LOCUS       NM_172439               3473 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus inositol polyphosphate 5-phosphatase J (Inpp5j), mRNA.
ACCESSION   NM_172439
VERSION     NM_172439.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3473)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3473)
  AUTHORS   Yu,H., Yong,W., Gao,T., Na,M., Zhang,Y., Kuguminkiriza,I.H.,
            Kenechukwu,A.A., Guo,Q., Zhang,G. and Deng,X.
  TITLE     Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a
            great increase of proline-rich inositol polyphosphate 5-phosphatase
            (PIPP) level in oocytes
  JOURNAL   In Vitro Cell Dev Biol Anim 57 (3), 342-349 (2021)
   PUBMED   33537929
  REMARK    GeneRIF: Hormesis of low-dose inhibition of pAkt1 (Ser473) followed
            by a great increase of proline-rich inositol polyphosphate
            5-phosphatase (PIPP) level in oocytes.
REFERENCE   3  (bases 1 to 3473)
  AUTHORS   Ooms,L.M., Binge,L.C., Davies,E.M., Rahman,P., Conway,J.R.,
            Gurung,R., Ferguson,D.T., Papa,A., Fedele,C.G., Vieusseux,J.L.,
            Chai,R.C., Koentgen,F., Price,J.T., Tiganis,T., Timpson,P.,
            McLean,C.A. and Mitchell,C.A.
  TITLE     The Inositol Polyphosphate 5-Phosphatase PIPP Regulates
            AKT1-Dependent Breast Cancer Growth and Metastasis
  JOURNAL   Cancer Cell 28 (2), 155-169 (2015)
   PUBMED   26267533
REFERENCE   4  (bases 1 to 3473)
  AUTHORS   Ooms,L.M., Fedele,C.G., Astle,M.V., Ivetac,I., Cheung,V.,
            Pearson,R.B., Layton,M.J., Forrai,A., Nandurkar,H.H. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 5-phosphatase, PIPP, Is a novel
            regulator of phosphoinositide 3-kinase-dependent neurite elongation
  JOURNAL   Mol Biol Cell 17 (2), 607-622 (2006)
   PUBMED   16280363
REFERENCE   5  (bases 1 to 3473)
  AUTHORS   Gurung,R., Tan,A., Ooms,L.M., McGrath,M.J., Huysmans,R.D.,
            Munday,A.D., Prescott,M., Whisstock,J.C. and Mitchell,C.A.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235850.1, BC131634.1 and BY629401.1.
            
            On Oct 30, 2009 this sequence version replaced NM_172439.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136908.1, AK034272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY235850.1         1-5
            6-3278              BC131634.1         1-3273
            3279-3473           BY629401.1         204-398
FEATURES             Location/Qualifiers
     source          1..3473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.45 cM"
     gene            1..3473
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /note="inositol polyphosphate 5-phosphatase J"
                     /db_xref="GeneID:170835"
                     /db_xref="MGI:MGI:2158663"
     exon            1..178
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..3085
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /note="proline-rich inositol polyphosphate 5-phosphatase;
                     phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A;
                     phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase;
                     phosphatidylinositol 1,3,4,5-tetrakisphosphate
                     5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate
                     5-phosphatase A"
                     /protein_id="NP_766027.2"
                     /db_xref="CCDS:CCDS24364.1"
                     /db_xref="GeneID:170835"
                     /db_xref="MGI:MGI:2158663"
                     /translation="MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLP
                     AKNSGPASSEPRLTLAPVGPRAAVSPPSERPRLVLSSPRPVLAPLSIAGEQKRPPPPH
                     SSNRAAKSVGQLVVSAAAASKPPPVASVSILAPKSLGQLVISASAMPRPSPAPLGSVL
                     TPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQEGH
                     LAAASVTSTPASERQLPARQKDTAVPRPTPPADKCLYTPERAAGPATSPPRAQAFSDP
                     RLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSPGLPESGTRSPGLLSPTFRPGIPS
                     SQTVPPPLPKPPRSPSRSPSRSPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQ
                     ESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDN
                     DGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLL
                     FAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAE
                     QRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQ
                     LWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWK
                     VKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRL
                     EVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNI
                     YQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSE
                     GEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALHPSSRERRGGSRSPSPQS
                     RQLPRVAPDRGHSSSSRGSSEEGPSGLPGPWAFPPSVPRSLGLLPALRLETVDPGGGG
                     SWGADQEAPDPNSLSPSPQGRLGLEEGGLGP"
     exon            179..1335
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1449
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1558
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1675
