LOCUS       NM_001024617            4429 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus inositol polyphosphate-4-phosphatase, type II
            (Inpp4b), transcript variant 2, mRNA.
ACCESSION   NM_001024617 XM_006530859 XM_134427
VERSION     NM_001024617.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4429)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4429)
  AUTHORS   Peng,V., Trsan,T., Sudan,R., Bhattarai,B., Cortez,V.S., Molgora,M.,
            Vacher,J. and Colonna,M.
  TITLE     Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK
            cells through an AKT-driven pathway
  JOURNAL   J Exp Med 221 (3) (2024)
   PUBMED   38197946
REFERENCE   3  (bases 1 to 4429)
  AUTHORS   Zhang,M., Ceyhan,Y., Mei,S., Hirz,T., Sykes,D.B. and Agoulnik,I.U.
  TITLE     Regulation of EZH2 Expression by INPP4B in Normal Prostate and
            Primary Prostate Cancer
  JOURNAL   Cancers (Basel) 15 (22), 5418 (2023)
   PUBMED   38001678
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4429)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   5  (bases 1 to 4429)
  AUTHORS   Saffi,G.T., Wang,C.A., Mangialardi,E.M., Vacher,J., Botelho,R.J.
            and Salmena,L.
  TITLE     Inhibition of lipid kinase PIKfyve reveals a role for phosphatase
            Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics
            through VPS34 activity
  JOURNAL   J Biol Chem 298 (8), 102187 (2022)
   PUBMED   35760104
  REMARK    GeneRIF: Inhibition of lipid kinase PIKfyve reveals a role for
            phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome
            dynamics through VPS34 activity.
REFERENCE   6  (bases 1 to 4429)
  AUTHORS   Maekawa,M., Terasaka,S., Mochizuki,Y., Kawai,K., Ikeda,Y.,
            Araki,N., Skolnik,E.Y., Taguchi,T. and Arai,H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   7  (bases 1 to 4429)
  AUTHORS   Balakrishnan,A. and Chaillet,J.R.
  TITLE     Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in
            the generation of ovarian teratomas
  JOURNAL   Dev Biol 373 (1), 118-129 (2013)
   PUBMED   23078915
  REMARK    GeneRIF: Hyperactivation of the PI3K/AKT pathway caused by the
            decrease in INPP4B in granulosa cells promotes an ovarian
            environment defective in folliculogenesis and conducive to teratoma
            formation.
REFERENCE   8  (bases 1 to 4429)
  AUTHORS   Ferron,M., Boudiffa,M., Arsenault,M., Rached,M., Pata,M.,
            Giroux,S., Elfassihi,L., Kisseleva,M., Majerus,P.W., Rousseau,F.
            and Vacher,J.
  TITLE     Inositol polyphosphate 4-phosphatase B as a regulator of bone mass
            in mice and humans
  JOURNAL   Cell Metab 14 (4), 466-477 (2011)
   PUBMED   21982707
  REMARK    GeneRIF: In vivo mice deficient in Inpp4b displayed increased
            osteoclast differentiation rate and potential resulting in
            decreased bone mass and osteoporosis
REFERENCE   9  (bases 1 to 4429)
  AUTHORS   Ferron,M. and Vacher,J.
  TITLE     Characterization of the murine Inpp4b gene and identification of a
            novel isoform
  JOURNAL   Gene 376 (1), 152-161 (2006)
   PUBMED   16631325
  REMARK    GeneRIF: Inpp4bbeta localized to the Golgi apparatus whereas
            Inpp4balpha was mainly cytosolic, suggesting a different cellular
            function for this isoform.
REFERENCE   10 (bases 1 to 4429)
  AUTHORS   Barnache,S., Le Scolan,E., Kosmider,O., Denis,N. and
            Moreau-Gachelin,F.
  TITLE     Phosphatidylinositol 4-phosphatase type II is an
            erythropoietin-responsive gene
  JOURNAL   Oncogene 25 (9), 1420-1423 (2006)
   PUBMED   16247441
  REMARK    GeneRIF: This study provides first insight for a physiological role
            of PI-4-phosphatase II in the proerythroblast by controlling Epo
            responsiveness through a negative regulation of the PI3K/Akt
            pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ296611.1, BC064813.1, AC115778.11 and AK139397.1.
