LOCUS       NM_008916               2660 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus inositol polyphosphate 5-phosphatase K (Inpp5k), mRNA.
ACCESSION   NM_008916 XM_484052 XM_489699
VERSION     NM_008916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Manzolillo,A., Gresing,L., Hubner,C.A. and Franzka,P.
  TITLE     Knockdown of INPP5K compromises the differentiation of N2A cells
  JOURNAL   Front Mol Neurosci 17, 1356343 (2024)
   PUBMED   38559586
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Davies,E.M., Gurung,R., Le,K.Q., Roan,K.T.T., Harvey,R.P.,
            Mitchell,G.M., Schwarz,Q. and Mitchell,C.A.
  TITLE     PI(4,5)P2-dependent regulation of endothelial tip cell
            specification contributes to angiogenesis
  JOURNAL   Sci Adv 9 (13), eadd6911 (2023)
   PUBMED   37000875
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Kauer,S.D., Fink,K.L., Li,E.H.F., Evans,B.P., Golan,N. and
            Cafferty,W.B.J.
  TITLE     Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting
            of Corticospinal Tract Axons after CNS Trauma
  JOURNAL   J Neurosci 42 (11), 2190-2204 (2022)
   PUBMED   35135857
  REMARK    GeneRIF: Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances
            Sprouting of Corticospinal Tract Axons after CNS Trauma.
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   McGrath,M.J., Eramo,M.J., Gurung,R., Sriratana,A., Gehrig,S.M.,
            Lynch,G.S., Lourdes,S.R., Koentgen,F., Feeney,S.J., Lazarou,M.,
            McLean,C.A. and Mitchell,C.A.
  TITLE     Defective lysosome reformation during autophagy causes skeletal
            muscle disease
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   33119550
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Gurung,R., Tan,A., Ooms,L.M., McGrath,M.J., Huysmans,R.D.,
            Munday,A.D., Prescott,M., Whisstock,J.C. and Mitchell,C.A.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Zheng,B., Mills,A.A. and Bradley,A.
  TITLE     A system for rapid generation of coat color-tagged knockouts and
            defined chromosomal rearrangements in mice
  JOURNAL   Nucleic Acids Res 27 (11), 2354-2360 (1999)
   PUBMED   10325425
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Hamilton,B.A., Smith,D.J., Mueller,K.L., Kerrebrock,A.W.,
            Bronson,R.T., van Berkel,V., Daly,M.J., Kruglyak,L., Reeve,M.P.,
            Nemhauser,J.L., Hawkins,T.L., Rubin,E.M. and Lander,E.S.
  TITLE     The vibrator mutation causes neurodegeneration via reduced
            expression of PITP alpha: positional complementation cloning and
            extragenic suppression
  JOURNAL   Neuron 18 (5), 711-722 (1997)
   PUBMED   9182797
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   D'Eustachio,P., Meyuhas,O., Ruddle,F. and Perry,R.P.
  TITLE     Chromosomal distribution of ribosomal protein genes in the mouse
  JOURNAL   Cell 24 (2), 307-312 (1981)
   PUBMED   7237550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066112.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_489699.1, XM_484052.1, NM_008916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066112.1, U96724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2660              BC066112.1         1-2660
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..2660
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /note="inositol polyphosphate 5-phosphatase K"
                     /db_xref="GeneID:19062"
                     /db_xref="MGI:MGI:1194899"
     exon            1..178
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1487
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="skeletal muscle and kidney enriched inositol
                     polyphosphate phosphatase; skeletal muscle and
                     kidney-enriched inositol phosphatase; putative
                     PI-5-phosphatase; PI-5-phosphatase related;
                     phosphatidylinositol-4,5-bisphosphate 5-phosphatase;
                     phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase"
                     /codon_start=1
                     /product="inositol polyphosphate 5-phosphatase K"
                     /protein_id="NP_032942.1"
                     /db_xref="CCDS:CCDS25053.1"
                     /db_xref="GeneID:19062"
                     /db_xref="MGI:MGI:1194899"
                     /translation="MQHGDRNTPGYREGIMSAVSLRRPSAPKGFALSVHVVTWNVASA
                     APTVDLSDLLQLNNQDLNLDIYIIGLQEMNFGIISLLSDAAFEDPWSSLFMDMLSPLN
                     FVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYY
                     VSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDF
