LOCUS       NM_026574               6354 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus INO80 complex subunit (Ino80), mRNA.
ACCESSION   NM_026574 XM_355376
VERSION     NM_026574.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6354)
  AUTHORS   Chakraborty,P. and Magnuson,T.
  TITLE     INO80 regulates chromatin accessibility to facilitate suppression
            of sex-linked gene expression during mouse spermatogenesis
  JOURNAL   PLoS Genet 20 (10), e1011431 (2024)
   PUBMED   39405305
  REMARK    GeneRIF: INO80 regulates chromatin accessibility to facilitate
            suppression of sex-linked gene expression during mouse
            spermatogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6354)
  AUTHORS   Ren,Z., Zhao,W., Li,D., Yu,P., Mao,L., Zhao,Q., Yao,L., Zhang,X.,
            Liu,Y., Zhou,B. and Wang,L.
  TITLE     INO80-Dependent Remodeling of Transcriptional Regulatory Network
            Underlies the Progression of Heart Failure
  JOURNAL   Circulation 149 (14), 1121-1138 (2024)
   PUBMED   38152931
  REMARK    Erratum:[Circulation. 2024 Apr 2;149(14):e1066. doi:
            10.1161/CIR.0000000000001235.. PMID: 38557126]
REFERENCE   3  (bases 1 to 6354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6354)
  AUTHORS   Thang,N.X., Han,D.W., Park,C., Lee,H., La,H., Yoo,S., Lee,H.,
            Uhm,S.J., Song,H., Do,J.T., Park,K.S., Choi,Y. and Hong,K.
  TITLE     INO80 function is required for mouse mammary gland development, but
            mutation alone may be insufficient for breast cancer
  JOURNAL   Front Cell Dev Biol 11, 1253274 (2023)
   PUBMED   38020889
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6354)
  AUTHORS   Chakraborty,P. and Magnuson,T.
  TITLE     INO80 requires a polycomb subunit to regulate the establishment of
            poised chromatin in murine spermatocytes
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35006254
  REMARK    GeneRIF: INO80 requires a polycomb subunit to regulate the
            establishment of poised chromatin in murine spermatocytes.
            Erratum:[Development. 2023 Jul 15;150(14):dev202158. doi:
            10.1242/dev.202158.. PMID: 37449853]
REFERENCE   6  (bases 1 to 6354)
  AUTHORS   Min,J.N., Tian,Y., Xiao,Y., Wu,L., Li,L. and Chang,S.
  TITLE     The mINO80 chromatin remodeling complex is required for efficient
            telomere replication and maintenance of genome stability
  JOURNAL   Cell Res 23 (12), 1396-1413 (2013)
   PUBMED   23979016
  REMARK    GeneRIF: The mIno80 chromatin remodeling complex plays important
            roles in telomere replication, HDR-mediated repair of dysfunctional
            telomeres, and maintenance of genome stability.
REFERENCE   7  (bases 1 to 6354)
  AUTHORS   Gospodinov,A., Vaissiere,T., Krastev,D.B., Legube,G., Anachkova,B.
            and Herceg,Z.
  TITLE     Mammalian Ino80 mediates double-strand break repair through its
            role in DNA end strand resection
  JOURNAL   Mol Cell Biol 31 (23), 4735-4745 (2011)
   PUBMED   21947284
  REMARK    Erratum:[Mol Cell Biol. 2012 Mar;32(5):1030]
REFERENCE   8  (bases 1 to 6354)
  AUTHORS   Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J.,
            Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y.
  TITLE     A YY1-INO80 complex regulates genomic stability through homologous
            recombination-based repair
  JOURNAL   Nat Struct Mol Biol 14 (12), 1165-1172 (2007)
   PUBMED   18026119
  REMARK    GeneRIF: observations reveal a link between YY1 and INO80 and roles
            for both in homologous recombination-based repair, providing new
            insight into mechanisms that control the cellular response to
            genotoxic stress
REFERENCE   9  (bases 1 to 6354)
  AUTHORS   Bakshi,R., Mehta,A.K., Sharma,R., Maiti,S., Pasha,S. and
            Brahmachari,V.
  TITLE     Characterization of a human SWI2/SNF2 like protein hINO80:
            demonstration of catalytic and DNA binding activity
  JOURNAL   Biochem Biophys Res Commun 339 (1), 313-320 (2006)
   PUBMED   16298340
REFERENCE   10 (bases 1 to 6354)
  AUTHORS   Bakshi,R., Prakash,T., Dash,D. and Brahmachari,V.
