LOCUS       NM_001297596            8367 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus inositol polyphosphate-4-phosphatase, type II
            (Inpp4b), transcript variant 4, mRNA.
ACCESSION   NM_001297596
VERSION     NM_001297596.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8367)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 8367)
  AUTHORS   Peng,V., Trsan,T., Sudan,R., Bhattarai,B., Cortez,V.S., Molgora,M.,
            Vacher,J. and Colonna,M.
  TITLE     Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK
            cells through an AKT-driven pathway
  JOURNAL   J Exp Med 221 (3) (2024)
   PUBMED   38197946
REFERENCE   3  (bases 1 to 8367)
  AUTHORS   Zhang,M., Ceyhan,Y., Mei,S., Hirz,T., Sykes,D.B. and Agoulnik,I.U.
  TITLE     Regulation of EZH2 Expression by INPP4B in Normal Prostate and
            Primary Prostate Cancer
  JOURNAL   Cancers (Basel) 15 (22), 5418 (2023)
   PUBMED   38001678
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8367)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   5  (bases 1 to 8367)
  AUTHORS   Saffi,G.T., Wang,C.A., Mangialardi,E.M., Vacher,J., Botelho,R.J.
            and Salmena,L.
  TITLE     Inhibition of lipid kinase PIKfyve reveals a role for phosphatase
            Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics
            through VPS34 activity
  JOURNAL   J Biol Chem 298 (8), 102187 (2022)
   PUBMED   35760104
  REMARK    GeneRIF: Inhibition of lipid kinase PIKfyve reveals a role for
            phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome
            dynamics through VPS34 activity.
REFERENCE   6  (bases 1 to 8367)
  AUTHORS   Maekawa,M., Terasaka,S., Mochizuki,Y., Kawai,K., Ikeda,Y.,
            Araki,N., Skolnik,E.Y., Taguchi,T. and Arai,H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   7  (bases 1 to 8367)
  AUTHORS   Balakrishnan,A. and Chaillet,J.R.
  TITLE     Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in
            the generation of ovarian teratomas
  JOURNAL   Dev Biol 373 (1), 118-129 (2013)
   PUBMED   23078915
  REMARK    GeneRIF: Hyperactivation of the PI3K/AKT pathway caused by the
            decrease in INPP4B in granulosa cells promotes an ovarian
            environment defective in folliculogenesis and conducive to teratoma
            formation.
REFERENCE   8  (bases 1 to 8367)
  AUTHORS   Ferron,M., Boudiffa,M., Arsenault,M., Rached,M., Pata,M.,
            Giroux,S., Elfassihi,L., Kisseleva,M., Majerus,P.W., Rousseau,F.
            and Vacher,J.
  TITLE     Inositol polyphosphate 4-phosphatase B as a regulator of bone mass
            in mice and humans
  JOURNAL   Cell Metab 14 (4), 466-477 (2011)
   PUBMED   21982707
  REMARK    GeneRIF: In vivo mice deficient in Inpp4b displayed increased
            osteoclast differentiation rate and potential resulting in
            decreased bone mass and osteoporosis
REFERENCE   9  (bases 1 to 8367)
  AUTHORS   Ferron,M. and Vacher,J.
  TITLE     Characterization of the murine Inpp4b gene and identification of a
            novel isoform
  JOURNAL   Gene 376 (1), 152-161 (2006)
   PUBMED   16631325
  REMARK    GeneRIF: Inpp4bbeta localized to the Golgi apparatus whereas
            Inpp4balpha was mainly cytosolic, suggesting a different cellular
            function for this isoform.
REFERENCE   10 (bases 1 to 8367)
  AUTHORS   Barnache,S., Le Scolan,E., Kosmider,O., Denis,N. and
            Moreau-Gachelin,F.
  TITLE     Phosphatidylinositol 4-phosphatase type II is an
            erythropoietin-responsive gene
  JOURNAL   Oncogene 25 (9), 1420-1423 (2006)
   PUBMED   16247441
  REMARK    GeneRIF: This study provides first insight for a physiological role
            of PI-4-phosphatase II in the proerythroblast by controlling Epo
            responsiveness through a negative regulation of the PI3K/Akt
            pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ296611.1, AK141502.1 and AC121136.11.
