LOCUS       NM_178641               4740 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus inositol polyphosphate-5-phosphatase F (Inpp5f),
            transcript variant 1, mRNA.
ACCESSION   NM_178641
VERSION     NM_178641.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4740)
  AUTHORS   Zhou,Q., Lin,J., Yan,Y., Meng,S., Liao,H., Chen,R., He,G., Zhu,Y.,
            He,C., Mao,K., Wang,J., Zhang,J., Zhou,Z. and Xiao,Z.
  TITLE     INPP5F translocates into cytoplasm and interacts with ASPH to
            promote tumor growth in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 41 (1), 13 (2022)
   PUBMED   34996491
  REMARK    GeneRIF: INPP5F translocates into cytoplasm and interacts with ASPH
            to promote tumor growth in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4740)
  AUTHORS   Cao,M., Park,D., Wu,Y. and De Camilli,P.
  TITLE     Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's
            disease mutation of synaptojanin 1
  JOURNAL   Proc Natl Acad Sci U S A 117 (22), 12428-12434 (2020)
   PUBMED   32424101
  REMARK    GeneRIF: Absence of Sac2/INPP5F enhances the phenotype of a
            Parkinson's disease mutation of synaptojanin 1.
REFERENCE   3  (bases 1 to 4740)
  AUTHORS   Bai,D., Zhang,Y., Shen,M., Sun,Y., Xia,Q., Zhang,Y., Liu,X.,
            Wang,H. and Yuan,L.
  TITLE     Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative
            feedback loop in the diabetic heart
  JOURNAL   Sci Rep 6, 22068 (2016)
   PUBMED   26908121
  REMARK    GeneRIF: Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f
            negative feedback loop in the diabetic heart.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4740)
  AUTHORS   Zou,Y., Stagi,M., Wang,X., Yigitkanli,K., Siegel,C.S., Nakatsu,F.,
            Cafferty,W.B. and Strittmatter,S.M.
  TITLE     Gene-Silencing Screen for Mammalian Axon Regeneration Identifies
            Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal
            Cord Injury
  JOURNAL   J Neurosci 35 (29), 10429-10439 (2015)
   PUBMED   26203138
  REMARK    GeneRIF: This study reveals Inpp5f (Sac2) as a novel suppressor of
            CNS axon repair after spinal cord injury
REFERENCE   5  (bases 1 to 4740)
  AUTHORS   Hsu,F., Hu,F. and Mao,Y.
  TITLE     Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2
            regulates endocytic recycling
  JOURNAL   J Cell Biol 209 (1), 97-110 (2015)
   PUBMED   25869669
REFERENCE   6  (bases 1 to 4740)
  AUTHORS   Trivedi,C.M., Luo,Y., Yin,Z., Zhang,M., Zhu,W., Wang,T., Floss,T.,
            Goettlicher,M., Noppinger,P.R., Wurst,W., Ferrari,V.A.,
            Abrams,C.S., Gruber,P.J. and Epstein,J.A.
  TITLE     Hdac2 regulates the cardiac hypertrophic response by modulating
            Gsk3 beta activity
  JOURNAL   Nat Med 13 (3), 324-331 (2007)
   PUBMED   17322895
REFERENCE   7  (bases 1 to 4740)
  AUTHORS   Choi,J.D., Underkoffler,L.A., Wood,A.J., Collins,J.N.,
            Williams,P.T., Golden,J.A., Schuster,E.F. Jr., Loomes,K.M. and
            Oakey,R.J.
  TITLE     A novel variant of Inpp5f is imprinted in brain, and its expression
            is correlated with differential methylation of an internal CpG
            island
  JOURNAL   Mol Cell Biol 25 (13), 5514-5522 (2005)
   PUBMED   15964807
  REMARK    GeneRIF: A novel variant of Inpp5f is imprinted in brain, and its
            expression is correlated with differential methylation of an
            internal CpG island.
REFERENCE   8  (bases 1 to 4740)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 4740)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4740)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122767.16.