  TITLE     In silico characterization of the INO80 subfamily of SWI2/SNF2
            chromatin remodeling proteins
  JOURNAL   Biochem Biophys Res Commun 320 (1), 197-204 (2004)
   PUBMED   15207721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844862.12 and AL929318.11.
            
            On Apr 25, 2018 this sequence version replaced NM_026574.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AL844862.12        102379-102687       c
            310-495             AL844862.12        83081-83266         c
            496-665             AL844862.12        81572-81741         c
            666-733             AL844862.12        81385-81452         c
            734-895             AL844862.12        79056-79217         c
            896-1016            AL844862.12        76330-76450         c
            1017-1231           AL844862.12        75003-75217         c
            1232-1285           AL844862.12        73205-73258         c
            1286-1489           AL844862.12        71856-72059         c
            1490-1685           AL844862.12        70461-70656         c
            1686-1753           AL844862.12        69447-69514         c
            1754-1963           AL844862.12        67383-67592         c
            1964-2044           AL844862.12        66613-66693         c
            2045-2140           AL844862.12        64375-64470         c
            2141-2200           AL844862.12        59149-59208         c
            2201-2343           AL844862.12        58191-58333         c
            2344-2428           AL844862.12        56928-57012         c
            2429-2546           AL844862.12        55988-56105         c
            2547-2632           AL844862.12        53477-53562         c
            2633-2800           AL844862.12        51900-52067         c
            2801-2934           AL844862.12        51589-51722         c
            2935-3002           AL844862.12        50705-50772         c
            3003-3096           AL844862.12        50259-50352         c
            3097-3268           AL844862.12        48605-48776         c
            3269-3409           AL844862.12        43321-43461         c
            3410-3635           AL844862.12        37402-37627         c
            3636-3763           AL844862.12        31816-31943         c
            3764-3858           AL844862.12        27330-27424         c
            3859-3931           AL844862.12        17853-17925         c
            3932-4090           AL844862.12        8350-8508           c
            4091-4193           AL844862.12        7864-7966           c
            4194-4282           AL844862.12        6910-6998           c
            4283-4438           AL844862.12        4966-5121           c
            4439-4598           AL844862.12        4563-4722           c
            4599-4814           AL844862.12        2347-2562           c
            4815-6354           AL929318.11        160858-162397       c
FEATURES             Location/Qualifiers
     source          1..6354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..6354
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /note="INO80 complex subunit"
                     /db_xref="GeneID:68142"
                     /db_xref="MGI:MGI:1915392"
     exon            1..309
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..495
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..5032
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /EC_number="3.6.4.12"
                     /note="DNA helicase INO80; yeast INO80-like protein;
                     putative DNA helicase INO80 complex homolog 1; INO80
                     complex subunit A; DNA helicase-related protein INO80; DNA
                     helicase-related INO80 complex homolog 1"
                     /codon_start=1
                     /product="chromatin-remodeling ATPase INO80"
                     /protein_id="NP_080850.2"
                     /db_xref="CCDS:CCDS16602.1"
                     /db_xref="GeneID:68142"
                     /db_xref="MGI:MGI:1915392"
                     /translation="MASELGAGDDGSSTELAKPLYLQYLERALRLDHFLRQTSAIFNR