            
            Transcript Variant: This variant (4) uses an alternate last exon
            compared to variant 1. The resulting isoform (4) has a shorter and
            distinct C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ296611.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849379 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               DQ296611.1         1-369
            370-2855            AK141502.1         367-2852
            2856-3238           DQ296611.1         2856-3238
            3239-8367           AC121136.11        96954-102082
FEATURES             Location/Qualifiers
     source          1..8367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 39.02 cM"
     gene            1..8367
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /note="inositol polyphosphate-4-phosphatase, type II"
                     /db_xref="GeneID:234515"
                     /db_xref="MGI:MGI:2158925"
     exon            1..236
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            237..299
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            300..492
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..3185
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /EC_number="3.1.3.66"
                     /note="isoform 4 is encoded by transcript variant 4; type
                     II inositol 3,4-bisphosphate 4-phosphatase;
                     phosphatidylinositol-3,4-bisphosphate 4-phosphatase;
                     phosphoinositide 4-phosphatase;
                     D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase"
                     /codon_start=1
                     /product="type II inositol 3,4-bisphosphate 4-phosphatase
                     isoform 4"
                     /protein_id="NP_001284525.1"
                     /db_xref="CCDS:CCDS80902.1"
                     /db_xref="GeneID:234515"
                     /db_xref="MGI:MGI:2158925"
                     /translation="MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFI
                     LACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDY
                     PIYEETRIKLTVYDVKDKSHDTIRTSVLPEHKDPLPEVARSFLGCASFKVGELLKSKE
                     QLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESL
                     SGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKED
                     LCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGE
                     KTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETER
                     RNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLL
                     SEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQD
                     SIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHT
                     LEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLT
                     LRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGML
                     EDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQ
                     LLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISH
                     FQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSV
                     TLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKC
                     YRPPEGTYGKADT"
     exon            493..537
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..656
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            657..773
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            774..824
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..904
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1016
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1089
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1237
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1368
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1473
