LOCUS       NM_010566               4940 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus inositol polyphosphate-5-phosphatase D (Inpp5d),
            transcript variant 1, mRNA.
ACCESSION   NM_010566
VERSION     NM_010566.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4940)
  AUTHORS   Matera,A., Compagnion,A.C., Pedicone,C., Kotah,J.M., Ivanov,A.,
            Monsorno,K., Labouebe,G., Leggio,L., Pereira-Iglesias,M., Beule,D.,
            Mansuy-Aubert,V., Williams,T.L., Iraci,N., Sierra,A., Marro,S.G.,
            Goate,A.M., Eggen,B.J.L., Kerr,W.G. and Paolicelli,R.C.
  TITLE     Microglial lipid phosphatase SHIP1 limits complement-mediated
            synaptic pruning in the healthy developing hippocampus
  JOURNAL   Immunity 58 (1), 197-217 (2025)
   PUBMED   39657671
REFERENCE   2  (bases 1 to 4940)
  AUTHORS   Dabin,L.C., Kersey,H., Kim,B., Acri,D.J., Sharify,D.,
            Lee-Gosselin,A., Lasagna-Reeves,C.A., Oblak,A.L., Lamb,B.T. and
            Kim,J.
  TITLE     Loss of Inpp5d has disease-relevant and sex-specific effects on
            glial transcriptomes
  JOURNAL   Alzheimers Dement 20 (8), 5311-5323 (2024)
   PUBMED   38923164
  REMARK    GeneRIF: Loss of Inpp5d has disease-relevant and sex-specific
            effects on glial transcriptomes.
REFERENCE   3  (bases 1 to 4940)
  AUTHORS   Soni,D.M., Lin,P.B., Lee-Gosselin,A., Lloyd,C.D., Mason,E.,
            Ingraham,C.M., Perkins,A., Moutinho,M., Lamb,B.T., Chu,S. and
            Oblak,A.L.
  TITLE     Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse
            model of Tauopathy
  JOURNAL   Alzheimers Dement 20 (7), 4985-4998 (2024)
   PUBMED   38923171
  REMARK    GeneRIF: Inpp5d haplodeficiency alleviates tau pathology in the
            PS19 mouse model of Tauopathy.
REFERENCE   4  (bases 1 to 4940)
  AUTHORS   Ahat,E., Shi,Z., Chu,S., Bui,H.H., Mason,E.R., Soni,D.M.,
            Roth,K.D., Chalmers,M.J., Oblak,A.L., Zhang,J., Gutierrez,J.A. and
            Richardson,T.
  TITLE     SHIP1 modulation and proteome characterization of microglia
  JOURNAL   J Proteomics 302, 105198 (2024)
   PUBMED   38777089
  REMARK    GeneRIF: SHIP1 modulation and proteome characterization of
            microglia.
REFERENCE   5  (bases 1 to 4940)
  AUTHORS   Safari,F., Yeoh,W.J., Perret-Gentil,S., Klenke,F., Dolder,S.,
            Hofstetter,W. and Krebs,P.
  TITLE     SHIP1 deficiency causes inflammation-dependent retardation in
            skeletal growth
  JOURNAL   Life Sci Alliance 7 (5), e202302297 (2024)
   PUBMED   38388173
  REMARK    GeneRIF: SHIP1 deficiency causes inflammation-dependent retardation
            in skeletal growth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4940)
  AUTHORS   Liu,Q. and Dumont,D.J.
  TITLE     Molecular cloning and chromosomal localization in human and mouse
            of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen
            EST Program
  JOURNAL   Genomics 39 (1), 109-112 (1997)
   PUBMED   9027494
REFERENCE   7  (bases 1 to 4940)
  AUTHORS   Kang,A.D., Wong,P.M., Chen,H., Castagna,R., Chung,S.W. and
            Sultzer,B.M.
  TITLE     Restoration of lipopolysaccharide-mediated B-cell response after
            expression of a cDNA encoding a GTP-binding protein
  JOURNAL   Infect Immun 64 (11), 4612-4617 (1996)
   PUBMED   8890215
REFERENCE   8  (bases 1 to 4940)
  AUTHORS   Chacko,G.W., Tridandapani,S., Damen,J.E., Liu,L., Krystal,G. and
            Coggeshall,K.M.
  TITLE     Negative signaling in B lymphocytes induces tyrosine
            phosphorylation of the 145-kDa inositol polyphosphate
            5-phosphatase, SHIP
  JOURNAL   J Immunol 157 (6), 2234-2238 (1996)
   PUBMED   8805618
REFERENCE   9  (bases 1 to 4940)
  AUTHORS   Lioubin,M.N., Algate,P.A., Tsai,S., Carlberg,K., Aebersold,A. and
            Rohrschneider,L.R.