                     NISSDDSEDGLDDNNPLLPESGDPLIQVKEEPPNSLLGETSGASSSGLLNPYSLNGVL
                     QSESKSDKGNLYNFSKLKKSRKWLKSILLSDESSEADSQSEDNDDEEEELSLSREELH
                     NMLRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEDK
                     KLKAKLKKVKKKRRRDEEFSSEESPRHHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLN
                     ARRRKVWLSIVKKELPKANKQKSSARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKET
                     LPRARRLTKEMLLYWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLIT
                     QTELYAHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFK
                     AQALKNAENAYHIHQARTRSFDEDAKESRAAALRAADKSGSGFGESYSLANPSIRAGE
                     DIPQPTIFNGKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERE
                     NIWGPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSQKTLYTQDA
                     PFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLT
                     GTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSRLHMI
                     LKPFMLRRIKKDVENELSDKIEILTYCQLTSRQKLLYQALKNKISIEDLLQSSMGSTQ
                     QAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYEISKFIYRHGQIRVFN
                     HSRDRWLKVLLSPFAPDYIQQSLFHRKGINEGSCFSFLRFIDVSPAEMANLMLQGLLA
                     RWLALFLSLKASYRLHQLRSWAEPDGTSHQSYLRNKDFLLGVDFPLSFPNLCSCPLLK
                     SLVFSSHCKAVSGYSDHVVHQRRSATSSLRCCLLTELPSFLCVASPRVTAVPLDSYCN
                     DRSAEYERGVLKEGGSLAAKQCLLNGAPELATDWLSRRSQFFPEPAGGLLSIRPQNGW
                     SFIRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHT
                     YMRLDGSSKISERRDMVADFQTRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPT
                     VDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTL
                     KPKEVVSLLLDDEELEKKLRLRQEEKRQQEESNRVKERKRKREKYAEKKKKEDELDGK
                     RRKEGVNLVIPFVPSADNSNLSADGDDSFISVDSAMPSPFSEISISSELHTGSIPPDE
                     SSSDMLVIVDDPASSAPQSRATNSPASITGSVSDTVNGISIQEVPAAGRGHSARSRGR
                     PKGSGSTAKGAGKGRSRKSTAGSAAAMAGAKAGAAAASAAAYAAYGYNVSKGISASSP
                     LQTSIVRPAGLADFGPSSASSPLSSPLNKGNNIPGTPKSLHMTSSLASDSLIRKQGKG
                     TNPSGGR"
     exon            496..665
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..733
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..895
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1016
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1231
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1285
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1489
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1685
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1753
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1963
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2044
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2140
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2200
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2343
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2428
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2546
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2632
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2800
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2934
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3002
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3096
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3268
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3409
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3635
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3763
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3858
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3859..3931
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4090
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4193
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4282
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4438
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4598
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4814
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..6354