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1582
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1760
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1964
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2130
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2303
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2427
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2545
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2686
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2784
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2897
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3052
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..8367
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8343..8348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8364
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggcgggcgg agcgtgagct gccagcccag agcagggagc ggggagcggg gaggctcggc
       61 ccgcgccctg cacgctacca tcctccgggt tcccagcccc gggtgctgag ctcgccgcta
      121 taaatagcag gttacagctt ctgcttgggc gcacacgctt tcactggaga acgcaggaaa
      181 gtcatcctga aaagtgtctg ccgctgctat cgccccctac tcagcctctg caagagaacc
      241 caaagaaatg gtgtcacctg gcaagagatc tgccgtgttt catgaaaaaa cagcccaagt
      301 ggactattaa tgtgaagata cgccaacgtt aaaccggagc tcattatttg gtaccatttg
      361 aaaaagacac cgtggagaat aggtccgttg tgaggtggat catggaaatc aaagaggaag
      421 gaacatcaga agaaggccag cattttcttc ctgcagctca ggcaaatgac cctgaggaca
      481 ttcagtttac cagcatccag aagattccga acgagccaca gttggaattc attctcgcct
      541 gcagggatct tgtggctcct gtcagtgatc ggaaactgaa tacagtagtc cagatctcag
      601 taatccaccc ggtggagcag accctgacga ggtactccag cacagaaatt gtggagggaa
      661 caaaagaccc actgttccta acgggtgtca cattcccacc ggactacccc atctatgaag
      721 agacaagaat aaaactgaca gtctacgatg tcaaggataa gtctcatgat actattcgaa
      781 ccagtgtcct tccggaacac aaggatcccc tgccagaagt tgcgagaagc ttcctgggct
      841 gtgccagttt taaagttggg gagctgctga agtccaagga gcagctgctg tccctgagcc
      901 tgagaacctc agatggtggc aaagtggtcg gcaccataga agtcagcctc gtgaagatgg
      961 gagagattga ggatggggac accgaccaca tcacaacaga tgtgcaggga caaaagtgtg
     1021 cactaatgta tgaatccaca gcaccagaaa gtctgagcgg gaaggaaaac ttacctttta
     1081 tgaatgcagt cttaaggaat cctgtgtgta agctgtatag attccccaca tctgacaata
     1141 agtggatgcg aatccgtgag cagatgtcag aaagcatcct ttcttttcat attcctaagg
     1201 aattgatttc ccttcacata aaagaagact tatgtagaaa ccaggagtta aaagaacttg
     1261 gtgacctttc cccacactgg gacaacctac ggaaaaatgt cctttctcac tgtgatcaaa
     1321 tggtgactat gtaccaagac attctgacag aactttccaa agaaacaggg tcctctttca
     1381 aatccagcag cagcaaagga gagaaaacat tagaatttgt tccagtaaat ctacacttgc
     1441 aacggatgca ggtgcacagc cctcacctga aagatgctct ctatgatgtc atcactgtgg
     1501 gggccccagc tgcccatttt cagggattca agaacggtgg tcttcgtaaa ctcctccata
     1561 ggtttgagac agagagaagg aacaccggct accagtttat ttactattca cctgagaaca
     1621 cagcgaaggc aaaggaagtt ctcagcagca tcaatcagct acaacctctc atagcaactc
     1681 atgcagacct gctgctaacc tctgccagcc agcgttctcc agacagcctg aagagctctt
     1741 taaagctgct ttcagaaaaa actgagcttt ttgtccatgc cttcaaggac cagctggtca
     1801 ggagtgctct tttagctctc tacactgcaa ggccaggagg catccttaag aagccaccct
     1861 ctcctaatgt cagcacagag gagaaaagta ctcagcatga taccccacag cttagaagac
     1921 aagactccat accacatcat tctgactatg atgaagaaga gtgggatagg gtgtgggcca
     1981 acgtggggaa gagcctgaac tgcattatcg ctaaagtaga caaactgatc gagagagaca
     2041 gtcacaacga agaaggtgct ggaggcagca gtagcaagga tggagaggca gaccataccc
     2101 tggaagattc catcacatct cacccacgtg aggactggta tgaacagctg cacccactca
     2161 tccttacctt gaaggagtgc atgggagaag tggtgaaccg agcaaagcaa tccctgacat
     2221 ttgtactgct tcaggaactg gcctacagtc tgccccagtg tttgatgctg actctgagaa
     2281 gagacattgt cttcagtcag gcgcttgctg gattggtttg tggttttatc atcaaattac