  TITLE     p150Ship, a signal transduction molecule with inositol
            polyphosphate-5-phosphatase activity
  JOURNAL   Genes Dev 10 (9), 1084-1095 (1996)
   PUBMED   8654924
REFERENCE   10 (bases 1 to 4940)
  AUTHORS   Damen,J.E., Liu,L., Rosten,P., Humphries,R.K., Jefferson,A.B.,
            Majerus,P.W. and Krystal,G.
  TITLE     The 145-kDa protein induced to associate with Shc by multiple
            cytokines is an inositol tetraphosphate and phosphatidylinositol
            3,4,5-triphosphate 5-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1689-1693 (1996)
   PUBMED   8643691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY197864.1, AK143560.1 and AC159967.2.
            
            On Jun 25, 2014 this sequence version replaced NM_010566.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52044.1, AK143560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BY197864.1         2-65
            65-4063             AK143560.1         2-4000
            4064-4064           AC159967.2         43814-43814         c
            4065-4930           AK143560.1         4002-4867
            4931-4940           AC159967.2         42938-42947         c
FEATURES             Location/Qualifiers
     source          1..4940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.44 cM"
     gene            1..4940
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /note="inositol polyphosphate-5-phosphatase D"
                     /db_xref="GeneID:16331"
                     /db_xref="MGI:MGI:107357"
     exon            1..320
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..3753
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SH2-containing inositol phosphatase SHIP; SH2
                     domain-containing inositol phosphatase 1; inositol
                     polyphosphate-5-phosphatase, 145 kDa; Src homology 2
                     domain-containing inositol-5-phosphatase; SH2
                     domain-containing inositol 5'-phosphatase 1;
                     phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1;
                     phosphatidylinositol-4,5-bisphosphate 5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 1 isoform 1"
                     /protein_id="NP_034696.2"
                     /db_xref="CCDS:CCDS35655.1"
                     /db_xref="GeneID:16331"
                     /db_xref="MGI:MGI:107357"
                     /translation="MPAMVPGWNHGNITRSKAEELLSRAGKDGSFLVRASESIPRAYA
                     LCVLFRNCVYTYRILPNEDDKFTVQASEGVPMRFFTKLDQLIDFYKKENMGLVTHLQY
                     PVPLEEEDAIDEAEEDTVESVMSPPELPPRNIPMSAGPSEAKDLPLATENPRAPEVTR
                     LSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLLLDSDFLKTGSSNLPHLKKLMSL
                     LCKELHGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEASPITMVAKLSQLTSLLS
                     SIEDKVKSLLHEGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKLIVKKSK
                     DGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQ
                     QMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIY
                     VIGTQEDPLGEKEWLELLRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHI
                     CTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFL
                     ALGDKKLSPFNITHRFTHLFWLGDLNYRVELPTWEAEAIIQKIKQQQYSDLLAHDQLL
                     LERKDQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKS
                     YPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLACY
                     ATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVRFGETLPKLKPIISDPE
                     YLLDQHILISIKSSDSDESYGEGCIALRLETTEAQHPIYTPLTHHGEMTGHFRGEIKL
                     QTSQGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPSGRVPACGVSSLNEMI
                     NPNYIGMGPFGQPLHGKSTLSPDQQLTAWSYDQLPKDSSLGPGRGEGPPTPPSQPPLS
                     PKKFSSSTANRGPCPRVQEARPGDLGKVEALLQEDLLLTKPEMFENPLYGSVSSFPKL
                     VPRKEQESPKMLRKEPPPCPDPGISSPSIVLPKAQEVESVKGTSKQAPVPVLGPTPRI
                     RSFTCSSSAEGRMTSGDKSQGKPKASASSQAPVPVKRPVKPSRSEMSQQTTPIPAPRP
