag
     4321 cctccccgag ggccctcgga ctatggccgg cccctcagct tccctccacc ccgcatccgg
     4381 gagagcatcc aagaagactt ggcagaggag gctccgtgcc cgcagggcgg gcgggccagc
     4441 gggctgggag aggcgggcat gggtgcctgg ctgcgggcca tcggcttgga gcgctatgag
     4501 gagggcctgg tgcacaatgg ctgggacgac ctggagtttc tcagtgacat cactgaggaa
     4561 gaccttgagg aagctggggt gcaggatcct gctcacaagc gccttcttct ggacaccttg
     4621 cagctcagca aatgattgca gaggtgctgc ccagctgcaa aagcggagct ggatgggcac
     4681 gtgcaaccag gggttgaaag ttcggagcgg tgtggccgtg catctctatt tattggggat
     4741 cagagttccc tactgcccag ttgtttggga cattctagtt aaaacatcgt gctccccagc
     4801 tccccaccta gcttttaggc ccgggggggg gggggtgcgc agggggaggt tagtagcctg
     4861 tggtgattgt gaagatcggt ggttacgctg gtgcagacac ctccttgcct cagggttgtg
     4921 cgtggggcac acctgagtcc tcacttccac tgatgttttc acctccctcc cacgggcctg
     4981 aaccacagag gaagagttcc ttacagctcc tactctgggg acatccatcc gtccggaaat
     5041 gaaggaagag cccaggaccg ggccggactt atttaagttt ttctgtgtgg gttttgggaa
     5101 gggagggcac gttaatttta ttggggtggg gcaggacctc ggccataaaa tgccaaattg
     5161 gcgtcagagg acagtgctgc agtttatccc accttgggca ctcagaaagg tggtcggctt
     5221 gttgtcttca ataaattaag ttttatttgg attgagcaaa atcaccttaa taaattacac
     5281 gtttttcaaa gaaaaaataa aggaaaagga aaacca
//
