LOCUS       NM_030266               5748 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus inositol polyphosphate-4-phosphatase, type I (Inpp4a),
            transcript variant 1, mRNA.
ACCESSION   NM_030266
VERSION     NM_030266.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5748)
  AUTHORS   Arvind,M., Pattnaik,B., Gheware,A., Prakash,Y.S., Srivastava,M.,
            Agrawal,A. and Bhatraju,N.K.
  TITLE     Plausible role of INPP4A dysregulation in idiopathic pulmonary
            fibrosis
  JOURNAL   Physiol Rep 12 (9), e16032 (2024)
   PUBMED   38720166
  REMARK    GeneRIF: Plausible role of INPP4A dysregulation in idiopathic
            pulmonary fibrosis.
REFERENCE   2  (bases 1 to 5748)
  AUTHORS   Xu,Y., Tong,X., Liu,P., Huang,J., Chen,S., Liu,D., Gu,T., Xie,Y.,
            Guo,D. and Xu,Y.
  TITLE     Deficiency of INPP4A promotes M2 macrophage polarization in
            eosinophilic chronic rhinosinusitis with nasal polyps
  JOURNAL   Inflamm Res 73 (4), 581-595 (2024)
   PUBMED   38363325
  REMARK    GeneRIF: Deficiency of INPP4A promotes M2 macrophage polarization
            in eosinophilic chronic rhinosinusitis with nasal polyps.
REFERENCE   3  (bases 1 to 5748)
  AUTHORS   Tran,D.M., Yoshioka,N., Bizen,N., Mori-Ochiai,Y., Yano,M.,
            Yanai,S., Hasegawa,J., Miyashita,S., Hoshino,M., Sasaki,J.,
            Sasaki,T. and Takebayashi,H.
  TITLE     Attenuated cerebellar phenotypes in Inpp4a truncation mutants with
            preserved phosphatase activity
  JOURNAL   Dis Model Mech 16 (7) (2023)
   PUBMED   37415561
  REMARK    GeneRIF: Attenuated cerebellar phenotypes in Inpp4a truncation
            mutants with preserved phosphatase activity.
REFERENCE   4  (bases 1 to 5748)
  AUTHORS   Zhou,Y., Zhang,T., Yan,Y., You,B., You,Y., Zhang,W. and Chen,J.
  TITLE     MicroRNA-223-3p regulates allergic in fl ammation by targeting
            INPP4A
  JOURNAL   Braz J Otorhinolaryngol 87 (5), 591-600 (2021)
   PUBMED   32631807
  REMARK    GeneRIF: MicroRNA-223-3p regulates allergic in fl ammation by
            targeting INPP4A.
REFERENCE   5  (bases 1 to 5748)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5748)
  AUTHORS   Shin,H.W., Hayashi,M., Christoforidis,S., Lacas-Gervais,S.,
            Hoepfner,S., Wenk,M.R., Modregger,J., Uttenweiler-Joseph,S.,
            Wilm,M., Nystuen,A., Frankel,W.N., Solimena,M., De Camilli,P. and
            Zerial,M.
  TITLE     An enzymatic cascade of Rab5 effectors regulates phosphoinositide
            turnover in the endocytic pathway
  JOURNAL   J Cell Biol 170 (4), 607-618 (2005)
   PUBMED   16103228
REFERENCE   7  (bases 1 to 5748)
  AUTHORS   Ivetac,I., Munday,A.D., Kisseleva,M.V., Zhang,X.M., Luff,S.,
            Tiganis,T., Whisstock,J.C., Rowe,T., Majerus,P.W. and Mitchell,C.A.
  TITLE     The type Ialpha inositol polyphosphate 4-phosphatase generates and
            terminates phosphoinositide 3-kinase signals on endosomes and the
            plasma membrane
  JOURNAL   Mol Biol Cell 16 (5), 2218-2233 (2005)
   PUBMED   15716355
REFERENCE   8  (bases 1 to 5748)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5748)
  AUTHORS   Nystuen,A., Legare,M.E., Shultz,L.D. and Frankel,W.N.
  TITLE     A null mutation in inositol polyphosphate 4-phosphatase type I
            causes selective neuronal loss in weeble mutant mice
  JOURNAL   Neuron 32 (2), 203-212 (2001)
   PUBMED   11683991
REFERENCE   10 (bases 1 to 5748)
  AUTHORS   Vyas,P., Norris,F.A., Joseph,R., Majerus,P.W. and Orkin,S.H.
  TITLE     Inositol polyphosphate 4-phosphatase type I regulates cell growth
            downstream of transcription factor GATA-1
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13696-13701 (2000)
   PUBMED   11087841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133096.3, BY274715.1, AF317838.1, AK149414.1, AK035867.1 and
            AC084390.1.