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6324..6329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /note="hexamer: AATAAA"
     polyA_site      6354
                     /gene="Ino80"
                     /gene_synonym="2310079N15Rik; 4632409L19Rik; Inoc1"
                     /note="major polyA site"
ORIGIN      
        1 tatggcgcct ctcctccccc ccgccatggc tccccgtgtc cctgctccgc tcctctcagt
       61 gagtgaaagt ggccgccgcc gccgccggcc cagcgcccgc agccgcctca gcgccgccgc
      121 catcttgggg tcccaggagc cgccgaggga gcgagctagg agcgttcccg tccaacgcag
      181 tcaccgtccc tcggcctccg agagcgaagc gcggctccac agtcggcggg gcgacccccc
      241 cctccggacc ccgcccgccc cccgcccccc ctccgccgcc gccgcggcgg cggggcccct
      301 cggcccgagc tgtgcagttg gaggtcctcg tgcatgaaga caaatttgtt ctatggcctc
      361 ggagttgggt gccggggacg atggcagcag cactgagctg gcaaagcccc tttatcttca
      421 gtacctggag agagccttgc ggttggacca ctttctgcga caaacatcag ccatcttcaa
      481 caggaatatt tctagtgatg acagtgaaga tggactggat gacaataatc ccttattgcc
      541 tgagtctggg gatcccttaa tacaagtaaa agaagagcct ccaaattcat tgcttggcga
      601 aacctctgga gcaagcagtt ctgggttgtt gaacccatat tcactgaacg gcgttctgca
      661 gtcagaatca aaatctgaca aggggaattt atataacttc tctaagttga agaaaagcag
      721 aaagtggcta aagagcattc ttttaagtga tgagtccagt gaggcagatt ctcagagtga
      781 agacaatgat gatgaagaag aagaactcag tctcagcaga gaagaacttc acaacatgct
      841 tcgattacac aaatataaga aacttcacca aaataaatat agtaaagata aggagttgca
      901 gcagtaccag tactacagtg caggcctgct ctctacatac gaccctttct atgagcaaca
      961 gcgccacttg cttggaccca aaaagaagaa attcaaggaa gacaagaagc ttaaagccaa
     1021 gttgaaaaaa gtgaagaaaa aaagaagacg tgatgaagag ttttcctctg aagaatctcc
     1081 acgtcaccac catcaccaga ccaaagtctt tgctaagttt tctcatgatg cacctccccc
     1141 tggcaccaag aagaaacact tatccattga gcagcttaat gcccgccgca ggaaagtgtg
     1201 gctgagcatc gtgaaaaagg aactaccaaa ggccaacaag cagaagtctt cagctcgaaa
     1261 cttatttctt accaatagcc gaaagcttgc ccatcaatgc atgaaggagg tgcgtcgagc
     1321 tgctttgcaa gcacagaaaa actgtaagga gactctgcct cgagcccggc gcctaacaaa
     1381 agagatgctt ctgtactgga agaagtatga gaaggtggag aaggagcacc gcaagcgagc
     1441 agagaaggaa gctctggagc agcgcaagtt ggatgaggaa atgcgggagg ccaagaggca
     1501 acaacgaaaa ctcaacttct taatcactca gacagaattg tatgctcatt ttatgagtcg
     1561 aaaacgtgat atgggtcatg atggaatcca ggaagaaatc ttaaggaaac tagaagatag
     1621 ttctacccag agacaaattg acattggtgg aggagtggtg gttaacatca cccaagaaga
     1681 ctatgatagt aaccatttta aagcccaggc cctgaagaat gctgaaaatg cttatcatat
     1741 tcaccaagct cgaacaaggt catttgatga agatgcaaaa gaaagtcggg cagctgccct
     1801 tagggcagca gacaagtctg gctctgggtt tggggagagt tatagcttag caaatccatc
     1861 tatccgggcc ggtgaggata ttccgcaacc cactattttc aatggcaagt tgaaaggtta
     1921 ccagctgaaa ggcatgaact ggttagcaaa tttatatgaa cagggtatta atggaattct
     1981 tgctgatgaa atgggtcttg gtaaaactgt acagagcatt gccctcctgg cccatctggc
     2041 tgagagagaa aacatttggg gacctttctt aataatttca cctgcttcta cacttaataa
     2101 ttggcaccag gagtttacaa gatttgttcc taaatttaag gtgctaccat attggggaaa
     2161 tcctcatgat agaaaagtta tccggagatt ctggagtcag aagaccttat atactcagga
     2221 tgcccccttt catgtggtca tcactagcta ccagctggtg gttcaggatg tcaagtactt
     2281 ccagcgggtc aagtggcaat acatggtact ggatgaagct caggcactga agagcagttc
     2341 cagtgttcgt tggaagattc tcttacaatt ccagtgtcga aatcgacttt tgttaactgg
     2401 aacccccatt cagaatacca tggcagagct ctgggctctg ctacatttca ttatgccaac
     2461 attatttgat tcgcatgaag aatttaatga atggttttcc aaagacattg aaagtcatgc
     2521 tgaaaacaaa tctgctattg atgagaatca actctctcgt ttacacatga tcttgaaacc
     2581 atttatgctg agaagaatca aaaaagatgt agaaaatgaa ttgtctgaca agattgagat
     2641 tctaacgtac tgccaattga ccagtcgaca aaaactctta tatcaggcac taaagaataa
     2701 aatttccatt gaggacttac tgcagtcttc aatgggctcc acacaacaag cacagaacac
     2761 caccagcagc ctcatgaatt tagtcatgca attcaggaag gtgtgtaatc acccagagtt
     2821 attcgaacgg caagaaacgt ggtctccatt tcatatttct ctaaagccat atgaaatttc
     2881 gaagtttatt tatcgtcatg gacagatcag ggtcttcaac cactcacgag ataggtggtt
     2941 gaaggttctt ctctctccgt ttgcaccaga ttatatccag cagtctctct tccataggaa
     3001 aggtattaat gaaggaagct gtttttcttt ccttcgattt attgatgtct cgccagcaga
