LOCUS       NM_033134               4186 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e),
            transcript variant 1, mRNA.
ACCESSION   NM_033134
VERSION     NM_033134.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Tham,M.S., Cottle,D.L., Zylberberg,A.K., Short,K.M., Jones,L.K.,
            Chan,P., Conduit,S.E., Dyson,J.M., Mitchell,C.A. and Smyth,I.M.
  TITLE     Deletion of Aurora kinase A prevents the development of polycystic
            kidney disease in mice
  JOURNAL   Nat Commun 15 (1), 371 (2024)
   PUBMED   38191531
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Chee,J.M., Lanoue,L., Clary,D., Higgins,K., Bower,L., Flenniken,A.,
            Guo,R., Adams,D.J., Bosch,F., Braun,R.E., Brown,S.D.M., Chin,H.G.,
            Dickinson,M.E., Hsu,C.W., Dobbie,M., Gao,X., Galande,S.,
            Grobler,A., Heaney,J.D., Herault,Y., de Angelis,M.H., Mammano,F.,
            Nutter,L.M.J., Parkinson,H., Qin,C., Shiroishi,T., Sedlacek,R.,
            Seong,J.K., Xu,Y., Brooks,B., McKerlie,C., Lloyd,K.C.K.,
            Westerberg,H. and Moshiri,A.
  CONSRTM   International Mouse Phenotyping Consortium
  TITLE     Genome-wide screening reveals the genetic basis of mammalian
            embryonic eye development
  JOURNAL   BMC Biol 21 (1), 22 (2023)
   PUBMED   36737727
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Dewees,S.I., Vargova,R., Hardin,K.R., Turn,R.E., Devi,S.,
            Linnert,J., Wolfrum,U., Caspary,T., Elias,M. and Kahn,R.A.
  TITLE     Phylogenetic profiling and cellular analyses of ARL16 reveal roles
            in traffic of IFT140 and INPP5E
  JOURNAL   Mol Biol Cell 33 (4), ar33 (2022)
   PUBMED   35196065
  REMARK    GeneRIF: Phylogenetic profiling and cellular analyses of ARL16
            reveal roles in traffic of IFT140 and INPP5E.
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Stilling,S., Kalliakoudas,T., Benninghoven-Frey,H., Inoue,T. and
            Falkenburger,B.H.
  TITLE     PIP2 determines length and stability of primary cilia by balancing
            membrane turnovers
  JOURNAL   Commun Biol 5 (1), 93 (2022)
   PUBMED   35079141
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Kong,A.M., Speed,C.J., O'Malley,C.J., Layton,M.J., Meehan,T.,
            Loveland,K.L., Cheema,S., Ooms,L.M. and Mitchell,C.A.
  TITLE     Cloning and characterization of a 72-kDa inositol-polyphosphate
            5-phosphatase localized to the Golgi network
  JOURNAL   J Biol Chem 275 (31), 24052-24064 (2000)
   PUBMED   10806194
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Kawamoto,S., Matsumoto,Y., Mizuno,K., Okubo,K. and Matsubara,K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732541.11 and BC052717.1.