            
            On May 2, 2007 this sequence version replaced NM_178641.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030870.1, AK129249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AC122767.16        91239-91565
            328-408             AC122767.16        116032-116112
            409-545             AC122767.16        138890-139026
            546-674             AC122767.16        143512-143640
            675-842             AC122767.16        143851-144018
            843-899             AC122767.16        144123-144179
            900-1098            AC122767.16        147471-147669
            1099-1278           AC122767.16        148288-148467
            1279-1346           AC122767.16        149805-149872
            1347-1471           AC122767.16        155172-155296
            1472-1549           AC122767.16        156603-156680
            1550-1670           AC122767.16        157871-157991
            1671-1799           AC122767.16        159591-159719
            1800-1917           AC122767.16        162122-162239
            1918-2116           AC122767.16        164960-165158
            2117-2188           AC122767.16        170501-170572
            2189-2262           AC122767.16        171626-171699
            2263-2391           AC122767.16        172128-172256
            2392-2479           AC122767.16        173519-173606
            2480-4740           AC122767.16        174050-176310
FEATURES             Location/Qualifiers
     source          1..4740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.32 cM"
     gene            1..4740
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /note="inositol polyphosphate-5-phosphatase F"
                     /db_xref="GeneID:101490"
                     /db_xref="MGI:MGI:2141867"
     exon            1..327
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..3629
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /EC_number="3.1.3.25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositide phosphatase SAC2; sac
                     domain-containing inositol phosphatase 2; sac
                     domain-containing phosphoinositide 5-phosphatase 2; sac
                     domain-containing phosphoinositide 4-phosphatase 2"
                     /codon_start=1
                     /product="phosphatidylinositide phosphatase SAC2 isoform
                     1"
                     /protein_id="NP_848756.2"
                     /db_xref="CCDS:CCDS21899.1"
                     /db_xref="GeneID:101490"
                     /db_xref="MGI:MGI:2141867"
                     /translation="MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPIC
                     LGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQEL
                     ELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTNIKSNVSAPNKKKVKESKEKEKLER
                     RLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQA
                     LTEIGTPDVDFWIIPIIQGFVQIEELVVNYNESSDDDKSSPETPPQDSTCVDDIHPRF
                     LVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHHHTLSFIQTRGSVPVFW
                     SQVGYRYNPRPRLDKSEKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYL
                     KQVLLFNNPKLTYVSFDFHEHCRGMKFENVQTLTDAIHDIIIDMKWCWVDQAGVICKQ
                     EGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRTYQIMWANN
                     GDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQ
                     GVPVTEDLYSIFTKEKEHEALHKESQRSHQELISQLLQSYMQLLLPGDEKFHGGWALV
                     DCDPSLTDAAHRDVEVLLLLSNAAYYVAYYDDEVDKVNQYQRLGLEDLERIEIGPEPT
                     LFGKPKFSCMRLHYRCKEAGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLD
                     VPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKSFLMSKFSSLNQKVKQTKSNVNIG
                     NLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENPGVMGNKVQGESDGDISSDN
                     DSYHSDEFLTNSKSEEDKQLANSLESVGPIDYILPSCGIIVSAPRLGSRSQSASSIDV