     3061 aatggcaaac ctcatgcttc agggactttt ggccaggtgg ttagctcttt tcctatctct
     3121 gaaagcctcc tacaggctcc accagctgcg ctcttgggca gagccggatg ggacaagcca
     3181 tcagagctat ctgagaaaca aggattttct tctcggagtt gatttcccac tttccttccc
     3241 taacctttgc agctgccctt tgttaaagtc tcttgttttc agcagccact gtaaagcagt
     3301 gagtggctac tcagaccatg ttgtccatca gcggagatca gctacctcct cacttcgttg
     3361 ctgcctcctc actgagctgc cgtctttttt gtgtgtggcc agtccacgag tcaccgcagt
     3421 gccgttggat tcttactgta atgacagaag tgcagagtat gagagaggag ttctgaagga
     3481 aggagggagt ctggctgcca agcagtgttt gttgaatggg gctcctgagc tggctacgga
     3541 ttggctgagt cgcagatccc agttcttccc agagccagct ggagggctgc tgagcattag
     3601 accccagaac ggctggtctt tcatcagaat tccaggcaag gagagcctca tcactgacag
     3661 tggaaagctg tatgcccttg atgtcctgtt gactcggctc aagtctcaag gacatagggt
     3721 ccttatctac tctcagatga ccagaatgat agacctgctg gaggaatata tggtatacag
     3781 gaagcatacc tacatgaggc tggatggctc gtccaagatc tcagagagac gggacatggt
     3841 ggctgatttt cagaccagga acgacatctt tgtgtttctg ttaagcacgc gagctggagg
     3901 actgggtatc aatctcacag ctgcagacac agtgattttc tacgacagtg actggaaccc
     3961 cactgtagac cagcaggcca tggatagggc ccaccgcttg gggcaaacaa aacaggtcac
     4021 tgtgtaccgg cttatctgta aaggcacaat tgaggagcgt attctgcaga gagccaagga
     4081 aaagagtgag attcagcgca tggtgatttc tggtgggaac ttcaaaccag ataccttgaa
     4141 acccaaagag gtggttagcc ttcttctaga tgacgaagaa ctggaaaaga aactgagact
     4201 gcggcaggaa gagaaacggc agcaggagga aagcaaccga gtgaaagaac gcaaacgcaa
     4261 gcgggagaag tacgcagaaa agaagaaaaa ggaagatgag ttggatggga agaggaggaa
     4321 agagggtgtg aacctcgtga tcccgtttgt tccctctgct gacaactcca acctctccgc
     4381 tgatggggat gattccttca tcagtgtcga ctcagccatg cccagccctt tcagtgagat
     4441 ctcaatcagc agtgaactgc acactggctc tattccccct gatgagagca gcagtgacat
     4501 gttagtcatc gtggatgacc cagcctcctc agcacctcag tcgagagcca ccaactctcc
     4561 tgcttccata acaggctctg tgtcagacac tgtgaatgga atttccattc aggaagtgcc
     4621 agctgcagga cgtggtcact cagctcgaag ccgaggccgc cccaagggtt caggaagcac
     4681 agccaaagga gcaggcaaag gccgaagccg caagtccact gcaggcagtg ctgctgcgat
     4741 ggcaggagcc aaagcagggg ctgcagcagc ttctgcagct gcttatgctg catacgggta
     4801 caatgtgtct aaaggaatct ccgcaagcag tcctctgcag acatccattg tccgacctgc
     4861 tggccttgca gactttggac cttcaagcgc ctcttctccc ttaagttccc ctctgaacaa
     4921 aggaaataat attcctggga ctcctaaaag cctccacatg accagcagcc tagcctcaga
     4981 ctccttgatc cggaaacagg gcaaaggcac caacccctct ggaggacggt aaccatggta
     5041 accatctctg ccctctagct tccttcaacc aaaccagggg ctacagtcct gagccatagg
     5101 tggtctttgg atggcttgcc tagtgtggca tcttgcatcc tatttggaga gtggaaagga
     5161 ccagttgtag caggagagaa caggcaggtg gttggtgtga gcacttttat cacctgtttc
     5221 caaaggaata tcctgggttc ggccccacag catcttagat gtactctgca gccgtactct
     5281 taacctcttt ctggggacgg gcctgacaca gaaccctttt atagatgctc aggcacactg
     5341 tctccatccc catcctactc ttcagctctg accatgtccc tcatgaaagc tccatgggtg
     5401 ctgtgaagag ccttccatag tggagacttg tctaaaggtt atggtttcct gcaggactag
     5461 ggaggaagtg gttccctggc atccatagtc tgggaccgct cctgggtctc taaaccctgt
     5521 ttgccacagt gtcatcactg aagaacagaa cacagtgaat gccagagaag atggtggctg
     5581 taaggatgag aggctggagc aagcagagcc acaggcagtt atcccagcat ttcctcctgt
     5641 ccagcacagt tcacaccagg gaagctttag gtcccaccag caacagtagc agcagctccc
     5701 actcaaggga cttcccagaa gccagtaaag agaccaggaa ccacctcaat cagcaggaca
     5761 tcctcaccac cctcttgcag atgccccttt gcccatcctg aatgcacagc ctccccggct
     5821 ttgcccttca gcccctgctt ggctgtatgc actgtctgta ttgcactgag aaagaaggga
     5881 cagcaggagt gagatgggga gggagctggc tcagcaccac ccctcccagc cctgccccac
     5941 tcgcctgagc ttgctgccct ctgagagggg aaaagggcgg ctgggagggc tttccacctg
     6001 atgtccctgg tggaacaggt gcttctgggc gggccagcct ctaatttgca cacctgaaat
     6061 cgcggaattg agtttagata gattgatttt ttaaacactt tttttttttt tggagtaggt
     6121 gtaggggaat catttaattt aaatcataaa gattccccta cccaaaccct gactcctgtg
     6181 tacagatgct ctttagaggg aatcagaaaa atgccaagcc tttttttctc tttgaatgtg
     6241 ctgtctattt ttataactga acttgtacat atgtataaag agagacacat ctttctttta
     6301 ctaactggat aaaaaaaatc ttaaataaaa tggagtgaga taattttatg taaa
//