     2341 atacaagttt gcatgaccct ggcttcctac agcagcttca tacagtgggc ttgatagtac
     2401 aatacgaagg actgctaagt acttacagtg atgaaattgg aatgctggag gacatggcag
     2461 tcggcatttc agatttgagg aaagttgcat ttaaaataac tgaagccacg tccaatgatg
     2521 tccttcctgt tctcacgggg agacgggaac actatgtggt ggaggtcaag cttccagcta
     2581 cagtatttga gtcgctccca ctgcagatta aagaaggcca gttgcttcat gtgtatcccg
     2641 ttctgtttaa tgtcggaatc aatgagcagc agactctggc tgagaggttt ggagatgttt
     2701 ctttgcaaga aagtattaat caagaaaatt ttgaacttgt acaagaatat tattcaatat
     2761 ttatggaaaa gatgcctcct gattatattt cacattttca agaacaaact gatttaaaag
     2821 gactgttgga caatctccac caaaatattc aagccaaaaa aagaaagaat gtagaaatca
     2881 tgtggctggc agcaacgatt tgtcggaaac tcaatggcat tcgttttacc tgctgtaaaa
     2941 gtgccaaaga caggacatcg atgtcggtga cactggaaca gtgctccatc ctgagagacg
     3001 agcatcaact gcacaaagac tttttcatca gagctttaga ttgcatgaga agagaaggat
     3061 gccgcataga gaatgtactg aagaatatca aatgcaggag gtatgctttc aacatgctac
     3121 agctgatggc tttccccaag tgctacagac ctccagaagg cacttatgga aaagctgaca
     3181 cctaatttta ccatcatgga gacaaacagg aacacaaata cactgagctt tgaagatctc
     3241 cacctctgtc atttttattt ttttatcgtt atgagtaggg tgaggcgctc atgagtgttg
     3301 ctcccatgaa gaccagtaca ttactcagaa agcaacccag atctgaagtc ttaccagcac
     3361 ttccgtgtcc agtctatctg ttctcctttg tgttaacaca cctcactggt tgaggttagt
     3421 tgagaaagtg taattccatt tgtagggtat ttaaataaaa catgtcctga gaaaactagg
     3481 ttgttcccat ggtgccaggg atgacttgga gaatgccacc ctccacctaa gcaaataaac
     3541 gtccatgtga tgctacttta gagtcctgac tgcagacaac ctcagagtcc agcttactgg
     3601 cttttatata atatgtgtat agtaaatgca attagggatt ggcaaaacat gcccttgatt
     3661 actgacatgg tttgcaggta tgcttgtaca aatctttgtc atccacttca gatgtgatcc
     3721 cactttctaa gctagtagat gaaagtgtga tcagagtcat gagctacaac aaaaatctat
     3781 ggcttttcac aaaactgatg tgggttgggt aacccaccta gacacagcaa tgtagagcct
     3841 gtaatggtat agtgggaaaa cactttaagg cactaaagtt acaaagaaat ttaaggatag
     3901 tgcctgctga tgacccaaat gcaaatctcc agcagcttaa aattcacttg gaaaaattca
     3961 tgagagagag agaggagtat tatgagatgt ttcctgggag tcctcttaag tgtgtaaatt
     4021 tgctttttgt cataggtcaa tatatgtgaa gtaaataacc ctaaaacatg tgtgtagcca
     4081 taaacagtaa taaatcaaca cagtacctgt cagctaattc ttacagtaaa ataacaccaa
     4141 atgtaaaatt actaatattc caagttagtc atttccttgg agactacgtt gcaagagaag
     4201 tgaatgaatt aaggcactgg acttgatgac tgtagaatag ccatctcagc cacccttgcc
     4261 atcttgctct ttaaacttcc taacctacag ctttcttctt ctagattgct gtgctatgtg
     4321 tgaatattga cagaggagag ccaaataaaa attagaattt atcactgaat taacattcag
     4381 aataaagtga tataaaaaag tttattcttc cttttctcca agctcatatc tccccagagc
     4441 atgctagagg cttcttacat tgatagttct ctgctatgac ttcattcata gagccatatt
     4501 gcttatcttc atgtgtataa catgatagcc atttgcctaa aaggctccct tcctgtaaag
     4561 gtttttcaag tagccatata gtcccacgtt gagttttcca agagactgaa aacagaagat
     4621 gaccctcaga ggcttctcac agtggaaata tccattcttt ttaaaggtaa tgacctatgg
     4681 ctgttaccaa actatttata gccttcaaaa agaaaaataa tgcatttata tataaaatta
     4741 tcttagtgtt cacagactta gtctctgttt tagtcattta gtataatgtt tgtaattatt
     4801 ctgtttttat caaggtggta agatttgtgg ttaattttgt tactgtactg agtttaaggt
     4861 agagagagtt gtgacccaag agtgtctatt cctgatcttt tcttagtatc tcaagtagag
     4921 atatgcagtc caggacacat tatataattt aaggtcatct tgattcaaat atggtaaata
     4981 tttattaacc agaaagccaa taccagggtt tcccagtttt gcatgacatt tcataggata
     5041 cattttcttt gtcaataaat gcttatgtag aaatatcaaa ggttgacctc tctaatgcac
     5101 aggaatgaag ttttactcat tgacagcagc agcatttcct atggggatca gacgtgtgta
     5161 catcctcgcc agaggagttt aacaagaaaa ttcctatttc ctaagtgtga ctgctcttct
     5221 ctaaatgcac tcaggcaacc aagccatgac acatcattac caagactttc agaaccaaac
     5281 attaaatgaa acctttaaaa aaatctccct ttcctaaaca tagctgcagc catacagctc