                     STHAPSEAAAGPGSELGKGLESPLKKSPSADSIHTRTGFTKPMDVYCQRFVQDAQNKM
                     NDLSEIRSVAQKSEEGSHKTNRVSNEETQSEPMGQTPPRPSQLNVSCSVAGPPFLSVE
                     PVHSVLSQKTPSSGSSLLELEAGLCVTPSSESSSSRAVSPFAKIRSSMVQVANITQAG
                     LTHGINLAVAKVQKSPAEPEAVNEIQQNELKNMFTQCQTRIIQI"
     exon            328..408
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..545
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..674
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..842
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..899
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1098
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1278
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1346
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1471
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1549
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1670
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1799
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1917
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2116
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2188
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2262
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2391
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2479
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..4740
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4553..4558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /note="hexamer: ATTAAA"
     polyA_site      4578
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /note="major polyA site"
     regulatory      4639..4644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
                     /note="hexamer: CATAAA"
     polyA_site      4666
                     /gene="Inpp5f"
                     /gene_synonym="5830435P03Rik; cI-27; hSAC2; mKIAA0966;
                     SAC2"
ORIGIN      
        1 gagggggaaa aggcctcccg ggcctcggcc gcccaagcgt gttcttggcc cgcgggtcag
       61 gcccccgagt gcttccccac tctgttcttc cgtgggctgg gtcctcggag tctccttgag
      121 gcacggactc tggtggtctc ggtggaggag gactccagca tcgctccagg gcgggccgct
      181 gccgtgcctg ggccggggga ccgccgcctc ccggagcgcg tggggccggc atggagctct
      241 ttcaggctaa ggaccactac atcctgcagc agggcgagcg tgccctgtgg tgcagccggc
      301 gcgacggcgg cctgcagctc cgaccggcca cggatctgct tcttgcctgg aaccccattt
      361 gtttgggatt agtggaaggt gtaattggga aaattcaact tcattcagat cttccatggt
      421 ggcttatttt aattcggcag aaagcgttgg taggcaaact cccaggagac catgaggtct
      481 gtaaagtcac caagattgct gtattgtcac tttctgaaat ggaacctcag gagcttgagc
      541 tggagctctg taagaagcat cattttggaa ttaacaagcc tgagaagatt ataccatctc
      601 ctgacgactc caagtttcta ctgaagacat ttacaaatat caaatccaac gtgtctgctc
      661 ccaacaaaaa gaaagttaaa gaaagtaaag aaaaggagaa actggagcgg cgtttgcttg
      721 aggagttgct gaagatgttc atggactcag agtccttcta ttatagcttg acctatgacc
      781 tgaccaactc ggtgcagaga cagagcactg gggagaggga tggccgtccc ctgtggcaga
      841 aggttgatga ccgatttttc tggaataagt acatgatcca agctctcact gagattggta
      901 ctccggatgt ggacttctgg atcatcccca ttatccaggg ttttgtgcag attgaagaac
      961 ttgtggttaa ttacaatgag tcctcggatg atgacaagag cagcccagag acgccccctc
     1021 aggactccac ttgtgtagat gacattcacc cacgatttct agtggctctt atatctcgaa
     1081 gaagtaggca cagagcagga atgcggtata aacgaagagg agtggataaa aatggaaatg
     1141 ttgcgaatta tgtggagact gagcagttaa tccatgttca tcatcatacc ctgtcattta
     1201 tccaaactcg aggctctgtg ccggtctttt ggagccaggt tgggtatcgc tataatccaa
     1261 gacctcggct agacaaaagt gagaaggaaa cggttgactg tttctgtgcc cattttgaag
     1321 aacaactgaa aatttacaaa aaacaggtta ttgttaactt ggtagaccag gctggaaggg
     1381 agaagattat tggtgatgct tacctgaagc aggtgctgct cttcaacaac cccaagctca
     1441 cctatgtctc cttcgatttc catgagcact gccgaggaat gaagttcgag aatgttcaaa
     1501 ccctcacgga tgccattcat gacatcatca ttgacatgaa gtggtgttgg gttgatcaag
     1561 ctggtgtgat atgtaagcaa gaagggattt ttcgagttaa ttgcatggac tgcctggatc