                     PLPVKSPAVLQLQHSKGRDYRDNTELPHHGKHRQEEGLLGRTAMQ"
     exon            321..384
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            385..535
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            536..710
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            711..851
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            852..939
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1020
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1092
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1216
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1323
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1426
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1623
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1741
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1838
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1977
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2086
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2175
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2257
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2347
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2461
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2544
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2632
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2782
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2879
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3155
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3750
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..4940
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4913..4918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /note="hexamer: AATAAA"
     polyA_site      4933
                     /gene="Inpp5d"
                     /gene_synonym="p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /note="major polyA site"
ORIGIN      
        1 agtttcctct ccctcgctga gtgcctgaaa caggaagtca gtcagttaag ctggtaggag
       61 cagcagaggc aatttctgag aggcaacagg cggcaggtct cagcctagag agggccctga
      121 actactttgc tggagtgtcc gtcctgggag tggctgctga cccagtccag gagacccatg
      181 cctgccatgg tccctgggtg gaaccatggc aacatcaccc gctccaaggc agaggagcta
      241 ctttccagag ccggcaagga cgggagcttc cttgtgcgtg ccagcgagtc catcccccgg
      301 gcctacgcac tctgcgtgct gttccggaat tgtgtttaca cttacaggat tctgcccaat
      361 gaggacgata aattcactgt tcaggcatcc gaaggtgtcc ccatgaggtt cttcacgaag
      421 ctggaccagc tcatcgactt ttacaagaag gaaaacatgg ggctggtgac ccacctgcag
      481 taccccgtgc ccctggagga ggaggatgct attgatgagg ctgaggagga cactgtagaa
      541 agtgtcatgt caccacctga gctgcctccc agaaacattc ctatgtctgc cgggcccagc
      601 gaggccaagg accttcctct tgcaacagag aacccccgag cccctgaggt cacccggctg
      661 agtctctccg agacactgtt tcagcgtcta cagagcatgg ataccagtgg gcttcccgag
      721 gagcacctga aagccatcca ggattatctg agcactcagc tcctcctgga ttccgacttt
      781 ttgaagacgg gctccagcaa cctccctcac ctgaagaagc tgatgtcact gctctgcaag
      841 gagctccatg gggaagtcat caggactctg ccatccctgg agtctctgca gaggttgttt
      901 gaccaacagc tctccccagg ccttcgccca cgacctcagg tgcccggaga ggccagtccc
      961 atcaccatgg ttgccaaact cagccaattg acaagtctgc tgtcttccat tgaagataag
     1021 gtcaagtcct tgctgcacga gggctcagaa tctaccaaca ggcgttccct tatccctccg
     1081 gtcacctttg aggtgaagtc agagtccctg ggcattcctc agaaaatgca tctcaaagtg
     1141 gacgttgagt ctgggaaact gatcgttaag aagtccaagg atggttctga ggacaagttc
     1201 tacagccaca aaaaaatcct gcagctcatt aagtcccaga agtttctaaa caagttggtg
     1261 attttggtgg agacggagaa ggagaaaatc ctgaggaagg aatatgtttt tgctgactct
     1321 aagaaaagag aaggcttctg tcaactcctg cagcagatga agaacaagca ttcggagcag
     1381 ccagagcctg acatgatcac catcttcatt ggcacttgga acatgggtaa tgcaccccct
     1441 cccaagaaga tcacgtcctg gtttctctcc aaggggcagg gaaagacacg ggacgactct
     1501 gctgactaca tcccccatga catctatgtg attggcaccc aggaggatcc ccttggagag
     1561 aaggagtggc tggagctact caggcactcc ctgcaagaag tcaccagcat gacatttaaa
     1621 acagttgcca tccacaccct ctggaacatt cgcatagtgg tgcttgccaa gccagagcat
