LOCUS       NP_032942                468 aa            linear   ROD 07-MAY-2024
DEFINITION  inositol polyphosphate 5-phosphatase K [Mus musculus].
ACCESSION   NP_032942 XP_484052 XP_489699
VERSION     NP_032942.1
DBSOURCE    REFSEQ: accession NM_008916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 468)
  AUTHORS   Manzolillo,A., Gresing,L., Hubner,C.A. and Franzka,P.
  TITLE     Knockdown of INPP5K compromises the differentiation of N2A cells
  JOURNAL   Front Mol Neurosci 17, 1356343 (2024)
   PUBMED   38559586
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 468)
  AUTHORS   Davies,E.M., Gurung,R., Le,K.Q., Roan,K.T.T., Harvey,R.P.,
            Mitchell,G.M., Schwarz,Q. and Mitchell,C.A.
  TITLE     PI(4,5)P2-dependent regulation of endothelial tip cell
            specification contributes to angiogenesis
  JOURNAL   Sci Adv 9 (13), eadd6911 (2023)
   PUBMED   37000875
REFERENCE   4  (residues 1 to 468)
  AUTHORS   Kauer,S.D., Fink,K.L., Li,E.H.F., Evans,B.P., Golan,N. and
            Cafferty,W.B.J.
  TITLE     Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting
            of Corticospinal Tract Axons after CNS Trauma
  JOURNAL   J Neurosci 42 (11), 2190-2204 (2022)
   PUBMED   35135857
  REMARK    GeneRIF: Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances
            Sprouting of Corticospinal Tract Axons after CNS Trauma.
REFERENCE   5  (residues 1 to 468)
  AUTHORS   McGrath,M.J., Eramo,M.J., Gurung,R., Sriratana,A., Gehrig,S.M.,
            Lynch,G.S., Lourdes,S.R., Koentgen,F., Feeney,S.J., Lazarou,M.,
            McLean,C.A. and Mitchell,C.A.
  TITLE     Defective lysosome reformation during autophagy causes skeletal
            muscle disease
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   33119550
REFERENCE   6  (residues 1 to 468)
  AUTHORS   Gurung,R., Tan,A., Ooms,L.M., McGrath,M.J., Huysmans,R.D.,
            Munday,A.D., Prescott,M., Whisstock,J.C. and Mitchell,C.A.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
REFERENCE   7  (residues 1 to 468)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   8  (residues 1 to 468)
  AUTHORS   Zheng,B., Mills,A.A. and Bradley,A.
  TITLE     A system for rapid generation of coat color-tagged knockouts and
            defined chromosomal rearrangements in mice
  JOURNAL   Nucleic Acids Res 27 (11), 2354-2360 (1999)
   PUBMED   10325425
REFERENCE   9  (residues 1 to 468)
  AUTHORS   Hamilton,B.A., Smith,D.J., Mueller,K.L., Kerrebrock,A.W.,
            Bronson,R.T., van Berkel,V., Daly,M.J., Kruglyak,L., Reeve,M.P.,
            Nemhauser,J.L., Hawkins,T.L., Rubin,E.M. and Lander,E.S.
  TITLE     The vibrator mutation causes neurodegeneration via reduced
            expression of PITP alpha: positional complementation cloning and
            extragenic suppression
  JOURNAL   Neuron 18 (5), 711-722 (1997)
   PUBMED   9182797
REFERENCE   10 (residues 1 to 468)
  AUTHORS   D'Eustachio,P., Meyuhas,O., Ruddle,F. and Perry,R.P.
  TITLE     Chromosomal distribution of ribosomal protein genes in the mouse
  JOURNAL   Cell 24 (2), 307-312 (1981)
   PUBMED   7237550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066112.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XP_489699.1, XP_484052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066112.1, U96724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     Protein         1..468
                     /product="inositol polyphosphate 5-phosphatase K"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="skeletal muscle and kidney enriched inositol
                     polyphosphate phosphatase; skeletal muscle and
                     kidney-enriched inositol phosphatase; putative
                     PI-5-phosphatase; PI-5-phosphatase related;
                     phosphatidylinositol-4,5-bisphosphate 5-phosphatase;
                     phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase"
                     /calculated_mol_wt=54028
     Region          32..339
                     /region_name="EEP"
                     /note="Exonuclease-Endonuclease-Phosphatase (EEP) domain
                     superfamily; cl00490"
                     /db_xref="CDD:469791"
     Region          34..337
                     /region_name="Catalytic. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5L6.2)"
     Site            order(40,72,167,210,212,287,329..330)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197306"
     Site            order(72,329)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:197306"
     Site            order(167,212,330)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197306"
     Region          318..448
                     /region_name="Required for interaction with GPR78 and
                     PAK1. /evidence=ECO:0000250|UniProtKB:Q9BT40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5L6.2)"
     Region          340..468
                     /region_name="Required for ruffle localization"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5L6.2)"
     Region          350..450
                     /region_name="SKICH"
                     /note="SKICH domain; pfam17751"
                     /db_xref="CDD:465482"
     CDS             1..468
                     /gene="Inpp5k"
                     /gene_synonym="C62; Pps; SKIP"
                     /coded_by="NM_008916.2:81..1487"
                     /db_xref="CCDS:CCDS25053.1"
                     /db_xref="GeneID:19062"
                     /db_xref="MGI:MGI:1194899"
ORIGIN      
        1 mqhgdrntpg yregimsavs lrrpsapkgf alsvhvvtwn vasaaptvdl sdllqlnnqd
       61 lnldiyiigl qemnfgiisl lsdaafedpw sslfmdmlsp lnfvkisqvr mqgllllvfa
      121 kyqhlpyiqi istkstptgl ygywgnkggv nvclklygyy vsiinchlpp hmynndqrle
      181 hfdrileslt fegydvpnil dhdlilwfgd mnfriedfgl lfvqesitrk yykelwekdq
      241 lfiakkndql lrefqegpll fpptykfdrh snnydtsekk rkpawtdril wrlkrqpsqa
      301 splassvpts yflltlknyv shmaysisdh kpvtgtfdle lnplmsvpli tmmpehlwtm
      361 endmlisyts tpeflssswd wiglykvgmr hindyvayvw vgdnqvsygn npnqvyinis
      421 aipdtedqfl lcyysnnlhs vvgisqpfki pirsflredt lyepepqi
//