            
            On Mar 13, 2014 this sequence version replaced NM_033134.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052717.1, AK154097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL732541.11        117106-117136
            32-4186             BC052717.1         1-4155
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.88 cM"
     gene            1..4186
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="inositol polyphosphate-5-phosphatase E"
                     /db_xref="GeneID:64436"
                     /db_xref="MGI:MGI:1927753"
     exon            1..1453
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     CDS             633..2576
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="isoform a is encoded by transcript variant 1; 72
                     kDa inositol polyphosphate 5-phosphatase;
                     phosphatidylinositol polyphosphate 5-phosphatase type IV;
                     inositol polyphosphate-5-phosphatase, 72 kDa;
                     phosphatidylinositol 4,5-bisphosphate 5-phosphatase;
                     phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol polyphosphate 5-phosphatase
                     type IV isoform a"
                     /protein_id="NP_149125.1"
                     /db_xref="CCDS:CCDS15805.1"
                     /db_xref="GeneID:64436"
                     /db_xref="MGI:MGI:1927753"
                     /translation="MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASD
                     SQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRG
                     SQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSL
                     WSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDP
                     EHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSY
                     LEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQ
                     DLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVE
                     YSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALA
                     LPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALL
                     QHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSR
                     HKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIPLAAGKFDRELYLIGIKRR
                     ISKEIQRQEALKSQSSSAVCTVS"
     exon            1454..1577
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1675
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1800
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1920
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2028
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2190
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2306
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2443
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..4166
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="hexamer: ATTAAA"
     polyA_site      3115
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="major polyA site"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="hexamer: AATAAG"
     polyA_site      3361
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
     regulatory      3657..3662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="hexamer: AATAAA"
     polyA_site      3679
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
     regulatory      3887..3892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="hexamer: ATTAAA"
     polyA_site      3908
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
     regulatory      4131..4136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
                     /note="hexamer: ATTAAA"
     polyA_site      4153
                     /gene="Inpp5e"
                     /gene_synonym="1200002L24Rik; 72kDa; mKIAA0123"
ORIGIN      
        1 agttctccgg aagactacag aacggaacct gagccagggt gaccactaga ctgagctggg
       61 gcgaaccctg ggcgggggcg ggggccgagg cacggggccg cagtcgttgt tccagctgcc
      121 accgtgactg gcctaggtcc gcctccgcca gcgctgggcc cggctgaatc agacctcggg
      181 cgtccggcgg cgggtctgct gccgaacgga gggcgcaggt gagcctagga cgctgagcgc
      241 gctgccctac tctgcctcgg cggggtggag ggctggccgg gggtgctgga cagacttgtg
      301 cagctccgtg aagtgcagcc ccgaccccct ggcgcctgtt ctcacgaagt cgcttttaag
      361 actagcgagc tgacttcggg gagccaagag atttttctgc gtttcctcag gcatcggtga
      421 gaactctcaa gtctccagcc atgcagctac aggccctcct ccaaaaggac cgccccatgc
      481 cacaaaggga gccactcgag ttttcatggc atcgagctgg cgaactctga cgtgcatcct
      541 tgacaacaag agttgcttgt taacctccca gggaggatcc ctttccttag gagggccagg