     1621 gcaccaacgt ggtccaggct gccatagcgc gcgtggtcat ggaacagcag cttaaaaaac
     1681 taggtgtgat gcccccagag cagccactac ctgtgaaatg taatcggacc taccagataa
     1741 tgtgggccaa caacggtgac tccatcagca ggcagtatgc tgggactgct gctctaaagg
     1801 gtgactttac aagaacagga gaaaggaagt tggcaggagt tatgaaagat ggcgttaact
     1861 cggcaaatag gtactacctc agtcggttca aggatgccta caggcaagcc gtcatagatc
     1921 tgatgcaagg cgtcccagtg acagaagacc tttactccat atttaccaag gagaaggagc
     1981 atgaagcttt gcataaggag agccagagaa gccaccagga gctcatcagc cagctcttac
     2041 agagttatat gcagttgctg ctgccgggtg acgagaagtt ccacgggggc tgggccctgg
     2101 ttgactgcga ccccagcctc actgacgctg cgcacagaga tgtggaagtg ctgctgctgc
     2161 tgtctaacgc tgcctactat gtggcctatt atgatgacga agttgataaa gtaaaccagt
     2221 atcaacgact gggcctagaa gacctggaaa gaatagaaat aggtcctgaa cctactcttt
     2281 tcggcaaacc caagttctcg tgcatgcggc tgcactacag gtgtaaagaa gcaggcggtt
     2341 acttccatac gctaagagct gtgccacgta gtcctgaaga agatggcaaa gacactcttc
     2401 agtgcatcgc agagatgctg cagatcacca agcaagccat gggactggac gttcctatca
     2461 ttgagaagaa acttgagagg aaaagcagta agcctcatga agacatcatt ggtatcagat
     2521 ctcaaaacca aggctctctt gcccagggga aaagcttttt aatgagcaaa ttttcatctc
     2581 taaatcaaaa agtaaagcag accaaatcca atgtgaacat cggcaaccta cgaaaattag
     2641 gaaactttac aaagcctgaa atgaaagtta actttctaaa accaaactta aaagtcaatc
     2701 tttggaagtc agatagtagt cttgagacca tggaaaaccc aggagtgatg ggtaataagg
     2761 tccaggggga gtctgatggg gacatttctt cagataacga ctcgtaccac tctgatgaat
     2821 tccttacaaa ttctaagtcg gaggaagaca agcagctagc caattcttta gagagcgtag
     2881 ggccaataga ttacattctc ccaagctgtg ggattattgt gtcagcacct cgattaggca
     2941 gtcggtctca gtctgccagc agtatcgacg tcagcactca tgccccctca gaagctgctg
     3001 ctggtcctgg aagtgaactt gggaaaggcc tggagtctcc cctgaagaaa agcccttctg
     3061 ctgacagcat acacacacgg actggcttca caaagcccat ggatgtttac tgccagagat
     3121 ttgtgcagga tgcacagaac aaaatgaatg acctgtcaga gatcaggtct gtagctcaga
     3181 agagtgagga gggaagtcac aagactaacc gtgtgtctaa tgaagaaacc cagtcagaac
     3241 caatgggaca gacgcctcct cgaccctctc agttaaacgt ctcttgttct gtggcaggcc
     3301 caccattctt atcagttgaa ccagtacatt cagtgctatc tcagaagacg cccagctccg
     3361 ggtccagcct tctggaactt gaggcagggc tctgcgtaac tccctcttca gagagcagca
     3421 gcagcagggc agtctctccc tttgcaaaga tccgcagctc catggtccaa gtcgctaata
     3481 ttacccaagc tgggctaact catgggataa acttggcggt tgccaaagtt cagaagagtc
     3541 cagcagaacc cgaagcggtt aacgaaattc aacaaaatga acttaaaaat atgtttacac
     3601 aatgccagac acgaataatt cagatttaga ttttagtcac attcctttgt cttttattta
     3661 aaaattcaaa atgaagtttt cacctttcag gctattttaa cctgtactga atctagggat
     3721 ttcaaattct aattatgttt attggcaatt gttttacaag gagtctgaac cttagcaaat
     3781 ttccagatat gtaagctaag actacaggca gtcatcctgg aatatggacc agagtagcaa
     3841 acactagaat ggtctgtgca tctcacttgg gaaggagcag gaaagaaacc aagctcgtgt
     3901 ctagaggggg agacactctc aagcaggtgt ggtgtggaca tctgtttatg gtggtagcat
     3961 ttttttgctc tgtcagttca ttcctcaata ctgcttcata aaggaaatta tgcatttaga
     4021 ttttagtgat actagtgtgc attagtatct aaattaaaaa agtagtctcg tggcttaacc
     4081 attctctgaa gttgagaatt aacaatggta aaactgtatt tttcctttga ccccactctc
     4141 tcccgtatat acattttttt ttctctctct ctcaaattct taagtatggg cttgcccgtc
     4201 ataaaataac ttgctgcagg aatataagat catgtttatt gactctagag atctctagaa
     4261 aagtcgtttg aactctttca agggggacat ttagcatctc ttgtaggttc tagaactatg
     4321 gaaaacatca aagtccaggt taaactggtt ttattcagta actaaccacc aagaacctct
     4381 tctgtaaccc agagtgagaa agctgtaggc atattctagc aggtatcaat gtctctggca
     4441 tcctttagag ccttactctg gttaactgac tctcagttta acattatgtc tgttaaaact
     4501 ctgacaagca ttccgatttt gttatttatt agcagtgtca agtcttgtga ctattaaaag
     4561 aaccactgta attcaaaaca tcagcgtatg agaatttctt gtatagcatt taatagtaag
     4621 agttgtcttc aaagaattca taaatggtaa gtttgcttta accaaacact tgttttgaac
     4681 tttcaatttt aaaaatgaaa actgtatttt aaatcccaga cattaaaaac tgaatgctgt
//