            
            On Mar 20, 2014 this sequence version replaced NM_030266.3.
            
            Transcript Variant: This variant (1) uses several alternate
            in-frame splice sites in the coding region, compared to variant 3.
            The encoded protein (isoform 1) is shorter than isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF317838.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC133096.3         47853-47909         c
            58-470              BY274715.1         1-413
            471-1003            AF317838.1         24-556
            1004-1610           AK149414.1         929-1535
            1611-1979           AF317838.1         1164-1532
            1980-2170           AK035867.1         857-1047
            2171-2432           AF317838.1         1724-1985
            2433-3134           AK035867.1         1277-1978
            3135-3267           AF317838.1         2688-2820
            3268-5748           AC084390.1         90106-92586
FEATURES             Location/Qualifiers
     source          1..5748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.46 cM"
     gene            1..5748
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /note="inositol polyphosphate-4-phosphatase, type I"
                     /db_xref="GeneID:269180"
                     /db_xref="MGI:MGI:1931123"
     exon            1..281
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..343
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            344..553
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..3267
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /EC_number="3.1.3.66"
                     /note="isoform 1 is encoded by transcript variant 1; type
                     I inositol 3,4-bisphosphate 4-phosphatase; 4-Ptase-1;
                     inositol polyphosphate 4-phosphatase-1; inositol
                     polyphosphate-4-phosphatase type I A"
                     /codon_start=1
                     /product="inositol polyphosphate-4-phosphatase type I A
                     isoform 1"
                     /protein_id="NP_084542.2"
                     /db_xref="CCDS:CCDS35539.1"
                     /db_xref="GeneID:269180"
                     /db_xref="MGI:MGI:1931123"
                     /translation="MTAREHSPRHGARARAMQRASTIDVAADMVGLSLAGNIQDPDEP
                     ILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA
                     FFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAES
                     DRVGNITVIGWQMEEKSDQQPPVTRSLDTVNGRMVLPVDESLTEALGIRSKYASLRKD
                     SLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCE
                     LEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFV
                     PTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEE
                     CCTSSSGQSIIYIPQDITRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLA
                     ILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMA
                     RWAGRSSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDAFPC
                     SSTCSSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQDSAP
                     TIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLS
                     TYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASNDMLPVITGNRDGFNVRIPLPGPL
                     FDSLPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQ
                     FKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTS
                     CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYA
                     FNSLQLKAFPKHYRPPEGTYGKVET"
     exon            554..598
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..717
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            718..834
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..914
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1026
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1117
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1265
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1396
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1501