      601 ctgagggggt cagggctggc caggtctgga ctatgccatc caagtcagct tgcctgcgtc
      661 acactgaggc acctgggcag ctagaaggca gaatgctcca gggacagcct ccgaacacgg
      721 aaaagaagct catcccaaca ccaggcttct taccagcctc tgactctcag ggttcagaga
      781 caaaccccat gcctcctttc agcattccag caaaaacaag caaccagaac ccacaaacta
      841 aggcaaatct catcacccca cagccaccca ttagacccaa gttggagcga accctgtccc
      901 tcgatgacaa gggctggaga aggaggcgtt tccggggtag tcaggaggat ctgactgtcc
      961 agaatggggc cagtccctgc aggggctcct tgcaagactc agtagcccag tcccctgcct
     1021 acagccgtcc cctgccctgc ctcagcacat ccttgcagga gatacctaag tcccgaaggg
     1081 ccacaggcag tgagggaggg agcccatcct tgtggagtga ctgtctttct ggaatgatca
     1141 gcacctcctt ggacctcctg cacagagatg ctgcctcagg tgggcccccc tccaggttgg
     1201 caagtttgca tgcctcacac acaccaccag ctatggacct cagcatagcc tccagctccc
     1261 tgagaacagc aaacaaggtt gaccccgagc acacggacta caagctccgc atgcagacca
     1321 gactggtcag ggcccacagc aacctgggcc ctagcagacc ccggagcccc ttggctggtg
     1381 acgatcactc cattcactca gccagatctt tcagccttct ggcccccatc cgcaccaagg
     1441 acatcagaag caggagctat ctggagggaa gtcttctggc cagtggggcc ctgctaggag
     1501 cagaagagct ggccaggtac ttcccagacc gaaacatggc tctcttcgtg gctacctgga
     1561 acatgcaggg ccagaaggag ctcccagcga gcctggatga gtttctgctc cccaccgagg
     1621 ctgactacac tcaggacctg tatgtcattg gaattcagga gggctgctct gacaggcggg
     1681 agtgggagac acgcctgcag gagacactgg gccctcagta tgtactgctg tcatcagcag
     1741 cacatggggt cctgtacatg tccctgttta tccgtaggga cctcatctgg ttctgctcag
     1801 aggtcgagta ctccacagta actacacgca tcgtgtctca gatcaagacc aagggggccc
     1861 tgggcgtcag cttcaccttt tttggcacct ccttcctctt catcacatct cacttcacct
     1921 ctggagatgg gaaggtagca gagcggctac tggactacag cagaaccatc caagccctag
     1981 ccctgccccg gaatgtgcca gacacaaatc cctaccgctc tagtgcaggg gatgtcacta
     2041 cccggtttga tgaggtcttc tggtttgggg acttcaactt ccgcctgagt ggtggacgag
     2101 tggctgtgga ggccttcctg aagcagaaac ctgaggtgga tgtgctggct ctcctccaac
     2161 acgaccagct cacccgggag atgaagaaag ggtccatctt caggggcttt gaggaggcag
     2221 agattcactt tcttccatcc tacaagtttg acattgggaa ggacacctac gacagcacct
     2281 ccaagcaaag gacaccctcc tacacagacc gagtcctata caaaagccgt cacaagggtg
     2341 acatctgtcc catgaagtat tcctcttgtc ctgggatcaa gacttcagac caccgtcctg
     2401 tgtatggctt gttccaggtg aaagtgaggc caggacgaga caacatccca ttagctgccg
     2461 gcaagtttga ccgagaattg tacttgatag gaattaaaag gcggatttca aaggagattc
     2521 agagacagga agcactgaag agccagagct ccagtgcagt ttgcaccgtg tcctgaagat
     2581 tccagaccag gactggccac agcaacgggg gccaaggtca ctgcaaagga tgggcttctt
     2641 ctcagctgct cctgtaatgc tgggattcta atccaccacg gccaggggct ccctgctctc
     2701 accacagacc cagccctcag gacatttata ccatgttccc acaggcacat ggcagggcat
     2761 gtggacacca agcagcagtt ttgtcctcag gagtagtcca gacttcttgc ccttgagcac
     2821 tgctgtctct tcaaactcct tttatttatt cctgttctca tgctagagcc caggttctcc
     2881 atctgtatcc tcctagtagc tccttccctc cagggaagga tcaggcaacc tctggtatcc
     2941 tagatgctca atgcctagaa cctgccagga cttcaattct gggatattcc ctacagacat
     3001 tttgacaggc tttgaggttc tacatcctgg tcccaggctc ccaaccccca gttgagtagg
     3061 gacctctcca ctctacaggc caagcctagc tatattaaac tcatagtttt taggagcttc
     3121 agaccatttg cttttgtgct gctagtcccg gaaaggcatg agaaattgtt accagacagc
     3181 accttgctgg gtttcactcc ttgaagaaag cttaggagca tcattgctct caatcttacc
     3241 ccaccccttc agacatagcc ttgaatgtac agacacctag gggcatccac tctagtcttc
     3301 taaatcattt atttttccat atttatattt ttaaataaat aaggatatat tcaattgtaa
     3361 actctttctg gccaaagagt gaaccttgga agaagtctgc atgcatcttg gggcctcagg
     3421 acaccccagg gttttaaaag gacatagaag tcaaaggcca aacatttggt ctcagctgtc
     3481 acctgctact cagtcccatc ccaggtcttt ctgctaggta ctgtccctgc tcacagccag
     3541 aagcagcaat agctggaaaa agtgacgact tgggactcca gtgaaccata ataaaccaac
     3601 gaataaggtg aaactcaaca gcatcagctt ctccaatatg gaaagtcacc tgcttcaata
     3661 aaccactgtg aactgcaaat tctactggga agacagcctt ttctctccca gacaggctgc
     3721 cctggacttc ataatcctgc ctcaactatt cctggcttga ataaggtttg atgtggtaag
     3781 agttccagac aggtttctct gtagccccgg ctgtcctgga actctctgta gaccaggctg
     3841 gcctcgaact tggagaacca cctgcttctg cctcctgaat gctgggatta aaggcgtgca
     3901 ctaccacagc ccagcagttt ggtgcttctt tgtggacatt ctctggcacc ttagaaaaga
     3961 ctgaggtaat cctggaactt cccagtttgg cccaagatca agatcataaa gtcttagggg
     4021 tcggggggca aagtacagcc atagcaattt acatttagat agcctttaca tttagagggc
     4081 atttcagttg gaaaagttaa acacgtaaac tagtgcagat gaagtgggaa attaaaactg
     4141 gacttgtaaa taattgtgag atacaaaaaa aaaaaaaaaa aaaaaa
//