                     GLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDT
                     SEKKRKPAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVT
                     GTFDLELNPLMSVPLITMMPEHLWTMENDMLISYTSTPEFLSSSWDWIGLYKVGMRHI
                     NDYVAYVWVGDNQVSYGNNPNQVYINISAIPDTEDQFLLCYYSNNLHSVVGISQPFKI
                     PIRSFLREDTLYEPEPQI"
     exon            179..286
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            287..395
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            396..512
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            513..688
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            689..800
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            801..910
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1100
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1238
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1322
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1427
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2641
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /note="hexamer: TATAAA"
     polyA_site      2641
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /note="major polyA site"
ORIGIN      
        1 tccgaatccg gaagaaaaac aatccggagg gagcagtgct gctgagaccg gagaccaagg
       61 gctgctccgg ctcgcactag atgcagcacg gagacaggaa cacaccgggt taccgcgagg
      121 gaataatgtc ggctgtgagt ctaaggaggc cgagcgcacc gaaaggcttt gcactcagcg
      181 tacatgttgt gacgtggaat gtggcctccg cagcccccac tgtagacctc agtgacctac
      241 ttcaactgaa caaccaagac ctgaatctgg acatatatat cattggtttg caggaaatga
      301 attttggaat cataagcctt ctttctgatg ctgcttttga agacccatgg agcagtctct
      361 tcatggatat gctttcccca ctgaactttg tcaagatctc tcaagtccgt atgcaggggc
      421 ttctcttact ggtctttgcc aagtaccagc atttgcccta catccagatc atctctacga
      481 aatccacccc cactggcctc tacgggtact gggggaacaa agggggagtc aacgtctgcc
      541 tgaagcttta tggctactac gtcagcatca tcaattgcca cctgcctcct catatgtata
      601 acaatgacca gcgcctggaa cactttgacc gaatcttgga gagtctgact tttgagggat
      661 atgatgtccc caacatcctg gaccatgacc tcattctgtg gtttggagac atgaactttc
      721 gaattgagga ctttgggttg ctctttgtgc aggagagtat aacgaggaag tactacaaag
      781 agctgtggga gaaagatcag ctcttcattg ccaagaaaaa tgaccagctg ctccgcgagt
      841 tccaggaagg cccgctgctc ttcccaccca cctacaagtt tgaccgtcac tccaacaact
      901 atgacaccag tgagaaaaaa cgcaagcctg cgtggactga ccgcatcctg tggaggttga
      961 agcggcagcc gtcccaggcc agccccttgg cctccagtgt accaacctcc tacttcttgc
     1021 tgacactgaa gaactatgtc agccacatgg catacagcat cagtgaccat aagcctgtca
     1081 ctggcacctt tgacttggag ctgaacccac tgatgtctgt cccactgatc actatgatgc
     1141 ctgaacacct gtggaccatg gagaacgaca tgctgatcag ctacacctcc accccagagt
     1201 tcctcagcag ctcctgggac tggatcggac tatacaaggt ggggatgcgt cacattaatg
     1261 actatgtagc ctatgtctgg gtcggcgaca accaagtctc ctatggtaac aacccaaacc
     1321 aggtgtatat caacatcagt gctatccctg acactgagga tcagtttctt ctctgttact
     1381 atagcaacaa cctgcactct gtagtgggga taagtcaacc cttcaagatc ccgattcgct
     1441 cctttttgag agaggacaca ctgtatgagc ctgagccaca gatctgagcc cagatggaag
     1501 tgaatgaatc cagggcggag gctagagctg gaagccagct ctgcttcagc actgccagca
     1561 gcgctgggtc tggcccagcc cctgaggagg ctcctgacta tcctccagct ccccacctcc
     1621 cagaggagct cagctagact cctctgctct ctccaggcca gaggaactgg ccctttaata
     1681 caggtttttg ttacagagat gtgattgaaa cagagtagtg tgtcaatagt gaagacttgg
     1741 agacggtcca ctgcatatag acttgcttgc ttccactagc ttgcatgcca tttctttttt
     1801 ctccctttca tccacacata aacactccct ctcacattca agcagtcgtg ccaggcacat
     1861 gccctatctg gcacaggcct gcattcctat cacaccatcc tgggcctcag gctgcctggg
     1921 agggggacgt tcacatttgt acaggccctg tcagttgggt ggcacgaaca gcactgggtt
     1981 ccaaattctt ggcatctcat ggtttgtccc cacggggatg agcagagact ctgagatccc
     2041 tgctttcagc tgaagcactg tgacagtagt gtaatgtcca tctctactct ggagagtgga
     2101 tctgaccagg aagtcctagg gcctaaggtt agcttctgca ggtgagtgca gctgcatgtc
     2161 cccacctgcc ctttcctgag agtggacagg tggaggagga gccatagcca ccaacctcta
     2221 gggtggtctt cagatcacga tcatgctcat cttcactggc aaagcactgc tcctccctct
     2281 gggccctgct ggacctagaa gtgggaagca gcagaggaac taggtgcaag acattttgga
     2341 ggacctagcg gcaagaagaa gcctcagcac tctctgggag ccatgtggat atggcctgtc
     2401 cctgttcctg ccaacagtga ctcagtgcct cttctcccag gagaagacac ctcagggagt
     2461 cttgccctgt aatgctcacg tccatcctgt aacctaagag tcactccagt tgctccaggg
     2521 tctgtattct atcttgggag ccaccgggtg ttaagaataa gcccccaggc ttctagtgag
     2581 ctgtggctgt ctgttctctg tgtgttgtca tattggaggt taattataaa tatggctttt
     2641 aaaaaaaaaa aaaaaaaaaa
//