            
            On or before Jul 5, 2014 this sequence version replaced
            XM_006530859.1, NM_001024617.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               DQ296611.1         1-299
            300-645             BC064813.1         2-347
            646-646             AC115778.11        101172-101172       c
            647-4420            BC064813.1         349-4122
            4421-4429           AK139397.1         3898-3906
FEATURES             Location/Qualifiers
     source          1..4429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 39.02 cM"
     gene            1..4429
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /note="inositol polyphosphate-4-phosphatase, type II"
                     /db_xref="GeneID:234515"
                     /db_xref="MGI:MGI:2158925"
     exon            1..236
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            237..299
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            300..363
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..566
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            567..611
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..730
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            731..847
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            848..927
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1039
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1112
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1260
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1391
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1496
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1605
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1783
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1987
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2153
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2326
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2450
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2568
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2709
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2807
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2920
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3075
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..4429
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4401..4406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4419
                     /gene="Inpp4b"
                     /gene_synonym="E130107I17Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggcgggcgg agcgtgagct gccagcccag agcagggagc ggggagcggg gaggctcggc
       61 ccgcgccctg cacgctacca tcctccgggt tcccagcccc gggtgctgag ctcgccgcta
      121 taaatagcag gttacagctt ctgcttgggc gcacacgctt tcactggaga acgcaggaaa
      181 gtcatcctga aaagtgtctg ccgctgctat cgccccctac tcagcctctg caagagaacc
      241 caaagaaatg gtgtcacctg gcaagagatc tgccgtgttt catgaaaaaa cagcccaaga
      301 gccctaaaac cagcgaaaca ataatcaaag gtacaaggtg ttgaagaaca caacctatat
      361 cagaatttca cagtggacta ttaatgtgaa gatacgccaa cgttaaaccg gagctcatta
      421 tttggtacca tttgaaaaag acaccgtgga gaataggtcc gttgtgaggt ggatcatgga
      481 aatcaaagag gaaggaacat cagaagaagg ccagcatttt cttcctgcag ctcaggcaaa
      541 tgaccctgag gacattcagt ttaccagcat ccagaagatt ccgaacgagc cacagttgga
      601 attcattctc gcctgcaggg atcttgtggc tcctgtcagt gatcggaaac tgaatacagt
      661 agtccagatc tcagtaatcc acccggtgga gcagaccctg acgaggtact ccagcacaga
      721 aattgtggag ggaacaaaag acccactgtt cctaacgggt gtcacattcc caccggacta
      781 ccccatctat gaagagacaa gaataaaact gacagtctac gatgtcaagg ataagtctca
      841 tgatactaga agcttcctgg gctgtgccag ttttaaagtt ggggagctgc tgaagtccaa
      901 ggagcagctg ctgtccctga gcctgagaac ctcagatggt ggcaaagtgg tcggcaccat
      961 agaagtcagc ctcgtgaaga tgggagagat tgaggatggg gacaccgacc acatcacaac
     1021 agatgtgcag ggacaaaagt gtgcactaat gtatgaatcc acagcaccag aaagtctgag
     1081 cgggaaggaa aacttacctt ttatgaatgc agtcttaagg aatcctgtgt gtaagctgta
     1141 tagattcccc acatctgaca ataagtggat gcgaatccgt gagcagatgt cagaaagcat