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1610
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1628
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1812
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2031
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2170
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2203
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2376
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2500
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2627
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2768
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2866
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2979
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3134
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..5748
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5721..5726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5744
                     /gene="Inpp4a"
                     /gene_synonym="107kDa; 9630012D15; D130048C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcggt cggggagtgg ggcgcgcatg cgcggtgagg gggcggaacc ggggcggggt
       61 tgtgcgctgt gttctgagag aaggcggtgg caggattcgg gctgcgcggg gacggcgggt
      121 tcgggtctgg ggtggacgcc accggccgga gtgaggcggc caggaaacaa atcccggccg
      181 gtcttcagga ccggacagca accagcgggg ccgaggccgg ggtgtgcggc ctggaggaca
      241 gaggccaagg ctgagcaagt gtccgggccg gggcgcgcca gatgatggat ctggatgtcc
      301 ttctgtgacg caatgccacg tggtccaaaa gcaagcatgt atgggctact gccatcgtag
      361 gagtccaggg cctggagacg gctctgcttt gaggaatcag gtgaggtgtg acccaggaac
      421 aagaagcata ccctcaccaa tgacatcatg acagcaagag agcacagccc tcgccatggt
      481 gccagggccc gtgcgatgca gcgggcttcc accattgacg tggcagccga catggttggc
      541 ctctctttgg caggaaatat ccaagatcca gatgagccca ttttagaatt cagcttagct
      601 tgcagtgagc tgcacactcc atcgctagat cgaaaaccaa atagttttgt ggctgtgagt
      661 gtcaccaccc ctccgcaggc gttctggacg aagcacgcac agacggagat catcgaggga
      721 accaacaacc ctatctttct aagcagcatt gccttctttc aagactccct tatcaatcag
      781 atgacccaga tcaagctgtc tgtgtatgat gtcaaagaca gatctcaggg aacaatgtac
      841 ttactgggct ctggaacatt cgtggtcaaa gatctgctcc aggacaggca tcacagattg
      901 catctgacac tgaggtctgc agagagtgac cgtgtcggca acataactgt gatcggctgg
      961 cagatggagg agaagtccga ccagcagccc cctgtgaccc ggtctctgga cactgtcaat
     1021 ggaaggatgg ttctgcccgt tgatgaaagc ttgactgagg ccttgggaat ccgatccaaa
     1081 tatgcttctt tgcgaaaaga cagcttactg aaagcagtgt ttggtggtgc catctgccgc
     1141 atgtaccgct tcccaactac tgatggtaac cacctacgga tcctggagca gatggcagag
     1201 agcgtcctct ccctgcacgt gcctcggcag tttgtgaagc tactgctgga agaagatgca
     1261 gccagggtat gtgagttgga agagttgggg gagctgtccc cttgctggga gagcctccgg
     1321 cgccagattg tcacccagta tcagactatc atcctcacct accaggagaa tctgactgac
     1381 ctccatcagt acaaaggtcc ttcctttaaa gcaagcagtt tgaaagcaga taaaaagtta
     1441 gaatttgttc ccacaaacct gcacatacaa cggatgcgag ttcaagatga tggaggctca
     1501 gatcagaact acgatgtcgt cactattgga gccccagcag cacactgcca aggttttaag
     1561 tcaggaggtc ttcgaaaaaa gctgcacaag tttgaagagg ccaagaaaca cagttttgag
     1621 gagtgttgta catcttctag tggccagtcc atcatctaca taccacagga catcacccga
     1681 gccaaggaga tcattgccca gatcaacacc ctaaaaaccc aggtcagcta ctacgcggaa
     1741 cggctctcaa gggctgcgaa ggacaggtca gctactggcc ttgagaggac tctcgccatc
     1801 ttggcagaca agactcggca gttggtgact gtctgtgact gtaagctgct ggccaactcc
     1861 atccatgggc tgaatgcagc tcggcccgac tacatcgctt ccaaggcctc ccctacctcg
     1921 actgaggagg agcaggtgat gcttcggaat gaccaggaca ccctgatggc caggtgggcg
     1981 gggagaagca gccggtcttc cctgcaggtg gactggcatg aggaggagtg ggagaaagtg
     2041 tggctgaatg tggacaagag cctggagtgc atcattcagc gggtggacaa gctgctgcag
     2101 aaggagcgtc tgcatgggga gggctgcgag gatgctttcc cctgttcgag cacctgctcc
     2161 agcaagaaag attgcagccc ccctcctgaa gagtccagtc caggtgagtg gagcgaggcc
     2221 ctttaccctc tgctgaccac cctcacagac tgtgtggcca tgatgagcga caaggccaag
     2281 gcagccatgg tcttcctgct catgcaggac agtgccccca ccattgcctc gtacctcagc
     2341 ctgcagtatc gccgtgacgt cgtcttctgc caaaccctga cagccctcat ctgtggcttt
     2401 atcatcaagc tgaggaactg cctgcacgac ggtggcttcc tgcggcagct ctacaccatc