     5341 tatcagcagc cttcctactg tctcaaacgt gcttccattt aagagccata ccagcaggcg
     5401 gatctgcgga gatcatgtag agtcaaacaa tttatcaaga aaataacata tccaaacatt
     5461 gaagtgggtt tttttctttc tttctcaaaa aaaaaatgct tttcttctta acaactgcag
     5521 gtatcaattc tggtttaact atttacagag caatcagaga aatgtattaa aagcaaaaaa
     5581 aggagagcac acccatgctt attatccaaa ggtctagagt ttgtgtgttt tctcaggaca
     5641 actaaatatc tctttgaaac atctgattga agaaaaggta catttgtgtg caccacgcca
     5701 ctgagtttcc acctctgctt ttctgcctaa aatattgctt tgagctttac cacacgctgc
     5761 ttaaaacagc ttctaaatgc taacattttg gtcagtctgg taacccagta gagccatgat
     5821 aactgtatga tgtagctgat gaattcttta aaaccagtcc ctccccagtc atgcagcact
     5881 ccctatggcc actagacatg caataaacca ttgcttctga cagacagtgc tgccttgaaa
     5941 gccagcacag actgggtcat acagcaccgc ccccccattt tcacacatta aatgattaga
     6001 aaaaaatgtg attttttttt tctagtcaga tccctccctc tgcacctctg caaagatgtt
     6061 gtgccaggag gctttcttcc aggggtccct gaggtggctg attcatgaga ggttttcatt
     6121 gagttttctg gaattgtaca aaataactgc tacacgcgac catgattagc catgttatga
     6181 aatgactttg ttaaaagtaa agatgaaaat aaaatcttgt aacttcctgc cttttttcta
     6241 tcagattttg ctatctatta tatttctaag tgtagttagc ccttatggtt ctgcactgtt
     6301 caaattcttt gttgataata tgcaaccgtg aaccactaga ctccacattt aggaacacaa
     6361 tgttggtatc ttgaaatcac ccactgtggg aatatttaaa ccacagaaat tgccaaatgt
     6421 tataaactag gatatttatt ttttagaaca ccagttgtta aacatttacc agccagagta
     6481 tggctccatg ccactacaaa tattcttttt tcctccagaa aataacaaat tattggaagg
     6541 aggataattt tagaatggtt tttaaaggaa agcagtcttt tatcagatta ttataatttt
     6601 attgtagatt ttatcttcct taaggaactt atatccagta tactggatac ttatatttat
     6661 tcataattca gttactaaaa ataaagcaat tgttttatta attaaattaa tcatctgctg
     6721 caagtagtcc ttagaatcct agctttatta taaataatat gtcaccacca aattcaggaa
     6781 agtgttaatt taatcataat accccaaaat tcataagttt aagattatgt tattgttgaa
     6841 ataaaagcag atttatatca ttatacccaa tgtttactaa attgagcaca gttgaaaccc
     6901 attttgttta attaaataaa ttctggcaat atagcaagaa agcatagata tacatatttg
     6961 attctgacat gtgtggcaca acattttagt ccaatctgtg ggacacattt tataatctct
     7021 taagaaataa atgaattttg aaacacattt gaggaatatg tctgagacac actgatcagc
     7081 atctgtggag agcagtatat cggacacaaa acatttctaa tagttagaac ctgtataaaa
     7141 tatacgatgt tcataactga aaagaataat taatttttaa gaactagaat gatttattga
     7201 catttttaac ataaattcat attcatccag cctacctcca atccgtgtaa gctatgattc
     7261 catatttatc atgttagctt ttaaagtaaa agaggagggg cttacattta tcttttcttt
     7321 ctctgacagc ttgaaattag aagtttccac acaaagatgc taactatagc aaatattgac
     7381 ttcaaaaata caaagctaat aaccagtggt tttgataaaa tacagtatgc cagtcagtat
     7441 ggagataagg aacaaaaatt tgcactcttt attttttttt ctgagcaatg gggcatgtta
     7501 gtttctcttt gtattttatt tctaagactc caaaatacaa ccattcttct aattaagagg
     7561 gccatataat acttaactag aaaaaggggt gcatataagg taatgctaat ctccaaaatg
     7621 gtgaatgcaa ttggttttcc tacacttaga tttgcactca ggcatgcata cttaaggaag
     7681 tagaagctca gaatttagtt acagagaatg tgggtattag tgtaaataca acttgcataa
     7741 atgattctgt ctgtaagcca tgtgccatag atgcatgtta gcacaatctg caatgcagta
     7801 aaagcgatat ttaaggaaag aggtataaac cattctgtgg tggaagaata gatttttcca
     7861 taatatttct acaatcttta aaattattcc tagataacaa agggcaaagt gtaacattct
     7921 gtcttttata ataatctgcg aatttggcca atatttctgt aatacctgtg taatttttta
     7981 agacgagtca tgtcatgatc aacagcaaaa cctatctcgc gttgaaaagc cttcacagtt
     8041 ttcaaagggc agaaccttca tttatctgtg catgccccac cctttgtgca ttctttgtga
     8101 acattttttc ttttaattta atgcatcttc agtttcctgt agtactcatt tgaaaggttg
     8161 gcacttgctt tctttttatg ttagatatat attctagata aaccaataat gtgttgtatt
     8221 cccatatgtc atggaaatga gtcatgtgta ggtcacttta tattagaatt ggaagaaata
     8281 tcacatccat tttattttct gtaaatcata ttcattgtgt actgtatgta tatttttgtt
     8341 gaaataaata tggctttatt tttatgt
//