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1851
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1963
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2073
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2257
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2395
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2473
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2578
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..3473
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3345..3350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /note="hexamer: ATTAAA"
     polyA_site      3363
                     /gene="Inpp5j"
                     /gene_synonym="Pib5pa; Pipp"
                     /note="major polyA site"
ORIGIN      
        1 ggttcctggg agctgaggag ctggagccag aacccaaggg agccaggctg ggctgccggg
       61 ggctgctgca gacatggaag gccagaccag gagtggtagt gccaggcccg ggaccaggac
      121 tggactggga cccttgcctg ggactcatgg ggtcttgcaa gctgagatac cctcgaagaa
      181 ggtaaactca agttttcagc ttccagcaaa gaactcgggc ccagcatctt cggaaccaag
      241 gttgaccctg gcacctgtgg gaccacgagc agctgtgtca cctccttcag agaggccgag
      301 actggttttg tcatctcccc gacctgtcct agcgccactg tccatcgctg gagaacagaa
      361 aaggcctccg ccccctcaca gctccaacag ggcagccaag tctgtgggcc aactggtagt
      421 atctgctgct gcagcatcca agcctccacc agtcgcctca gtctcaatcc tggctccgaa
      481 gtctctgggg cagctagtaa tatctgcctc tgctatgcca aggccatctc cggctcccct
      541 ggggtccgtc ctaactccaa cttctaggga tcagaagcag ttatcaccca cctctgtggg
      601 acctaagcca gcattggcaa cctcaggcct aagcctagcg ctggcctctc aggagcagcc
      661 cccgcagtcc ccctccagtc cttcccctgt gccgagtccc gttctgtcac cctctcagga
      721 gggtcacctg gctgcagcat ctgtgacatc taccccagct tctgagagac agttgccggc
      781 tagacagaag gataccgcag ttcccaggcc cactcctcct gcagacaagt gtctctacac
      841 tccagagcgg gcagctggtc ccgccacctc tccaccaagg gcccaagctt tctcagaccc
      901 tcggctttcc ccctctttcc gcgcgagacc agaggctcca cgccacagcc cagaggatcc
      961 cgtcttgccg ccgccaccgc agaccctgcc cttggatgtg agcccaggcc ttccagagtc
     1021 tggcacccgt tcccctggac ttctgtcccc tacctttcgg ccaggaatcc cttcaagcca
     1081 gactgtgccc ccacctctgc caaagccacc tcggtctccc agccgctccc cgagtcgctc
     1141 tcccaaccgc tctccctgtt tgcccccagc ccctgaggtg gcactcccaa aacctgtcac
     1201 ccaggctgca gggtctggca ggtgcccaag ccctaaccta caggcacaag aaagtccagc
     1261 agccgccacc accaccacct caccaacatc ttcttggtca gctcagccta cttgcaagag
     1321 cgaccctgga ttccggatca ctgtggttac atggaatgtg gggaccgcca tgccccctga
     1381 tgatgtcaca tctcttcttc acctgggcag tggccacgac aatgatggtg cagatatgat
     1441 tgccataggg ttgcaagaag tcaattccat gatcaacaag cggctcaagg atgctctctt
     1501 tactgaccag tggagtgagc tcttcatgga tgcactgggg cctttcaact ttgtgctggt
     1561 gagcaccgtg aggatgcagg gcgtcattct gctgctcttt gccaagtact accacctacc
     1621 gttcctacgg gacgtgcaga cagactgtac tcgtactggc ctgggtggct actggggtaa
     1681 caagggcgga gtaagtgtgc gcttagcagc cttcgggcac atgctgtgct tcctaaactg
     1741 ccacttgccc gcacacatgg acaaggcaga acagcgcaag gataactttc aaactatcct
     1801 tagcctccag caattccagg gacctggtgc acacggcatc ttggatcatg atcttgtatt
     1861 ctggtttggg gacctgaact tccgcattga gagctatgac ctacactttg tcaagttcgc
     1921 catagacagc aaccaactcc atcagctctg ggagaaggac cagctcaaca tggccaagaa
     1981 cacttggccc atcttgaaag gtttccagga agggcccctt aactttgctc ccactttcaa
     2041 gtttgacgtg ggtaccaaca aatatgatac cagtgccaaa aagcggaagc cagcctggac
     2101 agatcgcatt ctgtggaagg tcaaggctcc aagtggaggt cccagtccct caggacgaga
     2161 gagtcatagg ctccaggtga cccagcacag ctaccgcagc cacatggagt acactgtcag
     2221 tgaccacaag cctgttgctg cccagttcat tctgcagttt gccttcaggg atgatgttcc
     2281 tctggtgcgg ctggaggtag ccgatgaatg ggcaaggcca gagcaggccg tggtgaggta
     2341 ccgcgtggaa acagtatttg cccgaagctc ctgggactgg atcggcttgt accgggtggg
     2401 cttccgtcac tgtaaggact atgtggctta cgtctgggcc aagcatgagg aagtggatgg
     2461 gaatatctac caggtgacct tcagtgagga gtcactgccc aagggccacg gagacttcat
     2521 tctgggttac tatagccacc accacagcat cctcattggc gtcacagaac cctttcagat
     2581 ctcgctgcct acctcagaat ctgccagcag cagcacagac agctcgggca ccagctcgga
     2641 gggggaggat gacagcactc tggagctgct ggcacccaag tcccgcagcc ccagccctgg
     2701 caagtccaag agacaccgta gtcgcagccc tggcctagcc cgcttcccca gtctcgctct
     2761 ccatccctcg tcccgtgaac gccgtggtgg cagccgaagt ccctcacccc agagccgcca
     2821 actgcctcgg gtagcccctg acaggggtca cagtagtagc agccgaggta gtagtgagga
     2881 ggggccctct gggctgcctg gaccctgggc cttcccaccc tctgtgcctc gaagcctggg
     2941 cctgcttcca gccttgcgcc tggagaccgt agaccctggt ggtggaggct cctggggagc
     3001 tgaccaggag gcccctgacc ctaatagcct ctcccctagc ccccagggcc gactggggct
     3061 ggaggaaggg ggtttggggc cctgataggg gaggcagacg gcctagacag tctcattctg
     3121 cctatcttcc acaagcctgc ctgcctgcct ctctcttgct gcttctccag ccgttaacca
     3181 catctgccac tctgtcttgg ccaggagcgg cctactgggg ggtccccaaa ctcagtcctg
     3241 gtaccacctc aactgtgaca atcagcaaag cctcgcctgg gccctcatct gggatgatgg
     3301 ggggaacgga cagatattcc catcttggag gtcatccatt aggaattaaa ttctccagct
     3361 tcactcttgg ctccttcctg acttgttagc agttgcagat gtgacagagt gatagaactg
     3421 acatatatta ggcaccagct gtatatggaa acatgccatc tttcatttcc acc
//
