LOCUS       NM_008384               1786 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus inositol polyphosphate-1-phosphatase (Inpp1), mRNA.
ACCESSION   NM_008384
VERSION     NM_008384.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Majerus,P.W., Kisseleva,M.V. and Norris,F.A.
  TITLE     The role of phosphatases in inositol signaling reactions
  JOURNAL   J Biol Chem 274 (16), 10669-10672 (1999)
   PUBMED   10196133
  REMARK    Review article
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Levy,N., Boettger-Tong,H., Dohmae,K., Agoulnik,A.I., Ty,T.I.,
            Nishimune,Y. and Bishop,C.E.
  TITLE     Physical and genetic linkage of glutaminase (Gls), signal
            transducer and activator of transcription 1 (Stat1), and xeroderma
            pigmentosum complementation group G (Xpg) on mouse proximal
            chromosome 1
  JOURNAL   Genomics 54 (2), 355-356 (1998)
   PUBMED   9828143
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Varfolomeev,E.E., Schuchmann,M., Luria,V., Chiannilkulchai,N.,
            Beckmann,J.S., Mett,I.L., Rebrikov,D., Brodianski,V.M.,
            Kemper,O.C., Kollet,O., Lapidot,T., Soffer,D., Sobe,T.,
            Avraham,K.B., Goncharov,T., Holtmann,H., Lonai,P. and Wallach,D.
  TITLE     Targeted disruption of the mouse Caspase 8 gene ablates cell death
            induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal
            prenatally
  JOURNAL   Immunity 9 (2), 267-276 (1998)
   PUBMED   9729047
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Acharya,J.K., Labarca,P., Delgado,R., Jalink,K. and Zuker,C.S.
  TITLE     Synaptic defects and compensatory regulation of inositol metabolism
            in inositol polyphosphate 1-phosphatase mutants
  JOURNAL   Neuron 20 (6), 1219-1229 (1998)
   PUBMED   9655509
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Okabe,I. and Nussbaum,R.L.
  TITLE     Identification and chromosomal mapping of the mouse inositol
            polyphosphate 1-phosphatase gene
  JOURNAL   Genomics 30 (2), 358-360 (1995)
   PUBMED   8586440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713450.1, AK078382.1 and BY700907.1.
            
            [WARNING] On Aug 1, 2024 this sequence was replaced by NM_008384.3.
            
            On Mar 21, 2008 this sequence version replaced NM_008384.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078382.1, U27295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               BY713450.1         2-114
            114-1772            AK078382.1         2-1660
            1773-1786           BY700907.1         370-383
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..1786
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /note="inositol polyphosphate-1-phosphatase"
                     /db_xref="GeneID:16329"
                     /db_xref="MGI:MGI:104848"
     exon            1..287
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            288..539
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            540..600
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..801
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            802..976
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1776
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1776
                     /gene="Inpp1"
                     /gene_synonym="2300002C06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtgttttcc tggcggcttg ccctccggct gtgcccgcca caggaggatt gcgccaggtc
       61 ccagcgcgac cacctccagg cgttggcact cccttcctcc tctctcgccc ctcctccgcc
      121 tcttccgttt ctctgggaaa ggctgtatcc tccttggggc tctgcatcct cgcttaggta
      181 atccgctttc ctgctttcgc cacccctccc cggtgtccag cgtctccacc tccgcgcatt
      241 tgggtccccg cgagcctcgc gcgctccatc gcctctgcag agggcagctg tgagccagag
      301 ggtgggtgag gctgagaaag aagcaggctt tagaaatgtc agacatcctc ctggagctgc
      361 tctgtgtctc cgagaaggct gctaacatcg ccagggcgtg caggcagcag gagaccctct
      421 tccagctgct cattgaggag aagaaaggtg cagagaagaa caagaagttt gctgcagatt
      481 tcaagaccct ggcggatgtg ctggtgcagg aagttataaa acagaacatg gaaaacaagt
      541 ttccaggctt ggggaaaaaa gtttttggag aagaatccaa tgagtttaca aatgatttgg
      601 gggaaaagat cacagtggag ctgcagtcca cggaggagga gacggcagag cttctcagca
      661 aggtccttaa cggcaacatg ccggcatcgg aagcgctggc tcaggtggtt catgaggacg
      721 tggacttaac tgatcccacg ctggagtccc tggacatcag catccctcac gagagtcttg
      781 ggatttgggt ggatcccatt gattcaacct atcagtatat taaaggttct gccaatgtta
      841 aatccaacca aggaattttc cccagcggac ttcagtgtgt aaccatttta attggcgtgt
      901 atgacctaca gacaggcctg cccctaatgg gagtcatcaa tcagcctttt gcgtcccaaa
      961 acctaactac tttaaggtgg aagggacagt gctactgggg cctttcgtac atggggacca
     1021 acatccattc cctgcagctc gccatctcta aaagcgacag tgaaacccag actgaaaact
     1081 cggacagaga gttctccagc cccttttctg cagtcatcag taccagcgaa aaagacacca
     1141 tcaaagctgc tctttcgcgc gtgtgcggag gtagcgtctt ccccgcggca ggggctggct
     1201 acaagagcct ctgtgtaatc cagggcttgg ctgacattta catcttctca gaggacacca
     1261 cgtacaagtg ggactcctgt gccgcccacg ccattctgag ggccatgggt gggggcattg
     1321 tagacatgaa agagtgctta gagagaagtc cagacacggg gttggatttg ccacagctgc
     1381 tgtatcatgt ggaaaataaa ggtgcttctg gggtggaact ctgggccaac aagggagggc
     1441 tgatagctta caggtccagg aatcggctgg acaccttcct gagccgcctc atccaaaacc
     1501 tcgggcctgt aaagacacaa gcataagact catctcaggg cccttcagcc gaactgcatc
     1561 ttttcctgtt atctcttgaa gatagttttg tcccactggt taaaattcac cttcctgttt
     1621 tgaggaacat tttctcatta tgtgttcatg atgtgaattt tagtaaatta gtggcatttg
     1681 tgtcacagtt aagttggtat atgacatcgt tatatgaaca ttgtgctgtt attgttgctt
     1741 ggaacccttc aataaaatac caagggagga gcaaaaaaaa aaaaaa
//