     1201 cctttctttt catattccta aggaattgat ttcccttcac ataaaagaag acttatgtag
     1261 aaaccaggag ttaaaagaac ttggtgacct ttccccacac tgggacaacc tacggaaaaa
     1321 tgtcctttct cactgtgatc aaatggtgac tatgtaccaa gacattctga cagaactttc
     1381 caaagaaaca gggtcctctt tcaaatccag cagcagcaaa ggagagaaaa cattagaatt
     1441 tgttccagta aatctacact tgcaacggat gcaggtgcac agccctcacc tgaaagatgc
     1501 tctctatgat gtcatcactg tgggggcccc agctgcccat tttcagggat tcaagaacgg
     1561 tggtcttcgt aaactcctcc ataggtttga gacagagaga aggaacaccg gctaccagtt
     1621 tatttactat tcacctgaga acacagcgaa ggcaaaggaa gttctcagca gcatcaatca
     1681 gctacaacct ctcatagcaa ctcatgcaga cctgctgcta acctctgcca gccagcgttc
     1741 tccagacagc ctgaagagct ctttaaagct gctttcagaa aaaactgagc tttttgtcca
     1801 tgccttcaag gaccagctgg tcaggagtgc tcttttagct ctctacactg caaggccagg
     1861 aggcatcctt aagaagccac cctctcctaa tgtcagcaca gaggagaaaa gtactcagca
     1921 tgatacccca cagcttagaa gacaagactc cataccacat cattctgact atgatgaaga
     1981 agagtgggat agggtgtggg ccaacgtggg gaagagcctg aactgcatta tcgctaaagt
     2041 agacaaactg atcgagagag acagtcacaa cgaagaaggt gctggaggca gcagtagcaa
     2101 ggatggagag gcagaccata ccctggaaga ttccatcaca tctcacccac gtgaggactg
     2161 gtatgaacag ctgcacccac tcatccttac cttgaaggag tgcatgggag aagtggtgaa
     2221 ccgagcaaag caatccctga catttgtact gcttcaggaa ctggcctaca gtctgcccca
     2281 gtgtttgatg ctgactctga gaagagacat tgtcttcagt caggcgcttg ctggattggt
     2341 ttgtggtttt atcatcaaat tacatacaag tttgcatgac cctggcttcc tacagcagct
     2401 tcatacagtg ggcttgatag tacaatacga aggactgcta agtacttaca gtgatgaaat
     2461 tggaatgctg gaggacatgg cagtcggcat ttcagatttg aggaaagttg catttaaaat
     2521 aactgaagcc acgtccaatg atgtccttcc tgttctcacg gggagacggg aacactatgt
     2581 ggtggaggtc aagcttccag ctacagtatt tgagtcgctc ccactgcaga ttaaagaagg
     2641 ccagttgctt catgtgtatc ccgttctgtt taatgtcgga atcaatgagc agcagactct
     2701 ggctgagagg tttggagatg tttctttgca agaaagtatt aatcaagaaa attttgaact
     2761 tgtacaagaa tattattcaa tatttatgga aaagatgcct cctgattata tttcacattt
     2821 tcaagaacaa actgatttaa aaggactgtt ggacaatctc caccaaaata ttcaagccaa
     2881 aaaaagaaag aatgtagaaa tcatgtggct ggcagcaacg atttgtcgga aactcaatgg
     2941 cattcgtttt acctgctgta aaagtgccaa agacaggaca tcgatgtcgg tgacactgga
     3001 acagtgctcc atcctgagag acgagcatca actgcacaaa gactttttca tcagagcttt
     3061 agattgcatg agaagcagac aaacccaggg agccttgaat gaatccgatg atcctgagac
     3121 aggctgccta actgataaca agccaacttc tcgacacttc tatcctgtcg ccttgcttct
     3181 tgtcagctca cacctgctag ttgtgtggct tattttaagt cttgcattac tcttagccaa
     3241 ataccaataa gttttatgtt gtgttccttg cttttctaca aatgacaatg gactttaatt
     3301 ctggggacaa tgttgtaaga tttctacatt ttcagattca cagaacttaa aaaaaaacta
     3361 gaagaaatgt ttgaattgtg gttttgtttt gtttttgttt ttccctaaaa cttaaaggca
     3421 aaaggtacta tgcattaagt ggattatttt gctcttttgt tcatggaaaa gtgttttacc
     3481 tactgttaaa tagctaaaga caagttttta acttattgtc tttggaataa gacaaagaat
     3541 agaatcctgc aagcttgaag ttccgaacct cctcttccca ggtcatttat taaagaaatt
     3601 aggtctgaca ttgtgcagca gttaagcccc caagacaatc cgggaagcgg aggttgcaga
     3661 ctttctttcc actgtgctaa tattaacata gttgtcatcg gctgatcgaa atgtgtctgc
     3721 tttcttactc tgttcctagt caccccttac tcatccatgt gtttaacctt cttctgtcaa
     3781 gtgactttat ggaaagaatg gctatttctg ttttgtaatt aaattaacct gtttgtaact
     3841 cttgtttggg ttgacttggc tttcagacta cttttctatt ctttttaaca aggtctcatt
     3901 tgtgtcttga tgcgccattt ttagcacctg tgacttttgt actgctggag aggaacggct
     3961 gttcagaaag ccattttctc tctgcaatgc atagctaaaa caatgaggta aagtagggat
     4021 ggaatttcct ttaaaaatct atagggccag acttaataaa ttaaatgcct tattcctaga
     4081 actgcatcct tagggctaca tgtagatttt aatgtgtttt aagggacaga tagttaattt
     4141 gtggaaaagt tatacaaagg cagatatatt tatgaaatta aagtaaagct gtattgtgaa
     4201 gcaaattata tttaaagagt ttattaaaag tcaaataact gttaagaaac ttaatcatat
     4261 ctttccgaag gcaataatgg tattgggcct ggcctaggat ttaattttgt aagatgtatc
     4321 atcacttgtg gaaaaacaaa atgtagagtt gaatctttgt tatttttact tggactgttg
     4381 ctgcaactct gcattgaaca aataaagcat atttatttat tctgtgttt
//