     2461 ggccttctgg cccagtttga gagcctgctg agcacctacg gagaggagtt ggccatgttg
     2521 gaggacatga gccttggaat catggacctg aggaatgtga cctttaaagt cactcaggcc
     2581 acttcgaatg catcaaatga catgctgccg gtcatcacag gaaaccggga tggctttaac
     2641 gtgcggatcc ctctgccagg cccactgttt gactccctcc ccagagagat ccagagtggc
     2701 atgctgctgc gggtgcagcc tgtcctcttc aacgtgggca tcaatgagca acagacactg
     2761 gctgagaggt ttggagatac gtccttacaa gaagttatca atgtggagag cttggtgcgg
     2821 ttaaattcct actttgagca gtttaaggag gttttgccgg aggactgtct acctcgatct
     2881 cggagtcaga cctgccttcc agagctgctg cggttcctgg gacagaatgt ccatgcacgc
     2941 aagaataaga atgtggacat cctctggcaa gctgctgagg tctgtcgccg ccttaacggg
     3001 gtccgattca ccagctgcaa gagtgccaag gaccgcacag ccatgtcggt gaccctggag
     3061 cagtgtctga tcctgcagca cgagcacggc atggccccgc aggtcttcac acaagccctg
     3121 gagtgcatgc gcagtgaggg ttgtcggcga gaaaacacaa tgaagaatgt tggaagtcgc
     3181 aaatatgcat ttaactccct gcagctgaag gccttcccca agcattacag gcctccagaa
     3241 gggacttacg gaaaagttga gacatgaaca cacggtttcc tctaattagc tgttacgtaa
     3301 tcaatgtggg tccctgtagt gtcacataag attcttcaag aagacctgaa ggattggctt
     3361 ttatttttgt gtttttaaag acacgtcact gaagagtgta tggagcatga ttttgtgctg
     3421 gaatctgtag ggtcacatgt gggtcaatag cgtggatagt aatggctgct ctcaacacca
     3481 gctttcagct gtcactgtac cgttaatgtc atagttccta gatgccagct aggtctgcta
     3541 aaactccagc agacttttca aatatccact tagccctgct caccccgttt atttttctat
     3601 tcagtaactc acaggtgagc attgacttaa actctgcttt aaaaaggact gaatataaaa
     3661 caggaagtac ctaccccctt acacttcagg tccttggtag aacagtagat gttaactcag
     3721 cttgggggaa aagaacctcc aagctatgag agaggctggt tctagtggcc ctcaaaggcc
     3781 gccaggttct gtgaaaccca aagtagaaag aaagcttggt tggtcatatc aggagctcac
     3841 acacctgggg ccacactgtt cctgcccctt acaagtcata gatgagtgtt tgcttgagat
     3901 gtaaagccag ctgtgaggtc cctggacgct gcttcccacc ccacctccac ccctgtatgc
     3961 tccatgtata tttagctcta ccccacaggg tgtatctccc tttgttctct ggcaatcagg
     4021 accttcaatg tggcttgtca tgggtctggg agacaactct ccagatggag atttagagcc
     4081 ggagagacag tcgaaactta gatattttca gaataaatgt gcttctggga actttctaat
     4141 aatcttccag aggctgtata ttatgtttga atgtctagag aaagggtctt agtttctggt
     4201 ttgcaatgat ggttaagtct cccttctgtt tcacagctat tgagaaacag ttaaacctgt
     4261 cccctacctt gagagtctaa gaggagatta tgggacagga aatgagggat ttcatacact
     4321 ttagtctgtt catcttttac aaggtgatga tgagtcttat ctgcacgtgg cagattcttt
     4381 tccttagaga tttatgtttt ataggttctg ttcatcgtaa ttctgtttat atgttattta
     4441 aaaggctgta aaaaagaagt gtatctggac tgtattcatg acactgatac taatggtctg
     4501 tgaccaccat gggattctta gagaagtcta gctagttttt tcttgttttg tttttttgtt
     4561 ttttttgttt ttgttttgtt ttggtttttt gttttttgtt tttttttttt tttttttttt
     4621 tttttttggc tccttttaga aacaggtaac agcttggatc tgggacattt gaggcttaag
     4681 caggaccagt cttggcaaga gtcagggagg gtgcaggcat ccctctccat aagtgcagac
     4741 agcctcctgt ctcccctgcc tgctgggagg aagatgtgct ctgctaaggg gtggtgtggc
     4801 tcactgcccc accctctagg cagggctgtg gaaggtgaga gccaggaagc tctcttcccc
     4861 taaccctcct cccaggcctg ctctgctggt atcagattgg cctgaagccc caggcctgat
     4921 caaagatggc tgagtctcag tgtggctggt tgagcctttt aactcttggt tggttcattt
     4981 actcttagtc ttttgttttt tgtttgtttg gttttgctca ttttgacatc actgcctttt
     5041 agaaatattt cttcaggttt tagaattaaa tgtttcccac gttctccagc tttcctttct
     5101 gtccaaaggg catttgacct gtccacactt acaaagggaa cgggcggggc tgacgcatcc
     5161 gtaggcttct ggatgggaac tcttttcgcc gtttctgttt tataatatga atcactgtaa
     5221 aactctaaga cttggctaat cacagaaaag attgtggctt cagtgttttc tctgaaggct
     5281 ttgtgactgg tttccagagc ctcacacatg cctggaaggg tcatctcgca cagcgtgggc
     5341 tcagcaagct cctgggctgc gcacaggggc caagctgttc cctgcaggag gaaaagagtt
     5401 ttccagacgg cccgtcctgc ttctatcccc atttaaagga acgtgcagtc tccggtcagc
     5461 tgggaatgcc gtgcggatcc tgtcagagct cctgcagctc agctgccttt actgtccttt
     5521 aaagatgtaa agatgttgta cagaactgtt tcctctcccg acacttggat ttgcccagct
     5581 tagtgcattt aaatactttt atttatttat ttgtttggga cagtattaat atatatgaac
     5641 atatagtcac tgttttatat attcttagct tattcaaagc catgtatgct gtaaatgtgc
     5701 ttgtctttag aatgataaat aataaaactg acaagaacat taaactga
//