     1681 gagaatcgga tcagccatat ctgcactgac aacgtgaaga caggcatcgc caacaccctg
     1741 ggaaacaagg gagcagtggg agtgtccttc atgttcaatg gaacctcctt ggggttcgtc
     1801 aacagccact tgacttctgg aagtgaaaaa aagctcagga gaaatcaaaa ctatatgaac
     1861 atcctgcggt tcctggccct gggagacaag aagctaagcc catttaacat cacccaccgc
     1921 ttcacccacc tcttctggct tggggatctc aactaccgcg tggagctgcc cacttgggag
     1981 gcagaggcca tcatccagaa gatcaagcaa cagcagtatt cagaccttct ggcccacgac
     2041 caactgctcc tggagaggaa ggaccagaag gtcttcctgc actttgagga ggaagagatc
     2101 accttcgccc ccacctatcg atttgaaaga ctgacccggg acaagtatgc atacacgaag
     2161 cagaaagcaa cagggatgaa gtacaacttg ccgtcctggt gcgaccgagt cctctggaag
     2221 tcttacccgc tggtgcatgt ggtctgtcag tcctatggca gtaccagtga catcatgacg
     2281 agtgaccaca gccctgtctt tgccacgttt gaagcaggag tcacatctca attcgtctcc
     2341 aagaatggtc ctggcactgt agatagccaa gggcagatcg agtttcttgc atgctacgcc
     2401 acactgaaga ccaagtccca gactaagttc tacttggagt tccactcaag ctgcttagag
     2461 agttttgtca agagtcagga aggagagaat gaagagggaa gtgaaggaga gctggtggta
     2521 cggtttggag agactcttcc caagctaaag cccattatct ctgaccccga gtacttactg
     2581 gaccagcata tcctgatcag cattaaatcc tctgacagtg acgagtccta tggtgaaggc
     2641 tgcattgccc ttcgcttgga gaccacagag gctcagcatc ctatctacac gcctctcacc
     2701 caccatgggg agatgactgg ccacttcagg ggagagatta agctgcagac ctcccagggc
     2761 aagatgaggg agaagctcta tgactttgtg aagacagagc gggatgaatc cagtggaatg
     2821 aaatgcttga agaacctcac cagccatgac cctatgaggc aatgggagcc ttctggcagg
     2881 gtccctgcat gtggtgtctc cagcctcaat gagatgatca atccaaacta cattggtatg
     2941 gggccttttg gacagcccct gcatgggaaa tcaaccctgt ccccagatca gcaactcaca
     3001 gcttggagtt atgaccagct acccaaagac tcctccctgg ggcctgggag gggggagggt
     3061 cctccaaccc ctccctccca accacctctg tcgccaaaga agttttcatc ttccacagcc
     3121 aaccgaggtc cctgccccag ggtgcaagag gcaagacctg gggatctggg aaaggtggaa
     3181 gctctgctcc aggaggacct gctgctgacg aagcccgaga tgtttgagaa cccactgtat
     3241 ggatccgtga gttccttccc taagctggtg cccaggaaag agcaggagtc tcccaagatg
     3301 ctgcggaagg agcccccgcc ctgtccagac ccaggaatct catcacccag catcgtgctc
     3361 cccaaagccc aagaggtgga gagtgtcaag gggacaagca aacaggcccc tgtgcctgtc
     3421 cttggcccca caccccggat ccgctccttt acctgttctt cttctgctga gggcagaatg
     3481 accagtgggg acaagagcca agggaagccc aaggcctcag ccagttccca agccccagtg
     3541 ccagtcaaga ggcctgtcaa gccttccagg tcagaaatga gccagcagac aacacccatc
     3601 ccagctccac ggccacccct gccagtcaag agtcctgctg tcctgcagct gcaacattcc
     3661 aaaggcagag actaccgtga caacacagaa ctcccccacc atggcaagca ccgccaagag
     3721 gaggggctgc ttggcaggac tgccatgcag tgagctgctg gtgatcggag cctggaggaa
     3781 cagcacaaag cagacctgcg cctctctcag gatgcctctc tcaggatgcc tcttggagga
     3841 cctcctgcta gctcttcttg cctagcttca agtcccaggc tgtgtatttt ttttcaggaa
     3901 acggcctcac ttctctgtgg tccaagaagt gtgctgctgg ctgccacact gtgcggcaga
     3961 tgctaaagct ggatgacaaa cgcacgccat acagacagca gacagcggca ctgggtctca
     4021 gaacttggat tcctgggcct tcttccagtc gccgttttaa agaaaggaac taacggagct
     4081 gctcatccga gggtgaagat ataaataata atattattaa taataataac agtcaggtgc
     4141 catgtgctgt gttaagtgct ttatgaacat ttgtcgggct ggcctccagt gctgaggtgc
     4201 cagtcagcct gaaccctatg cccaggccca ctaatcccaa atggtgggtc ctgagatgtt
     4261 tttaaaaagc attaaagaaa accatcggtc tcttagagct aaccggccgg gctctactgc
     4321 agggacccga acagtctgca tggctaagtg gcacaaggag cctggccctg tccagcttca
     4381 gagatccaag ctgctttttg ctggggttct gtcacaggcc tgatcctctt ggtttttatg
     4441 gggtttcaag tctgccagag tcagaaatca gctctaactc gccagtgaag agatctggcc
     4501 ttaacttaag ccagccacgt caggcccctg ctgagcctat ggaccaataa atactccccg
     4561 tgccactgga ggtgggcagc tatcaccata ccctgagttg ggccaagccc accccacccc
     4621 taccctgcaa catttctgat gtactgagga agagtctcca ccatagtccc caagggctga
     4681 gttctccagc ctgctatcag ggaaggtgag cattggtccc aggctctcaa aatagtgcag
     4741 cctcttcttc ccaagctctg gggtgcaccc tgtgtccttg gttaccagga gactagggtt
     4801 gtgatatctt ttcttgtctt gctttttgat atatcaggat taatgtagga aaccagacct
     4861 agattattca ggagagtagg tatatcccct gtgtttccca gtctgagtga ccaataaaat
     4921 tgtgcctttc taactgggcc
//
